In the twentieth century, science and art had a grand paradigmatic shift each other. This study aims at comparing the epistemologies of surrealism and quantum mechanics that emerged in the 1930s and interpreting the paintings from a physical viewpoint, with a focus on the Copenhagen interpretation. In terms of epistemologies, the arbitrary relationship between an object and an image advocated by Magritte may correspond to the indeterminacy between physical entities and measurement. This study analysed the paintings of Magritte from the (...) point of view of the features of the Copenhagen interpretation categories of wave–particle duality, indeterminacy, probabilistic interpretation and quantum hypothesis. Based on such discussions, this study gives some implications for enhancing creativity through an interdisciplinary approach. (shrink)