Human cerebral organoids are three-dimensional biological cultures grown in the laboratory to mimic as closely as possible the cellular composition, structure, and function of the corresponding organ, the brain. For now, cerebral organoids lack blood vessels and other characteristics of the human brain, but are also capable of having coordinated electrical activity. They have been usefully employed for the study of several diseases and the development of the nervous system in unprecedented ways. Research on human cerebral organoids is proceeding at (...) a very fast pace and their complexity is bound to improve. This raises the question of whether cerebral organoids will also be able to develop the unique feature of the human brain, consciousness. If this is the case, some ethical issues would arise. In this article, we discuss the necessary neural correlates and constraints for the emergence of consciousness according to some of the most debated neuroscientific theories. Based on this, we consider what the moral status of a potentially conscious brain organoid might be, in light of ethical and ontological arguments. We conclude by proposing a precautionary principle and some leads for further investigation. In particular, we consider the outcomes of some very recent experiments as entities of a potential new kind. (shrink)

Intuitively, we can conceive of the existence of a conscious state as a pure activity that does not necessarily require a body (or even a brain). This idea has found new support in certain recent theories that present the possibility of a totally disconnected and disembodied consciousness. Against this hypothesis, I argue that human experience is intrinsically embodied and embedded, though in a specific way. Using Sartre’s phenomenology of the body, I first analyze the concept of consciousness as intentionality and (...) a world-disclosing activity, thus explaining how conscious activity can only be expressed through a body that is spatiotemporally related to the world. Then, I argue that bodily consciousness does not necessarily imply the actual presence of an anatomical body but, rather, a process of spatialization and temporalization (hodological space and temporal synthesis) through the “spatiotemporal body”. Finally, I test my thesis by critiquing some cases of apparent disembodied/disconnected consciousness, i.e., dreams, out-of-body experiences, and the brain-in-a-vat scenario. (shrink)

: This paper uses Extended Mind Theory to explore Brain-Computer Interfaces, demonstrating how this conceptual framework provides a wide-ranging interpretation of the potential integration of user and computer. After a preliminary analysis of first- and second-wave EMT arguments and other pragmatic criteria, I present BCI technology, addressing the issues that arise. Can BCIs extend our mental processes and to what degree? What EMT criteria should be applied to this technology? What is the role of the body in the process of (...) integrating user and computer? What are current limits to complete cognitive and bodily extension by BCIs? In line with this discussion, I suggest a pluralist approach to BCIs, allowing for specific and appropriate application of the various models and paradigms. I also advocate greater focus on the integration of body and tool, primarily for clinical purposes, but also for applications that will meet daily needs in the future. Keywords : Extended Mind; Brain-Computer Interface; Embodiment; Parity Principle; Cognitive Artefacts. Mente estesa e brain-computer interface. Un approccio pluralista all’integrazione uomo-macchina Riassunto: Il presente articolo fa uso della Extended Mind Theory per indagare le Brain-Computer Interfaces, dimostrando che questo framework concettuale offre un’interpretazione ad ampio raggio della potenziale integrazione tra utente e computer. Dopo un’analisi preliminare degli argomenti della EMT di prima e seconda generazione e altri criteri pragmatici, presenterò la tecnologia delle BCIs, affrontando alcune questioni a essa collegate. Le BCIs possono estendere i nostri processi mentali e fino a che punto? Quali criteri della EMT dovrebbero essere applicati a questa tecnologia? Qual è il ruolo del corpo nel processo di integrazione utente-computer? Quali sono gli attuali limiti per completare l’estensione cognitiva e corporea da parte delle BCIs? In linea con questa discussione, suggerirò un approccio pluralistico alle BCIs che permetta un’applicazione specifica e appropriata dei vari modelli e paradigmi. Sosterrò inoltre la necessità di una maggiore attenzione all’integrazione tra corpo e strumento, principalmente per scopi clinici ma anche per applicazioni future che soddisfino le esigenze quotidiane. Parole chiave: Mente estesa; Brain-Computer Interface ; Incorporamento; Principio di Parità; Artefatti cognitivi. (shrink)

Enactivism maintains that the mind is not produced and localized inside the head but is distributed along and through brain-body-environment interactions. This idea of an intrinsic relationship between the agent and the world derives from the classical phenomenological investigations of the body (Merleau-Ponty in particular). This paper discusses similarities and differences between enactivism and Jean-Paul Sartre’s phenomenology, which is not usually considered as a paradigmatic example of the relationship between phenomenological investigations and enactivism (or 4E theories in general). After a (...) preliminary analysis of the three principal varieties of enactivism (sensorimotor, autopoietic and radical), I will present Sartre’s account of the body, addressing some key points that can be related to the current enactivist positions: perception-action unity, anti-representationalism, anti-internalism, organism-environment interaction, and sense-making cognition. Despite some basic similarities, enactivism and Sartre’s phenomenology move in different directions as to how these concepts are developed. Nevertheless, I will suggest that Sartre’s phenomenology is useful to the enactivist approaches to provide a broader and more complete analysis of consciousness and cognition, by developing a pluralist account of corporeality, enriching the investigation of the organism-environment coupling through an existentialist perspective, and reincluding the concept of subjectivity without the hypostatisation of an I-subject detached from body and world. (shrink)

Riassunto : Nonostante le difficoltà teoretiche ed epistemologiche nell’affrontare il fenomeno della coscienza, l’autore individua una metodologia pragmatica e sperimentalmente consistente, fondata sull’approccio neurocognitivo bidimensionale: per evitare di rimanere incagliati nel “problema complesso” della coscienza, è preferibile infatti concentrarsi sul “problema reale”, ovvero sui meccanismi empiricamente rilevabili, lasciando in secondo piano le caratteristiche epistemiche e fenomenologiche degli stati mentali coscienti. Dall’analisi della relazione gerarchica tra stato di veglia e contenuto di coscienza emerge un’interessante interpretazione che tenta di rendere ragione dell’unitarietà (...) della coscienza e, al contempo, della sua varietà fenomenica. Tuttavia, alcuni studi sul sonno, sulla fase REM e sugli incubi potrebbero mettere in discussione una certa versione forte di questa relazione gerarchica tra stati di coscienza. È inoltre importante chiedersi se una prospettiva bidimensionale sia sufficiente a definire esaustivamente le caratteristiche oggettive della coscienza o se sia auspicabile un diverso approccio tridimensionale. Keywords : Coscienza; Problema reale; Veglia; Consapevolezza; Fase REM A Pragmatic Approach to the “Real Problem” of Consciousness: Despite the theoretical and epistemological complexities involved in dealing with the phenomenon of consciousness, the author describes defines a pragmatic and experimental methodology, based on a two-dimensional neurocognitive approach. Indeed, in order to avoid the hard problem of consciousness, it would be better to focus on the real problem, i.e. on mechanisms that can be empirically observed, leaving out all of the epistemic and phenomenological features of conscious states. The idea of a hierarchical relationship between the level and the content of consciousness could give rise to an interpretation which justifies both the unity and, at the same time, the phenomenal variety of consciousness. However, studies on sleep, REM phase and nightmares might challenge at least the strong version of this hypothetical relationship between different features of consciousness. Furthermore, it is important to consider whether a two-dimensional perspective, rather than a three-dimensional one, would be sufficient to exhaustively define all the objective features of consciousness. Keywords : Consciousness; Real Problem; Wakefulness; Awareness; REM Phase. (shrink)

Human brain organoids (HCOs) are laboratory-grown biological entities that have been added to the catalog of living entities for just over a decade. How they are formed and may continue to develop for some time is not irrelevant, given their peculiarity, which is that they mimic the human brain with a high degree of similarity. Revolving around this key issue is the discussion on our target article (Zilio and Lavazza 2023), for which we are grateful to all the commentators.

Can addiction be credibly invoked as an excuse for moral harms secondary to particular decisions to use drugs? This question raises two distinct sets of issues. First, there is the question of whether addiction is the sort of consideration that could, given suitable assumptions about the details of the case, excuse or mitigate moral blameworthiness. Most discussions of addiction and moral responsibility have focused on this question, and many have argued that addiction excuses. Here I articulate what I take to (...) be the best argument for this view, based on the substantial difficulty that people with severe addiction experience in controlling drug-related behavior. This, I argue, may in some cases be sufficient to ground a mitigating excuse, given the way in which addiction undermines agents’ responsiveness to relevant moral reasons to do otherwise. Much less attention has been devoted to a second set of issues that critically affect the possibility of applying this mitigating excuse in particular cases, derived from the ambivalent nature of agential control in addiction. In order to find a fitting response to moral harm, the person with the right standing to blame must make a judgment about the extent to which the agent possessed certain morally relevant capacities at the time of the act. In practice, this will often prove tremendously difficult to assess. The ethical challenge for the person with the right standing to blame is fundamentally one of making a judgment about matters that seem underdetermined by the available evidence. (shrink)

It is often assumed that, except perhaps in a few rare cases, people with addiction can be aptly held responsible for having acquired the condition. In this chapter, I consider the argument that supports this view and draw attention to a number of challenges that can be raised against it. Assuming that early decisions to use drugs were made in possession of normal-range psychological capacities, I consider the key question of whether drug users who later became addicted should have known (...) that addiction was a likely outcome of their decisions to use drugs in a way that makes them blameworthy for their lack of foresight. I focus on three different points of contention surrounding this claim: how likely the outcome to be predicted was, how tolerable risk should be weighed against the expected value of decisions to use, and how reliable the relevant predictive abilities of the average person are. Once we consider in some detail what would have to be true in order for someone to be aptly held responsible for becoming addicted, the prospects for making a convincing case to that effect look, I argue, somewhat more uncertain than they might at first appear. (shrink)

In this paper I argue that Fricker’s influential account of testimonial injustice (hereafter ‘TI’) should be expanded to include cases of TI from mutually neutralising countervailing prejudices. In this kind of case, the hearer is given due credibility by the speaker. I describe a relevant case, defend it from objections, highlight how it differs from extant cases of due-credibility TI and describe its distinctive features. This case demonstrates how paying attention to the way multiple prejudices operate in concert leads to (...) expanding the repertoire of cases of TI and casts light on the harms of TI. (shrink)

Plato's political thought gave rise to a number of concepts and issues - such as the idea of a normative theory, the philosophical foundation of politics, the philosopher-kings, the standard of utopian theory - which have played a significant role on Western political and philosophical thought. -/- This volume aspires to bring out Plato's concept of efficacy in a normative theory. -/- By efficacy, the author means the way in which the theory conceives of its practical realization. If in the (...) Republic this issue is particularly problematic, in the Laws, instead, the claim of realizability becomes the main concern. -/- By defining the concept of efficacy and going through the main works of Plato, this conceptual and textual analysis aims to shed a new light on Plato's political thought, which is neither a utopia, nor a short term political program, but the first normative theory encompassing a theory of efficacy. (shrink)

O julgamento da ADPF 54 pelo Supremo Tribunal Federal teve como efeito a regulamentação do início da proteção constitucional à vida, silenciada na Constituição Federal de 1988 e na legislação ordinária. Todavia, a tramitação perante o Legislativo de Projeto de Lei prevendo a criminalização da interrupção da gravidez por diagnóstico de anencefalia fetal reacende as tensões acerca dos limites da atuação dos poderes Judiciário e Legislativo na concretização dos direitos fundamentais, as quais serão analisadas no presente trabalho à luz do (...) direito comparado, a fim de compreender como a regulamentação do direito à vida se estabeleceu em outros Estados Democráticos. (shrink)

While some form of loss of control is often assumed to be a common feature of the diverse manifestations of addiction, it is far from clear how loss of control should be understood. In this paper, I put forward a concept of decrease in control in addiction that aims to fill this gap and thus provide a general framework for thinking about addictive behavior. The development of this account involves two main steps. First, I present a view of degrees of (...) control as the degree to which an agent would be responsive to potential or counterfactual sufficient reasons to do otherwise. Second, I sketch an account of the relevant control-undermining factors in addiction that is consonant with my proposed view of degrees of control. Being a high-level functional property, reasons-responsiveness is particularly well suited to frame an account of control-undermining factors that is doubly pluralistic: it encompasses the contribution of factors both internal and external to the agent, and it is consistent with various proposals as to the precise nature of the anomaly taking place in the psychology of addiction. (shrink)

Advancements and deployments of AI-based systems, especially Deep Learning-driven generative language models, have accomplished impressive results over the past few years. Nevertheless, these remarkable achievements are intertwined with a related fear that such technologies might lead to a general relinquishing of our lives’s control to AIs. This concern, which also motivates the increasing interest in the eXplainable Artificial Intelligence (XAI) research field, is mostly caused by the opacity of the output of deep learning systems and the way that it is (...) generated, which is largely obscure to laypeople. A dialectical interaction with such systems may enhance the users’ understanding and build a more robust trust towards AI. Commonly employed as specific formalisms for modelling intra-agent communications, dialogue games prove to be useful tools to rely upon when dealing with user’s explanation needs. The literature already offers some dialectical protocols that expressly handle explanations and their delivery. This paper fully formalises the novel Explanation–Question–Response (EQR) dialogue and its properties, whose main purpose is to provide satisfactory information (i.e., justified according to argumentative semantics) whilst ensuring a simplified protocol, in comparison with other existing approaches, for humans and artificial agents. (shrink)

This paper explores the concept of moral expertise in the contemporary philosophical debate, with a focus on three accounts discussed across moral epistemology, bioethics, and virtue ethics: an epistemic authority account, a skilled agent account, and a hybrid model sharing key features of the two. It is argued that there are no convincing reasons to defend a monistic approach that reduces moral expertise to only one of these models. A pluralist view is outlined in the attempt to reorient the discussion (...) about moral expertise. (shrink)

L’article propose une interprétation théorique du processus de rupture entre les attentes créées par les conversations sur les applications de rencontres et le moment du premier face-à-face. Cet effet est connu par les utilisateurs de ces applications. Néanmoins, il a été moins analysé dans la littérature. Dans un premier temps, l’auteur analyse le processus de désillusion à l’ère de la rencontre en ligne. Ensuite, à travers la phénoménologie sociale et la sociologie interactionniste, l’article présente une interprétation de ce phénomène d’une (...) part par les dynamiques de la rencontre en ligne qui commence dans la sphère des contemporains pour avancer vers la sphère des consociés, selon la théorie socio-phénoménologique et, d’autre part, par la production d’une identité virtuelle qui nécessite confirmation dans la réalité hors ligne, selon la sociologie interactionniste. (shrink)

We argue that microbiome research should be more reflective on the methods that it relies on to build its datasets due to the danger of facing a methodological problem which we call “epistemic misalignment.” An epistemic misalignment occurs when the method used to answer specific scientific questions does not track justified answers, due to the material constraints imposed by the very method. For example, relying on 16S rRNA to answer questions about the function of the microbiome generates epistemic misalignments, due (...) to the different temporal scales that 16S rRNA provides information about and the temporal scales that are required to know about the functionality of some microorganisms. We show how some of these exist in contemporary microbiome science and urge microbiome scientists to take some measures to avoid them, as they may question the credibility of the field as a whole. (shrink)

In previous works, an ontology of properties for quantum mechanics has been proposed, according to which quantum systems are bundles of properties with no principle of individuality. The aim of the present article is to show that, since quasi-set theory is particularly suited for dealing with aggregates of items that do not belong to the traditional category of individual, it supplies an adequate meta-language to speak of the proposed ontology of properties and its structure.

A restrictive view of self-control identifies exercises of self-control with synchronic intrapsychic processes, and pictures diachronic and externally-scaffolded strategies not as proper instances of self-control, but as clever ways of avoiding the need to exercise that ability. In turn, defenders of an inclusive view of self-control typically argue that we should construe self-control as more than effortful inhibition, and that, on grounds of functional equivalence, all these diverse strategies might be properly described as instances of self-control. In this paper, I (...) take a fresh look at this debate by focusing on cases of addiction. I argue that addicted agents face a paradigmatic sort of self-control challenge, which makes addiction an important test case for theories of self-control. And I discuss evidence that highlights both the unreliability of synchronic intrapsychic strategies and the crucial role that is played by diachronic and externally-scaffolded strategies in successful attempts at achieving abstinence by addicted individuals. Abstaining addicts are a paradigmatic case of agents who successfully exercise self-control, and they mostly do so by relying on diachronic and externally-scaffolded strategies. This, I argue, lends further support to an inclusive view of self-control. (shrink)

We propose a new interpretation of the equation E=mc² in special relativity by generalizing ideas of ontological emergence to fundamental physics. This allows us to propose that mass, as a property, can be considered to emerge from energy, using a well-known definition of weak ontological emergence. Einstein’s famous equation gains in this way a clearer philosophical interpretation, one that avoids the problems of previous attempts, and is fully consistent with the kinematic properties of special relativity, while yielding fresh insights concerning (...) the nature of mass. (shrink)

We discuss the mathematical structures that underlie quantum probabilities. More specifically, we explore possible connections between logic, geometry and probability theory. We propose an interpretation that generalizes the method developed by R. T. Cox to the quantum logical approach to physical theories. We stress the relevance of developing a geometrical interpretation of quantum mechanics.

According to Marshall et al. (2024), some of the patients who refuse to stay in observation after being resuscitated following an opioid overdose are likely not making an autonomous choice. While I do not intend to dispute this claim, it merits discussion what is the concept of autonomy at play in making this assessment. I contend that the concept at work is more substantive than Marshall et al. acknowledge—and more substantive, too, than the form of autonomy usually thought to underpin (...) the moral justification of the requirement of informed consent . (shrink)

We take for granted that only certain kind of things exist - electrons but not angels, passports but not nymphs. This is what we understand as `reality'. But in fact, `reality' varies with each era of the world, in turn shaping the field of what is possible to do, think and imagine. Our contemporary age has embraced a troubling and painful form of reality: Technic. Under Technic, the foundations of reality begin to crumble, shrinking the field of the possible and (...) freezing our lives in an anguished state of paralysis. Technic and Magic shows that the way out of the present deadlock lies much deeper than debates on politics or economics. By drawing from an array of Northern and Southern sources - spanning from Heidegger, Junger and Stirner's philosophies, through Pessoa's poetry, to Advaita Vedanta, Bhartrhari, Ibn Arabi, Suhrawardi and Mulla Sadra's theosophies - Magic is presented as an alternative system of reality to Technic. While Technic attempts to capture the world through an `absolute language', Magic centres its reconstruction of the world around the notion of the `ineffable' that lies at the heart of existence. Technic and Magic is an original philosophical work, and a timely cultural intervention. It disturbs our understanding of the structure of reality, while restoring it in a new form. This is possibly the most radical act: if we wish to change our world, first we have to change the idea of `reality' that defines it. (shrink)

The paper offers an interpretation of the thesis developed by Fichte in the Erste Einleitung in die Wissenschaftslehre following “the philosophy one chooses depends on the man one is” as a deepening of symbolic practices and dispositions that philosophy shares with ordinary consciousness. To support this interpretation, the paper describes how Fichte defines individual character formation and how it relates to a historical determinate is presented through a quick excursion in the Nicolaischrift of 1801 (§2). Through a critical and synthetic (...) view of the process of initiation into philosophy, the paper shows how the choice of philosophy is a choice for philosophy (§ 3) and invests a certain “skill” that is produced in the pre-philosophical dimension (§ 4). Through discussion of the Fichtian concepts of “instinct of reason” and “new sensory,” how the choice for philosophy, interpretable as the production of a new habitus, the fichtean doctrine of Science realizes itself fully as ‘critique’ (§ 5). (shrink)

Quantum Mechanics is a fundamental physical theory about atomic-scale processes. It was built between 1920 and 1940 by the most distinguished physicists of that time. The accordance between the predictions of the theory and experimental results is remarkable. The physical interpretation of its mathematical constructs, however, raised unprecedented controversies. Ontological, semantic, and epistemic vagueness abound in the orthodox interpretations and have resulted in serious misunderstandings that are often repeated in textbooks and elsewhere. In this work, we identify, criticize, and clarify (...) the most spread ones. (shrink)

Science is the most powerful tool of the twentieth century, but is its influence properly harnessed? This book examines the often-difficult relationship between scientists and those who govern them. A distinguished group of specialists looks at the history of this relationship, where it stands today, and what needs to be done to ensure that science is used in the future for the greatest good of the greatest number.