Studies on ‘Big Science’ have shifted our perspective from the complexity of scientific objects and their representations to the complexity of sociotechnical arrangements. However, how scientists in large-scale research attend to this complexity to facilitate and afford knowledge production has rarely been considered to date. In this article, we locate organizational complexity on the level of organizing practices that follow multiple and divergent logics. We identify three strategies of managing organizational complexity, drawing on existing literature on large-scale research as well (...) as own empirical research. The three strategies are: segmenting research infrastructure, introducing elements of bureaucratic governance, and implementing standards and standardization. We illustrate these strategies with examples from our empirical case study on experimental particle physics research at CERN’s Large Hadron Collider. While the strategies we identified help to cope with the complexity of some organizational tasks by dividing, ordering, or mediating between divergent organizational logics, we find that organizational complexity overall is not reduced but rather displaced. We argue that dealing with complexity is a dynamic and ongoing process, which inevitably generates novel organizational complexity. (shrink)