Switch to: References

Add citations

You must login to add citations.
  1. A telomerase mutant defective in sister chromatid separation at mitosis.Yukinobu Nakaseko & Mitsuhiro Yanagida - 1997 - Bioessays 19 (7):557-559.
    The telomere is a functional domain of the chromosome, located at the extreme ends, and is essential for normal chromosome stability. Chromosomes lacking telomeres are inherited improperly, and mutations in the telomeric repeat sequences are thought to lead to senescence and possibly to cancer. The molecular mechanisms maintaining chromosomes by telomeres, however, have been unclear. Results recently reported by Kirk et al.(1) offer an insight into new telomerase function. They have identified a novel telomerase mutation that blocks sister chromatid separation (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  • Chromosome rearrangements resulting from telomere dysfunction and their role in cancer.John P. Murnane & Laure Sabatier - 2004 - Bioessays 26 (11):1164-1174.
    Telomeres play a vital role in protecting the ends of chromosomes and preventing chromosome fusion. The failure of cancer cells to properly maintain telomeres can be an important source of the chromosome instability involved in cancer cell progression. Telomere loss results in sister chromatid fusion and prolonged breakage/fusion/bridge (B/F/B) cycles, leading to extensive DNA amplification and large deletions. These B/F/B cycles end primarily when the unstable chromosome acquires a new telomere by translocation of the ends of other chromosomes. Many of (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  • Chromosome healing: Spontaneous and programmed de novo telomere formation by telomerase.Meni Melek & Dorothy E. Shippen - 1996 - Bioessays 18 (4):301-308.
    Telomeres are protective caps for chromosome ends that are essential for genome stability. Broken chromosomes missing a telomere will not be maintained unless the chromosome is ‘healed’ with the formation of a new telomere. Chromosome healing can be a programmed event following developmentally regulated chromosome fragmentation, or it may occur spontaneously when a chromosome is accidentally broken. In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomeres de novo (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations