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  1. Moral uncertainty and the farming of human-pig chimeras.Julian Koplin & Dominic Wilkinson - 2019 - Journal of Medical Ethics 45 (7):440-446.
    It may soon be possible to generate human organs inside of human-pig chimeras via a process called interspecies blastocyst complementation. This paper discusses what arguably the central ethical concern is raised by this potential source of transplantable organs: that farming human-pig chimeras for their organs risks perpetrating a serious moral wrong because the moral status of human-pig chimeras is uncertain, and potentially significant. Those who raise this concern usually take it to be unique to the creation of chimeric animals with (...)
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  • ‘It’s not worse than eating them’: the limits of analogy in bioethics.Julian J. Koplin - 2020 - Monash Bioethics Review 38 (2):129-145.
    Bioethicists often defend novel practices by drawing analogies with practices that we are already familiar with and currently tolerate. If some novel practice is less bad than some widely-accepted practice, then (it is argued) we cannot rightly reject it. Using the bioethics literature on xenotransplantation and interspecies blastocyst complementation as a case study, I show how this style of argument can go awry. The key problem is that our moral intuitions about familiar practices can be distorted by their seeming normality. (...)
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  • Human‐Animal Chimeras: The Moral Insignificance of Uniquely Human Capacities.Julian J. Koplin - 2019 - Hastings Center Report 49 (5):23-32.
    Human‐animal chimeras—creatures composed of a mix of animal and human cells—have come to play an important role in biomedical research, and they raise ethical questions. This article focuses on one particularly difficult set of questions—those related to the moral status of human‐animal chimeras with brains that are partly or wholly composed of human cells. Given the uncertain effects of human‐animal chimera research on chimeric animals’ cognition, it would be prudent to ensure we do not overlook or underestimate their moral status. (...)
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  • Ethical Arguments Concerning Human-Animal Chimera Research: A Systematic Review.Koko Kwisda, Lucie White & Dietmar Hübner - 2020 - BMC Medical Ethics 21:1-14.
    The burgeoning field of biomedical research involving the mixture of human and animal materials has attracted significant ethical controversy. Due to the many dimensions of potential ethical conflict involved in this type of research, and the wide variety of research projects under discussion, it is difficult to obtain an overview of the ethical debate. This paper attempts to remedy this by providing a systematic review of ethical reasons in academic publications on human-animal chimera research. We conducted a systematic review of (...)
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  • What Do Chimeras Think About?Benjamin Capps - 2023 - Cambridge Quarterly of Healthcare Ethics 32 (4):496-514.
    Non-human animal chimeras, containing human neurological cells, have been created in the laboratory. Despite a great deal of debate, the status of such beings has not been resolved. Under normal definitions, such a being could either be unconventionally human or abnormally animal. Practical investigations in animal sentience, artificial intelligence, and now chimera research, suggest that such beings may be assumed to have no legal rights, so philosophy could provide a different answer. In this vein, therefore, we can ask: What would (...)
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  • Philosophy is Still Missing from the Human-Mouse Chimera Debate.Benjamin Capps - 2021 - American Journal of Bioethics 21 (1):61-63.
    Given the broad coverage of “Human Brain Surrogates Research: The Onrushing Ethical Dilemma,” this commentary focuses on the section “human/nonhuman brain chimeras,” and specifically, the questions...
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