In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive immune systems. One question that has not been addressed yet is the transgenerational aspect of the CRISPR-Cas9-based response. If immunity is acquired and inherited, how to distinguish evolutionary from immunological adaptation? To shed light (...) on this issue and obtain conceptual clarity, I will investigate the inheritance of small RNA responses to pathogens in the nematode C. elegans as a further potential instantiation of a transgenerational adaptive immune system. I will explore how to make sense of systems that lie at the crossroads between genetic, immunological, and evolutionary spheres and explore the consequences of a transgenerational perspective on immune systems for immunology and its philosophy. (shrink)

This article presents a challenge that those philosophers who deny the causal interpretation of explanations provided by population genetics might have to address. Indeed, some philosophers, known as statisticalists, claim that the concept of natural selection is statistical in character and cannot be construed in causal terms. On the contrary, other philosophers, known as causalists, argue against the statistical view and support the causal interpretation of natural selection. The problem I am concerned with here arises for the statisticalists because the (...) debate on the nature of natural selection intersects the debate on whether mathematical explanations of empirical facts are genuine scientific explanations. I argue that if the explanations provided by population genetics are regarded by the statisticalists as non-causal explanations of that kind, then statisticalism risks being incompatible with a naturalist stance. The statisticalist faces a dilemma: either she maintains statisticalism but has to renounce naturalism; or she maintains naturalism but has to content herself with an account of the explanations provided by population genetics that she deems unsatisfactory. This challenge is relevant to the statisticalists because many of them see themselves as naturalists. (shrink)

I respond to recent criticism of my analysis of the permissive-instructive distinction and outline problems with the alternative analysis on offer. Amongst other problems, I argue that the use of formal measures is unclear and unmotivated, that the distinction is conflated with others that are not equivalent, and that no good reasons are provided for thinking the alternative model or formal measure tracks what biologists are interested in. I also clarify my own analysis where it has been misunderstood or ignored.

I respond to recent criticism of my analysis of the permissive-instructive distinction and outline problems with the alternative analysis on offer. Amongst other problems, I argue that the use of formal measures is unclear and unmotivated, that the distinction is conflated with others that are not equivalent, and that no good reasons are provided for thinking the alternative model or formal measure tracks what biologists are interested in. I also clarify my own analysis where it has been misunderstood or ignored.

The interventionist account provides us with several notions permitting the qualification of causal relationships. In recent years, there has been a push toward formalizing these notions using information theory. In this paper, I discuss one of them, namely causal specificity. The notion of causal specificity is ambiguous as it can refer to at least two different concepts. After having presented these, I show that current attempts to formalize causal specificity in information theoretic terms have mostly focused on one of these (...) two concepts. I then propose and apply a new information-theoretic measure which captures the other concept. (shrink)

The interventionist account provides us with several notions permitting the qualification of causal relationships. In recent years, there has been a push toward formalizing these notions using information theory. In this paper, I discuss one of them, namely causal specificity. The notion of causal specificity is ambiguous as it can refer to at least two different concepts. After having presented these, I show that current attempts to formalize causal specificity in information theoretic terms have mostly focused on one of these (...) two concepts. I then propose and apply a new information-theoretic measure which captures the other concept. (shrink)

Heritability is routinely interpreted causally. Yet, what such an interpretation amounts to is often unclear. Here, I provide a causal interpretation of this concept in terms of range of causal influence, one of several causal dimensions proposed within the interventionist account of causation. An information-theoretic measure of range of causal influence has recently been put forward in the literature. Starting from this formalization and relying upon Woodward’s analysis, I show that an important problem associated with interpreting heritability causally, namely the (...) locality problem, amounts, at least partly, to a low invariance and low stability between the genotype/environment and the phenotype of individuals. In light of this, I plead for a causal interpretation of heritability that takes the notions of Woodward’s invariance and stability into consideration. In doing so, I defuse naive causal interpretations of heritability. (shrink)

Genome-wide association studies of human complex traits have provided us with new estimates of heritability. These estimates foreground the question of genetic causation. After having presen...

In recent years the notion of biological specificity has attracted significant philosophical attention. This paper focuses on host specificity, a kind of biological specificity that has not yet been discussed by philosophers, and which concerns the extent to which a species is selective in the range of other species it exploits for feeding and/or reproduction. Host specificity is an important notion in ecology, where it plays a variety of theoretical roles. Here I focus on the role of host specificity in (...) biological control, a field of applied ecology that deals with the suppression of pests through the use of living organisms. Examining host specificity and its role in biological control yields several valuable contributions to our understanding of biological specificity. In particular, I argue that host specificity cannot be fully understood in terms of Woodward’s well-known account of causal specificity. To adequately account for host specificity, we need a notion of causal specificity that takes into consideration the extent to which a variable’s effects are similar to one another – a dimension not captured in Woodward’s account. In addition, the literature on host specificity in biological control highlights certain aspects in which causally specific relationships can be practically valuable that have not yet been addressed in philosophical discussions of specificity. That literature also reveals that in certain contexts specificity can hinder rather than foster effective control, thus leading to a nuanced assessment of the practical value of specific causes. (shrink)

Following from my criticisms of Calcott’s analysis on the permissive/instructive distinction, I rebut his claims that 1) he clarifies my measure one-to-one specificity; 2) for all intents and purposes of his analysis his notion of precision is different from my measure of one- to-one specificity; 3) Waddington box is a better and different model than the extension of Woodward’s radio I propose.