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  1. Interdisciplinarity in the Making: Models and Methods in Frontier Science.Nancy J. Nersessian - 2022 - Cambridge, MA: MIT.
    A cognitive ethnography of how bioengineering scientists create innovative modeling methods. In this first full-scale, long-term cognitive ethnography by a philosopher of science, Nancy J. Nersessian offers an account of how scientists at the interdisciplinary frontiers of bioengineering create novel problem-solving methods. Bioengineering scientists model complex dynamical biological systems using concepts, methods, materials, and other resources drawn primarily from engineering. They aim to understand these systems sufficiently to control or intervene in them. What Nersessian examines here is how cutting-edge bioengineering (...)
  • Rethinking Ethnography for Philosophy of Science.Nancy J. Nersessian & Miles MacLeod - 2022 - Philosophy of Science 89 (4):721-741.
    We lay groundwork for applying ethnographic methods in philosophy of science. We frame our analysis in terms of two tasks: to identify the benefits of an ethnographic approach in philosophy of science and to structure an ethnographic approach for philosophical investigation best adapted to provide information relevant to philosophical interests and epistemic values. To this end, we advocate for a purpose-guided form of cognitive ethnography that mediates between the explanatory and normative interests of philosophy of science, while maintaining openness and (...)
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  • Mathematization in Synthetic Biology: Analogies, Templates, and Fictions.Andrea Loettgers & Tarja Knuuttila - 2017 - In Martin Carrier & Johannes Lenhard (eds.), Mathematics as a Tool: Tracing New Roles of Mathematics in the Sciences. Springer Verlag.
    In his famous article “The Unreasonable Effectiveness of Mathematics in the Natural Sciences” Eugen Wigner argues for a unique tie between mathematics and physics, invoking even religious language: “The miracle of the appropriateness of the language of mathematics for the formulation of the laws of physics is a wonderful gift which we neither understand nor deserve”. The possible existence of such a unique match between mathematics and physics has been extensively discussed by philosophers and historians of mathematics. Whatever the merits (...)
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  • Cognitive Instrumentalism about Mental Representations.Samuel D. Taylor - 2021 - Pacific Philosophical Quarterly 103 (3):518-550.
    Representationalists and anti-representationalists disagree about whether a naturalisation of mental content is possible and, hence, whether positing mental representations in cognitive science is justified. Here, I develop a novel way to think about mental representations based on a philosophical description of (cognitive) science inspired by cognitive instrumentalism. On this view, our acceptance of theories positing mental representations and our beliefs in (something like) mental representations do not depend on the naturalisation of content. Thus, I conclude that if we endorse cognitive (...)
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  • Specialisation and the Incommensurability Among Scientific Specialties.Vincenzo Politi - 2019 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 50 (1):129-144.
    In his mature writings, Kuhn describes the process of specialisation as driven by a form of incommensurability, defined as a conceptual/linguistic barrier which promotes and guarantees the insularity of specialties. In this paper, we reject the idea that the incommensurability among scientific specialties is a linguistic barrier. We argue that the problem with Kuhn’s characterisation of the incommensurability among specialties is that he presupposes a rather abstract theory of semantic incommensurability, which he then tries to apply to his description of (...)
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  • There Is "Noise," and Noise.Eleonora Montuschi - 2017 - Perspectives on Science 25 (2):204-225.
    What is noise? A tumultuous crowd is noisy or, more cheerfully, a group of students on holiday, or a flock of migrating birds. A loud conversation or loud laughter can be noisy if we are reading a philosophy article, or we are performing a physics experiment, or we are concentrating on a yoga exercise. In all such cases, noise is something that others do and that we unwillingly suffer, something that we perceive as an invasion of our perceptual space, or (...)
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  • Model templates within and between disciplines: from magnets to gases – and socio-economic systems.Tarja Knuuttila & Andrea Loettgers - 2016 - European Journal for Philosophy of Science 6 (3):377-400.
    One striking feature of the contemporary modelling practice is its interdisciplinary nature. The same equation forms, and mathematical and computational methods, are used across different disciplines, as well as within the same discipline. Are there, then, differences between intra- and interdisciplinary transfer, and can the comparison between the two provide more insight on the challenges of interdisciplinary theoretical work? We will study the development and various uses of the Ising model within physics, contrasting them to its applications to socio-economic systems. (...)
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  • Basic science through engineering? Synthetic modeling and the idea of biology-inspired engineering.Tarja Knuuttila & Andrea Loettgers - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):158-169.
    Synthetic biology is often understood in terms of the pursuit for well-characterized biological parts to create synthetic wholes. Accordingly, it has typically been conceived of as an engineering dominated and application oriented field. We argue that the relationship of synthetic biology to engineering is far more nuanced than that and involves a sophisticated epistemic dimension, as shown by the recent practice of synthetic modeling. Synthetic models are engineered genetic networks that are implanted in a natural cell environment. Their construction is (...)
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  • Design Methodologies and the Limits of the Engineering-Dominated Conception of Synthetic Biology.Tero Ijäs - 2018 - Acta Biotheoretica 67 (1):1-18.
    Synthetic biology is described as a new field of biotechnology that models itself on engineering sciences. However, this view of synthetic biology as an engineering field has received criticism, and both biologists and philosophers have argued for a more nuanced and heterogeneous understanding of the field. This paper elaborates the heterogeneity of synthetic biology by clarifying the role of design and the variability of design methodologies in synthetic biology. I focus on two prominent design methodologies: rational design and directed evolution. (...)
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  • Design Under Randomness: How Variation Affects the Engineering of Biological Systems.Tero Ijäs - 2018 - Biological Theory 13 (3):153-163.
    Synthetic biology offers a powerful method to design and construct biological devices for human purposes. Two prominent design methodologies are currently used. Rational design adapts the design methodology of traditional engineering sciences, such as mechanical engineering. Directed evolution, in contrast, models its design principles after natural evolution, as it attempts to design and improve systems by guiding them to evolve in a certain direction. Previous work has argued that the primary difference between these two is the way they treat variation: (...)
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  • Exploring biological possibility through synthetic biology.Tero Ijäs & Rami Koskinen - 2021 - European Journal for Philosophy of Science 11 (2):1-17.
    This paper analyzes the notion of possibility in biology and demonstrates how synthetic biology can provide understanding on the modal dimension of biological systems. Among modal concepts, biological possibility has received surprisingly little explicit treatment in the philosophy of science. The aim of this paper is to argue for the importance of the notion of biological possibility by showing how it provides both a philosophically and biologically fruitful category as well as introducing a new practically grounded way for its assessment. (...)
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  • Analogy and Composition in Early Nineteenth-Century Chemistry The Case of Aluminium.Sarah N. Hijmans - 2022 - European Journal for Philosophy of Science 12 (1):1-17.
    Around fifteen years before the chemical substance alumina could be decomposed in the laboratory, it was identified as a compound and predicted to contain a new element called ‘aluminium’. Using this episode from early nineteenth-century chemistry as a case study for the use of analogical reasoning in science, this paper examines how chemists relied on chemical classifications for the prediction of aluminium. I argue that chemists supplemented direct evidence of chemical decomposition with analogical inferences in order to evaluate the composition (...)
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  • Introduction: Interdisciplinary model exchanges.Till Grüne-Yanoff & Uskali Mäki - 2014 - Studies in History and Philosophy of Science Part A 48:52-59.
    The five studies of this special section investigate the role of models and similar representational tools in interdisciplinarity. These studies were all written by philosophers of science, who focused on interdisciplinary episodes between disciplines and sub-disciplines ranging from physics, chemistry and biology to the computational sciences, sociology and economics. The reasons we present these divergent studies in a collective form are three. First, we want to establish model-exchange as a kind of interdisciplinary event. The five case studies, which are summarized (...)
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  • When one model is not enough: Combining epistemic tools in systems biology.Sara Green - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):170-180.
    In recent years, the philosophical focus of the modeling literature has shifted from descriptions of general properties of models to an interest in different model functions. It has been argued that the diversity of models and their correspondingly different epistemic goals are important for developing intelligible scientific theories. However, more knowledge is needed on how a combination of different epistemic means can generate and stabilize new entities in science. This paper will draw on Rheinberger’s practice-oriented account of knowledge production. The (...)
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  • The simulation approach in synthetic biology.Gabriele Gramelsberger - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):150-157.
    Synthetic biology and systems biology are often highlighted as antagonistic strategies for dealing with the overwhelming complexity of biology (engineering versus understanding; tinkering in the lab versus modelling in the computer). However, a closer view of contemporary engineering methods (inextricably interwoven with mathematical modelling and simulation) and of the situation in biology (inextricably confronted with the intrinsic complexity of biomolecular environments) demonstrates that tinkering in the lab is increasingly supported by rational design methods. In other words: Synthetic biology and systems (...)
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  • The earth vibrates with analogies: The Dirac sea and the geology of the vacuum.Stefano Furlan & Rocco Gaudenzi - 2022 - Studies in History and Philosophy of Science Part A 93 (C):163-174.
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  • Noise and Synthetic Biology: How to Deal with Stochasticity?Miguel Prado Casanova - 2020 - NanoEthics 14 (1):113-122.
    This paper explores the functional role of noise in synthetic biology and its relation to the concept of randomness. Ongoing developments in the field of synthetic biology are pursuing the re-organisation and control of biological components to make functional devices. This paper addresses the distinction between noise and randomness in reference to the functional relationships that each may play in the evolution of living and/or synthetic systems. The differentiation between noise and randomness in its constructive role, that is, between noise (...)
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  • Skill Transmittance in Science Education.Brandon Boesch - 2019 - Science & Education 28 (1-2):45-61.
    It is widely argued that the skills of scientific expertise are tacit, meaning that they are difficult to study. In this essay, I draw on work from the philosophy of action about the nature of skills to show that there is another access point for the study of skills—namely, skill transmission in science education. I will begin by outlining Small’s Aristotelian account of skills, including a brief exposition of its advantages over alternative accounts of skills. He argues that skills exist (...)
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  • Contrasting Cases: The Lotka-Volterra Model Times Three.Tarja Knuuttila & Andrea Loettgers - 2016 - Boston Studies in the Philosophy of Science 319:151-178.
    How do philosophers of science make use of historical case studies? Are their accounts of historical cases purpose-built and lacking in evidential strength as a result of putting forth and discussing philosophical positions? We will study these questions through the examination of three different philosophical case studies. All of them focus on modeling and on Vito Volterra, contrasting his work to that of other theoreticians. We argue that the worries concerning the evidential role of historical case studies in philosophy are (...)
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  • An Artifactual Perspective on Idealization: Constant Capacitance and the Hodgkin and Huxley Model.Natalia Carrillo & Tarja Knuuttila - 2021 - In Alejandro Cassini & Juan Redmond (eds.), Models and Idealizations in Science: Fictional and Artefactual Approaches. Cham: Springer.
    There are two traditions of thinking about idealization offering almost opposite views on their functioning and epistemic status. While one tradition views idealizations as epistemic deficiencies, the other one highlights the epistemic benefits of idealization. Both of these, however, identify idealization with misrepresentation. In this article, we instead approach idealization from the artifactual perspective, comparing it to the distortion-to-reality accounts of idealization, and exemplifying it through the case of the Hodgkin and Huxley model of nerve impulse. From the artifactual perspective, (...)
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