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  1. Evidence for personalised medicine: mechanisms, correlation, and new kinds of black box.Mary Jean Walker, Justin Bourke & Katrina Hutchison - 2019 - Theoretical Medicine and Bioethics 40 (2):103-121.
    Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...)
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  • The epistemic benefits of generalisation in modelling I: Systems and applicability.Aki Lehtinen - 2021 - Synthese 199 (3-4):10343-10370.
    This paper provides a conceptual framework that allows for distinguishing between different kinds of generalisation and applicability. It is argued that generalising models may bring epistemic benefits. They do so if they show that restrictive and unrealistic assumptions do not threaten the credibility of results derived from models. There are two different notions of applicability, generic and specific, which give rise to three different kinds of generalizations. Only generalising a result brings epistemic benefits concerning the truth of model components or (...)
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  • Verification and Validation of Simulations Against Holism.Julie Jebeile & Vincent Ardourel - 2019 - Minds and Machines 29 (1):149-168.
    It has been argued that the Duhem problem is renewed with computational models since model assumptions having a representational aim and computational assumptions cannot be tested in isolation. In particular, while the Verification and Validation methodology is supposed to prevent such holism, Winsberg argues that verification and validation cannot be separated in practice. Morrison replies that Winsberg overstates the entanglement between the steps. The paper aims at arbitrating these two positions, by stressing their respective validity in relation to domains of (...)
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  • Conceptual and Computational Mathematics†.Nicolas Fillion - 2019 - Philosophia Mathematica 27 (2):199-218.
    ABSTRACT This paper examines consequences of the computer revolution in mathematics. By comparing its repercussions with those of conceptual developments that unfolded in the nineteenth century, I argue that the key epistemological lesson to draw from the two transformative periods is that effective and successful mathematical practices in science result from integrating the computational and conceptual styles of mathematics, and not that one of the two styles of mathematical reasoning is superior. Finally, I show that the methodology deployed by applied (...)
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  • Social Epistemology and Validation in Agent-Based Social Simulation.David Anzola - 2021 - Philosophy and Technology 34 (4):1333-1361.
    The literature in agent-based social simulation suggests that a model is validated when it is shown to ‘successfully’, ‘adequately’ or ‘satisfactorily’ represent the target phenomenon. The notion of ‘successful’, ‘adequate’ or ‘satisfactory’ representation, however, is both underspecified and difficult to generalise, in part, because practitioners use a multiplicity of criteria to judge representation, some of which are not entirely dependent on the testing of a computational model during validation processes. This article argues that practitioners should address social epistemology to achieve (...)
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  • Similarity, Adequacy, and Purpose: Understanding the Success of Scientific Models.Melissa Jacquart - 2016 - Dissertation, University of Western Ontario
    A central component to scientific practice is the construction and use of scientific models. Scientists believe that the success of a model justifies making claims that go beyond the model itself. However, philosophical analysis of models suggests that drawing inferences about the world from successful models is more complex. In this dissertation I develop a framework that can help disentangle the related strands of evaluation of model success, model extendibility, and the ability to draw ampliative inferences about the world from (...)
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