Prions, prion-related diseases and prion-like phenomena are not only the subjects of rapidly growing scientific research interests, but also appear to be interesting from a philosophical perspective. In this study, we first present a brief review of the current prion research that includes a conceptual expansion of the notion of “prion” as a pathogenic conformation of a specific mammalian protein, towards more general “prion-like phenomena”, that can sometimes assume important beneficial functions in a broad range of biological contexts. Next, we (...) introduce Gilbert Simondon’s theory of individuation, which is a philosophical framework applicable to all possible domains of becoming. In contrast to the common approach of dividing the realm of ontogenetic processes into distinct domains and treating them separately, Simondon distinguishes between different modes of the same process: i.e., the physical, vital, and psycho-collective modes. His theory thus appears relevant with regard to the notion of prion-like phenomena in the extended sense, which seems to provide a useful metaphor for better understanding different modes of individuation and transitions between them. In particular, the transition from the physical to the vital mode is closely related to some core questions of biosemiotics such as the emergence of life from non-life, as well as “how a molecule became a sign”, which today constitute blank spots where the classical specialised disciplines of natural sciences fall short of satisfactory explanations. When recent scientific findings on prion-related phenomena are interpreted in the context of Simondon’s ontogenetic framework, the question related to the origin of life in our provocative title gains a different meaning. (shrink)