Despite decades of research and thought on the meaning and identification of revolutions in science, there is no generally accepted definition for this concept. This paper presents 13 different characteristics that have been used by philosophers and historians of science to characterize revolutions in science, in general, and in chemistry, in particular. These 13 characteristics were clustered into six independent factors. Suggestions are provided as to the use of these characteristics and factors to evaluate historical events as to their possible (...) categorization as revolutions in chemistry. Challenges to the goal of creating a consensus definition of “revolutions in science” are also presented in this publication. (shrink)

Multiple simultaneous independent discoveries, so well enunciated by Robert K. Merton in the early 1960s but already discussed for several hundreds of years, is a classic concept in the sociology of science. In this paper, the concept of multiple simultaneous independent errors is proposed, analyzed, and discussed. The concept of Selective Pessimistic Induction is proposed and used to connect MIDs with MIEs. Five types of MIEs are discussed: multiple errors in the interpretation of experimental data or computational results; multiple misjudgments (...) of the value of another’s research results or conclusions; multiple cases of false anticipation of achieving a certain experimental result; multiples of ignoring or omitting relevant precedents; and multiple instances of failure due to a not-yet-conceived scientific concept or principle. Causal MIDs and MIEs are those that can be traced directly to antecedent knowledge. Acausal MIDs and MIEs are those involving a consequential and identifiable leap from antecedent knowledge. Examples of causal and acausal MIEs are provided, mostly but not exclusively from the discipline of chemistry. Comparisons are made between MIDs and MIEs. Topics for future research are discussed and implications of these concepts are proposed. (shrink)

A systems theory for chemistry is proposed in order to provide a general framework, which covers different theoretical approaches used in the molecular sciences.The basic elements of systems theory are introduced and discussed.By construction, this systems chemistry offers classification and categorizationschemes that will help to identify the range of applicability of certain theoretical approachesas well as to find yet unanswered fundamental questions. Consequently, it will be of value not only to thosewho want to understand and study the structure of chemistry, (...) but it might also be of importance to daily research in chemistry. (shrink)

Primary and methyl aliphatic halides and tosylates undergo substitution reactions with nucleophiles in one step by the classic S N 2 mechanism, which is characterized by second-order kinetics and inversion of configuration at the reaction center. Tertiary aliphatic halides and tosylates undergo substitution reactions with nucleophiles in two (or more) steps by the classic S N 1 mechanism, which is characterized by first-order kinetics and incomplete inversion of configuration at the reaction center due to the presence of ion pairs. When (...) the nucleophile is also the solvent, the substitution reaction is called a solvolysis, and both the S N 2 and S N 1 reactions now obey first-order kinetics. Schleyer and Bentley have provided solid, but not conclusive, evidence that secondary substrates undergo solvolysis by a merged mechanism, one that blends characteristics of both the S N 2 and S N 1 mechanisms. The following paper presents the history of their sustained pursuit of a merged mechanism and subsequent rebuttals to this claim. Several issues related to the philosophy and sociology of science are also discussed. (shrink)

The Science Wars have pitted defenders of science against those accused of attacking it with the weapons of constructivism and relativism. I argue that this defensive stance is in large part a consequence of two other -isms, organized skepticism and naïve methodism, that play a significant, if mostly unconscious, role in how scientists tend to think about science, and suggest that increased awareness of these -isms may help dissipate the perceptions of hostility.

A longstanding philosophical premise perceives simplicity as a desirable attribute of scientific theories. One of several raised justifications for this notion is that simple theories are more likely to indicate the true makeup of natural systems. Qualitatively parsimonious hypotheses and theories keep to a minimum the number of different postulated entities within a system. Formulation of such ontologically simple working hypotheses proved to be useful in the experimental probing of narrowly defined bio systems. It is less certain, however, whether qualitatively (...) parsimonious theories are effective indicators of the true nature of complex biological systems. This paper assesses the success of ontologically simple theories in envisaging the makeup of three complex systems in bacteriology, immunology, and molecular biology. Evidence shows that parsimonious theories completely misconstrued the actual ontologically complex constitutions of the three examined systems. Since evolution and selective pressures typically produce ontologically intricate rather than simple bio systems, qualitatively parsimonious theories are mostly inapt indicators of the true nature of complex biological systems. (shrink)