In this paper, I attempt to explain one of the most controversial views attributed to the Stoic Chrysippus: that the impossible can follow from the possible. My solution finds in Chrysippus a distinction later made by the medieval logician John Buridan: that between being possible (there being a state of affairs that may occur) and being possibly-true (there being some proposition whose truth-conditions are that state of affairs). Buridan and Chrysippus have radically opposing views on the nature of propositions. What (...) their conceptions share is the conclusion that at least some propositions must be contingent beings. They argue for this while maintaining a rigorous commitment to the view that propositions are strictly bivalent. In 2. I explain the Chrysippean passage in terms of a distinction Buridan makes explicitly. In 3. I show how the distinction follows implicitly from the Stoic theory of quantification. In 4. I compare the modality with other aspects of Stoic logic. In 5. I discuss how the distinction behaves in the future tense. (shrink)

This Paper Offers A New Interpretation of Phaedo 96a–103a. Plato has devoted the dialogue up to this point to a series of arguments for the claim that the soul is immortal. However, one of the characters, Cebes, insists that so far nothing more has been established than that the soul is durable, divine, and in existence before the incarnation of birth. What is needed is something more ambitious: a proof that the soul is not such as to pass out of (...) existence. According to Socrates’s initial response to Cebes at 95e8–96a1, giving such a demonstration requires a thorough investigation into “the reason for coming to be and passing away in general” (ὅλως γὰϱ δεῖ πεϱὶ γενέσεως ϰαὶ Φθοϱᾶς τὴν αἰτίαν διαπϱαγματεύσασθαι .. (shrink)

This paper is a brief discussion of the famous 'Third Man Argument' as it appears in Plato's dialogue Parmenides . I mention, criticise and refine the most influential analytic approach to the argument; show that the actual conclusion of the argument is different from the one attributed to it by the majority of scholars; and elaborate two responses to the argument, both of which shed interesting light on the Theory of Forms.

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

There is some complementarity of models for the origin of the electroencephalogram (EEG) and neural network models for information storage in brainlike systems. From the EEG models of Freeman, of Nunez, and of the authors' group we argue that the wavelike processes revealed in the EEG exhibit linear and near-equilibrium dynamics at macroscopic scale, despite extremely nonlinear – probably chaotic – dynamics at microscopic scale. Simulations of cortical neuronal interactions at global and microscopic scales are then presented. The simulations depend (...) on anatomical and physiological estimates of synaptic densities, coupling symmetries, synaptic gain, dendritic time constants, and axonal delays. It is shown that the frequency content, wave velocities, frequency/wavenumber spectra and response to cortical activation of the electrocorticogram (ECoG) can be reproduced by a “lumped” simulation treating small cortical areas as single-function units. The corresponding cellular neural network simulation has properties that include those of attractor neural networks proposed by Amit and by Parisi. Within the simulations at both scales, sharp transitions occur between low and high cell firing rates. These transitions may form a basis for neural interactions across scale. To maintain overall cortical dynamics in the normal low firing-rate range, interactions between the cortex and the subcortical systems are required to prevent runaway global excitation. Thus, the interaction of cortex and subcortex via corticostriatal and related pathways may partly regulate global dynamics by a principle analogous to adiabatic control of artificial neural networks. (shrink)

We outline fresh findings that show that our macroscopic electrocorticographic (ECoG) simulations can account for synchronous multiunit pulse oscillations at separate, simultaneously activated cortical sites and the associated gamma-band ECoG activity. We clarify our views on the approximations of dynamic class applicable to neural events at macroscopic and microscopic scales, and the analogies drawn to classes of ANN behaviour. We accept the need to introduce memory processes and detailed anatomical and physiological information into any future developments of our simulations. On (...) the issue of intrinsic cortical stability and the role of extrinsic fibre systems in maintaining stability, we argue that this position is not in extreme contradiction to those of our commentators, and that the mechanisms implicit in our simulations' properties imply rich computational possibilities. We discuss some of the reasons for and against the existence of significant global resonances in the brain and explain why such behaviour appears absent in our simulations. Last, we discuss other phenomena, such as rhythmic driving of the cortex, which have not yet been introduced into our models, and indicate lines for future development of the simulations. (shrink)

I would refer to the introductory paragraphs of J. Diggle's ‘Notes on Ovid's Tristia, Books I-II’ , 401–19). His list of modern editions does not include F. Della Corte, I Tristia , which I too have not seen. For Book IV we have an edition by T. J. de Jonge.

I would refer to the introductory paragraphs of J. Diggle's ‘Notes on Ovid's Tristia, Books I-II’, 401–19). His list of modern editions does not include F. Della Corte, I Tristia, which I too have not seen. For Book IV we have an edition by T. J. de Jonge.

The self seems to be a unitary entity remaining stable across time. Nevertheless, current theorizing conceptualizes the self as a number of interacting sub-systems involving perception, intention and action (self-model). One important function of such a self-model is to distinguish between events occurring as a result of one's own actions and events occurring as the result of somebody else's actions. We conducted an fMRI experiment that compared brain activation after an abrupt mismatch between one's own movement and its visual consequences (...) with an abrupt mismatch between one's own movement and somebody else's visually perceived hand movement. A right fronto-parietal network was selectively active during a sudden mismatch between one's own observed and performed hand action. (shrink)

A self-admittedly unorthodox attempt to apply the teachings of Buddha to the problems of contemporary India. Unostentatious in design, it is a highly personal interpretation of Buddhist teaching by a sensitive Indian thinker.--J. D. T. Jr.

A detailed scholarly examination of the distorted image of Islam that emerged in the West during the years 1100-1350. Although most of the book is concerned with documenting this image of Islam, Daniel also explores the motives and effects of this distortion. A series of comprehensive bibliographies is included. An authoritative, if somewhat tedious, study.--J. D. T., Jr.

On the basis of data gathered in a Mormon village and in a settlement of Texas homesteaders, the author sets up a schematism or "grammar" of values. The distinctions he draws between existential, normative, and idiosyncratic values seem arbitrary.--J. D. T., Jr.

A self-admittedly unorthodox attempt to apply the teachings of Buddha to the problems of contemporary India. Unostentatious in design, it is a highly personal interpretation of Buddhist teaching by a sensitive Indian thinker.--J. D. T. Jr.

A detailed scholarly examination of the distorted image of Islam that emerged in the West during the years 1100-1350. Although most of the book is concerned with documenting this image of Islam, Daniel also explores the motives and effects of this distortion. A series of comprehensive bibliographies is included. An authoritative, if somewhat tedious, study.--J. D. T., Jr.

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

The author has enjoyed successive careers as a union leader and business executive. The book is a clumsily expressed chronicle of the author's prejudices and opinions. --J. D. T. Jr.

Essays on nine French writers; a companion volume to the Studies in Human Time. Imaginatively conceived and brilliantly executed, it focuses on the individual artist's direct awareness of man's temporality and place.--J. D. T. Jr.

A well argued plea for the establishment of a capital insurance organization on the model of the F. H. A. which would guarantee loans to small investors. Such an organization, the authors argue, would stem the tide towards increasing concentration of capital in our society and would provide for a more equitable distribution of wealth. --J. D. T., Jr.

Having defined moral responsibility as "acting in a way that will contribute to human well-being," Kimpel views moral philosophy as an empirical discipline that is concerned with the relation of means to end. However, he does not sufficiently clarify the nature of ends.--J. D. T. Jr.

Six articles on various aspects of Hegel including time, alienation, substance, and theology, plus a study of Merleau-Ponty. The collection is distinguished by R. C. Whittemore's critique of the pantheistic interpretation of Hegel. --J. D. T. Jr.

An overview of the concept of Strong Emergence, and a summary of the papers within the special issue.

Having defined moral responsibility as "acting in a way that will contribute to human well-being," Kimpel views moral philosophy as an empirical discipline that is concerned with the relation of means to end. However, he does not sufficiently clarify the nature of ends.--J. D. T. Jr.