Clinical responses to dopamine replacement therapy for individuals with Parkinson’s disease are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response, and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography. MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical oscillatory frequency (...) profiles that best predicted medication state. Motor cortical profiles differed substantially across individuals and showed consistency across multiple data folds. There was a linear relationship between classification accuracy and SDR of lower limb bradykinesia, although this relationship did not persist after multiple comparison correction, suggesting that combinations of spectral power features alone are insufficient to predict clinical state. Factor score analysis of therapeutic response and novel subject-specific machine learning approaches based on subject-specific neuroimaging provide tools to predict outcomes of therapies for PD. (shrink)

Health care organizations are increasingly asked to show accountability about their performance. This paper proposes that accountability can best be achieved through evaluative methods that are based on evidence regarding the relationship between processes of care and expected outcomes. Root cause analysis (RCA) is used as an illustration of how a generic method of inquiring can be transformed into an ongoing monitoring, evaluation, user education and accountability strategy. The role of performance indicators, as well as patient and community expectations, is (...) discussed. (shrink)

L’intérêt de ma thèse est d’étudier les relations entre le féminisme et le pacifisme en France au XXe siècle, sous l’angle de la biographie de Jeanne Mélin (1877-1964), pacifiste, féministe, écrivaine. Le sens de cette recherche est de souligner l’ambiguïté de la mise en perspective par Jeanne Mélin du féminisme et du pacifisme, d’étudier son appropriation des concepts d’identité féminine, de masculinité et de différence des sexes. Selon elle, le droit de vote féminin est avant tout le sésame de la (...) paix. Contrairement à d’autres féministes, son engagement pacifiste n’est pas une stratégie de reconnaissance politique. D’un pacifisme modéré, avant 1914, elle évolue vers le pacifisme intégral la sclérosant en 1940. C’est aussi une autodidacte auteure de romans, voyageant en Europe pour la paix et le suffrage féminin, soutenant le vote intégral en 1915, favorable au contrôle des naissances, candidate au nom de la parité à la Présidence de la République en 1947, militante de l’abolition du salariat et du partage des richesses. (shrink)

Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url } This part of the Soviet philosophy that corresponds approximately to theoretical philosophy and philosophy of science on the example of Estonia and proceeding from the University of Tartu is discussed. The author concentrates on the period of approximately 1960–1990, when he himself was engaged in the field, i.e. the time before 1960 is not included. The aim of this paper is not to provide an overview of the individual philosophers in Estonia (...) at the time and their works, but to give a more general description of the philosophy of the Soviet era. The Soviet and the East European philosophy of the time have received rather little critical treatment in literature in English. However, a few general overviews trying to prove that this Soviet and East European philosophical legacy is worth studying have still been published. This paper is focused on the question what kind of philosophical researches it was possible to engage oneself in under the abnormal conditions at the time and whether some starting points and problem issues in theseresearches might be viable also today. Estonian experience confirms the general conclusion of these authors who, analyzing the legacy of Marxism, have found that although Marxism is nowadays—not to mention how it existed in the Soviet totalitarian regime—mainly not considered a serious philosophy but rather an ideological basis of a failed political doctrine, it has nevertheless quite something to offer when treated in a more depoliticized manner, in the general context of philosophical quests. Teoreetiline ja teadusfilosoofia Nõukogude ajal: mõned märkused Eesti näitel 1960-1990 Vaatluse all on Eesti näitel ja lähtudes Tartu ülikoolist see osa Nõukogudeaegsest filosoofiast, mis vastab umbes teoreetilisele filosoofiale ja teadusfilosoofiale. Autor peatub ajavahemikul umbes 1960–1990, mil ta ka ise tegev oli, st 1960-ndate aastate eelset aega ei käsitleta. Artikli eesmärgiks ei ole ülevaate andmine Eestis sel ajal tegutsenud filosoofidest ja nende töödest, vaid Nõukogudeaegse filosoofia üldisem iseloomustamine. Nõukogude ja selleagset Ida-Euroopa filosoofiat on ingliskeelses kirjanduses üsna vähe kriitiliselt uuritud. Üksikuid ülevaateteoseid, milles on püütud näidata, etsee Nõukogude ja Ida-Euroopa filosoofiline pärand väärib uurimist, on siiski ilmunud. Käesolevas artiklis on keskendutud eelkõige küsimusele, mis laadi filosoofilise uurimistööga sai tolle aja ebanormaalsetes tingimustes tegelda ja kas mõned lähtekohad ja probleemipüstitused selles on elujõulised ka veel nüüd. Eesti kogemus kinnitab nende autorite üldist järeldust, kes marksismi pärandit uurides on leidnud, et kuigi marksismi tänapäeval — rääkimata sellest, missugune see oli Nõukogude totalitaarses režiimis — enamasti ei peeta tõsiseltvõetavaks filosoofiaks, vaid pigem läbikukkunud poliitilise õpetuse ideoloogiliseks aluseks, on tal siiski nii mõndagi öelda, kui teda käsitleda depolitiseeritumalt, filosoofiliste otsingute üldises kontekstis. Märksõnad: dialektiline materialism, dialektika, ‘eessõna-marksism’, filosoofia põhiküsimus, Nõukogude filosoofia, ‘ontologistid’ ja ‘epistemologistid’, praktika. (shrink)

Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} This part of the Soviet philosophy that corresponds approximately to theoretical philosophy and (...) philosophy of science on the example of Estonia and proceeding from the University of Tartu is discussed. The author concentrates on the period of approximately 1960–1990, when he himself was engaged in the field, i.e. the time before 1960 is not included. The aim of this paper is not to provide an overview of the individual philosophers in Estonia at the time and their works, but to give a more general description of the philosophy of the Soviet era. The Soviet and the East European philosophy of the time have received rather little critical treatment in literature in English. However, a few general overviews trying to prove that this Soviet and East European philosophical legacy is worth studying have still been published. This paper is focused on the question what kind of philosophical researches it was possible to engage oneself in under the abnormal conditions at the time and whether some starting points and problem issues in these researches might be viable also today. Estonian experience confirms the general conclusion of these authors who, analyzing the legacy of Marxism, have found that although Marxism is nowadays—not to mention how it existed in the Soviet totalitarian regime—mainly not considered a serious philosophy but rather an ideological basis of a failed political doctrine, it has nevertheless quite something to offer when treated in a more depoliticized manner, in the general context of philosophical quests. Normal 0 21 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Teoreetiline ja teadusfilosoofia Nõukogude ajal: mõned märkused Eesti näitel 1960-1990 (Resümee) Vaatluse all on Eesti näitel ja lähtudes Tartu ülikoolist see osa Nõukogudeaegsest filosoofiast, mis vastab umbes teoreetilisele filosoofiale ja teadusfilosoofiale. Autor peatub ajavahemikul umbes 1960–1990, mil ta ka ise tegev oli, st 1960-ndate aastate eelset aega ei käsitleta. Artikli eesmärgiks ei ole ülevaate andmine Eestis sel ajal tegutsenud filosoofidest ja nende töödest, vaid Nõukogudeaegse filosoofia üldisem iseloomustamine. Nõukogude ja selleagset Ida-Euroopa filosoofiat on ingliskeelses kirjanduses üsna vähe kriitiliselt uuritud. Üksikuid ülevaateteoseid, milles on püütud näidata, et see Nõukogude ja Ida-Euroopa filosoofiline pärand väärib uurimist, on siiski ilmunud. Käesolevas artiklis on keskendutud eelkõige küsimusele, mis laadi filosoofilise uurimistööga sai tolle aja ebanormaalsetes tingimustes tegelda ja kas mõned lähtekohad ja probleemipüstitused selles on elujõulised ka veel nüüd. Eesti kogemus kinnitab nende autorite üldist järeldust, kes marksismi pärandit uurides on leidnud, et kuigi marksismi tänapäeval — rääkimata sellest, missugune see oli Nõukogude totalitaarses režiimis — enamasti ei peeta tõsiseltvõetavaks filosoofiaks, vaid pigem läbikukkunud poliitilise õpetuse ideoloogiliseks aluseks, on tal siiski nii mõndagi öelda, kui teda käsitleda depolitiseeritumalt, filosoofiliste otsingute üldises kontekstis. Märksõnad: dialektiline materialism, dialektika, ‘eessõna-marksism’, filosoofia põhiküsimus, Nõukogude filosoofia, ‘ontologistid’ ja ‘epistemologistid’, praktika. (shrink)