A crucial question for a process view of life is how to identify a process and how to follow it through time. The genidentity view can contribute decisively to this project. It says that the identity through time of an entity X is given by a well-identified series of continuous states of affairs. Genidentity helps address the problem of diachronic identity in the living world. This chapter describes the centrality of the concept of genidentity for David Hull and proposes an (...) extension of Hull’s view to the ubiquitous phenomenon of symbiosis. Finally, using immunology as a key example, it shows that the genidentity view suggests that the main interest of a process approach is epistemological rather than ontological and that its principal claim is one of priority, namely that processes precede and define things, and not vice versa. (shrink)

Both philosophers and psychologists have argued for the existence of distinct kinds of explanations, including teleological explanations that cite functions or goals, and mechanistic explanations that cite causal mechanisms. Theories of causation, in contrast, have generally been unitary, with dominant theories focusing either on counterfactual dependence or on physical connections. This paper argues that both approaches to causation are psychologically real, with different modes of explanation promoting judgments more or less consistent with each approach. Two sets of experiments isolate the (...) contributions of counterfactual dependence and physical connections in causal ascriptions involving events with people, artifacts, or biological traits, and manipulate whether the events are construed teleologically or mechanistically. The findings suggest that when events are construed teleologically, causal ascriptions are sensitive to counterfactual dependence and relatively insensitive to the presence of physical connections, but when events are construed mechanistically, causal ascriptions are sensitive to both counterfactual dependence and physical connections. The conclusion introduces an account of causation, an "exportable dependence theory," that provides a way to understand the contributions of physical connections and teleology in terms of the functions of causal ascriptions. (shrink)

Philosophers have already recognized the importance of causal preemption involving “positive” events. First, preemption with positive events raises problems for counterfactual theories of causation. Second, theories of moral and legal responsibility rely heavily on the concept of causation, so accurately assessing responsibility in preemption cases requires correctly assessing their causal structure. However, philosophers have not discussed preemption involving “negative” events or omissions. This paper argues that cases of preemptive omissions exist and have important implications for theories of causation and for (...) moral and legal responsibility. Of theoretical importance, the alterations made to counterfactual theories of causation to address preemption with positive events do not seem to work for accommodating preemptive omissions. Of practical importance, there have been actual legal cases involving preemptive omissions, and at least one such case was, this paper contends, decided incorrectly on erroneous causal grounds. This paper identifies what must happen for preemptive omissions to obtain. It then argues for the existence of preemptive omissions by constructing a series of cases and drawing structural parallels between preemption cases with positive events and cases with omissions. It ultimately presents a formula for generating preemptive omissions and examines both why “traditional” methods of generating preemption fail for omissions and why the proposed method avoids such concerns. (shrink)

Recent years have seen increasing interest in interventionist analyses of metaphysical explanation. One area where interventionism traditionally shines, is in providing an account of explanatory depth; the sense in which explanation comes in degrees. However, the literature on metaphysical explanation has left the notion of depth almost entirely unexplored. In this paper I shall attempt to rectify this oversight by motivating an interventionist analysis of metaphysical explanatory depth (MED), in terms of the range of interventions under which a metaphysically explanatory (...) generalization remains invariant. After elucidating the notion through a toy-example, I demonstrate the important work which MED can perform in characterizing debate within contemporary metaphysics. Focusing upon rival approaches to explaining the identity and distinctness of concrete objects, I argue that the progress achieved in this debate can be characterized in terms of increasing explanatory depth. Having made an initial case for the utility of MED, I then turn this analysis to the metaphysics of explanation itself. By adopting an interventionist framework with respect to MED, I will show that we can assess the depth of competing theories of explanation. This application has two interesting results: first, it suggests that an interventionist analysis of explanation provides deeper explanations of the connection between explanans and explanandum than rival accounts; and second, it suggests that explanations provided by interventionism become deeper still, if one accepts that this methodology ranges over metaphysical, as well as causal, instances. (shrink)

In Zhong (Philos Phenomenol Res 83:129–147, 2011; Analysis 72:75–85, 2012), I argued that, contrary to what many people might expect, the counterfactual theory of causation will generate (rather than solve) the exclusion problem. Recently some philosophers raise an incisive objection to this argument. They contend that my argument fails as it equivocates between different notions of a physical realizer (see Christensen and Kallestrup in Analysis 72:513–517, 2012). However, I find that their criticism doesn’t threaten the central idea of my view. (...) In this paper, I make two separate responses that appeal to two unequivocal notions of physical realizers, respectively. I aim to show that a modified argument that uses either notion would work. (shrink)

Hume argued that experience could not justify commonly held beliefs in singular causal effcacy, according to which individual or singular causes produce their effects or make their effects happen. Hume's discussion has been influential, as motivating the view that Causal reductionism (denying that causal efficacy is an irreducible feature of natural reality) requires Causal generalism (according to which causal relations are metaphysically constituted by patterns of events). Here I argue that causal reductionists---indeed, Hume himself---have previously unappreciated resources for making sense (...) of Causal singularism, associated with a relation that has been curiously underexploited in the causation debates: resemblance. The core idea I explore here is that causation may be metaphysically and epistemologically indicated by the coming-to-be of a resemblance. Comings-to-be of resemblances are epistemically available in the singular instance, even by Hume's strict lights, and, I argue, can justify (albeit fallibly) belief in the holding of singular causal relations; hence Hume's general argument for generalism fails. More to the contemporary metaphysical point, comings-to-be of resemblances provide valuable resources for existing singularist accounts: while neither changes (Ducasse) nor transfers of physical quantities (Fair, Dowe, Salmon) provide a suffciently fine-grained basis for the individuation of causes, either changes or transfers, in combination with comings-to-be of resemblances, can do so. (shrink)

Part I of this paper introduces a range of mechanistic theories of causality, including process theories and the complex-systems theories, and some of the problems they face. Part II argues that while there is a decisive case against a purely mechanistic analysis, a viable theory of causality must incorporate mechanisms as an ingredient, and describes one way of providing an analysis of causality which reaps the rewards of the mechanistic approach without succumbing to its pitfalls.

There is a systematic and suggestive analogy between grounding and causation. In my view, this analogy is no coincidence. Grounding and causation are alike because grounding is a type of causation: metaphysical causation. In this paper I defend the identification of grounding with metaphysical causation, drawing on the causation literature to explore systematic connections between grounding and metaphysical dependence counterfactuals, and I outline a non-reductive counterfactual theory of grounding along interventionist lines.

Is the common cause principle merely one of a set of useful heuristics for discovering causal relations, or is it rather a piece of heavy duty metaphysics, capable of grounding the direction of causation itself? Since the principle was introduced in Reichenbach’s groundbreaking work The Direction of Time (1956), there have been a series of attempts to pursue the latter program—to take the probabilistic relationships constitutive of the principle of the common cause and use them to ground the direction of (...) causation. These attempts have not all explicitly appealed to the principle as originally formulated; it has also appeared in the guise of independence conditions, counterfactual overdetermination, and, in the causal modelling literature, as the causal markov condition. In this paper, I identify a set of difficulties for grounding the asymmetry of causation on the principle and its descendents. The first difficulty, concerning what I call the vertical placement of causation, consists of a tension between considerations that drive towards the macroscopic scale, and considerations that drive towards the microscopic scale—the worry is that these considerations cannot both be comfortably accommodated. The second difficulty consists of a novel potential counterexample to the principle based on the familiar Einstein Podolsky Rosen (EPR) correlations in quantum mechanics. (shrink)

In the literature on scientific explanation two types of pluralism are very common. The first concerns the distinction between explanations of singular facts and explanations of laws: there is a consensus that they have a different structure. The second concerns the distinction between causal explanations and uni.cation explanations: most people agree that both are useful and that their structure is different. In this article we argue for pluralism within the area of causal explanations: we claim that the structure of a (...) causal explanation depends on the causal structure of the relevant fragment of the world and on the interests of the explainer. (shrink)

According to an increasing number of authors, the best, if not the only, argument in favour of physicalism is the so-called 'overdetermination argument'. This argument, if sound, establishes that all the entities that enter into causal interactions with the physical world are physical. One key premise in the overdetermination argument is the principle of the causal closure of the physical world, said to be supported by contemporary physics. In this paper, I examine various ways in which physics may support the (...) principle, either as a methodological guide or as depending on some other laws and principles of physics. (shrink)

In this paper I argue that inconsistencies in scientific theories may arise from the type of causality relation they—tacitly or explicitly—embody. All these seemingly different causality relations can be subsumed under a general strategy developed to defeat the paradoxes which inevitably occur in our experience of the real. With respect to this, scientific theories are just a subclass of the larger class of metaphysical theories, construed as theories that attempt to explain a (part of) the world consistently. All metaphysical theories (...) share a common structural backbone specificially designed to defeat paradoxes, their often wildly diverging ontological claims notwithstanding. This common structure shapes the procedures which govern the invention of ideas in the context of such theories, by codifying some onto-logical a priori assumptions regarding the consistency of reality into its bare conceptual framework. Causality plays a key rôle here, because it implies conservation of identity, itself a far from simple notion. It imposes strong demands on the universalising power of the theories concerned. These demands are often met by the introduction of a metalevel which encompasses the notions of ‘system’ and ‘lawful behaviour’. In classical mechanics, the division between universal and particular leaves its traces in the separate treatment of cinematics and dynamics. The fundamental backbone’s specific gestalt thus functions as a theory’s individual signature and paves the way to a comparative historical approach towards their study. An important part of my paper therefore explores the strong connections between paradoxes as they appear and are dealt with in ancient philosophy and their re-appearance in early modern natural philosophy and science. This analysis is applied to the mechanical theories of Newton and Leibniz, with some surprising results. (shrink)

The controversy about intentional explanation of action concerns how these explanations work. What kind of model allows us to capture the dependency or relevance relation between the explanans, i.e. the beliefs and desires of the agent, and the explanandum, i.e. the action? In this paper, I argue that the causal mechanical model can do the job. Causal mechanical intentional explanations consist in a reference to the mechanisms of practical reasoning of the agent that motivated the agent to act, i.e. to (...) a causally relevant set of beliefs and desires. Moreover, the causal mechanical model can provide in efficient and unproblematic applications, unlike action explanations using ceteris paribus laws or counterfactuals. The drawback of the latter models of explanation is their modal requirement: the explanans must mention or implies sufficient and/or necessary conditions for the explanandum. Such a requirement is too strong when it comes to intentional explanation of action. (shrink)

It is widely thought that there is an important argument to be made that starts with premises taken from the science of physics and ends with the conclusion of physicalism. The standard view is that this argument takes the form of a causal argument for physicalism. Roughly, physics tells us that the physical realm is causally complete, and so minds (among other entities) must be physical if they are to interact with the world as we think they do. In what (...) follows, I raise problems for this view. After an initial review of the causal argument, I begin my case by showing that the totality of physical truths do not deductively entail the causal completeness of the physical realm, using a double-prevention scenario and causation by omission to show that nonphysical causes of physical effects would not need to violate physical conservation laws. I then move on to raise problems for an inductive argument for causal completeness by drawing on the neo-Russellian view that there is no causation in fundamental physics, and so causation must itself be a realized or derived entity. I conclude by suggesting that the underlying problem is that the causal argument has fallen out of touch with the sophisticated understanding that philosophers have developed of the role of causation within physics. (shrink)

“Perception is controlled hallucination,” according to proponents of predictive processing accounts of vision. I say they are right that something like this is a consequence of their view but wrong in how they have pursued the idea. The focus of my counterproposal is the causal theory of perception, which I develop in terms of a productive concept of causation. Cases of what otherwise seem like successful perception are instead mere veridical hallucination if predictive processing accounts are correct, I argue, because (...) of the role played within such accounts by absences, which cannot enter into productive causal relations. -/- I offer two arguments in support of the productive theory of perception. The first is loosely Kantian, focusing on the role that receptivity and spontaneity play in perception. The second focuses on what perception and hallucination have in common. I conclude with a series of objections and replies. (shrink)

The principle that causes always render their effects more likely is fundamental to the enterprise of reducing facts of causation to facts about (objective) chances. This reductionist enterprise faces famous difficulties in accommodating common-sense intuitions about causal processes, if it insists on cashing out causal processes in terms of streams of events in which every event that belongs to the stream is a cause of the adjoining event downstream of it. I shall propose modifications to this way of cashing out (...) causal processes, still well within the reductionist faith. These modifications will allow the reductionist to handle processes successfully, on the assumption that the reductionist proposal is itself otherwise satisfactory. I shall then argue that the reductionist enterprise lies squarely behind the Theory of Relativity, and so has all the confirmatory weight of Relativity behind it. However this is not all good news for reductionists. For throughout I shall simply assume that the reductionist proposal, to the effect that causes are just chance-raisers, is correct. And I shall sidestep problems with that proposal as such. And so I shall show that, if in the end we find the reductionist proposal unsatisfactory, it cannot be on grounds of its treatment of causal processes as such. Thus, while I shall argue that causal processes pose no extra trouble for reductionists, I shall be making a case that all the action between reductionists and their opponents should be focused upon the proposal to reduce the two-term causal relation itself to relations amongst probabilities. (shrink)

Hans Reichenbach’s posthumous book The Direction of Time ends somewhere between Socratic aporia and historical irony. Prompted by Feynman’s diagrammatic formulation of quantum electrodynamics, Reichenbach eventually abandoned the delicate balancing between the macroscopic foundation of the direction of time and microscopic descriptions of time order undertaken throughout the previous chapters in favor of an exclusively macroscopic theory that he had vehemently rejected in the 1920s. I analyze Reichenbach’s reasoning against the backdrop of the history of Feynman diagrams and the current (...) practice of particle physics. Building upon the debates about processes and conserved quantities between Wesley Salmon and Phil Dowe in the 1990s, and the exchange between Reichenbach and the gestalt theorist Kurt Lewin during the 1920s about topology and genidentity, I investigate whether the aporia about local time order could be avoided by following a strategy that Reichenbach adopted elsewhere in the book and develop a notion of functional genidentity that captures the practice of present-day elementary particle physics and the fact that Feynman diagrams have to be understood in the context of a complex mathematical description of scattering processes. (shrink)

In this paper, we attempt to explicate Salmon’s idea of a causal process, as defined in terms of the mark method, in the context of C*-dynamical systems. We prove two propositions, one establishing mark manifestation infinitely many times along a given interval of the process, and, a second one, which establishes continuous manifestation of mark with the exception of a countable number of isolated points. Furthermore, we discuss how these results can be implemented in the context of the Haag–Araki theories (...) of relativistic quantum fields on Minkowski spacetime. (shrink)

This paper argues that the semantic facts about ‘because’ are best explained via a metaphorical treatment of metaphysical explanation that treats causal explanation as explanation par excellence. Along the way, it defends a commitment to a unified causal sense of ‘because’ and offers a proprietary explanation of grounding skepticism. With the causal metaphor account of metaphysical explanation on the table, an extended discussion of the relationship between conceptual structure and metaphysics ends with a suggestion that the semantic facts about ‘because’ (...) tell against grounding-causation unity. (shrink)

General Process Theory (GPT) is a new (non-Whiteheadian) process ontology. According to GPT the domains of scientific inquiry and everyday practice consist of configurations of ‘goings-on’ or ‘dynamics’ that can be technically defined as concrete, dynamic, non-particular individuals called general processes. The paper offers a brief introduction to GPT in order to provide ontological foundations for research programs such as interactivism that centrally rely on the notions of ‘process,’ ‘interaction,’ and ‘emergence.’ I begin with an analysis of our common sense (...) concept of activities, which plays a crucial heuristic role in the development of the notion of a general process. General processes are not individuated in terms of their location but in terms of ‘what they do,’ i.e., in terms of their dynamic relationships in the basic sense of one process being part of another. The formal framework of GPT is thus an extensional mereology, albeit a non-classical theory with a non-transitive part-relation. After a brief sketch of basic notions and strategies of the GPT-framework I show how the latter may be applied to distinguish between causal, mechanistic, functional, self-maintaining, and recursively self-maintaining interactions, all of which involve ‘emergent phenomena’ in various senses of the term. (shrink)

When two rocks shatter the window at once, what causes the window to shatter? Is the throwing of each individual rock a cause of the window shattering, or are the throwings only causes collectively? This question bears on the analysis of causation, and the metaphysics of macro-causation. I argue that the throwing of each individual rock is a cause of the window shattering, and generally that individual overdeterminers are causes.

Sydney Shoemaker's "Subset Account" offers a new take on determinable properties and the realization relation as well as a defense of non-reductive physicalism from the problem of mental causation. At the heart of this account are the claims that (1) mental properties are determinable properties and (2) the causal powers that individuate a determinable property are a proper subset of the causal powers that individuate the determinates of that property. The second claim, however, has led to the accusation that the (...) effects caused by the instantiation of a determinable property will also be caused by the instantiation of the determinates of that property—so instead of solving the problem of mental causation, the Subset Account ends up guaranteeing that the effects of mental properties (and all other types of determinable property) will be causally overdetermined! In this paper, I explore this objection. I argue that both sides in this debate have failed to engage the question at the heart of the objection: Given that both a determinable property and its determinates have the power to cause some effect (E), does it follow that both will actually cause E when the relevant conditions obtain? To make genuine progress towards answering this question, we need to take a serious look at the metaphysics of causation. With the debate properly reframed and issues about the metaphysics of causation front and center, I explore the question of whether the Subset Account is doomed to result in problematic causal overdetermination. (shrink)

The physical and/or intrinsic connection approach to causation has become prominent in the recent literature, with Salmon, Dowe, Menzies, and Armstrong among its leading proponents. I show that there is a type of causation, causation by disconnection, with no physical or intrinsic connection between cause and effect. Only Hume-style conditions approaches and hybrid conditions-connections approaches appear to be able to handle causation by disconnection. Some Hume-style, extrinsic, absence-relating, necessary and/or sufficient condition component of the causal relation proves to be needed.

This paper presents a drastically revised version of the theory of causality, based on analyses of causal processes and causal interactions, advocated in Salmon (1984). Relying heavily on modified versions of proposals by P. Dowe, this article answers penetrating objections by Dowe and P. Kitcher to the earlier theory. It shows how the new theory circumvents a host of difficulties that have been raised in the literature. The result is, I hope, a more satisfactory analysis of physical causality.

This paper discusses several distinct process theories of causality offered in recent years by Phil Dowe and me. It addresses problems concerning the explication of causal process, causal interaction, and causal transmission, whether given in terms of transmission of marks, transmission of invariant or conserved quantities, or mere possession of conserved quantities. Renouncing the mark-transmission and invariant quantity criteria, I accept a conserved quantity theory similar to Dowe's--differing basically with respect to causal transmission. This paper also responds to several fundamental (...) constructive criticisms contained in Christopher Hitchcock's discussion of both the mark-transmission and the conserved quantity theories. (shrink)

According to Russo and Williamson (Int Stud Philos Sci 21(2):157–170, 2007, Hist Philos Life Sci 33:389–396, 2011a, Philos Sci 1(1):47–69, 2011b ), in order to establish a causal claim of the form, ‘_C_ is a cause of _E_’, one typically needs evidence that there is an underlying mechanism between _C_ and _E_ as well as evidence that _C_ makes a difference to _E_. This thesis has been used to argue that hierarchies of evidence, as championed by evidence-based movements, tend to (...) give primacy to evidence of difference making over evidence of mechanisms and are flawed because the two sorts of evidence are required and they should be treated on a par. An alternative approach gives primacy to evidence of mechanism over evidence of difference making. In this paper, we argue that this alternative approach is equally flawed, again because both sorts of evidence need to be treated on a par. As an illustration of this parity, we explain how scientists working in the ‘EnviroGenomarkers’ project constantly make use of the two evidential components in a dynamic and intertwined way. We argue that such an interplay is needed not only for causal assessment but also for policy purposes. (shrink)

The need to find an intrinsic characterization of what makes a relation between events causal arises not only in local theories of causation like Salmon's process theory but also in global approaches like Lewis' counterfactual theory. According to the localist intuition, whether a process connecting two events is causal should depend only on what goes on between the events, not on conditions that hold elsewhere in the world. If such intrinsic characterizations could be found, an identification of the causal relation (...) in the actual world (though not in other possible worlds) with physical processes may be feasible (the a posteriori identification). I consider recent proposals made for intrinsic characterizations of causality and conclude that none of them is able to deliver the intended result. (shrink)

This paper examines tracer techniques in neuroscience, which are used to identify neural connections in the brain and nervous system. These connections capture a type of “structural connectivity” that is expected to inform our understanding of the functional nature of these tissues. This is due to the fact that neural connectivity constrains the flow of signal propagation, which is a type of causal process in neurons. This work explores how tracers are used to identify causal information, what standards they are (...) expected to meet, the forms of causal information they provide, and how an analysis of these techniques contributes to the philosophical literature, in particular, the literature on mark transmission and mechanistic accounts of causation. (shrink)

We discuss Russell's 1913 essay arguing for the irrelevance of the idea of causation to science and its elimination from metaphysics as a precursor to contemporary philosophical naturalism. We show how Russell's application raises issues now receiving much attention in debates about the adequacy of such naturalism, in particular, problems related to the relationship between folk and scientific conceptual influences on metaphysics, and to the unification of a scientifically inspired worldview. In showing how to recover an approximation to Russell's conclusion (...) while explaining scientists' continuing appeal to causal ideas (without violating naturalism by philosophically correcting scientists) we illustrate a general naturalist strategy for handling problems around the unification of sciences that assume different levels of naïveté with respect to folk conceptual frameworks. We do this despite rejecting one of the premises of Russell's argument, a version of reductionism that was scientifically plausible in 1913 but is not so now. (shrink)

Empirical research has recently emerged as a key method for understanding the nature of causation, and our concept of causation. One thread of research aims to test intuitions about the nature of causation in a variety of classic cases. These experiments have principally been used to try to resolve certain debates within analytic philosophy, most notably that between proponents of transference and dependence views of causation. The other major thread of empirical research on our concept of causation has investigated the (...) role that normative considerations play in causal judgments. These experimental results suggest that philosophical accounts of our concept of causation should take a broader view of what might be relevant. For both lines of research, we describe some of the significant experiments and outline key philosophical morals that have been drawn, all while pointing out various limitations. We conclude by considering other kinds of empirical research that should be philosophically interesting for those studying the nature of causation and our concept of causation. In particular, we point towards the need for philosophical research about causal perception, causal reasoning, and causal learning, as well as ways in which this research could play a role in prescriptive metaphysics. (shrink)

Recent philosophical work on causation has focused on distinctions across types of causal relationships. This paper argues for another distinction that has yet to receive attention in this work. This distinction has to do with whether causal relationships have “material continuity,” which refers to the reliable movement of material from cause to effect. This paper provides an analysis of material continuity and argues that causal relationships with this feature are associated with a unique explanatory perspective, are studied with distinct causal (...) investigative methods, and provide different types of causal control over their effects. (shrink)

Achieving understanding of nature is one of the aims of science. In this paper we offer an analysis of the nature of scientific understanding that accords with actual scientific practice and accommodates the historical diversity of conceptions of understanding. Its core idea is a general criterion for the intelligibility of scientific theories that is essentially contextual: which theories conform to this criterion depends on contextual factors, and can change in the course of time. Our analysis provides a general account of (...) how understanding is provided by scientific explanations of diverse types. In this way, it reconciles conflicting views of explanatory understanding, such as the causal-mechanical and the unificationist conceptions. (shrink)

Jaegwon Kim’s views on mental causation and the exclusion argument are evaluated systematically. Particular attention is paid to different theories of causation. It is argued that the exclusion argument and its premises do not cohere well with any systematic view of causation.

A defence of non-causal explanations of events is presented in cases where explanation is understood as modal explanation. In such cases the source of modal information is crucial. All explanations implicitly use contrast classes, and relative to a particular contrast we can privilege some difference makers over others. Thinking about changes in these privileged “actual” difference makers is then the source of modal information for any given explanandum. If an actual difference maker is non-causal, then we have a principled definition (...) of a non-causal explanation of an event regardless of how much causal information is also contained in the explanans. A demarcation of explanation into causal and non-causal in this way recovers ordinary language about explanation as well as reflecting genuine differences in practice, such as the in-principle evidential base for any modal claim. (shrink)

If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...) the other side, so-called In Silico Clinical Trials face the same criticisms addressed against standard modelling and simulation techniques, and cannot be equated to experiments Philosophy of molecular medicine: foundational issues in research and practice, Routledge, New York, 2017; Parker in Synthese 169:483–496, 2009; Parke in Philos Sci 81:516–536, 2014; Diez Roux in Am J Epidemiol 181:100–102, 2015 and related discussions in Frigg and Reiss in Synthese 169:593–613, 2009; Winsberg in Synthese 169:575–592, 2009; Beisbart and Norton in Int Stud Philos Sci 26:403–422, 2012). We undertake a formal analysis of both methods in order to identify their distinct contribution to causal inference in the clinical setting. Britton et al.’s study :E2098–E2105, 2013) on the impact of ion current variability on cardiac electrophysiology is used for illustrative purposes. We deduce that, by predicting variability through interpolation, ISCTs aid with problems regarding extrapolation of RCTs results, and therefore in assessing their external validity. Furthermore, ISCTs can be said to encode “thick” causal knowledge —as opposed to “thin” difference-making information inferred from RCTs. Hence, ISCTs and RCTs cannot replace one another but rather, they are complementary in that the former provide information about the determinants of variability of causal effects, while the latter can, under certain conditions, establish causality in the first place. (shrink)

Although the literature on the issue of pluralism within the philosophy of science is very extensive, this paper focuses on the metaphysical causal pluralism that emerges from the new mechanistic discussion on causality. The main aim is to situate the new mechanistic views on causation within the account of varieties of causal pluralism framed by Psillos ( 2009 ). Paying attention to his taxonomy of metaphysical views on causation (i.e., the straightjacket view, the functional view, the two-concept view, the agnostic (...) view and the atheist view) will help clarify differences in opinion and, at the same time, make it possible to elucidate the main metaphysical theses present within the new mechanistic debate. Special attention is given to S. Glennan’s theory of causation, since it is unique in offering an overall metaphysical view of the issue. It is also argued that mechanists are not “atheists” on causation: while all of them are causal realists, most mechanists are “agnostic” on causation, with a few exceptions such as S. Glennan, P. Machamer and J. Bogen. (shrink)

Synthetic biology research is often described in terms of programming cells through the introduction of synthetic genes. Genetic material is seemingly attributed with a high level of causal responsibility. We discuss genetic causation in synthetic biology and distinguish three gene concepts differing in their assumptions of genetic control. We argue that synthetic biology generally employs a difference-making approach to establishing genetic causes, and that this approach does not commit to a specific notion of genetic program or genetic control. Still, we (...) suggest that a strong program concept of genetic material can be used as a successful heuristic in certain areas of synthetic biology. Its application requires control of causal context, and may stand in need of a modular decomposition of the target system. We relate different modularity concepts to the discussion of genetic causation and point to possible advantages of and important limitations to seeking modularity in synthetic biology systems. (shrink)

The basic kinds of physical causality that are foundational for other kinds of causality involve objects and the causal relations between them. These interactions do not involve events. If events were ontologically significant entities for causality in general, then they would play a role in simple mechanical interactions. But arguments about simple collisions looked at from different frames of reference show that events cannot play a role in simple mechanical interactions, and neither can the entirely hypothetical causal relations between events. (...) These arguments show that physics, which should be authoritative when it comes to the metaphysics of causality, gives no reasons to believe that events are causal agents. Force relations and some cases of energy-momentum transfer are examples of causal relations, with forces being paradigmatic in the macroscopic world, though it is conceivable that there are other kinds of causal relation. A relation between two objects is a causal relation if and only if when it is instantiated by the two objects there is a possibility that the objects that are the terms of the relation could change. The basic metaphysics of causality is about objects, causal relations, changes in objects, and a causal primitive. The paper also includes a discussion of the metaphysics of forces and a discussion of the metaphysics of energy and momentum exchanges. (shrink)

Causal analysis in the social sciences takes advantage of a variety of methods and of a multi-fold source of information and evidence. This pluralistic methodology and source of information raises the question of whether we should accordingly have a pluralistic metaphysics and epistemology. This paper focuses on epistemology and argues that a pluralistic methodology and evidence don’t entail a pluralistic epistemology. It will be shown that causal models employ a single rationale of testing, based on the notion of variation. Further, (...) I shall argue that this monistic epistemology is also involved in alternative philosophical theories of causation. (shrink)