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  1. Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and Conflicts.David Lorenzo, Montse Esquerda, Francesc Palau, Francisco J. Cambra & Grup Investigació en Bioética - 2022 - NanoEthics 16 (3):313-321.
    The field of genetics has seen major advances in recent decades, particularly in research, prevention and diagnosis. One of the most recent developments, the genomic editing technique Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, has opened the possibility for genetic therapies through genome modification. The technique marks an improvement on previous procedures but poses some serious ethical conflicts. Bioethics is the discipline geared at finding answers to ethical challenges posed by progress in medicine and biology and examining their repercussions for (...)
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  • States of Uncertainty, Risk–Benefit Assessment and Early Clinical Research: A Conceptual Investigation.Marcel Mertz & Antje Schnarr - 2022 - Science and Engineering Ethics 28 (6):1–21.
    It can be argued that there is an ethical requirement to classify correctly what is known and what is unknown in decision situations, especially in the context of biomedicine when risks and benefits have to be assessed. This is because other methods for assessing potential harms and benefits, decision logics and/or ethical principles may apply depending on the kind or degree of uncertainty. However, it is necessary to identify and describe the various epistemic states of uncertainty relevant to such estimates (...)
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  • Frame Reflection Lab: a Playful Method for Frame Reflection on Synthetic Biology.Marjoleine G. van der Meij, Anouk A. L. M. Heltzel, Jacqueline E. W. Broerse & Frank Kupper - 2018 - NanoEthics 12 (2):155-172.
    Synthetic biology is an emerging technology that asks for inclusive reflection on how people frame the field. To unravel how we can facilitate such reflection, this study evaluates the Frame Reflection Lab. Building upon playfulness design principles, the FRL comprises a workshop with video-narratives and co-creative group exercises. We studied how the FRL facilitated frame reflection by organizing workshops with various student groups. Analysis of 12 group conversations and 158 mini-exit surveys yielded patterns in first-order reflection as well as patterns (...)
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  • Is It All About Revising, Correcting, and Transferring Genes?Vasilija Rolfes, Uta Bittner, Heiner Fangerau & Karsten Weber - 2020 - American Journal of Bioethics 20 (8):30-32.
    Volume 20, Issue 8, August 2020, Page 30-32.
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  • Islamic Perspectives on CRISPR/Cas9-Mediated Human Germline Gene Editing: A Preliminary Discussion.Noor Munirah Isa, Nurul Atiqah Zulkifli & Saadan Man - 2020 - Science and Engineering Ethics 26 (1):309-323.
    The recent development of CRISPR/Cas9 technology has rekindled the ethical debate concerning human germline modification that has begun decades ago. This inexpensive technology shows tremendous promise in disease prevention strategies, while raising complex ethical concerns about safety and efficacy of the technology, human dignity, tampering with God’s creation, and human genetic enhancement. Germline gene editing may result in heritable changes in the human genome, therefore the question of whether it should be allowed requires deep and careful discussion from various perspectives. (...)
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  • Walking a Fine Germline: Synthesizing Public Opinion and Legal Precedent to Develop Policy Recommendations for Heritable Gene-Editing.Shawna Benston - 2022 - Journal of Bioethical Inquiry 19 (3):421-431.
    Gene-editing technologies, such as CRISPR/Cas9, are internationally ethically fraught. In the United States, policy surrounding gene-editing has yet to be implemented, while the science continues to speed ahead. However, it is not enough that policy be implemented: in order for policy to establish limits for the technology such that benefits are possible while threats are kept at bay, such policy must be ethical. In turn, the ethics of gene-editing is a culturally determined field of inquiry. This piece presents a proposal (...)
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  • Everything in moderation, even hype: learning from vaccine controversies to strike a balance with CRISPR.Shawna Benston - 2017 - Journal of Medical Ethics 43 (12):819-823.
    The ease and applicability of CRISPR/Cas9––a new and precise gene editing and reproductive technology––have garnered hype and heightened concern about its potential ‘unprecedented and horrific consequences’ and have led many scientific leaders to call for a moratorium on its research and use. CRISPR appears distinctly more controversial than previous technological innovations, with a greater reach and speed of human treatment and enhancement; however, we have seen similarly inflated hopes and fears in response to other medical innovations for well over a (...)
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  • Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.Karla Alex & Eva C. Winkler - forthcoming - Journal of Medical Ethics.
    Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...)
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