Philosophers of science diverge on the question what drives the growth of scientific knowledge. Most of the twentieth century was dominated by the notion that theories propel that growth whereas experiments play secondary roles of operating within the theoretical framework or testing theoretical predictions. New experimentalism, a school of thought pioneered by Ian Hacking in the early 1980s, challenged this view by arguing that theory-free exploratory experimentation may in many cases effectively probe nature and potentially spawn higher evidence-based theories. Because (...) theories are often powerless to envisage workings of complex biological systems, theory-independent experimentation is common in the life sciences. Some such experiments are triggered by compelling observation, others are prompted by innovative techniques or instruments, whereas different investigations query big data to identify regularities and underlying organizing principles. A distinct fourth type of experiments is motivated by a major question. Here I describe two question-guided experimental discoveries in biochemistry: the cyclic adenosine monophosphate mediator of hormone action and the ubiquitin-mediated system of protein degradation. Lacking underlying theories, antecedent data bases, or new techniques, the sole guides of the two discoveries were respective substantial questions. Both research projects were similarly instigated by theory-free exploratory experimentation and continued in alternating phases of results-based interim working hypotheses, their examination by experiment, provisional hypotheses again, and so on. These two cases designate theory-free, question-guided, stepwise biochemical investigations as a distinct subtype of the new experimentalism mode of scientific enquiry. (shrink)

This paper aims to advance two claims. First, it aims to show that Hume's argument against the rationality of induction is sound. However, I claim that the conclusion does not follow merely from the self-defeating attempts to justify the rule of induction, unlike traditional readings of the argument. Rather, the skeptical conclusion must also take into account Hume's argument that the secret powers that are present in bodies and give rise to sensible qualities are unknowable. The paper's second aim is (...) to show that Newtonian induction escapes Hume's secret powers argument, given that it includes a transductive inference, from observable phenomena to the powers present in the ultimate parts of matter. Consequently Hume's argument against the rationality of induction does not demonstrate the non-rational nature of Newtonian induction. (shrink)

This paper aims to advance two claims. First, it aims to show that Hume’s argument against the rationality of induction is sound. However, I claim that the conclusion does not follow merely from the self-defeating attempts to justify the rule of induction, unlike traditional readings of the argument. Rather, the skeptical conclusion must also take into account Hume’s argument that the secret powers that are present in bodies and give rise to sensible qualities are unknowable. The paper’s second aim is (...) to show that Newtonian induction escapes Hume’s secret powers argument, given that it includes a transductive inference, from observable phenomena to the powers present in the ultimate parts of matter. Consequently Hume’s argument against the rationality of induction does not demonstrate the non-rational nature of Newtonian induction. (shrink)

State of the art paper on the problem of induction: how to justify the conclusion that ‘all Fs are Gs’ from the premise that ‘all observed Fs are Gs’. The most prominent theories of contemporary philosophical literature are discussed and analysed, such as: inductivism, reliabilism, perspective of laws of nature, rationalism, falsificationism, the material theory of induction and probabilistic approaches, according to Carnap, Reichenbach and Bayesianism. In the end, we discuss the new problem of induction of Goodman, raised by the (...) grue predicate. (shrink)