Physical activity has wide-ranging consequences for people’s physical, mental, and social health. Although the beneficial effects of physical activity on well-being were widely studied, how it promotes well-being remained unclear. The present study utilized the measure of physical activity rating scale, flourishing scale, Chinese- meaning in life questionnaire, and general self-efficacy scale to examine the connection between physical activity and flourishing and the multiple mediation effects of meaning and self-efficacy with 827 Chinese undergraduates. The results indicated that physical activity positively (...) predicted flourishing; meaning in life and self-efficacy played mediating roles in physical activity and flourishing, separately and jointly. Our findings revealed the mechanism of physical activity fostering flourishing, thereby providing an empirical basis for promoting health and flourishing, especially during COVID-19. (shrink)