This essay discusses the semiotic scaffolding of modern science, the roots of which lie in the Protestant Reformation and the latter’s repudiation of the “semiotics of nature” upon which medieval theology depended. Taking the fourteenth-century battles between realism and nominalism as the semiotic scaffolding of the Reformation which was subsequently built on nominalist principles, and the Reformation as what made possible the development of early modern science, this essay argues that nominalism, Protestantism, and early modern science were all infected by (...) the gnostic influences which had always accompanied Christianity from the start. Indicating that forms of creative discovery, in the arts, humanities and sciences, are closer to poetic forms than they are to the Baconian model which informed modern science, the essay goes on to link the latter gnostic-influenced metaphysics, motivated by a Reformation anxiety about sin and error, to the development of the modern “megamachine” as described by Lewis Mumford in The Myth of the Machine volumes 1 and 2. Finally the essay suggests that semiotically revivified life sciences might be capable of resolving some of the systemic and ecological problems which Mumford identifies. (shrink)