Reaching understanding is one of our central epistemic goals, dictated by our important motivational epistemic virtue, namely inquisitiveness about the way things hang together. Understanding of humanly important causal dependencies is also the basic factual-theoretic ingredient of wisdom on the anthropocentric view proposed in the article. It appears at two levels. At the first level of immediate, spontaneous wisdom, it is paired with practical knowledge and motivation ( phronesis ), and encompasses understanding of oneself (a distinct level of self-knowledge having (...) to do with one’s dispositions capacities, vulnerabilities, and ways of reacting), of other people, of possibilities of meaningful life, and of relevant courses of events. It is partly resistant to skeptical scenarios, but not completely. On the second and reflective level, understanding helps fuller holistic integration of one’s first order practical and factual-theoretic knowledge and motivation, thus minimizing potential and actual conflicts between all these components. It also participates in the reflective control whose exercise is needed for full reflective wisdom, the crucial epistemic-practical virtue or human excellence. (shrink)