One will be hard-pressed to find a morally perfect agent in this world. It’s not that there aren’t any morally good people. It just takes a lot to be morally perfect. However, theists claim that God is morally perfect. (Atheists claim that if God exists, God is morally perfect.) Perhaps they are mistaken. This chapter presents an argument for the conclusion that God is not morally perfect. The argument depends upon two things: (1) the nature of the concept of moral (...) perfection, and (2) the modest theistic claim that God is involved in the affairs of the world. (shrink)

Disagreements about, within, and between religions are widespread. It’s no surprise, then, that there’s an enormous philosophical literature on religious diversity. But in recent years, philosophers working in mainstream epistemology have done a lot of work on disagreement in general. This work has focused in particular upon the epistemology of peer disagreement, i.e., disagreements between parties who are justifiably believed to be epistemic equals regarding the matter at hand. In this paper, I intend to defend a thesis in the epistemology (...) of peer disagreement from a significant objection. The thesis I intend to defend is the Equal Weight View (EWV). The objection, pressed by philosophers such as Alvin Plantinga, Timothy O’Connor, Charles Taliaferro, Brian Weatherson, and Adam Elga, is that EWV is self-undermining. In short, I argue two things. First, I argue that EWV is not self-undermining. Second, I argue that even if it were, this would give us no reason to think that EWV is false since there are obviously true epistemic principles that self-undermine (or at least do so potentially). The self-undermining objection to EWV fails. (shrink)

In this paper, we’ll present, explain, and defend a Christian ethic for sport that takes loving all individuals as the fundamental moral imperative. First, we’ll begin by taking a seeming detour through views about the morality of war. More specifically, we’ll consider realism, according to which, roughly, moral requirements and rules are suspended during war such that it is misguided to attempt to apply moral terms to acts performed within the context of war. Second, by paying attention to relevant surveys (...) and testimonies, we’ll see how this sort of realism seems to be prevalent within the sports world. We’ll see that a singular focus upon winning seems to cultivate this orientation toward realism and its corresponding relaxed attitude toward rule exploitation and violation and the imposition of harms upon one’s opponents. Third, we’ll present an argument from counterexamples against realism about war and then we’ll consider a structurally identical argument against realism in sport. Fourth, we’ll fill the resulting void by presenting, explaining, and defending the aforementioned Christian ethic for sport. Finally, we’ll apply our Christian ethic for sport, tracing some of its implications for fighting in the NHL, taunting and trash-talking, and telling the truth within gameplay. (shrink)

Richard Feldman and Ram Neta have recently noted that philosophers give relatively little attention to specifying the conditions under which S has something as evidence at a time. This issue is significant to evidentialists. Evidentialism states that which doxastic attitude S is epistemically justified in taking toward a proposition at a time depends upon what is supported by the total evidence S has at that time. What we regard as being necessary and sufficient for S’s having something as evidence partly (...) determines evidentialism’s implications in all cases. Evidentialists need to offer a plausible account that, when conjoined with evidentialism, yields plausible results about epistemic justification in all cases. Here’s what I do in this paper. After considering and rejecting two attempts to identify when S has something as evidence, I present and explain Richard Feldman’s recent account. I argue that evidentialists ought to reject Feldman’s account, too. (shrink)

This paper defends “Animal Universalism,” the thesis that all sentient non-human animals will be brought into Heaven and remain there for eternity. It assumes that God exists and is all-powerful, perfectly loving, and perfectly just. From these background theses, the authors argue that Animal Universalism follows. If God is perfectly loving, then God is concerned about the well-being of non-human animals, and God chooses to maximize the well-being of each individual animal when doing so does not harm other individual creatures (...) or violate creaturely freedom. If God is perfectly just, then God does not arbitrarily discriminate against non-human animals by offering humans an opportunity to enter Heaven but not offering the same to each animal. Each of these conclusions implies Animal Universalism. (shrink)

Richard Feldman and Ram Neta have recently noted that philosophers give relatively little attention to specifying the conditions under which S has something as evidence at a time. This issue is significant to evidentialists. Evidentialism states that which doxastic attitude S is epistemically justified in taking toward a proposition at a time depends upon what is supported by the total evidence S has at that time. What we regard as being necessary and sufficient for S’s having something as evidence partly (...) determines evidentialism’s implications in all cases. Evidentialists need to offer a plausible account that, when conjoined with evidentialism, yields plausible results about epistemic justification in all cases. Here’s what I do in this paper. After considering and rejecting two attempts to identify when S has something as evidence, I present and explain Richard Feldman’s recent account. I argue that evidentialists ought to reject Feldman’s account, too. (shrink)

Relevant logics are a family of non-classical logics characterized by the behavior of their implication connectives. Unlike some other non-classical logics, such as intuitionistic logic, there are multiple philosophical views motivating relevant logics. Further, different views seem to motivate different logics. In this article, we survey five major views motivating the adoption of relevant logics: Use Criterion, sufficiency, meaning containment, theory construction, and truthmaking. We highlight the philosophical differences as well as the different logics they support. We end with some (...) questions for future research. (shrink)

Few debates in environmental philosophy have been more heated than the one over the nature of wilderness. And yet, when one surveys the present scene, one finds that a variety of different conceptions of wilderness are still quite popular – some more so in certain professions than others. In this paper, I look at three popular conceptions of wilderness with an eye toward sussing out the good and the bad them. I look at what I call (1) the folk view (...) of wilderness, (2) Leopold’s conception of wilderness, and (3) the legal conception of wilderness (as found in the Wilderness Act of 1964). In the final part of the paper, I sketch out a sort of spectrum account of wilderness, one that I argue allows us to capture more cases of wilderness and might serve as a useful tool in future conservation efforts. (shrink)

Environmental philosophy plays an important role, directly and indirectly, in many parts of society, including land and wildlife management (Leopold, 1949; Minteer, 2015), political activism (Abbey, 1968; Malm, 2020),and technological research and development (Baum & Owe, 2022; Donhauser et al., 2021). Environmental philosophy uncovers the ethical relationships existing between humans and the living and non-living world. It reveals the nuances of our scientific ecological concepts. And it tries to tell us how we might act – individually or collectively – to (...) better achieve our environmental goals. The aim of this special issue is to explore the limits and ever-expanding outer edges of this increasingly important area of philosophical thought. (shrink)

An “insightful” and in-depth look at anti-science politics and its deadly results (Maria Konnikova, New York Times–bestselling author of The Biggest Bluff). Thomas Jefferson said, “Wherever the people are well informed, they can be trusted with their own government.” But what happens when they aren’t? From climate change to vaccinations, transportation to technology, health care to defense, we are in the midst of an unprecedented expansion of scientific progress—and a simultaneous expansion of danger. At the very time we need them (...) most, scientists and the very idea of objective knowledge are being bombarded by a vast, well-funded war on science, and the results are deadly. Whether it’s driven by identity politics, ideology, or industry, the result is an unprecedented erosion of thought in Western democracies as voters, policymakers, and justices actively ignore scientific evidence, leaving major policy decisions to be based more on the demands of the most strident voices. This compelling book investigates the historical, social, philosophical, political, and emotional reasons why evidence-based politics are in decline and authoritarian politics are once again on the rise on both left and right—and provides some compelling solutions to bring us to our collective senses, before it's too late. “If you care about attacks on climate science and the rise of authoritarianism, if you care about biased media coverage and shake-your-head political tomfoolery, this book is for you.”—The Guardian. (shrink)

This interdisciplinary analysis presents an innovative examination of the nature of pride and humility, including all their slippery nuances and points of connection. By combining insights from visual art, literature, philosophy, religious studies, and psychology, this volume adapts a complementary rather than an oppositional approach to examine how pride and humility reinforce and inform one another. This method produces a robust, substantial, and meaningful description of these important concepts. The analysis takes into account key elements of pride and humility, including (...) self-esteem and self-confidence, human interconnectedness, power's function and limitations, and the role of fear. Shawn R. Tucker explores the many inflections of these terms, inflections that cast them by turns as positive or negative, emboldening or discouraging, and salubrious or vicious depending upon the context and manner in which they are used. (shrink)

This book applies the various principles of Stoicism, as explicated by these founders, practitioners, and evangelists, to the realities of modern life, particularly as lived by educators—teachers, principals, para-educators, and all of the others who toil in schools—post Covid.

In Steve Jobs and Philosophy, sixteen philosophers take a close look at the inspiring yet often baffling world of Steve Jobs. What can we learn about business ethics from the example of Jobs? What are the major virtues of a creative innovator? How could Jobs successfully defy and challenge conventional business practices? How did Jobs combine values and attitudes previously believed to be unmixable? What does it really mean to “think different”? Can entrepreneurs be made or are they just born? (...) If Jobs didn’t make any major inventions, just what was his contribution? How is Jobs’s life illuminated by Buddhism? How does a counter-culture transform mainstream culture? What does Jobs teach us about the notions of simplicity and functionality in design? How do Jobs’s achievements alter the way we think about technology in relation to human life? (shrink)

Justification logics provide frameworks for studying the fine structure of evidence and justification. Traditionally, these logics do not impose any closure requirements on justification. In this paper, we argue that for some applications they should subject justification to closure under some variety of logical consequence. Specifically, we argue, building on ideas from Beall, that the non-classical logic FDE offers a particularly attractive notion of consequence for this purpose and define a justification logic where justification is closed under FDE consequence. We (...) show the resulting logic to be sound and complete. Lastly, we discuss how the closure of justification under FDE ontrasts closure under related non-classical logics and how our approach contrasts with some alternatives. (shrink)

Growth in CSR-washing claims in recent decades has been dramatic in numerous academic and activist contexts. The discourse, however, has been fragmented, and still lacks an integrated framework of the conditions necessary for successful CSR-washing. Theorizing successful CSR-washing as the joint occurrence of five conditions, this paper undertakes a literature review of the empirical evidence for and against each condition. The literature review finds that many of the conditions are either highly contingent, rendering CSR-washing as a complex and fragile outcome. (...) This finding runs counter to the dominant perception in the general public, among activists, and among a vocal contingent of academics that successful CSR-washing is rampant. (shrink)

Attention to care in modern society has fallen out of view as an ethos of personal responsibility, free markets, and individualism has been in the ascendant. The Liberalism of Care argues that contemporary liberalism is suffering from a crisis of care, manifest in a decaying sense of collective political responsibility for citizens' well- being and for the most vulnerable members of our communities. The book maintains that this practical crisis stems from a theoretical one. We have lost the political language (...) of care, which, prior the 19th century, was commonly used to express these dimensions of political life. To recover that language, Shawn C. Fraistat turns to three prominent philosophers-Plato, Jean-Jacques Rousseau, and William Godwin-who illuminate the varied ways caring language and caring values have structured core debates in the history of Western political thought about the proper role of government, as well as the rights and responsibilities of citizens. The Liberalism of Care presents a distinctive vision for our liberal politics where political communities and citizens can utilize the ethic and practices of care to face practical challenges. (shrink)

Various theorists have endorsed the “communication argument”: communicative capacities are necessary for morally responsible agency because blame aims at a distinctive kind of moral communication. I contend that existing versions of the argument, including those defended by Gary Watson and Coleen Macnamara, face a pluralist challenge: they do not seem to sit well with the plausible view that blame has multiple aims. I then examine three possible rejoinders to the challenge, suggesting that a context-specific, function-based approach constitutes the most promising (...) modification of the communication argument. (shrink)

An advanced-level logic textbook that presents proof construction on equal footing with model building. Potentially relevant to students of mathematics and computer science as well.

The equivocal contours of arielismo-one of the most influential anti-imperialist ideologies, spiritual movements, cultural models, and utopian pedagogies for Latin American youth in an epoch of rampant US interventionism.

BackgroundRecent advancements in neuroscientific techniques have allowed us to make huge progress in our understanding of memories, and in turn has paved the way for new memory modification technologies that can modulate memories with a degree of precision, which was not previously possible. With advancements in such techniques, new and critical ethical questions have emerged. Understanding and framing these ethical questions within the current philosophical theories is crucial in order to systematically examine them as we translate these techniques to the (...) clinic.Main bodyIn this paper, we discuss the ethical implications of modern neuroscience techniques that aim to disrupt or enhance memories. We attempt to frame the MMTs in the context of existing ethical philosophical theories to provide a cohesive analysis of the myriad of ethical quagmires that might emerge from such technologies. We argue the application of Aristotle’s Golden Mean and multiple accounts of authenticity are useful in approaching the ethical questions surrounding MMTs. We then propose a framework in which ethical considerations can be systematically examined. Lastly, we provide caveats and considerations for the use of this framework. Overall, we provide a practical approach for the ethical use of MMTs depending on the situation.ConclusionWhile at face value, our model appears to put severe limitations on the application of MMTs, we are not completely opposed to their use, but rather our framework guides the agent to consider the implications before making any decisions. Most importantly, we argue that the use of MMTs does not reduce the responsibility of the initial decision, and the agent must accept the post-MMT self as the new “true self” regardless of the outcome. As the developmental trajectory of MMTs suggests we are getting closer to practical clinical applications, ethical concerns across a wide range of disciplines need to be addressed to develop best strategies and policies when dealing with MMTs. If this can be achieved, we believe the ethical use of MMTs is not only possible but would also be of tremendous benefit to many people suffering from memory-related mental disorders. (shrink)

It is widely agreed that reactive attitudes play a central role in our practices concerned with holding people responsible. However, it remains controversial which emotional attitudes count as reactive attitudes such that they are eligible for this central role. Specifically, though theorists near universally agree that guilt is a reactive attitude, they are much more hesitant on whether to also include shame. This paper presents novel arguments for the view that shame is a reactive attitude. The arguments also support the (...) view that shame is a reactive attitude in the sense that concerns moral accountability. The discussion thereby challenges both the view that shame is not a reactive attitude at all, suggested by philosophers such as R. Jay Wallace and Stephen Darwall, and the view that shame is a reactive attitude but does not concern moral accountability, recently defended by Andreas Carlsson and Douglas Portmore. (shrink)

How does the complex nature of ecological systems affect ecologists' ability to study them? This Element argues that ecological systems are complex in a rather special way: they are causally heterogeneous. The author presents an updated philosophical account with an optimistic outlook of the methods and status of ecological research.

A common refrain in and outside academia is that prominent sports figures ought to engage more in the public discourse about political issues. This idea parallels the idea that athletes ought to be role models in general. This paper first examines and critiques the “athlete as role model” argument and then applies this critique to the “athlete as political activist” argument. Appealing to the empirical political psychological literature, the paper sketches an argument that athlete activism might actually do more harm (...) than good. (shrink)

One of the many claims about the value of local food is that local food exchanges generate trust between producers and consumers. To what degree is this actually the case and how does such trust develop? Drawing on interview and fieldwork data in one local food system in the Northeastern U.S., I show how local food participants build trust and reciprocity with one another in order to mitigate the challenges imposed by the conventional system. This trust and reciprocity builds primarily (...) through three mechanisms: reliable, positive relationships; demonstrations of good will toward one another; and a shared understanding of the value of locally-oriented food. Through these mechanisms, local food operators are able to build a healthy, stable local food system, able to better resist the pressures of the conventional system in which it must continually operate. (shrink)

One of the many claims about the value of local food is that local food exchanges generate trust between producers and consumers. To what degree is this actually the case and how does such trust develop? Drawing on interview and fieldwork data in one local food system in the Northeastern U.S., I show how local food participants build trust and reciprocity with one another in order to mitigate the challenges imposed by the conventional system. This trust and reciprocity builds primarily (...) through three mechanisms: reliable, positive relationships; demonstrations of good will toward one another; and a shared understanding of the value of locally-oriented food. Through these mechanisms, local food operators are able to build a healthy, stable local food system, able to better resist the pressures of the conventional system in which it must continually operate. (shrink)

In classically based modal logic, there are three common conceptions of necessity, the universal conception, the equivalence relation conception, and the axiomatic conception. They provide distinct presentations of the modal logic S5, all of which coincide in the basic modal language. We explore these different conceptions in the context of the relevant logic R, demonstrating where they come apart. This reveals that there are many options for being an S5-ish extension of R. It further reveals a divide between the universal (...) conception of necessity on the one hand, and the axiomatic conception on the other: The latter is consistent with motivations for relevant logics while the former is not. For the committed relevant logician, necessity cannot be the truth in all possible worlds. (shrink)

As local food activities expand and grow, an important question to answer is how various participants contribute to a local food system’s overall vitality and strength. This paper does so by focusing on the relationships between locally-oriented farm and retail actors and assessing what the configuration of these relationships tells us about the workings of the broader local food system. Such an analysis reveals two things. Empirically, it shows the important role food retailers play in the overall vibrancy of local (...) food exchanges: food retailers form crucial links holding the broader system together and significantly expanding consumer access to local foods. Further, different retailer types have distinct impacts on network configurations, each serving particular roles in the development and maintenance of local food systems. Methodologically, this paper shows the value of applying social network analysis techniques to the study of local food systems: such an approach yields insights that may not be as readily assessable from other strategies. In this paper, I overview common network analysis techniques and apply them to a case study of local food activities in New England, suggesting how such an approach might be applied to local food systems in other places. (shrink)

In this article, I analyze how the Harry Potter novels bring to awareness two fundamental aspects of the human condition: the importance of one’s choices and the inevitability of one’s mortality. These are highlighted through the contrast of the characters of Harry Potter and Lord Voldemort.

This paper addresses the question of how local can be defined in practice. It contributes to the growing literature on local food systems and particularly our understanding of what counts as local and the elements that influence those contours. While most of our conceptions of local food tend to rely on an articulation of either proximity traveled or relationship between entities, I argue that a more nuanced and complete understanding must take account of both of these aspects. I draw on (...) a dataset of locally oriented farm and food-related establishments in southern New England to identify how far local food travels in this region and how interconnected local food establishments are with one another and use these and other measures to tease out the tension between proximity and relationship as measures of local. I find that these two aspects not only are connected to each other in a complex dynamic, but also are bound up with other structural factors as well. (shrink)

The ability to reason and think in a logical manner forms the basis of learning for most mathematics, computer science, philosophy and logic students. Based on the author's teaching notes at the University of Maryland and aimed at a broad audience, this text covers the fundamental topics in classical logic in an extremely clear, thorough and accurate style that is accessible to all the above. Covering propositional logic, first-order logic, and second-order logic, as well as proof theory, computability theory, and (...) model theory, the text also contains numerous carefully graded exercises and is ideal for a first or refresher course. (shrink)

The history of Wakanda began thousands of years ago when five African tribes fought over a meteorite containing vibranium. In the world of Black Panther, Killmonger's plan to arm African descendants across the globe represents the beginning stages of the Pan‐African ideal, where Blacks all over the world fight for liberation by any means necessary. Pan‐Africanism represents the expression of shared values and common interests of Africans across the diaspora. In a departure from liberalism toward a more realist theoretical approach, (...) African Americans realized with frustration that the expectation that emancipation would end exploitation of Blacks and restore their dignity was mistaken. Whereas Killmonger wants Wakanda to free oppressed Black communities all over the world, T'Challa wants to work through global institutions and the international community. (shrink)

There appears to be few, if any, limits on what sorts of logical connectives can be added to a given logic. One source of potential limitations is the motivating ideology associated with a logic. While extraneous to the logic, the motivating ideology is often important for the development of formal and philosophical work on that logic, as is the case with intuitionistic logic. One family of logics for which the philosophical ideology is important is the family of relevant logics. In (...) this paper, I explore the limits of what a relevant connective is, showing how some basic criteria motivated by the ideology of relevant logicians provide robust limits on potential connectives. These criteria provide some plausible necessary conditions on being a relevant connective. (shrink)

The Supernatural universe consists of both supernatural and natural beings and elements. The spernatural beings include God, archangels, minor gods, leviathans, angels, reapers, demons, and spirits. The natural beings are humans and other organic life. To see the differences between naturalist thinking and supernaturalist thinking, two possible explanations of a mental illness should be compared. A naturalist explanation would use neurobiology to explain mental illness as driven by brain anomalies either in structure or chemistry. By contrast, a supernatural explanation of (...) mental illness might involve the possession of the person by an evil spirit or demon. Due to the fact that organisms are self‐replicating, and replication cannot be perfect in the material world, genetic codes must evolve. A naturalist could hypothesize that souls self‐replicate through the very same biological process that delivers all our children, since whenever we replicate we tend to also increase the total number of souls. (shrink)

Functionalist accounts of blame have been rising in popularity. Proponents of the approach claim that, by defining blame in terms of its function or functions, their account has the advantage of being able to accommodate a wide range of attitudes and activities as blame; but their opponents question the extensional and explanatory adequacy of such accounts. This paper contributes to this burgeoning literature by presenting new challenges to the existing functionalist accounts. The fundamental problem, I shall argue, lies in the (...) fact that they all focus on using functions to define blame as a type of practice, but this strategy fails to pick out a unique moral-psychological type and does not offer a complete set of extension-determining criteria for the concept of blame. This amounts to a serious theoretical disadvantage. I consider various responses to the challenges throughout the paper, concluding that the best reply available to the functionalist theorist involves using functions to directly define blame tokens. (shrink)

In this paper, I motivate the addition of an actuality operator to relevant logics. Straightforward ways of doing this are in tension with standard motivations for relevant logics, but I show how to add the operator in a way that permits one to maintain the intuitions behind relevant logics. I close by exploring some of the philosophical consequences of the addition.

This book examines influential conceptions of sport and then analyses the interplay of challenging borderline cases with the standard definitions of sport. It is meant to inspire more thought and debate on just what sport is, how it relates to other activities and human endeavors, and what we can learn about ourselves by studying sport.

Classical Liberalism is a view that the only justifiable restraints on the actions and choices of individuals in political orders are ones necessary to preserve individual liberty. Central to this view of liberty is the individual being left free from coercive interference from other individuals and society as a whole. This view presumes the idea that the individual is, firstly, able to choose his ends and actions, and secondly, that the individual is the best judge of these. Thus, the individualism (...) of classical liberalism presupposes a view of human consciousness that is volitional: capable of engaging in choice and individual self-direction. If this view of human consciousness is in conflict with the physical casual and evolutionary accounts of the world, then classical liberalism would seem to have serious problem. Therefore, I argue that the correct conception of volitional consciousness is consistent with the physical causal and evolutionary accounts of the world. Presenting a conception of volitional consciousness that makes the best sense of our introspective experience and knowledge of the world, I then show how such a volitional consciousness is consistent with causality and biological evolution. (shrink)

When asked which of our concepts are normative concepts, metaethicists would be quick to list such concepts as GOOD, OUGHT, and REASON. When asked why such concepts belong on the list, metaethicists would be much slower to respond. Matti Eklund is a notable exception. In his recent book, Choosing Normative Concepts, Eklund argues by elimination for “the Normative Role view” that normative concepts are normative in virtue of having a “normative role” or being “used normatively”. One view that Eklund aims (...) to eliminate is “the Metaphysical view” that normative concepts are normative in virtue of referring to normative properties. In addition to arguing that Eklund’s objection looks doubtful by its own lights, we argue that there are several plausible versions of the Metaphysical view that Eklund doesn’t eliminate, defending various claims about normative concepts and their relationships to deliberation, competence, reference, and possession along the way. (shrink)

In relevant logics, necessary truths need not imply each other. In justification logic, necessary truths need not all be justified by the same reason. There is an affinity to these two approaches that suggests their pairing will provide good logics for tracking reasons in a fine-grained way. In this paper, I will show how to extend relevant logics with some of the basic operators of justification logic in order to track justifications or reasons. I will define and study three kinds (...) of frames for these logics. For the first kind of frame, I show soundness and highlight a difficulty in proving completeness. This motivates two alternative kinds of frames, with respect to which completeness results are obtained. Axioms to strengthen the justification logic portions of these logics are considered. I close by developing an analogy between the dot operator of justification logic and theory fusion in relevant logics. (shrink)

While traditionally Plato has been read as a critic of democracy and an advocate of philosopher-kingship, a number of more recent interpretations have argued that Plato’s views about these issues changed over the course of his life. Several scholars argue that Plato shifts from an authoritarian outlook in “middle period” dialogues, such as the Republic, to a more democratic view in “late” dialogues, such as the Laws. In contrast to these scholars, this article argues that Plato’s attitude towards authority and (...) democracy is consistent in his “middle” and “late” periods. I show that Plato defines law as the writing of political experts, and that the Laws turns to written law as a second-best method for instituting the rule of the wise. This interpretation enables us to understand the Laws as a dialogue about the political use of writing, which helps illuminate some of the more peculiar features of the Laws and account for its place in the Platonic corpus. (shrink)

Various cell types cooperate to create a highly organized and dynamic micro-environmental niche in the bone marrow. Over the past several years, the field has increasingly recognized the critical roles of the interplay between bone marrow environment and hematopoietic cells in normal and deranged hematopoiesis. These advances rely on several new technologies that have allowed us to characterize the identity and roles of these niches in great detail. Here, we review the progress of the last several years, list some of (...) the outstanding questions in the field and propose ways to target the diseased environment to better treat hematologic diseases. Understanding the extrinsic regulation by the niche will help boost hematopoiesis for regenerative medicine. Based on natural development of hematologic malignancies, we propose that combinatory targeting the niche and hematopoietic intrinsic mechanisms in early stages of hematopoietic malignancies may help eliminate minimal residual disease and have the highest efficacy. The bone marrow is the home for blood-forming hematopoietic stem and progenitor cells. Normal generation of blood and immune cells depends on highly regulated interactions between these stem and progenitor cells with their surrounding environment. Emerging evidence suggests that therapeutic interventions directed at these cellular interdependencies can help boost hematopoiesis and eradicate malignant hematopoietic cells. (shrink)