Biography as a genre of historiography had been dismissed for some years, criticized for being conservative, resistant to theoretical approaches, and hostile to methodological innovations. But the predominance of a historiography devoted to structures, functions, and statistics has, however, led to a renewed interest in the human factor in history. This paper argues that the pluralism of methods and theories which has emerged thereafter reopened the case for an innovative biography, thus facilitating the convergence of general history and the history (...) of science. (shrink)

This essay explores connections between bacteriology and the disciplinary evolution of biochemistry in this country during the 1930s. Many features of intermediary metabolism, a central component of biochemistry, originated as attempts to answer fundamental bacteriological questions. Thus, many bacteriologists altered their research programs to answer these questions. In so doing they changed their disciplinary focus from bacteriology to biochemistry. Chester Hamlin Werkman's (1893-1962) Iowa State career illustrates the research perspective that many bacteriologists adopted. As a junior faculty member in the (...) Bacteriology Department in the late 1920s, Werkman faced a powerful professional dilemma: establishing a research identity that distinguished him from his colleagues with flourishing national and international reputations. His solution was to radically alter his research program from traditional bacteriology to a biochemistry program, which reflected the influence of the Dutch microbiologist/biochemist, Albert Jan Kluyver (1888-1956). Werkman was extremely successful in this career change. His laboratory made significant contributions to biochemistry, and Werkman achieved a notable degree of personal success. His career began in the shadow of his departmental bacteriological colleagues; within a decade he became the department's dominant research figure, as a biochemist. Werkman's personal success, however, had profound consequences for the disciplinary future of bacteriology at Iowa State. (shrink)

The last forty years have produced a dramatic reversal in leading accounts of science. Once thought necessary to (explain) scientific progress, a rigid method of science is now widely considered impossible. Study of products yields to study of processes and practices, .unity gives way to diversity, generality to particularity, logic to luck, and final justification to heuristic scaffolding. I sketch the story, from Bacon and Descartes to the present, of the decline and fall of traditional scientific method, conceived as The (...) Central Planning Bureau for Science or as Rationality Czar. I defend a deflationary account of method and of rational judgment,. with emphasis on heuristic appraisal and cognitive economy. (shrink)

I outline a pragmatic view of scientists' use of observation which draws attention to non-discursive, instrumental and social contexts of observation, in order to explain scientists' agreement about the appearance and significance of new phenomena. I argue that: observation is embedded in a network of activities, techniques, and interests; that experimentalists make construals of new phenomena which enable them communicate exploratory techniques and their outcomes, and that empirical enquiry consists of communicative, exploratory and predictive strategies whose interdependence ensures that, notwithstanding (...) the constructedness of representations and the empirical underdetermination of theories, observations contain information about the natural world. (shrink)