Studies suggest that people's moral intuitions are sensitive to morally irrelevant factors, such as personal force, spatial distance, ethnicity or nationality. Findings of this sort have been used to construct debunking arguments. The most prominent champion of this approach is Joshua Greene, who has attempted to undermine deontology by showing that deontological intuitions are triggered by morally irrelevant factors. This article offers a critical analysis of such empirically informed debunking arguments from moral irrelevance, and of Greene’s effort to undermine deontology. (...) One problem with arguments from moral irrelevance concerns the hierarchy between the targeted case-specific intuitions and the more general intuitions about which factors are morally (ir)relevant. If we assume that general intuitions always take precedence over case-specific intuitions, arguments from moral irrelevance become dialectically useless. By contrast, if we assume that both case-specific and general intuitions should be taken seriously, particularly sweeping debunking projects, such as Greene’s, are unlikely to go through. Another problem concerns the experimental aspect of arguments from moral irrelevance. Empirically informed arguments from moral irrelevance have been presented as examples of how empirical moral psychology can advance moral theory. But arguments from moral irrelevance can also be constructed from the armchair. And basing these arguments on empirical findings about laypeople’s intuitions is even counterproductive. (shrink)