The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif. With PGRN family members in plants and slime mold, it represents one of the most ancient of the extracellular regulatory proteins still extant in modern animals. PRGN has multiple biological roles. It contributes to the regulation of early embryogenesis, to adult tissue repair and inflammation. Elevated PGRN levels often occur in cancers, and PGRN immunotherapy inhibits the (...) growth of hepatic cancer xenografts in mice. Recent studies have demonstrated roles for PGRN in neurobiology. An autosomal dominant mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia. In this review we will discuss current knowledge of the multifaceted biology of PGRN. (shrink)

Objective Cluster randomised trial (CRT) investigators face challenges in seeking informed consent from individual patients (cluster members). This study examined associations between reporting of patient consent in healthcare CRTs and characteristics of these trials. Study design Consent practices and study characteristics were abstracted from a random sample of 160 CRTs performed in primary or hospital care settings that were published from 2000 to 2008. Multivariable logistic regression was used to examine associations between reporting of patient consent and methodological characteristics, as (...) well as publication features such as date and journal of publication. Results 82 (53.8%) of 160 studies reported obtaining informed consent from individual patients. Reporting of patient consent was independently and positively associated with: smaller cluster size, the evaluation of experimental interventions targeted at patients, data collection from individual patients, publication later than 2004 and publication in higher-impact journals. Conclusions Reporting of consent practices in published CRTs should be improved. Consent practices in published CRTs appear to be related to the type of interventions under study, as well as journal impact and trends in research ethics practices. These findings will inform best practices in trial conduct and ethics review, remediation of errors in consent practices and ethics review and the development of regulatory guidance for CRTs. (shrink)

For many decades, researchers have explored the true potential of human achievement. The expertise field has come a long way since the early works of de Groot (1965) and Chase and Simon (1973). Since then, this inquiry has expanded into the areas of music, science, technology, sport, academia and art. Despite the vast amount of research to date, the capability of study methodologies to truly capture the nature of expertise remains questionable. Some considerations include (i) the individual bias in the (...) retrospective recall of developmental activities, (ii) the ability to develop ecologically valid tasks, and (iii) difficulties capturing the influence of confounding factors on expertise. This article proposes that expertise research in electronic sports (esports) presents an opportunity to overcome some of these considerations. Esports involves individuals or teams of players that compete in video game competitions via human-computer interaction. Advantages of applying the expert performance approach in esports include (i) developmental activities are objectively tracked and automatically logged online, (ii) the constraints of representative tasks correspond with the real-world environment of esports performance, and (iii) expertise has emerged without the influence of guided systematic training environments. Therefore, this article argues that esports research provides an ideal opportunity to further advance research on the development and assessment of human expertise. (shrink)

This paper posits that ethical leadership increases important organizational and individual outcomes by reducing politics in the workplace. Specifically, we propose that perceptions of organizational politics serve as a mechanism through which ethical leadership affects outcomes. We further argue that the modeled relationships are moderated by political skill. By means of data from 136 matched pairs of supervisors and subordinates employed by a state agency in the southern US, we found support for our predictions. Specifically, we found that perceptions of (...) organizational politics fully mediated the relationship between perceptions of ethical leadership and helping and promotability ratings. In addition, political skill was found to moderate the direct and indirect effects. (shrink)

What is this thing called literature? Why study it? And how? Relating literature to topics such as dreams, politics, life, death, the ordinary and the uncanny, This Thing Called Literature establishes a sense of why and how literature is an exciting and rewarding subject to study. Andrew Bennett and Nicholas Royle expertly weave an essential love of literature into an account of what literary texts do, how they work and the sort of questions and ideas they provoke. The (...) book's three parts reflect the fundamental components of studying literature: reading, thinking and writing. The authors use helpful and wide-ranging examples and summaries, offering rich reflections on the question 'What is literature?' and on what they term 'creative reading'. The new edition has been revised throughout with extensive updates to the further reading, and a new chapter on creative non-fiction. Bennett and Royle's accessible and thought-provoking style encourages a deep engagement with literary texts. This essential guide to the study of literature is as an eloquent celebration of the value and pleasure of reading. (shrink)

What is this thing called literature? What is the point of studying literature? How do I study literature? Relating literature to timeless topics such as dreams, politics, life, death, the ordinary and the crazy, this beautifully written book establishes a sense of why and how literature is an exciting and rewarding subject to study. Bennett and Royle delicately weave an essential love of literature into an account of what literary texts do, how they work and what sort of questions (...) and ideas they provoke.The book's three parts reflect the key components of studying literature: reading, thinking and writing. Part One comprises short chapters on reading a poem, reading a novel, reading a story, and reading a play. Part Two considers what thinking is, especially in relation to critical thinking and thinking about literature. Part three includes practical chapters on writing an essay, creative writing, and writing fiction. The authors use helpful, familiar examples throughout and offer brief reflections on questions such as 'What is literature?', on 'English' as a war zone, on crisis management and literary criticism, on dictionaries and on what the authors call creative reading. Bennett and Royle's lucid and friendly style engages and encourages personal experience of this thing called literature. (shrink)

pt. I. The mystical ambition.--pt. II. Revelation.--pt. III. Religion and morality.

Knowledge, Robert Rowland Smith remarks, is "derived by inference from specific cases in respect to a general order."1 The meaning of a literary work—our knowledge of it in that sense—is determined, according to this model, by the relationship between these two categories: between the "specific case" and the "general order." To gain knowledge of a text would be to understand what it means; and to understand what it means, one needs to negotiate from the particular to the general—thematically, contextually, generically, (...) intertextually, linguistically, rhetorically. But in this essay I argue that such a negotiation may be understood to generate serious difficulties when it comes to literary texts since, as Susan... (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

This article is intended as a response rather than counterpoint to Bennett's careful argument that amnesty cannot amount to an act of collective forgiveness. I agree that a state cannot forgive perpetrators of grave human rights violations. However, I am concerned that conceiving the question of amnesty strictly in terms of a choice between the Art of Compromise or the Hard Line of retribution may unduly limit our understanding of the potential relation between amnesty and forgiveness in politics. To (...) show this, I consider the question of amnesty in relation to the possibility of forgiving those ordinary citizens implicated in the perpetration of wrongs as bystanders and beneficiaries of an unjust regime. Following Arendt, I argue that political grounds for forgiveness in such circumstances are the frailty of the world and the natality of the other . On this account, forgiveness is not necessarily the final term in a process of reconciliation that restores a wrongdoer to the moral community. Rather, the disposition to forgive makes possible a politics in which members of a divided polity contest each other's understandings of the violence of the past and its significance for their political association. (shrink)

In the last ten years, there have been a number of attempts to refute Julian Savulescu's Principle of Procreative Beneficence; a principle which claims that parents have a moral obligation to have the best child that they can possibly have. So far, no arguments against this principle have succeeded at refuting it. This paper tries to explain the shortcomings of some of the more notable arguments against this principle. I attempt to break down the argument for the principle and in (...) doing so, I explain what is needed to properly refute it. This helps me show how and why the arguments of Rebecca Bennett, Sarah Stoller and others fail to refute the principle. Afterwards, I offer a new challenge to the principle. I attack what I understand to be a fundamental premise of the argument, a premise which has been overlooked in the literature written about this principle. I argue that there is no reason to suppose, as Savulescu does, that morality requires us to do what we have most reason to do. If we reject this premise, as I believe we have reason to do, the argument for Procreative Beneficence fails. (shrink)

Recent proposals by Taylor, Bennett, Wright and Cohen to identify teleological systems as systems governed by teleological laws and teleological laws as laws of a certain logical form are discussed. Suggested logical forms are treated with both extensional and simple non-extensional models of nomic necessity and shown to generate problematic entailments not derivable from the causal form alone.

On the standard reading of Hume, the belief that the necessity associated with the causal relation is “an entirely mind-independent phenomenon” in the world isunjustified. For example, Jonathan Bennett writes that necessary connections of the sort that Hume allows are not “relations which hold objectively between the ‘objects’ or events which we take to be causally related.” Similarly, Barry Stroud writes that, according to Hume, we believe falsely “that necessity is something that ‘resides’ in the relation between objects or (...) events in the objective world.” In this paper I argue that this reading of Hume is mistaken and that there is a sense of justification (viz., justification qua “proof”) according to which human beings are justified in holding the belief that the necessity associated with the causal relation is “an entirely mind-independent phenomenon” in the world. (shrink)

On the standard reading of Hume, the belief that the necessity associated with the causal relation is “an entirely mind-independent phenomenon” in the world isunjustified. For example, Jonathan Bennett writes that necessary connections of the sort that Hume allows are not “relations which hold objectively between the ‘objects’ or events which we take to be causally related.” Similarly, Barry Stroud writes that, according to Hume, we believe falsely “that necessity is something that ‘resides’ in the relation between objects or (...) events in the objective world.” In this paper I argue that this reading of Hume is mistaken and that there is a sense of justification (viz., justification qua “proof”) according to which human beings are justified in holding the belief that the necessity associated with the causal relation is “an entirely mind-independent phenomenon” in the world. (shrink)

This paper aims to bring together the study of normative judgments in mathematics as studied by the philosophy of mathematics and verbal hygiene as studied by sociolinguistics. Verbal hygiene (Cameron 1995) refers to the set of normative ideas that language users have about which linguistic practices should be preferred, and the ways in which they go about encouraging or forcing others to adopt their preference. We introduce the notion of mathematical hygiene, which we define in a parallel way as the (...) set of normative discourses regulating mathematical practices and the ways in which mathematicians promote those practices. To clarify our proposal, we present two case studies from 17th century France. First, we exemplify a case of mathematical hygiene proper: Descartes' algebraic geometry and Newton's subsequent criticism of it, a case of (im)purity in mathematics. Then, we compare Descartes' and Newton's mathematical hygiene with verbal hygiene from this period, as exemplified by the work of the grammarian Claude Favre de Vaugelas (Ayres-Bennett 1987). We argue that these early modern normative discourses on mathematics and language respectively can be seen as emanating from a common socio-political program: the development of a new bourgeois intellectual class. We conclude that the study of mathematical hygiene has the potential to yield new understandings of the social aspects of mathematical practice, and that similarities between mathematical and verbal hygiene at certain time periods, such as 17th century France, open up a new area of inquiry at the borders of linguistics and the philosophy of mathematics. (shrink)

This article—the first of a linked set of three outlining the development and practice of a different approach to science/religion dialogue—begins with an overview of some persistent tensions in the field. Then, using a threefold heuristic of encounter, engagement, and expression, it explores the routes taken by James Ashbrook and Andrew Newberg to develop a dialogue between theology and neuroscience, discussing some of the problems associated with these and their implications for attempts to further develop neurotheology. Finally, it proposes (...) a different way of thinking about this enterprise and points toward a new methodology for supporting this endeavor. (shrink)

Philosophers of social science have emphasized mechanistic approaches to causal inquiry for some time now, showing why focusing on the mechanisms behind correlations is preferable to focusing on correlations alone (cf. Johnson 2006, Little 1991, Reiss 2007, 2009, Steel 2004, see also King, Keohane, and Verba 1994 for an example of purely correlational research). In Process Tracing: from Metaphor to Analytic Tool, political scientists Andrew Bennett and Jeffrey Checkel present a concrete method for finding evidence of causal mechanisms, (...) process tracing. Process tracers give evidence for causal relations in terms of the observable implications of the underlying causal mechanisms through which a putative cause affects some effect of interest. Such observable implications often take the form of a chain of events, or process, which connects cause and effect. Though Process Tracing contains applications of mechanistic reasoning unfamiliar to philosophers, and as such will be of interest to those working in the mechanist tradition, Bennett and Checkel’s own discussion of the philosophical foundations of process tracing is limited. The reader will have to delve deep into the volume’s contributed chapters for links between the literature on causation and this new method. (shrink)

Challenges, possibilities, and opportunitie for re-founding the tradition of philosophical personalism today.

This paper examines the idea of objective phenomenology, or a way of understanding the phenomenal character of conscious experiences that doesn’t require one to have had the kinds of experiences under consideration. My central thesis is that structural facts about experience—facts that characterize purely how conscious experiences are structured—are objective phenomenal facts. I begin by precisifying the idea of objective phenomenology and diagnosing what makes any given phenomenal fact subjective. Then I defend the view that structural facts about experience are (...) objective. I also argue that structural facts about experience, despite being objective, nevertheless still give rise to an explanatory gap. (shrink)

What reasons can children have for coming to care about particular things so that they can develop into responsible adults? This question raises issues both about the status of such reasons as "internal" or "external" to the child’s subjective motivational set and about the role of adults in guiding children’s choices. In confronting this latter question, Tamar Schapiro argues that adults can adopt what amounts to a two-pronged strategy: of rewarding or punishing the child and of offering explanations and justifications. (...) Such a strategy, however, ignores the special role loving caregivers can play in a child’s life. By developing an account of such paternalistically loving relationships, I show how the caregiver’s conception of the child’s well-being can come to inform the child’s own sense of herself and so to provide her with essentially interpersonal reasons for caring. Indeed, such reasons can be both normatively and motivationally binding on the child even though she may not yet be in a position to understand them. That such reasons are essentially interpersonal seems to make otiose whether they are "internal" or "external," thereby rendering that distinction less important than we might have thought. (shrink)

This paper argues that hate differs from mere disliking in terms of its “depth,” which is understood via a notion of “othering,” whereby one rejects at least some aspect of the identity of the target of hate, identifying oneself as not being what they are. Fleshing this out reveals important differences between personal hate, which targets a particular individual, and impersonal hate, which targets groups of people. Moreover, impersonal hate requires focusing on the place hate has within particular sorts of (...) communities, enabling a further important distinction between “insider” and “outsider” hate in terms of whether the hater includes members of the targeted group within a particular community or rejects them as “beneath” membership in that community. (shrink)

Perception is riddled with cases of reliable misperception. These are cases in which a perceptual state is tokened inaccurately any time it is tokened under normal conditions. On the face of it, this fact causes trouble for theories that provide an analysis of perceptual content in non-semantic, non-intentional, and non-phenomenal terms, such as those found in Millikan (1984), Fodor (1990), Neander (2017), and Schellenberg (2018). I show how such theories can be extended so that they cover such cases without giving (...) up their core commitments. (shrink)

Some accounts of moral responsibility hold that an agent's responsibility is completely determined by some aspect of the agent's mental life at the time of action. For example, some hold that an agent is responsible if and only if there is an appropriate mesh among the agent's particular psychological elements. It is often objected that the particular features of the agent's mental life to which these theorists appeal (such as a particular structure or mesh) are not necessary for responsibility. This (...) is because there appear to be cases in which an agent acts at an earlier time which causes her to lack the appropriate psychological features at some later time and yet, intuitively, she is responsible at that later .. (shrink)

We are all familiar with the phenomenon of a proposition seeming true. Many think that these seeming states can yield justified beliefs. Very few have seriously explored what these seeming states are. I argue that seeming states are not plausibly analyzed in terms of beliefs, partial beliefs, attractions to believe, or inclinations to believe. Given that the main candidates for analyzing seeming states are unsatisfactory, I argue for a brute view of seemings that treats seeming states as irreducible propositional attitudes.

This is a discussion of the state of discussion on pragmatic reasons for belief.

In this paper I consider whether traditional behaviors of animals, like traditions of humans, are transmitted by imitation learning. Review of the literature on problem solving by captive primates, and detailed consideration of two widely cited instances of purported learning by imitation and of culture in free-living primates (sweet-potato washing by Japanese macaques and termite fishing by chimpanzees), suggests that nonhuman primates do not learn to solve problems by imitation. It may, therefore, be misleading to treat animal traditions and human (...) culture as homologous (rather than analogous) and to refer to animal traditions as cultural. (shrink)

This book brings together an international group of scholars to discuss the ramifications of Heidegger's Black Notebooks for philosophy and the humanities. In contrast to both those who seek to exonerate Heidegger and those who simply condemn him, they urge careful reading and rereading of his work to turn Heideggerian thought against itself.

For Kant, knowledge involves certainty. If “certainty” requires that the grounds for a given propositional attitude guarantee its truth, then this is an infallibilist view of epistemic justification. Such a view says you can’t have epistemic justification for an attitude unless the attitude is also true. Here I want to defend an alternative fallibilist interpretation. Even if a subject has grounds that would be sufficient for knowledge if the proposition were true, the proposition might not be true. And so there (...) is sometimes still rational room for doubt. The goal of this paper is to present four different models of what “certainty” amounts to, for Kant, each of which is compatible with fallibilism. (shrink)

While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...) organism. Second, it provides the conceptual resources to foster a discussion about which of these representations is necessary for an organism to count as having the capacity to mentally time travel. Third, it enables us to distinguish stricter from more liberal views of mental time travel that differ regarding which kind(s) of temporal representation is taken to be necessary for mental time travel. Fourth, it allows us to determine the benefits of taking a stricter or more liberal view of mental time travel. Finally, it ensures that disagreement about whether some species can mentally time travel is not merely the product of unrecognised disagreement about which temporal representation is necessary for mental time travel. We argue for a more liberal view, on the grounds that it allows us to view mental time travel as an evolutionarily continuous phenomenon, and to recognise that differences in the ways that organisms mentally time travel might reflect different temporal representations, or combinations thereof, that they employ. Our ultimate aim, however, is to create the conceptual framework for further discussion regarding what sorts of temporal representations are required for mental time travel. (shrink)

Lighten up about mathematics! Have fun. If you read this book, you will have to endure bad math puns and jokes and out-of-date pop culture references. You'll learn some really cool mathematics to boot. In the process, you will immerse yourself in living, thinking, and breathing logical reasoning. We like to call this proofs, which to some is a bogey word, but to us it is a boogie word. You will learn how to solve problems, real and imagined. After all, (...) math is a game where, although the rules are pretty much set, we are left to our imaginations to create. Think of this book as blueprints, but you are the architect of what structures you want to build. Make sure you lay a good foundation, for otherwise your buildings might fall down. To help you through this, we guide you to think and plan carefully. Our playground consists of basic math, with a loving emphasis on number theory. We will encounter the known and the unknown. Ancient and modern inquirers left us with elementary-sounding mathematical puzzles that are unsolved to this day. You will learn induction, logic, set theory, arithmetic, and algebra, and you may one day solve one of these puzzles. (shrink)

The aim of the Analytic of Concepts is to derive and deduce a set of pure concepts of the understanding, the categories, which play a central role in Kant’s explanation of the possibility of synthetic a priori cognition and judgment. This chapter is structured around two questions. First, what is a pure concept of the understanding? Second, what is involved in a deduction of a pure concept of the understanding? In answering the first, we focus on how the categories differ (...) from the pure forms of sensibility and examine whether they are known only to be the pure forms of human thinking or rather the forms of discursive cognition as such. In answering the second, we draw a distinction between the application and the exemplification of the categories and use it to identify different ways of understanding Kant’s project in the Transcendental Deduction of the Categories. These questions connect because the answer to the first determines how we should understand the kind of entitlement which is to be established in the Deduction. (shrink)

How can we motivate ourselves to do what we think we ought? How can we deliberate about personal values and priorities? Bennett Helm argues that standard philosophical answers to these questions presuppose a sharp distinction between cognition and conation that undermines an adequate understanding of values and their connection to motivation and deliberation. Rejecting this distinction, Helm argues that emotions are fundamental to any account of value and motivation, and he develops a detailed alternative theory both of emotions, desires (...) and evaluative judgements and of their rational interconnections. The result is an innovative theory of practical rationality and of how we can control not only what we do but also what we value and who we are as persons. (shrink)