This article deals with phenomena occurring at the interface of the existential, the religious, and scientific inquiry. On the basis of in-depth interviews with Polish physicists and biologists, I examine the role that science and religion play in their narrative of the meaning of the Universe and human life. I show that the narratives about meaning have a system-related character that is associated with responses to adjacent metaphysical questions, including those based on scientific knowledge. I reconstruct the typical amalgam questions (...) of Polish scientists and come to a conclusion about the stability of religious and nonreligious amalgams in this group. Critically referring to the thesis concerning the secularizing impact of science, I conclude that science by itself does not have a destructive effect on Polish scientists’ confidence that life and the Universe are meaningful, but is rather an exacerbating factor of the existing worldview system. (shrink)