The discovery of RNA interference in 1998 has made a lasting impact on biological research. Identifying the regulatory role of small RNAs changed the modes of molecular biological inquiry as well as biologists' understanding of genetic regulation. This article examines the early years of small RNA biology's success story. I query which factors had to come together so that small RNA research came into life in the blink of an eye. I primarily look at scientific repertoires as facilitators of rapid (...) scientific change. I show that for a short period of time, between the years 1998 and 2002, different model organism communities, investigative strategies, technological innovations, and research interests could be successfully aligned to take small RNA research off the ground. I discuss how the keystone discoveries were situated in specific experimental traditions and what strategies were employed to establish these discoveries as more general phenomena. Providing thus a practice-based approach of rapid scientific change, I ask how to relate the change in propositional bits of scientific knowledge with changes in scientific practice. (shrink)

In recent decades many sociologists and philosophers of science, especially the so-called ‘new experimentalists’, have stressed the need for detailed studies of real, ongoing experimental practices, and have claimed that a new image of science results from such an approach. Among the new objects of interest that have emerged from laboratory studies, an important one is the tacit dimension of scientific practices. Harry Collins, in particular, has insisted that irreducibly tacit presuppositions and skills are inevitably involved in experimental practices, and (...) that these tacit resources play an essential role in the stabilization of successful scientific achievements. What I will call the ‘opacity of experimental practices’ has been analyzed in different ways, but on the whole, it has been claimed to have harmful epistemological consequences with respect to crucial issues such as the nature of experimental facts, scientific realism, scientific rationality, and the contingency of what acquires the status of an established scientific result in practitioners’ eyes. Such claims remain highly controversial. The aim of this paper is to discuss the epistemological implications of the involvement of tacit resources in experimental practices and to provide helpful conceptual tools with respect to the issue of tacit resources in science. Specifically, the paper provides an analytical clarification of the relation between the opacity of experimental practices and the principle of experimenters substitutability, the latter being a principle commonly viewed as a necessary feature of any good science. Serious doubts are finally raised about the validity of the experimenters substitutability principle, and the impact of these doubts with respect to the contingency of scientific facts and results is considered. (shrink)

This article analyses 1,073 e-mails that were hacked from the Climatic Research Unit at the University of East Anglia in November 2009. The incident was popularly dubbed 'Climategate', indicating that the e-mails reveal a scientific scandal. Here we analyse them differently. Rather than objecting to the exchanges based on some idea about proper scientific conduct, we see them as a rare glimpse into a situation where scientists collectively prepare for participation in heated controversy, with much focus on methodology. This allows (...) us to study how scientists communicate informally about framing propositions of facts in the best possible way. Through the eyes of science and technology studies, the e-mails provide an opportunity to study communication as part of science in the making across disciplines and laboratories. Analysed as 'written conversation' the e-mails provide information about processes of consensus formation through 'agonistic evaluations' of other scientists' work and persuasion of others to support one's own work. Also, the e-mails contain judgements about other groups and individual scientists. Consensus-forming appeared as a precarious activity. Controversies could be quite resilient in the course of this decade-long exchange, probably reflecting the complexity of the methodological challenges involved. (shrink)

The reorganization of the astronomical community during the late nineteenth and early twentieth centuries, due to the rise of astrophysics, was seen by some scientists as an opportunity to join an international community of prestigious researchers. This was the case of astronomers such as Josep Comas i Solà, who publicly argued with Eugène Michel Antoniadi during the first decades of the twentieth century about the veracity of astronomical observations and theoretical conclusions on Mars and Jupiter. Their priority claims and public (...) disputes have to be understood in a new context that provided an exceptional opportunity for amateur and professional astronomers both to play an active role in the most interesting scientific debates of these years and to gain prestige, legitimacy and power. (shrink)

Since the completion of the Human Genome Project, personalized medicine has become one of the most influential visions guiding medical research. This paper focuses on the politics of personalized medicine in psychiatry as a medical specialty, which has rarely been investigated by social science scholars. I examine how this vision is being sustained and even increasingly institutionalized within the mental health arena, even though related research has repeatedly failed. Based on a document analysis and expert interviews, this article identifies discursive (...) strategies that help to sustain this vision and its promises: “complexity talk,” “extension,” and “boundary work.” These practices secure its plausibility, protect it from criticism, and maintain stakeholder support. (shrink)

As sociologists learn more about how scientific knowledge is created, they give historians the opportunity to rework their accounts from a more contextual perspective. It is relatively easy to do so in areas with large theoretical, cosmological or overtly ideological components. It is more difficult, but equally necessary, to open up very empirical accomplishments, and recent sociological analysis of the process of science gives us some interesting insights. This paper employs some of these on the apparently unpromising subject of the (...) ‘discovery of secular magnetic variation’ in 1634 by the Gresham professor Henry Gellibrand. (shrink)

ArgumentDuring the second quarter of the nineteenth century, an argument raged about the identity of a small freshwater fish: was the parr a distinct species, or merely the young of the salmon? This “Parr Controversy” concerned both fishermen and ichthyologists. A central protagonist in the controversy was a man of ambiguous social and scientific status: a gamekeeper from Scotland named John Shaw. This paper examines Shaw’s heterogeneous practices and the reception of his claims by naturalists as he struggled to find (...) a footing on the “gradient of attributed competence” (Rudwick 1985). The case demonstrates the context-specific nature of expert-lay boundaries and identities and explores a range of material and linguistic resources available for negotiating them. Arguing for a view of Shaw’s trajectory as simultaneously one of being a “practical man” and of becoming a naturalist, the paper explores both the permeability of social hierarchies in knowledge production and their effective role in the regulation of competency. (shrink)

A rise of academic capitalism over the past four decades has been well documented within many research-intensive universities. Largely missing, however, are in-depth studies of how particularly situated academic groups manage the uncertainties that come with intermittent and fickle commercial funding streams in their daily research practice and problem choice. To capture the strategies scientists adopt under these conditions, this article provides an ethnographically detailed (and true) story about how a single project in Artificial Intelligence grew over several years from (...) a peripheral idea to the very center of an academic lab’s commercial portfolio. The analysis theorizes an epistemic form—nimble knowledge production—and documents three of its lab-level features: 1) rapid prototyping to keep sunk costs low, 2) shared search for “real world problems” rather than “theoretical” ones, and 3) nimble commitment to research problem choice. While similar forms of academic knowledge transfer have been lauded as “mode 2,” “innovative,” or “hybrid” for initiating cross-institutional collaboration and pushing science beyond disciplinary silos, this case suggests it can rely on fleeting attention to problems resistant to a quick fix. (shrink)

This paper argues that, as all available accounts of how scientific and non-scientific goals might be distinguished rely upon distinctions as much in need of explication as the notion of scientific goals itself, naturalized accounts of science should reject the notion that there are characteristically scientific goals for a given time and place and instead countenance only the goals which happen to be had by individual scientists or their communities. This argument and the recommendation that follows from it are illustrated (...) by reference to Watson and Crick's discovery of the structure of DNA. (shrink)

This study seeks to examine the impact of alumni connections between the evaluators and evaluatees on the results of peer review ratings for the Korean national R&D project and selection success rate. Specifically, this study analyzed the evaluation results of 8,402 research proposal entries submitted between 2007 and 2011 for the “general researchers support project,” all in the Natural Science and Engineering areas and sponsored by the National Research Foundation of Korea. Each proposal entry was evaluated by three evaluators, and (...) approximately 39 percent of the proposals had at least one evaluator from the same university. The results of this study showed that evaluators have a tendency to give relatively high scores to research proposals submitted by the alumni of the same universities as their alma mater. Also, when an evaluator from the same university as an evaluatee was included in the evaluator group, the results of this study showed that the percentage of entry submissions was higher compared to the contrary. Such results show that in the process of peer review–based research proposal evaluations for national R&D projects, alumni connections have significant influence on evaluation results in South Korea. (shrink)

I outline a pragmatic view of scientists' use of observation which draws attention to non-discursive, instrumental and social contexts of observation, in order to explain scientists' agreement about the appearance and significance of new phenomena. I argue that: observation is embedded in a network of activities, techniques, and interests; that experimentalists make construals of new phenomena which enable them communicate exploratory techniques and their outcomes, and that empirical enquiry consists of communicative, exploratory and predictive strategies whose interdependence ensures that, notwithstanding (...) the constructedness of representations and the empirical underdetermination of theories, observations contain information about the natural world. (shrink)

This paper explores whether we can interpret the notion of ‘forensic culture’ as something akin to what Knorr-Cetina called an ‘epistemic culture’. Can we speak of a ‘forensic culture’, and, if so, how is it similar to, or different from, other epistemic cultures that exist in what is conventionally called ‘science’? This question has important policy implications given the National Academy Science’s recent identification of ‘culture’ as one of the problems at the root of what it identified as ‘serious deficiencies’ (...) in U.S. forensic science and ‘scientific culture’ as an antidote to those problems. Finding the NAS’s characterisation of ‘scientific culture’ overly general and naïve, this paper offers a preliminary exploration of what might be called a ‘forensic culture’. Specifically, the paper explores the way in which few of the empirical findings accumulated by sociologists of science about research science seem to apply to forensic science. Instead, forensic science seems to have developed a distinct culture for which a sociological analysis will require new explanatory tools. Faithful sociological analysis of ‘forensic culture’ will be a necessary prerequisite for the kind of culture change prescribed by external reformist bodies like the NAS. (shrink)

The Committee on Common Problems of Genetics, Paleontology, and Systematics (United States National Research Council) marks part of a critical transition in American evolutionary studies. Launched in 1942 to facilitate cross-training between genetics and paleontology, the Committee was also designed to amplify paleontologist voices in modern studies of evolutionary processes. During coincidental absences of founders George Gaylord Simpson and Theodosius Dobzhansky, an opportunistic Ernst Mayr moved into the project's leadership. Mayr used the opportunity for programmatic reforms he had been pursuing (...) elsewhere for more than a decade. These are evident in the Bulletins he distributed under Committee auspices. In his brief tenure as Committee leader, Mayr gained his first substantial foothold within the coalescing community infrastructure of evolutionary studies. Carrying this momentum forward led Mayr directly into the project to launch the journal Evolution. The sociology of interdisciplinary activity provides useful tools for understanding the Committee's value in the broad sweep of change in evolutionary studies during the synthesis period. (shrink)

This article reviews recent work in socio-historical technology studies. Four problems, frequently mentioned in critical debates, are discussed—relativism, reflexivity, theory, and practice. The main body of the article is devoted to a discussion of the latter two problems. Requirements for a theory on socio-technical change are proposed, and one concrete example of a conceptual framework that meets these requirements is discussed. The second point of the article is to argue that present technology studies are now able to break away from (...) a too academic, internalistic perspective and return to the politically relevant "Science, Technology & Society" issues that informed much of this work more than a decade ago. (shrink)