1. A Historical Look at Unity 2. Field Guide to Modern Concepts of Reduction and Unity 3. Kitcher's Revisionist Account of Unification 4. Critics of Unity 5. Integration Instead of Unity 6. Reduction via Mechanisms 7. Case Studies in Reduction and Unification across the Disciplines.

The problem of unifying knowledge represents the frontier between science and philosophy. Science approaches the problem analytically bottom-up whereas, prior to the end of the nineteenth century, philosophy approached the problem synthetically top-down. In the late nineteenth century, the approach of speculative metaphysics was rejected outright by science. Unfortunately, in the rush for science to break with speculative metaphysics, synthetic or top-down philosophy as a whole was rejected. This meant not only the rejection of speculative metaphysics, but also the implicit (...) rejection of empirically-led synthetic philosophy and the philosophy of nature. Since a change in the paradigm of science requires a change in the philosophy of nature underpinning science, the rejection of the philosophy of nature closes science to the possibility of a paradigm change. Given the foundational problems faced by science, there is a need for empirically-led synthetic philosophy in order to discover a new empirically-based philosophy of nature. Such a philosophy of nature may open science to the possibility of a paradigm change. (shrink)

As much as assumptions about mechanisms and mechanistic explanation have deeply affected psychology, they have received disproportionately little analysis in philosophy. After a historical survey of the influences of mechanistic approaches to explanation of psychological phenomena, we specify the nature of mechanisms and mechanistic explanation. Contrary to some treatments of mechanistic explanation, we maintain that explanation is an epistemic activity that involves representing and reasoning about mechanisms. We discuss the manner in which mechanistic approaches serve to bridge levels rather than (...) reduce them, as well as the different ways in which mechanisms are discovered. Finally, we offer a more detailed example of an important psychological phenomenon for which mechanistic explanation has provided the main source of scientific understanding. (shrink)

With the emergence of systems biology the notion of organizing principles is being highlighted as a key research aim. Researchers attempt to ‘reverse engineer’ the functional organization of biological systems using methodologies from mathematics, engineering and computer science while taking advantage of data produced by new experimental techniques. While systems biology is a relatively new approach, the quest for general principles of biological organization dates back to systems theoretic approaches in early and mid-20th century. The aim of this paper is (...) to draw on this historical background in order to increase the understanding of the motivation behind the systems theoretic approach and to clarify different epistemic aims within systems biology. We pinpoint key aspects of earlier approaches that also underlie the current practice. These are i) the focus on relational and system-level properties, ii) the inherent critique of reductionism and fragmentation of knowledge resulting from overspecialization, and iii) the insight that the ideal of formulating abstract organizing principles is complementary to, rather than conflicting with, the aim of formulating detailed explanations of biological mechanisms. We argue that looking back not only helps us understand the current practice but also points to possible future directions for systems biology. (shrink)