RESUMO Neste artigo pretendo expor sinteticamente os problemas levantados contra uma das formas de realismo científico conhecida como realismo experimental, além de propor uma formulação mais aceitável do mesmo, resistente a tais críticas. Os problemas alegados pelos oponentes do realismo experimental variam desde a acusação de inadequação em relação à prática da comunidade científica, até a inconsistência ao admitir entidades e propriedades postuladas teoricamente recusando, entretanto, as teorias em que tais entidades e propriedades aparecem. Some-se a essas críticas a de (...) que o próprio critério do realismo de entidades seria implausível, seja porque falha na produção de crenças verdadeiras ou porque não fornece garantias melhores do que outras formas de realismo científico. Argumentarei que, adotando o realismo experimental exclusivamente como um critério epistêmico e aplicando tal critério às propriedades é possível contornar as críticas, reabilitando uma proposta realista que muitos consideravam já descartada. ABSTRACT In this paper, I will expose briefly the problems raised against one kind of scientific realism known by experimental realism and also will propose an acceptable formulation of that realism, resistant to those criticisms. The problems claimed by the experimental realism’s opponents range from the accusation of inadequacy with the scientific community’s practice to the claim that the admission of entities and proprieties without accepting the theories in which those proprieties and entities are supposed is incoherent. Besides, there is another criticism which states that the entities realism’s criterion is implausible, either because it fails to produce true beliefs or because there is no better warranty in adopting it than other kinds of scientific realism. I will argue that adopting experimental realism exclusively as an epistemic criterion and applying that criterion to proprieties it is possible to escape the criticisms, rehabilitating a realist propose that many people though already discarded. (shrink)

This paper tells the story of G-protein coupled receptors, one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to (...) conceptually coordinate measurable effects distinctly to a specific object. We show that a scientific entity, such as GPCRs, is assigned varying degrees of reality throughout different stages of its discovery. The criteria of its reality, we further claim, cannot be made independently of the question about how this object becomes a standard by which the reality of neighbouring elements of enquiry is evaluated. (shrink)

The article investigates the intuition that both scientific realism and scientific antirealism are turning into degenerating research programs. The evolution of realism in reaction to pessimistic (meta)induction has certainly led to its increased sophistication as it has given rise to various versions of selective realism. However, many current discussions seem either too focused on semantic niceties or are turning into endless quarrels over case-study refutations of particular forms of realism. The point of finding a better understanding of the relations of (...) scientific knowledge to the world seems to get lost in the process. Magnus, Callender, and Saatsi are among those who see the problem. Although drawing on different observations, they agree that the source of the problem is the wholesale approach according to which it is possible to resolve the realism debate in one move, by finding a single universal method of interpreting any scientific theory. Instead, they call for a more modest approach, based on case-by-case analyses. Particularly promising is Saatsi's idea of exemplar realism, according to which realism should be an attitude motivating detailed case studies rather than a specific account of science in general. (shrink)

In this paper I investigate the prospects of integrated history and philosophy of science, by examining how philosophical issues concerning experimental practice and scientific realism can enrich the historical investigation of the careers of "hidden entities", entities that are not accessible to unmediated observation. Conversely, I suggest that the history of those entities has important lessons to teach to the philosophy of science. My overall aim is to illustrate the possibility of a fruitful two-way traffic between history and philosophy of (...) science. (shrink)