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  1. I—Elisabeth A. Lloyd: Varieties of Support and Confirmation of Climate Models.Elisabeth A. Lloyd - 2009 - Aristotelian Society Supplementary Volume 83 (1):213-232.
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  • Homepage Eckhart Arnold.Eckhart Arnold (ed.) - 2001 - Munich: Preprint.
    This is my personal homepage. Find my philosophical papers under "Philosophy".
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  • Models of Success Versus the Success of Models: Reliability without Truth.Eric Winsberg - 2006 - Synthese 152 (1):1-19.
    In computer simulations of physical systems, the construction of models is guided, but not determined, by theory. At the same time simulations models are often constructed precisely because data are sparse. They are meant to replace experiments and observations as sources of data about the world; hence they cannot be evaluated simply by being compared to the world. So what can be the source of credibility for simulation models? I argue that the credibility of a simulation model comes not only (...)
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  • Computer simulation and the philosophy of science.Eric Winsberg - 2009 - Philosophy Compass 4 (5):835-845.
    There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have (...)
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  • A tale of two methods.Eric Winsberg - 2009 - Synthese 169 (3):575 - 592.
    Simulations (both digital and analog) and experiments share many features. But what essential features distinguish them? I discuss two proposals in the literature. On one proposal, experiments investigate nature directly, while simulations merely investigate models. On another proposal, simulations differ from experiments in that simulationists manipulate objects that bear only a formal (rather than material) similarity to the targets of their investigations. Both of these proposals are rejected. I argue that simulations fundamentally differ from experiments with regard to the background (...)
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  • Current Bibliography of the History of Science and Its Cultural Influences 2005.Stephen P. Weldon - 2005 - Isis 96:1-242.
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  • Apuntes epistemológicos a la e-ciencia.Jordi Vallverdú - 2008 - Revista de filosofía (Chile) 64:193-214.
    En los inicios del siglo XXI está desarrollándose una e-ciencia, una ciencia electrónica y altamente computarizada que exige un replanteamiento sobre la epistemología científica. A través del ejemplo de la Bioinformática y las Biotecnologías, el autor muestra algunas características de esta nueva e-ciencia e indica algunos de los problemas con los que deben enfrentarse los filósofos de la ciencia contemporáneos. Right at the beginning of the 21st century an e-Science is emerging, a highly computerized electronic science which demands a new (...)
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  • Computational Construction of the Reality: Abstraction and Exploration-Driven Strategies in Constructing Protein–Protein Interfaces.Sim-Hui Tee - 2019 - Axiomathes 29 (3):311-328.
    Computational modeling is one of the primary approaches to constructing protein–protein interfaces in the laboratory. The algorithm-driven computational protein design has been successfully applied to the construction of functional proteins with improved binding affinity and increased thermostability. It is intriguing how a computational protein modeling approach can construct and shape the reality of new functional proteins from scratch. I articulate an account of abstraction and exploration-driven strategies in this computational endeavor. I aim to show that how a computational modelling approach, (...)
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  • Knowledge Building Expertise: Nanomodellers’ Education as an Example.Suvi Tala - 2013 - Science & Education 22 (6):1323-1346.
  • From data to phenomena and back again: computer-simulated signatures.Eran Tal - 2011 - Synthese 182 (1):117-129.
    This paper draws attention to an increasingly common method of using computer simulations to establish evidential standards in physics. By simulating an actual detection procedure on a computer, physicists produce patterns of data (‘signatures’) that are expected to be observed if a sought-after phenomenon is present. Claims to detect the phenomenon are evaluated by comparing such simulated signatures with actual data. Here I provide a justification for this practice by showing how computer simulations establish the reliability of detection procedures. I (...)
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  • Synthesizing insight: Artificial life as thought experimentation in biology.Liz Stillwaggon Swan - 2009 - Biology and Philosophy 24 (5):687-701.
    What is artificial life? Much has been said about this interesting collection of efforts to artificially simulate and synthesize lifelike behavior and processes, yet we are far from having a robust philosophical understanding of just what Alifers are doing and why it ought to interest philosophers of science, and philosophers of biology in particular. In this paper, I first provide three introductory examples from the particular subset of artificial life I focus on, known as ‘soft Alife’ (s-Alife), and follow up (...)
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  • Why is There No Successful Whole Brain Simulation (Yet)?Klaus M. Stiefel & Daniel S. Brooks - 2019 - Biological Theory 14 (2):122-130.
    With the advent of powerful parallel computers, efforts have commenced to simulate complete mammalian brains. However, so far none of these efforts has produced outcomes close to explaining even the behavioral complexities of animals. In this article, we suggest four challenges that ground this shortcoming. First, we discuss the connection between hypothesis testing and simulations. Typically, efforts to simulate complete mammalian brains lack a clear hypothesis. Second, we treat complications related to a lack of parameter constraints for large-scale simulations. To (...)
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  • Making coherent senses of success in scientific modeling.Beckett Sterner & Christopher DiTeresi - 2021 - European Journal for Philosophy of Science 11 (1):1-20.
    Making sense of why something succeeded or failed is central to scientific practice: it provides an interpretation of what happened, i.e. an hypothesized explanation for the results, that informs scientists’ deliberations over their next steps. In philosophy, the realism debate has dominated the project of making sense of scientists’ success and failure claims, restricting its focus to whether truth or reliability best explain science’s most secure successes. Our aim, in contrast, will be to expand and advance the practice-oriented project sketched (...)
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  • Why Computer Simulation Cannot Be an End of Thought Experimentation.N. K. Shinod - 2021 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 52 (3):431-453.
    Computer simulation and thought experiments seem to produce knowledge about the world without intervening in the world. This has called for a comparison between the two methods. However, Chandrasekharan et al. argue that the nature of contemporary science is too complex for using TEs. They suggest CS as the tool for contemporary sciences and conclude that it will replace TEs. In this paper, by discussing a few TEs from the history of science, I show that the replacement thesis about TE (...)
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  • Metaphysics within Chemical Physics: The Case of Ab Initio Molecular Dynamics. [REVIEW]Carsten Seck - 2012 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 43 (2):361-375.
    This paper combines naturalized metaphysics and a philosophical reflection on a recently evolving interdisciplinary branch of quantum chemistry, ab initio molecular dynamics. Bridging the gaps among chemistry, physics, and computer science, this cutting-edge research field explores the structure and dynamics of complex molecular many-body systems through computer simulations. These simulations are allegedly crafted solely by the laws of fundamental physics, and are explicitly designed to capture nature as closely as possible. The models and algorithms employed, however, involve many approximations and (...)
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  • A practical philosophy of complex climate modelling.Gavin A. Schmidt & Steven Sherwood - 2015 - European Journal for Philosophy of Science 5 (2):149-169.
    We give an overview of the practice of developing and using complex climate models, as seen from experiences in a major climate modelling center and through participation in the Coupled Model Intercomparison Project. We discuss the construction and calibration of models; their evaluation, especially through use of out-of-sample tests; and their exploitation in multi-model ensembles to identify biases and make predictions. We stress that adequacy or utility of climate models is best assessed via their skill against more naïve predictions. The (...)
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  • Modeling intentional agency: a neo-Gricean framework.Matti Sarkia - 2021 - Synthese 199 (3-4):7003-7030.
    This paper analyzes three contrasting strategies for modeling intentional agency in contemporary analytic philosophy of mind and action, and draws parallels between them and similar strategies of scientific model-construction. Gricean modeling involves identifying primitive building blocks of intentional agency, and building up from such building blocks to prototypically agential behaviors. Analogical modeling is based on picking out an exemplary type of intentional agency, which is used as a model for other agential types. Theoretical modeling involves reasoning about intentional agency in (...)
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  • What is a Computer Simulation? A Review of a Passionate Debate.Nicole J. Saam - 2017 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 48 (2):293-309.
    Where should computer simulations be located on the ‘usual methodological map’ which distinguishes experiment from theory? Specifically, do simulations ultimately qualify as experiments or as thought experiments? Ever since Galison raised that question, a passionate debate has developed, pushing many issues to the forefront of discussions concerning the epistemology and methodology of computer simulation. This review article illuminates the positions in that debate, evaluates the discourse and gives an outlook on questions that have not yet been addressed.
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  • Connecting ethics and epistemology of AI.Federica Russo, Eric Schliesser & Jean Wagemans - forthcoming - AI and Society:1-19.
    The need for fair and just AI is often related to the possibility of understanding AI itself, in other words, of turning an opaque box into a glass box, as inspectable as possible. Transparency and explainability, however, pertain to the technical domain and to philosophy of science, thus leaving the ethics and epistemology of AI largely disconnected. To remedy this, we propose an integrated approach premised on the idea that a glass-box epistemology should explicitly consider how to incorporate values and (...)
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  • Fictionalism, Semantics, and Ontology.Gordon Michael Purves - 2018 - Perspectives on Science 26 (1):52-75.
    In a previous article, I argued that some recent philosophical work on the use of fictions in science is, while illuminating about some aspects of current scientific practice, unduly limited to cases of well-established fictions. In other words, this earlier work contended, a philosophical account of scientific fictions can do more than merely describe scientific practices, but can aid in the resolution of disputes about the proper interpretation of scientific theories and the epistemic status of some scientific models. In the (...)
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  • Finding truth in fictions: identifying non-fictions in imaginary cracks.Gordon Michael Purves - 2013 - Synthese 190 (2):235-251.
    I critically examine some recent work on the philosophy of scientific fictions, focusing on the work of Winsberg. By considering two case studies in fracture mechanics, the strip yield model and the imaginary crack method, I argue that his reliance upon the social norms associated with an element of a model forces him to remain silent whenever those norms fail to clearly match the characteristic of fictions or non-fictions. In its place, I propose a normative epistemology of fictions which clarifies (...)
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  • A Minimalist Epistemology for Agent-Based Simulations in the Artificial Sciences.Giuseppe Primiero - 2019 - Minds and Machines 29 (1):127-148.
    The epistemology of computer simulations has become a mainstream topic in the philosophy of technology. Within this large area, significant differences hold between the various types of models and simulation technologies. Agent-based and multi-agent systems simulations introduce a specific constraint on the types of agents and systems modelled. We argue that such difference is crucial and that simulation for the artificial sciences requires the formulation of its own specific epistemological principles. We present a minimally committed epistemology which relies on the (...)
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  • Re-evaluating semi-empirical computer simulations in quantum chemistry.María Silvia Polzella & Penélope Lodeyro - 2019 - Foundations of Chemistry 21 (1):83-95.
    Usually within the context of computer simulations in quantum chemistry practices, there is a distinction between ab initio and semi-empirical methods. Related to this, a controversy within the scientific and philosophical communities came about regarding the superiority of the ab initio methods due to their theoretical rigor. In this article we re-evaluate the condition of the semi-empirical simulations in this area of research. We examine some of the aspects of this debate that have been considered in philosophy and provide additional (...)
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  • The hermeneutics of ecological simulation.Steven L. Peck - 2008 - Biology and Philosophy 23 (3):383-402.
    Computer simulation has become important in ecological modeling, but there have been few assessments on how complex simulation models differ from more traditional analytic models. In Part I of this paper, I review the challenges faced in complex ecological modeling and how models have been used to gain theoretical purchase for understanding natural systems. I compare the use of traditional analytic simulation models and point how that the two methods require different kinds of practical engagement. I examine a case study (...)
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  • Franklin, Holmes, and the epistemology of computer simulation.Wendy S. Parker - 2008 - International Studies in the Philosophy of Science 22 (2):165 – 183.
    Allan Franklin has identified a number of strategies that scientists use to build confidence in experimental results. This paper shows that Franklin's strategies have direct analogues in the context of computer simulation and then suggests that one of his strategies—the so-called 'Sherlock Holmes' strategy—deserves a privileged place within the epistemologies of experiment and simulation. In particular, it is argued that while the successful application of even several of Franklin's other strategies (or their analogues in simulation) may not be sufficient for (...)
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  • Does matter really matter? Computer simulations, experiments, and materiality.Wendy S. Parker - 2009 - Synthese 169 (3):483-496.
    A number of recent discussions comparing computer simulation and traditional experimentation have focused on the significance of “materiality.” I challenge several claims emerging from this work and suggest that computer simulation studies are material experiments in a straightforward sense. After discussing some of the implications of this material status for the epistemology of computer simulation, I consider the extent to which materiality (in a particular sense) is important when it comes to making justified inferences about target systems on the basis (...)
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  • Computing the uncomputable; or, The discrete charm of second-order simulacra.Matthew W. Parker - 2009 - Synthese 169 (3):447-463.
    We examine a case in which non-computable behavior in a model is revealed by computer simulation. This is possible due to differing notions of computability for sets in a continuous space. The argument originally given for the validity of the simulation involves a simpler simulation of the simulation, still further simulations thereof, and a universality conjecture. There are difficulties with that argument, but there are other, heuristic arguments supporting the qualitative results. It is urged, using this example, that absolute validation, (...)
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  • Models, measurement and computer simulation: the changing face of experimentation.Margaret Morrison - 2009 - Philosophical Studies 143 (1):33-57.
    The paper presents an argument for treating certain types of computer simulation as having the same epistemic status as experimental measurement. While this may seem a rather counterintuitive view it becomes less so when one looks carefully at the role that models play in experimental activity, particularly measurement. I begin by discussing how models function as “measuring instruments” and go on to examine the ways in which simulation can be said to constitute an experimental activity. By focussing on the connections (...)
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  • Demonstration by simulation: The philosophical significance of experiment in helmholtz's theory of perception.Patrick Joseph McDonald - 2003 - Perspectives on Science 11 (2):170-207.
    : Understanding Helmholtz's philosophy of science requires attention to his experimental practice. I sketch out such a project by showing how experiment shapes his theory of perception in three ways. One, the theory emerged out of empirical and experimental research. Two, the concept of experiment fills a critical conceptual gap in his theory of perception. Experiment functions not merely as a scientific technique, but also as a general epistemological strategy. Three, Helmholtz's experimental practice provides essential clues to the interpretation of (...)
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  • Coupling simulation and experiment: The bimodal strategy in integrative systems biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4a):572-584.
    The importation of computational methods into biology is generating novel methodological strategies for managing complexity which philosophers are only just starting to explore and elaborate. This paper aims to enrich our understanding of methodology in integrative systems biology, which is developing novel epistemic and cognitive strategies for managing complex problem-solving tasks. We illustrate this through developing a case study of a bimodal researcher from our ethnographic investigation of two systems biology research labs. The researcher constructed models of metabolic and cell-signaling (...)
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  • Building Simulations from the Ground Up: Modeling and Theory in Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Philosophy of Science 80 (4):533-556.
    In this article, we provide a case study examining how integrative systems biologists build simulation models in the absence of a theoretical base. Lacking theoretical starting points, integrative systems biology researchers rely cognitively on the model-building process to disentangle and understand complex biochemical systems. They build simulations from the ground up in a nest-like fashion, by pulling together information and techniques from a variety of possible sources and experimenting with different structures in order to discover a stable, robust result. Finally, (...)
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  • Varieties of support and confirmation of climate models.Elisabeth A. Lloyd - 2009 - Aristotelian Society Supplementary Volume 83 (1):213-232.
    Today's climate models are supported in a couple of ways that receive little attention from philosophers or climate scientists. In addition to standard 'model fit', wherein a model's simulation is compared to observational data, there is an additional type of confirmation available through the variety of instances of model fit. When a model performs well at fitting first one variable and then another, the probability of the model under some standard confirmation function, say, likelihood, goes up more than under each (...)
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  • I—Elisabeth A. Lloyd: Varieties of Support and Confirmation of Climate Models.Elisabeth A. Lloyd - 2009 - Aristotelian Society Supplementary Volume 83 (1):213-232.
  • The Promises of Complexity Sciences: A Critique.Fabrizio Li Vigni - 2023 - Perspectives on Science 31 (4):465-502.
    Complexity sciences have become famous worldwide thanks to several popular books that served as echo chambers of their promises. These consisted in departing from “classical science” defined as deterministic, reductionist, analytic and mono-disciplinary. Their founders and supporters declared that complexity sciences were going to give rise (or that they have given rise) to a post-Laplacian, antireductionist, holistic and interdisciplinary approach. By taking a closer look at their content and practices, I argue in this article that, because of their physics-oriented, computationalist, (...)
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  • Regimes of Evidence in Complexity Sciences.Fabrizio Li Vigni - 2021 - Perspectives on Science 29 (1):62-103.
    Since their inception in the 1980s, complexity sciences have been described as a revolutionary new domain of research. By describing some of the practices and assumptions of its representatives, the present article shows that this field is an association of subdisciplines laying on existing disciplinary footholds. The general question guiding us here is: On what basis do complexity scientists consider their inquiry methods and results as valuable? To answer it, I describe five “epistemic argumentative regimes,” namely the ways in which (...)
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  • Data and Model Operations in Computational Sciences: The Examples of Computational Embryology and Epidemiology.Fabrizio Li Vigni - 2022 - Perspectives on Science 30 (4):696-731.
    Computer models and simulations have become, since the 1960s, an essential instrument for scientific inquiry and political decision making in several fields, from climate to life and social sciences. Philosophical reflection has mainly focused on the ontological status of the computational modeling, on its epistemological validity and on the research practices it entails. But in computational sciences, the work on models and simulations are only two steps of a longer and richer process where operations on data are as important as, (...)
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  • Surprised by a Nanowire: Simulation, Control, and Understanding.Johannes Lenhard - 2006 - Philosophy of Science 73 (5):605-616.
    This paper starts by looking at the coincidence of surprising behavior on the nanolevel in both matter and simulation. It uses this coincidence to argue that the simulation approach opens up a pragmatic mode of understanding oriented toward design rules and based on a new instrumental access to complex models. Calculations, and their variation by means of explorative numerical experimentation and visualization, can give a feeling for a model's behavior and the ability to control phenomena, even if the model itself (...)
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  • Reproducibility and the Concept of Numerical Solution.Johannes Lenhard & Uwe Küster - 2019 - Minds and Machines 29 (1):19-36.
    In this paper, we show that reproducibility is a severe problem that concerns simulation models. The reproducibility problem challenges the concept of numerical solution and hence the conception of what a simulation actually does. We provide an expanded picture of simulation that makes visible those steps of simulation modeling that are numerically relevant, but often escape notice in accounts of simulation. Examining these steps and analyzing a number of pertinent examples, we argue that numerical solutions are importantly different from usual (...)
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  • Models and statistical inference: The controversy between Fisher and neyman–pearson.Johannes Lenhard - 2006 - British Journal for the Philosophy of Science 57 (1):69-91.
    The main thesis of the paper is that in the case of modern statistics, the differences between the various concepts of models were the key to its formative controversies. The mathematical theory of statistical inference was mainly developed by Ronald A. Fisher, Jerzy Neyman, and Egon S. Pearson. Fisher on the one side and Neyman–Pearson on the other were involved often in a polemic controversy. The common view is that Neyman and Pearson made Fisher's account more stringent mathematically. It is (...)
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  • Computer simulation: The cooperation between experimenting and modeling.Johannes Lenhard - 2007 - Philosophy of Science 74 (2):176-194.
    The goal of the present article is to contribute to the epistemology and methodology of computer simulations. The central thesis is that the process of simulation modeling takes the form of an explorative cooperation between experimenting and modeling. This characteristic mode of modeling turns simulations into autonomous mediators in a specific way; namely, it makes it possible for the phenomena and the data to exert a direct influence on the model. The argumentation will be illustrated by a case study of (...)
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  • Book review. [REVIEW]Johannes Lenhard - 2006 - Minds and Machines 16 (1):95-100.
  • Computing the perfect model: Why do economists Shun simulation?Aki Lehtinen & Jaakko Kuorikoski - 2007 - Philosophy of Science 74 (3):304-329.
    Like other mathematically intensive sciences, economics is becoming increasingly computerized. Despite the extent of the computation, however, there is very little true simulation. Simple computation is a form of theory articulation, whereas true simulation is analogous to an experimental procedure. Successful computation is faithful to an underlying mathematical model, whereas successful simulation directly mimics a process or a system. The computer is seen as a legitimate tool in economics only when traditional analytical solutions cannot be derived, i.e., only as a (...)
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  • Virtually Expert: Modes of Environmental Computer Simulation Modeling.Catharina Landström & Sarah J. Whatmore - 2014 - Science in Context 27 (4):579-603.
    ArgumentThis paper challenges three assumptions common in the literature on expertise: that expertise is linearly derived from scientific knowledge; that experts always align with the established institutional order; and that expertise is a property acquired by individuals. We criticize these ideas by juxtaposing three distinct expert practices involved with flood risk management in England. Virtual engineering is associated with commercial consultancy and relies on standardized software packages to assess local flood inundation. Mathematical experimentation refers to academic scientists creating new digital (...)
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  • How Digital Computer Simulations Explain Real‐World Processes.Ulrich Krohs - 2008 - International Studies in the Philosophy of Science 22 (3):277 – 292.
    Scientists of many disciplines use theoretical models to explain and predict the dynamics of the world. They often have to rely on digital computer simulations to draw predictions fromthe model. But to deliver phenomenologically adequate results, simulations deviate from the assumptions of the theoretical model. Therefore the role of simulations in scientific explanation demands itself an explanation. This paper analyzes the relation between real-world system, theoretical model, and simulation. It is argued that simulations do not explain processes in the real (...)
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  • Computersimulationen: Modellierungen 2. ordnung. [REVIEW]Günter Küppers & Johannes Lenhard - 2005 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 36 (2):305 - 329.
    Es soll ein Beitrag zur epistemischen Charakterisierung von Computersimulationen als jenseits von Experiment und Theorie geleistet werden. Es wird argumentiert, dass die in der Simulationstechnik eingesetzten Verfahren nicht numerische Lösungen liefern, sondern deren Dynamik mittels generativer Mechanismen imitieren. Die Computersimulationen in der Klimatologie werden als systematisches wie historisches Fallbeispiel behandelt. Erst "Simulationsexperimente" gestatten es, mittels Modellen eine Dynamik zu imitieren, ohne deren Grundgleichungen zu "lösen". /// Computer simulations will be characterized in epistemic respect as a method between experiment and theory. (...)
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  • Computersimulationen: Modellierungen 2. Ordnung.Günter Küppers & Johannes Lenhard - 2005 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 36 (2):305-329.
    Es soll ein Beitrag zur epistemischen Charakterisierung von Computersimulationen als jenseits von Experiment und Theorie geleistet werden. Es wird argumentiert, dass die in der Simulationstechnik eingesetzten Verfahren nicht numerische Lösungen liefern, sondern deren Dynamik mittels generativer Mechanismen imitieren. Die Computersimulationen in der Klimatologie werden als systematisches wie historisches Fallbeispiel behandelt. Erst "Simulationsexperimente" gestatten es, mittels Modellen eine Dynamik zu imitieren, ohne deren Grundgleichungen zu "lösen". /// Computer simulations will be characterized in epistemic respect as a method between experiment and theory. (...)
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  • Biological Control Variously Materialized: Modeling, Experimentation and Exploration in Multiple Media.Tarja Knuuttila & Andrea Loettgers - 2021 - Perspectives on Science 29 (4):468-492.
    This paper examines two parallel discussions of scientific modeling which have invoked experimentation in addressing the role of models in scientific inquiry. One side discusses the experimental character of models, whereas the other focuses on their exploratory uses. Although both relate modeling to experimentation, they do so differently. The former has considered the similarities and differences between models and experiments, addressing, in particular, the epistemic value of materiality. By contrast, the focus on exploratory modeling has highlighted the various kinds of (...)
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  • Basic science through engineering? Synthetic modeling and the idea of biology-inspired engineering.Tarja Knuuttila & Andrea Loettgers - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):158-169.
    Synthetic biology is often understood in terms of the pursuit for well-characterized biological parts to create synthetic wholes. Accordingly, it has typically been conceived of as an engineering dominated and application oriented field. We argue that the relationship of synthetic biology to engineering is far more nuanced than that and involves a sophisticated epistemic dimension, as shown by the recent practice of synthetic modeling. Synthetic models are engineered genetic networks that are implanted in a natural cell environment. Their construction is (...)
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  • Epistemological Framework for Computer Simulations in Building Science Research: Insights from Theory and Practice.Amos Kalua & James Jones - 2020 - Philosophies 5 (4):30.
    Computer simulations are widely used within the area of building science research. Building science research deals with the physical phenomena that affect buildings, including heat and mass transfer, lighting and acoustic transmission. This wide usage of computer simulations, however, is characterized by a divergence in thought on the composition of an epistemological framework that may provide guidance for their deployment in research. This paper undertakes a fundamental review of the epistemology of computer simulations within the context of the philosophy of (...)
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  • Modeling molecules: Computational nanotechnology as a knowledge community.Ann Johnson - 2009 - Perspectives on Science 17 (2):pp. 144-173.
    I propose that a sociological and historical examination of nanotechnologists can contribute more to an understanding of nanotechnology than an ontological definition. Nanotechnology emerged from the convergent evolution of numerous "technical knowledge communities"-networks of tightly-interconnected people who operate between disciplines and individual research groups. I demonstrate this proposition by sketching the co-evolution of computational chemistry and computational nanotechnology. Computational chemistry arose in the 1950s but eventually segregated into an ab initio, basic research, physics-oriented flavor and an industry-oriented, molecular modeling and (...)
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