Heterotrimeric G proteins, consisting of α, β, and γ subunits, couple ligand-bound seven transmembrane domain receptors to the regulation of effector proteins and production of intracellular second messengers. G protein signaling mediates the perception of environmental cues in all higher eukaryotic organisms, including yeast, Dictyostelium, plants, and animals. The nematode Caenorhabditis elegans is the first animal to have complete descriptions of its cellular anatomy, cell lineage, neuronal wiring diagram, and genomic sequence. In a recent paper, Jansen et al.(1) used sequence (...) searches of the C. elegans genome database to identify all heterotrimeric G protein genes (20 Gα, 2 Gβ, 2 Gγ). C. elegans encodes one ortholog of each of the four Gα classes found in metazoans and 16 new Gα genes. The orthologous genes are widely expressed, whereas 14 of the divergent Gα genes are almost exclusively expressed in sensory neurons where they may regulate perception and chemotaxis.BioEssays 21:713–717, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Philosophy of mind has made substantial progress on biologically-rooted approaches to understanding the mind and subjectivity through the enactivist perspective, but research on subjectivity within neuroscience has not kept apace. Indeed, we possess no principled means of relating experiential phenomena to neurophysiological processes. Here, we present the Nested States Model as a framework to guide empirical investigation into the relationship between subjectivity and neurobiology. Building on recent work in phenomenology and philosophy of mind, we develop an account of experiential states (...) as layered, or nested. We argue that this nested structure is also apparent in brain activity. The recognition of this structural homology — that both experiential and brain states can be characterized as systems of nested states — brings our views of subjective mental states into broad alignment with our understanding of general principles and properties of brain activity. This alignment enables a more systematic approach to formulating specific hypotheses and predictions about how the two domains relate to one another. (shrink)

The authors describe the ethical considerations underlying the inclusion of mental health services into a prioritized health care system. The Oregon Health Plan is a process for defining and delivering basic health services to an entire state. As the plan was developed, the mental health community needed to decide whether or not to participate in the process and, if so, how. Lengthy discussions among mental health consumers, family members, and providers led to a strategy that emphasized the integration of mental (...) health and chemical dependency services into a comprehensive and universal health care program. This approach appears to have achieved relative parity for mental health. (shrink)

There is a well-worn image and phrase for libertarianism: "atomized individualism." This hobgoblin has spread so thoroughly that even some libertarians think their philosophy unreservedly supports private persons, whatever the situation, whatever their behavior. Smith's Self-Interest and Social Order in Classical Liberalism, corrects this misrepresentation with careful intellectual surveys of Hume, Smith, Hobbes, Butler, Mandeville, and Hutcheson and their respective contributions to political philosophy.

While it is often argued that U.S. military strategy has gone through substantial changes over the post three decodes, it is not so clear if this is so, or why this should be so. Some changes in the real strategic problem of the west must be considered, including the growth of the Soviet nuclear arsenal. Changes in our perception of the problem may be at least as important, however, amid some possibilities of ‘Finlandisation’. Changes in the West’s opportunities must also (...) be considered, including ‘limited nuclear war’, and a totally conventional defense. Finally to be considered are the bureaucratic motivations of those advocating any such changes in western military postures, all of which suggest that current policies may still be better than the alternatives. (shrink)

Individualism is one of most criticized and least understood ideas in social and political thought. Is individualism the ability to act independently amidst a web of social forces? A vital element of personal liberty and a shield against conformity? Does it lead to or away from unifying individuals with communities? Individualism: A Reader provides a wealth of illuminating essays from the 17th to the early 20th centuries. In 26 selections from 25 writers individualism is explained and defended, often from unusual (...) perspectives. This anthology includes not only selections from well-known writers, but also many lesser-known pieces--reprinted here for the first time--by philosophers, social theorists, and economists who have been overlooked in standard accounts of individualism. The depth and complexity of ideas about individualism are reflected in the six sections in this collection. The first examines individuality generally, with the following five detailing social, moral, political, religious, and economic individualism. Throughout, individualism is analyzed and defended through the lenses of classical liberalism, free-market libertarianism, individual anarchism, voluntary socialism, religious individualism, abolitionism, free thought, and radical feminism. Both richly historical and sharply contemporary, Individualism: A Reader provides a multitude of perspectives and insights on personal liberty and the history of freedom. (shrink)

This is the first collection of essays examining Paul Ricoeur's writings on law, bringing together eminent Ricoeur scholars from around the world to demonstrate the importance of Ricoeur's philosophy for the juridical field while offering new paths to extend and build on his work.