Jakob Johannes von Uexküll’s biological thought influenced a new path to approach the view of a living being throughout of the twentieth century. At the beginning of the past century, in Spain a “new vertebrate way of thinking” was generated, as Ortega would say. And the work of Uexküll initiated an interest in the circles of thinkers of the likes of Julio Caro Baroja, José Ortega y Gasset, and Xavier Zubiri among others. My aim is describing how Uexküll plays a (...) part in the development in the foundations of thoughts of these thinkers; in particular, Ortega and Zubiri’s thought and their interactions between the circumstantiality and formality, respectively, and Uexküll’s Umwelt. In fact, Ortega’s biological thought was the foundation of his vitalism realism and made a giant step in philosophical anthropology existentialism in his Meditations of Quixote in 1911. We will also see the anthropologist Caro Baroja’s epistemic Uexküll influences. A retrospective view of Spanish thought will be developed, where the seeds of Uexküll made fruitful the development of several authors, as well as some transitive or indirect influences; even the generation of discrepancies in others. Finally, we will describe the development, in Spanish, that had the work of Thure von Uexküll, which includes the work of his father. With Thure, the Uexküll influences in Spain concluded until the start of interest in zoosemiotics and biosemiotics. (shrink)