This article focuses on medical trials performed by Dr. Albert Kligman on the inmates of Philadelphia's Holmesburg Prison between 1951 and 1974, which have been widely criticized as exploitative. I seek to investigate the mechanics behind the “ethical blind spot” that enabled the American medical community to laud Kligman for his efforts while simultaneously condemning the medical atrocities of the Holocaust and supporting the development of the Nuremberg Code. I argue that this nonrecognition hinges on a colonial logic by which (...) certain populations are produced as waste, both rhetorically and materially. Drawing on the incarcerated men’s accounts included in Allen Hornblum’s books on the subject, I trace the process by which human beings come to be reclassified as natural resources and their exploitation recast as industrious cultivation. (shrink)