Synthetic biology represents a relatively young field of research which has developed into an important scientific endeavour. Characterised by a high degree of interdisciplinary work crossing disciplinary boundaries, such as biology, mathematics and engineering, SynBio has been, since its beginning, devoted to creating new biological functions, metabolic pathways or even minimal organisms. Although its often-articulated aim of developing new forms of life has so far not been archived, SynBio nowadays represents a well-established biotechnological approach and it has also attracted public (...) concern, especially since Craig Venter’s work on Mycoplasma Mycoides JCVI-syn1.0. Taking these developments as a starting point, the paper empirically investigates the metaphorical representations of SynBio in two leading German media publications, the daily newspaper Die Frankfurter Allgemeine Zeitung and the weekly magazine Der Spiegel between 2000 and 2010. Using a novel combination of metaphor and co-occurrence analysis, the paper engages in a systematic examination of implicit moral implications inherent in linguistic images permeating this news coverage. It demonstrates a method of how media-metaphorical representations and their moral implications of SynBio could analytically be revealed and analysed. In doing so, it aims at contributing to empirical ethical analyses of the news coverage on SynBio in particular and offers an approach that methodologically adds to literature on responsible language use, which is emerging in science and technology studies and ethical analyses of new technologies. (shrink)

Abduction and metaphor are two significant concepts in cognitive science. It is found that the both mental processes are on the basis of certain similarity. The similarity inspires us to seek the answers to the following two questions: Whether there is a common cognitive mechanism behind abduction and metaphor? And if there is, whether this common mechanism could be interpreted within the unified frame of modern intelligence theory? Centering on these two issues, the paper attempts to characterize and interpret the (...) generation and evolution of scientific metaphors from the perspective of the cognitive mechanism of abductive inference. Then it interprets the common cognitive mechanism behind abduction and metaphor within Hawkins’ frame of intelligence theory. The commonality between abduction and metaphor indicates the potential to further explore human intelligence. (shrink)

Images in science are often beautiful but their beauty cannot be explained using traditional aesthetic theories. Available theories either rely upon concepts antithetical to science, e.g. regularity as an index of God’s design, or they omit concepts intrinsic to scientific imaging, e.g. the image is taken as a representation of “beautiful nature.” I argue that the scientific image is not a representation but a construction: a series of mutually defining intra-actions, where “intra-action” signifies that the object depicted cannot be extricated (...) from the technologies of picturing. But how can the beauty of intra-active, picturing-depicted constructions be explained, when philosophical aesthetics traditionally understands objects of appreciation to be distinct, discrete items? I argue that metaphor provides a model for the aesthetics of the scientific image, on the grounds that it is itself an intra-action that promotes salience in perception. (shrink)

Concepts are traditionally pictured as discrete containers that bring together objects or qualities based on the possession of shared, uniform properties. This paper focuses on a contrasting notion of the concept which holds that concepts are defined by their capacity to reach out and connect with other concepts. Two theories in recent continental philosophy maintain this view: one from Ricoeur, the other from Deleuze and Guattari. Both are offered as attempts to bring art and philosophy into relation, but they differ (...) over how the process of connection is theorized. With Ricoeur, a concept is only a concept if it is inherently predisposed to connect with others, and open to being misapplied through metaphor, whereas, with Deleuze and Guattari, connection is left as the general notion of each and every concept being mutually consistent with other concepts, with the consistency attributed to the external action of “bridging.” The author demonstrates the impact of this difference on how the philosophers perceive the art–philosophy relation, and argues that Ricoeur is better placed to provide a theory of philosophical discourse that is open to the aesthetic. Ricoeur can show it through metaphor, while Deleuze and Guattari can only assert or state an art–philosophy relation through a series of technical claims. The significance of the showing–saying distinction is that it can demonstrate the depth with which conceptual connectivity is located within the philosophers’ respective ontologies, and can help to reveal the value of conceptual connectivity for that ontology. (shrink)

In philosophy of science, abstraction tends to be subsumed under representation, often being described as the omission of a target’s features when it is represented. This approach to abstraction sidesteps cognitive aspects of abstraction processes. However, cognitive aspects of abstraction are important in understanding the role of historically grounded epistemic criteria supporting modeling in science. Drawing on recent work on the relation between metaphor and abstraction, we introduce the concept of paths of abstraction, and use historical and contemporary examples to (...) point to their role in guiding the development of relevance criteria which support modeling strategies in science. (shrink)

It is widely accepted that, in the course of interpreting a metaphorical utterance, both literal and metaphorical interpretations of the utterance are available to the interpreter, although there may be disagreement about the order in which these interpretations are accessed. I call this the dual availability assumption. I argue that it does not apply in cases of metaphorical singular reference. These are cases in which proper names, complex demonstratives or definite descriptions are used metaphorically; e.g., ‘That festering sore must go’, (...) referring to a derelict house. We are forced to give up dual availability in these cases because a process of predicate transfer happens in the restriction clauses of such metaphorically used definite phrases, so that a denotation-less definite concept is never constructed. A process of enriched composition yields only a metaphorical referent/denotation. I compare cases of metaphorical reference both to cases of metonymic reference and to uses of epithets of the ‘That N of an N’ form. Reflection on the former is helpful in getting clear about the kind of property transfer involved in referential metaphors. Such transfer happens directly at the level of properties and is not mediated via a correspondence between objects, as is the case with metonymic reference. Reflection on epithets such as ‘that festering sore of a house’ is helpful since these are a sort of intermediate case between cases of literal and metaphorical reference. They provide support for my claim that in cases of metaphorical reference there is only a single referent. Moreover, constraints on the use of these epithets suggest that referential metaphors are similarly constrained. In particular, I argue that referential metaphors can only be used when the implicit category restriction is highly salient, and that the evaluative information conveyed by the metaphor serves primarily to indicate the speaker’s attitude towards the referent rather than being intended to help the hearer identify the referent. (shrink)

We consider the varieties and directions of influence that the source and target domains involved in a conceptual metaphor can have on each other during the course of understanding metaphorical utterances based on the metaphor. Previous studies have been restricted both as to direction of influence and as to type of influence. They have been largely confined to the “forward” (source to target) direction of influence, and they have concentrated on the transfer of features or propositions and (to some extent) (...) the highlighting of aspects of a domain. By contrast, this article stresses the importance both of other varieties of influence (e.g., transfer of queries and uncertainty effects) and of “reverse” influence (target to source). We seek to curb the natural tendency to think that, because metaphor involves an overall move from source to target, therefore all inter-domain influences in the course of understanding go in that direction. The bulk of the article explores the theoretical issues involved. These issues have arisen out of a reasoning-based approach to metaphor, seeking to make best use of information from metaphorical utterance, context, source and target domains, and known metaphorical mappings, by applying a complex overall reasoning process. The article briefly explains the thorough implementation of reverse influence in a computer program for metaphorical reasoning called ATT-Meta, although the theoretical considerations are relevant to all disciplines concerned with metaphor. We make some suggestions for further computational and psychological research on metaphor. (shrink)

This article focuses on the significance of acoustical phenomena in the development of the subjectivity of the infant. An attribute of that development, beginning with the breakdown of psychological symbiosis for the infant, is the loss implicit in the eventual participation of the subject in a symbolic order and the consequent acquisition of language. The essay examines how such loss can contribute to the constitution of the subject and the ego of the subject. Two aspects of language, metaphor and metonymy, (...) are examined in regard to their fundamental relationship to subjectivity. The character Echo, from the myth of Narcissus and Echo, is the namesake for a phase of development, the Echo Phase, which is postulated to begin after the third month of life. During this phase, to some extent the development of the subject depends upon intersubjectivity and concomitant auditory and linguistic phenomena. It is an implicit purpose of this essay to understand the advent of the ego as the expression of a phenomenological structure, dependent upon language and intersubjectivity, that mediates between subject and world. ... By chance Narcissus lost track of his companions, started calling "Is anybody here?" and "Here!" said Echo. He looked around in wonderment, called louder "Come to me!" "Come to me!" came back the answer. He looked behind him, and saw no one coming; "Why do you run from me?" and heard his question Repeated in the woods. "Let us get together!" There was nothing Echo would ever say more gladly, "Let us get together!" And to help her words, Out of the woods she came, with arms all ready To fling around his neck. But he retreated: "Keep your hands off," he cried, "and do not touch me! I would die before I give you a chance at me." "I give you a chance at me," and that was all She ever said thereafter, spurned and hiding, Ashamed, in the leafy forests, in lonely caverns. She frets and pines, becomes all gaunt and haggard, Her body dries and shrivels till voice only And bones remain, and then she is voice only For the bones are turned to stone. She hides in woods And no one sees her now along the mountains, But all may hear her, for her voice is living. Ovid, Metamorphoses. (shrink)

This paper examines creative strategies employed inscientific modelling. It is argued that being creativepresents not a discrete event, but rather an ongoingeffort consisting of many individual `creative acts''.These take place over extended periods of time andcan be carried out by different people, working ondifferent aspects of the same project. The example ofextended extragalactic radio sources shows that, inorder to model a complicated phenomenon in itsentirety, the modelling task is split up into smallerproblems that result in several sub-models. This is away (...) of using cognitive resources efficiently and in away which overcomes their limitations. Another aspectof modelling that requires creativity is theemployment of visualisation in order to reassemble,i.e. recreate the unity of, the various sub-models bymeans of visualisation. This illustrates how thecreative effort required to deal with the complexityof the complicated phenomenon of radio sources ischannelled in order to use cognitive resourcesefficiently and to stay within their capacity. (shrink)

Anthropologists, through participant observation, play a large role in creating the very locus of their research: socio-cultural context. Challenges to the social-scientific ‘objectivity’ of this process draw strength from historical precedent, and serve a vital role in the larger anthropological project of confronting, as both critic and product of Western thought, its inherent tensions. In this paper, I focus on two types of epistemological bias that construct and reinforce the validity of objective knowledge: objectivism and literalism. An analysis of ethnographic (...) treatments of the philosophical concerns of metaphor theory and phenomenology of the senses illustrates both the difficulty and utility of taking on the epistemological underpinnings of social science. (shrink)

The distinction between literal and figurative use is well-known and embedded in ‘folk linguistics’. According to folk linguistics, figurative uses deviate from literal ones. But recent work on lexical modulation and polysemy shows that meaning deviation is ubiquitous, even in cases of literal use. Hence, it has been argued, the literal/figurative distinction has no value for theorising about communication. In this paper, we focus on metaphor and argue that here the literal–figurative distinction has theoretical importance. The distinction between literal and (...) metaphorical needs to be captured by our account of communication because literal uses transmit information in a way that metaphorical ones do not. We argue that there is a way to explain the literal/metaphorical distinction that preserves the core of the folk-linguistic idea and gives the distinction theoretical relevance. We propose that literal uses of a word are made with the intention to conform to an established practice of use, while metaphorical uses do not so conform, but depend on this pre-existing practice. Our account can deal with data that are problematic for other theories. A further advantage is that it extends naturally to other non-literal uses of words, including metonymy. (shrink)

This paper aims at integrating the work onanalogical reasoning in Cognitive Science into thelong trend of philosophical interest, in this century,in analogical reasoning as a basis for scientificmodeling. In the first part of the paper, threesimulations of analogical reasoning, proposed incognitive science, are presented: Gentner''s StructureMatching Engine, Mitchel''s and Hofstadter''s COPYCATand the Analogical Constraint Mapping Engine, proposedby Holyoak and Thagard. The differences andcontroversial points in these simulations arehighlighted in order to make explicit theirpresuppositions concerning the nature of analogicalreasoning. In the (...) last part, this debate in cognitivescience is applied to some traditional philosophicalaccounts of formal and material analogies as a basisfor scientific modeling, like Mary Hesse`s, and tomore recent ones, that already draw from the work inArtificial Intelligence, like that proposed byAronson, Harré and Way. (shrink)

This study reassesses the occult philosophy of the British polymath John Dee. Focusing on his treatise Monas hieroglyphica and his notorious angelic conversations in the 1580s, it describes Dee’s philosophical career as a continuous search for a language which could yield knowledge of both nature and God. Situating Dee’s philosophy in the context of early modern “symbolic exegesis”, a group of discursive practices aimed at uncovering the creative principles of God by means of language, the study is an attempt to (...) show how Dee’s seemingly divergent interests were interrelated. In Monas hieroglyphica he treated such disciplines as grammar, biblical exegesis, kabbalah, astronomy, alchemy, and mathematics as grounded on a common foundation, identical to the Word of God. By conceiving a graphical symbol, expressing God’s Word in visual form, Dee believed that he could bring these sciences to perfection. In the later angelic conversations, Dee’s aim was to recover the language spoken by the prelapsarian Adam. The Adamic language was conceived of as representing accurately God’s creative Word, and Dee’s recovery of this tongue would ultimately result in a complete restitution of both religion and knowledge. Dee’s works provide an example of how metaphoric associations between the Word of God, language, nature and the human soul could be exploited in Renaissance occult thought. Such metaphoric associations had an important role in shaping and legitimizing early modern views of symbolism, mysticism, and magic. Relying on Dee’s own sources, many of which still survive with his annotations, this study tries to reconstruct Dee’s search for the perfect language, while simultaneously stressing the syncretistic character of his views. (shrink)

Conceptual Metaphor Theory makes some strong claims against so-called Classical Theory which spans the accounts of metaphors from Aristotle to Davidson. Most of these theories, because of their traditional literal-metaphorical distinction, fail to take into account the phenomenon of conceptual metaphor. I argue that the underlying mechanism for explaining metaphor bears some striking resemblances among all of these theories. A mapping between two structures is always expressed. Conceptual Metaphor Theory insists, however, that the literal-metaphorical distinction of Classical Theories is empirically (...) wrong. I claim that this criticism is based rather on terminological decisions than on empirical issues. Conceptual Metaphor Theory focusses primarily on conventional metaphors and struggles to extend its mechanism to novel metaphors, whereas Classical Theories focus on novel metaphors and struggle to extend their mechanisms to conventional metaphors. Since all of these theories study metaphors from the synchronic point of view, they are unable to take into account any semantic change. A diachronic perspective is what we need here, one which would allow us to explain the role of metaphor in semantic change and the development of language in general. (shrink)

Analytic philosophy was introduced in Latin America in the mid-twentieth century. Its development has been heterogeneous in different countries of the region but has today reached a considerable degree of maturity and originality, with a strong community working within the analytic tradition in Latin America. This entry describes the historical development of analytic philosophy in Latin America and offers some examples of original contributions by Latin American analytic philosophers.

This paper offers both exegetical and systematic reconsiderations of Donald Davidson’s view on metaphor. In his essay What Metaphors Mean, Davidson argued against the idea that metaphors have any kind of propositional content beyond the literal meaning of the relevant sentence. Apart from this negative claim, Davidson also made a constructive proposal by suggesting that metaphor’s distinctive effect is to prompt a mental state of seeing-as. These two points seem connected insofar as Davidson makes the following assumptions. First, metaphors cause (...) their distinctive effects in an a-rational way. Second, seeing-as is a nonpropositional mental state. If we side with Davidson in thinking of meaning as rational and propositional, then it follows that metaphors’ distinctive effects cannot be an instance of meaning. They have the wrong format and are brought about in the wrong way. Against this background, I distinguish a strong reading and a modest reading of Davidson’s wrong-kind objection to metaphorical meaning. By taking into account some of Davidson’s later pronouncements on the matter, this paper aims to show that Davidson did not hold on to the strong version of the wrong-kind objection. This would open up the way to conceiving of metaphorical meaning in terms of speaker’s meaning, were it not for the fact that Davidson sticks to the wrong-way objection. The two concluding sections examine the cogency of the wrong-way objection as applied to metaphorical speaker’s meaning, and offer a model for thinking about the a-rational mental causation Davidson thought metaphors exhibit. (shrink)

This article focuses on two largely ignored aspects of the understanding of strong metaphors: the visual dimension and the emotional factors. Particularly, I intend to offer answers to the following questions: 1) What does it mean to understand a visual metaphor? 2) Can Wittgenstein’s ideas about the vision of aspects help to better understand this understanding? 3) In what sense does his notion of secondary sense enrich the philosophical reflection on the understanding of metaphors? 4) In what sense may emotions (...) be an important factor in the understanding of certain metaphors? The article is framed in a methodological proposal: I defend a phenomenology of the metaphor, that is, an accurate description of our experiences with metaphors, and in this case, its understanding. (shrink)

The backward induction controversy in game theory flared up and then practically ended within a decade – the 1990s. The protagonists, however, did not converge on an agreement about the source of the controversy. Why was this the case, if opposing sides had access to the same modelling techniques and empirical facts? In this paper I offer an explanation for this controversy and its unsettled end. The answer is not to be found in the modelling claims made by the opposing (...) protagonists, but in the tacit metaphors they operate under. Aristotle defined metaphor as giving a 'thing a name that belongs to something else' (Poetica, 1457b). The meaning of metaphors has not changed much since then – in contrast to models which are comparatively new, and still not well-understood, scientific tools. The controversy of backward induction in game theory provides a test bed for the explanatory power of metaphors. This paper frames the controversy in terms of metaphor choice to provide a common framework for the protagonists. This results in the identification of three different domains – mathematical logic, game theory and the world – each connected to the other via different metaphors. The controversy around backward induction is placed in, and tentatively explained by, this framework. (shrink)

Metaphors can be used as crucial tools for reaching shared understanding, especially where an epistemic imbalance of knowledge is at stake. However, metaphors can also represent a risk in intercultural or cross-cultural interactions, namely in situations characterised by little or deficient common ground between interlocutors. In such cases, the use of metaphors can lead to misunderstandings and cause communicative breakdowns. The conditions defining when metaphors promote, and hinder understanding have not been analyzed in detail, especially in intracultural contexts. This study (...) proposes an analysis of metaphors identified within an Italian corpus of diabetes care interviews. Through a coding scheme capturing the types and the probative weights of the linguistic evidence that can be used to detect misunderstandings, the communicative effectiveness of metaphors is indirectly assessed. The quantitative and qualitative analyses show a positive correlation between metaphor use and problematic understanding. A more detailed scrutiny of the interlocutors’ roles and topics of the metaphors points out that most of the problematic metaphors are used by patients, while most of the problematic ones used by providers concern non-clinical matters. These results can be explained as resulting from incorrect presumptions of common ground between the interlocutors. (shrink)

The concept of natural kind is center stage in the debates about scientific realism. Champions of scientific realism such as Richard Boyd hold that our most developed scientific theories allow us to “cut the world at its joints” (Boyd, 1981, 1984, 1991). In the long run we can disclose natural kinds as nature made them, though as science progresses improvements in theory allow us to revise the extension of natural kind terms.

The main purpose of this dissertation is to examine critically and discuss the role of imagination in science and religion, with particular emphasis on its possible epistemic, creative, and meaning-making functions. In order to answer my research questions, I apply theories and concepts from contemporary philosophy of mind on scientific and religious practices. This framework allows me to explore the mental state of imagination, not as an isolated phenomenon but, rather, as one of many mental states that co-exist and interplay (...) in our cogntive architecture. Based on the philosophical discourse of philosophy of mind, four types of imagination are indentified and conceptualized: sensory, propositional, experiential, and creative imagination. These categories are then employed on five phenomena that can be found in scientific and religious environments: metaphors, models, thought experiments, aspect perception, and - in the religious case - rituals. In relation to the concept of religious "seeing" I consider how imaginings may influence visionary experiences and visualization, and compare these phenomena with cases of scientific visualization and eureka experiences. In regard to scientific and religious models, a distinction is made between, on the one hand, two notions of truth and, on the other hand, truth-independent meaning-making. In light of these categories, I differentiate between, and critically discuss, the use of imagination in doxastic, non-doxastic and fictionalist accounts. In light of this investigation, I formulate and defend the position of interactivism, which acknowledges a constant interplay between different attitudes and mental states. In my examination of rituals and scientific and religious thought experiments, special attention is given to the mental capacity to recreate the experiences that are entailed in an imagined scenario. At the end of the investigation, I consider the possible impact that my study might have on how we view science and religion as well as the dialogue bewteen these two fields. (shrink)

The article develops and justifies, on the basis of the epistemological argumentation theory, two central pieces of the theory of evaluative argumentation interpretation: 1. criteria for recognizing argument types and 2. rules for adding reasons to create ideal arguments. Ad 1: The criteria for identifying argument types are a selection of essential elements from the definitions of the respective argument types. Ad 2: After presenting the general principles for adding reasons (benevolence, authenticity, immanence, optimization), heuristics are proposed for finding missing (...) reasons, for deductive arguments, e.g., semantic tableaux are suggested. (shrink)

Neste trabalho, avaliamos as implicações que o debate filosófico acerca das explicações em termos de função e objetivo podem ter no contexto educacional, particularmente no ensino e aprendizagem de biologia. Para alcançar este objetivo, investigamos como três obras didáticas de biologia do Brasil utilizam a linguagem teleológica na formulação de explicações para os assuntos que são objeto de estudo dessa ciência. Na análise das obras, exploramos os enunciados teleológicos e funcionais a partir de dois projetos explanatórios discutidos na filosofia da (...) biologia contemporânea, a saber: (i) etiológico, que fornece uma abordagem essencialmente histórica de explicação biológica; e (ii) organizacional, que orienta o estudo acerca das capacidades de sistemas complexos mediante o apelo às funções de seus componentes, ou seja, a contribuição das partes para a realização de uma capacidade global. Nossos resultados mostram que poucas explicações podem ser qualificadas como etiológicas, em razão de que os autores preterem a discussão de temas segundo um tratamento evolutivo. Associado a esse resultado, a maioria dos enunciados foi localizada no contexto do projeto organizacional de explicação científica. Na análise das explicações, destacamos os principais problemas que elas apresentam, como a falta de clareza na identificação do explanandum e explanans, situação que pode prejudicar a compreensão dos assuntos pelos estudantes. Por fim, colocamos que a recontextualização das duas abordagens centrais sobre as explicações funcionais na filosofia da biologia, a perspectiva etiológica e a organizacional, podem fornecer um embasamento epistemológico consistente para as explicações biológicas no ensino médio. (shrink)

This thesis examines the relationship between language and social reality. The position argued for is one which sees language as having a constitutive role to play in the formation and maintenance of the social world. It elaborates and develops a view expressed by Quentin Skinner, namely, that language and the social world are mutually supportive and exist in a state of dynamic interaction. Because language has this constitutive role in relation to the social world attention to the use of language (...) is important for the language we employ will be a significant factor in determining the nature of that world. The notion of ideology is defined in a critical sense as 'malign decontestation', i. e., the presentation of that which is contestable as if there were only one legitimate perspective. The concepts of absolutism and universalisation are taken as key ideological markers. Given the constitutive role of language, the identification of ideological language becomes important because aspects of the social world which are informed by such a language will reflect the errors inherent in the linguistic structures themselves. One of the central arguments of the thesis is that ideological language often arises when insufficient attention is paid to the ontological differences between activities whose subject matter is the natural world and those whose subject matter is the social world. There is a focus on educational issues because the impetus for this thesis arose out of a growing unease with the nature of the language used in relation to this topic. Although a concern with the language of education is not uncommon, the full significance of the language we use in this area is often unacknowledged because the necessary theoretical background is absent. It is the main purpose of this thesis to provide a philosophical justification for this concern. (shrink)

This research aims at unraveling relationships between rhetorical devices from elocutio and argumentative topoi from inventio in advertising. Studies on this topic have attempted to demonstrate not only that rhetorical devices condense argumentation schemes, but also that they have a strong argumentative force. I will try to achieve my goal by applying the Argumentum Model of Topics to a corpus of award-winning advertisements.

The use of metaphors and other tropes in science receives nowadays growing attention among the philosophers of science, mainly when related to theoretical models. In this paper I analyse basically issues like the cognitive value of scientific metaphors, the role played by analogy in the constructions of metaphors, and, mainly, the question of whether theoretical models are metaphors. Throughout the analysis of different current approaches to the relationships between metaphors and models in science, I claim that the analogy only plays (...) a fundamental role in the metaphorical proposals in science after analogue theoretical models are at our disposal. This nonetheless does not preclude for the analogy to become sometimes a guide in scientific creativity. (shrink)

Sometimes analogy researchers talk as if the freshness of an experience of analogy resides solely in seeing that something is like something else -- seeing that the atom is like a solar system, that heat is like flowing water, that paint brushes work like pumps, or that electricity is like a teeming crowd. But analogy is more than this. Analogy isn't just seeing that the atom is like a solar system; rather, it is seeing something new about the atom, an (...) observation enabled by 'looking' at atoms from the perspective of one's understanding of solar systems. The question for analogy researchers then is this: Where does this new knowledge about atoms come from? How can an analogy provide new knowledge and new understanding? (shrink)

Systems biology is sometimes presented as providing a superior approach to the problem of biological complexity. Its use of ‘unbiased’ methods and formal quantitative tools might lead to the impression that the human factor is effectively eliminated. However, a closer look reveals that this impression is misguided. Systems biologists cannot simply assemble molecular information and compute biological behavior. Instead, systems biology’s main contribution is to accelerate the discovery of mechanisms by applying models as heuristic tools. These models rely on a (...) variety of idealizing and simplifying assumptions in order to be efficient for this purpose. The strategies of systems biologists are similar to those of experimentalists in that they attempt to reduce the complexity of the discovery process. Analyzing and comparing these strategies, or ‘heuristics’, reveals the importance of the human factor in computational approaches and helps to situate systems biology within the epistemic landscape of the life sciences. (shrink)