This essay focuses on possible nonhuman applications of CRISPR/Cas9 that are likely to be widely overlooked because they are unexpected and, in some cases, perhaps even “frivolous.” We look at five uses for “CRISPR Critters”: wild de-extinction, domestic de-extinction, personal whim, art, and novel forms of disease prevention. We then discuss the current regulatory framework and its possible limitations in those contexts. We end with questions about some deeper issues raised by the increased human control over life on earth offered (...) by genome editing. (shrink)

In August 2001,just after President Bush announced his stem cell funding policy and the creation of a new Presidents Council on Bioethics PCB), the new chair of the PCB, Leon Kass, set out his philosophy for constructing public bioethics bodies: There are several ways of running commissions, he said. One is to stack it with your people, make them homogenous, and force a consensus. Another is to make them heterogeneous, so that you can only come to the lowest common denominator. (...) We re not going to adopt either. We are going to allow the debate to be developed and heard. Now, three years, sixteen meetings, and five reports later, there are nagging questions about whether this council indeed has allowed the debate to be developed and heard. And the charge of politicizing public bioethics to a degree heretofore unknown and stifling the voices of dissenting members comes not from the political left but from President Bushs own appointees, including one scientist who was dismissed from further service. (shrink)

In August 2001,just after President Bush announced his stem cell funding policy and the creation of a new Presidents Council on Bioethics PCB), the new chair of the PCB, Leon Kass, set out his philosophy for constructing public bioethics bodies: There are several ways of running commissions, he said. One is to stack it with your people, make them homogenous, and force a consensus. Another is to make them heterogeneous, so that you can only come to the lowest common denominator. (...) We re not going to adopt either. We are going to allow the debate to be developed and heard. Now, three years, sixteen meetings, and five reports later, there are nagging questions about whether this council indeed has allowed the debate to be developed and heard. And the charge of politicizing public bioethics to a degree heretofore unknown and stifling the voices of dissenting members comes not from the political left but from President Bushs own appointees, including one scientist who was dismissed from further service. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Principles and PragmatismR. Alta Charo (bio)Openly, privately, or implicitly, every public ethics committee struggles with its mandate. Is its job to identify a moral ideal?; a morally acceptable minimum that, realistically, could be adopted as policy?; or an optimal political compromise that can arguably meet ethical analysis? The answer appears to be different for each committee, depending upon its subject matter, its sponsoring political body, and the (...) details of its legal mandate. What is universal, however, is that even the most well-intentioned committee is likely to experience dissension over the interpretation of its task and that this dissension will often be played out in debates over particular policy recommendations.Ruth Macklin’s description of disagreement and moral integrity in the context of the Advisory Committee on Human Radiation Experiments demonstrates this phenomenon quite clearly (Macklin 1996). The epistemological debates concerning the evidence of past practices illuminate differing visions of the Committee’s mandate. For some it was to render moral judgment on past acts, without necessarily concluding that, if the acts were immoral, the individuals involved were themselves immoral. For others it was to use moral judgments to determine appropriate forms of restitution, thus balancing the reputational risks to past actors against the need for and feasibility of restitution to the victims. Still others appeared to focus on crafting specific political responses, and the historical data needed only be sufficient to bolster the policy recommendations.In this respect, the composition of any advisory committee becomes crucial. As fact-finders, committee members must determine the kind of evidence they will find persuasive. This determination, in turn, depends upon whether the committee sees itself primarily as (1) informational, in which case the standards employed by professional historians are probably the most appropriate, or (2) judgmental, in which case something closer to legal standards of proof might be better. The dilemma is not limited to committees looking at history; those rendering advice on science policy need to determine if they will use standards of proof prevalent in the scientific community (consensus following peer review) or the public (scientific consensus coupled with credibility of the scientific community as a whole). [End Page 319]When a committee is asked to base its judgments on ethical analysis, the conflicts only deepen. The “ethics” of policy recommendations are invariably balanced against the desire to see one’s work yield a concrete political response, the perception of political constraints on implementing an ethically “ideal” solution, and the subtle pressures exerted by the sponsoring political body to respond to the specific committee mandate, which was written with the needs of the sponsoring body in mind, not the needs of a wide-ranging ethics discussion.Another complication arises because ethics committees derive their credibility from the perception that moral truth is discoverable and unassailable. To horse trade among these moral truths undermines the credibility of their entire endeavor and can render bioethics advisory committees not only ineffective but even offensive. After all, if a moral truth exists, how ethical is it for “ethicists” to abandon it in the name of strategic concerns? If, on the other hand, no moral truth exists, then by what right do these “ethics” committees claim persuasive authority beyond that of any citizen advisory committee?This is a deep dilemma that relates to the discipline of bioethics itself. Lacking a core methodology or doctrine, bioethics has yet to justify itself to either its proponents or to the public. Bioethics scholars acknowledge that there are a variety of theories drawn from moral philosophy that could be used to guide the resolution of dilemmas that arise in the context of medical care and biomedical research. Such theories include utilitarianism, deontology, teleology, virtue theory, and justice theory, with no one theory being universally adopted by bioethics scholars and no one methodology being available to resolve conflicts among their respective conclusions. While deductivism is the predominant analytical style in the field, “[t]he central difficulty with deductivism is that there is no single comprehensive moral theory, nor even theories or principles of more limited scope, which is agreed to be true or correct” from which defensible conclusions will flow (Brock 1995).But if public ethics bodies cannot... (shrink)

And who can doubt that it will lead to the worst disorders when minds created free by God are compelled to submit slavishly to an outside will? When we are told to deny our senses and subject them to the whim of others? When people devoid of whatsoever competence are made judges over experts and are granted authority to treat them as they please? These are the novelties which are apt to bring about the ruin of commonwealths and the subversion (...) of the state. —Galileo, in the margin of his own copy of Dialogue on the Great World Systems1. (shrink)

The U.S. Supreme Court’s most recent pronouncement on abortion rights resembles the dieter’s dilemma: one knows exactly how to get where one is going but lacks the willpower to follow through. In an opinion filled with exceptionally progressive, equality-based arguments for reproductive freedom, the Court nonetheless manages to back away from its own ineluctably drawn conclusions. In the end it not only ignores its own best arguments but eviscerates its previous analyses of fundamental rights and judicial protection of personal liberties (...) from the excesses of the polity. (shrink)

The U.S. Supreme Court’s most recent pronouncement on abortion rights resembles the dieter’s dilemma: one knows exactly how to get where one is going but lacks the willpower to follow through. In an opinion filled with exceptionally progressive, equality-based arguments for reproductive freedom, the Court nonetheless manages to back away from its own ineluctably drawn conclusions. In the end it not only ignores its own best arguments but eviscerates its previous analyses of fundamental rights and judicial protection of personal liberties (...) from the excesses of the polity. (shrink)

The surprise announcement in November 2018 that a Chinese researcher had implanted and brought to term two gene-edited embryos, resulting in the birth of twin girls, had the effect of galvanizing a debate that goes back decades. Should we make heritable changes in our children's DNA? Until recently, this was hypothetical only, and the easy response was to say it is too uncertain and too unnecessary to be tolerated. Suddenly, however, the possibility that there might be real uses for mitochondrial (...) DNA replacement or for germline editing has led to a more nuanced debate, ranging from calls to double-down on prohibiting this technology to discussions of how to permit it for a... (shrink)

Bu araştırma notu, Râzî’nin el-Metâlibü’l-âliye adlı eserinin, epistemoloji, mantık ve ontoloji kısımlarını içeren ve şimdiye kadar kullanılmayan bir nüshasını ve bu nüshanın içeriğini tanıtmaktadır (Süleymaniye Kütüphanesi, Fatih 3145). Bununla yazı, Sekkâ neşrinin sebep olduğu el-Metâlibü’l-âliye’nin adı ve kapsamıyla ilgili iki temel yanlışı düzeltmekte ve el-Metâlibü’l-âliye’nin mantık, ontoloji, fizik ve teoloji kısımlarını içeren kuşatıcı bir ansiklopedik eser olduğunu göstermeyi amaçlamaktadır.

ABSTRACT Massimo Reichlin, in an earlier article in this journal, defended a version of the ‘argument from potential’ (AFP), which concludes that the human embryo should be protected from the moment of conception. But R. Alta Charo, in her essay entitled ‘Every Cell is Sacred: Logical Consequences of the Argument from Potential in the Age of Cloning’, claims that versions of the AFP like Reichlin’s are vulnerable to a rather embarrassing problem: with the advent of human cloning, such (...) versions of the AFP entail that every somatic cell in the human body ought to be protected. Since this entailment is clearly absurd, Charo argues, these versions of the AFP should be rejected. I argue that the reasons Charo cites for believing in this entailment are inconclusive. For example, the four reasons she gives for doubting any differences between the nature of skin cells and zygotes are ultimately unconvincing. Against Charo, I maintain that there is a relevant distinction between the sort of potential possessed by the somatic cell and the sort of potential possessed by the early human embryo. Since only the latter sort of potential falls within the scope of the AFP, the alleged absurd entailment Charo invites us to consider is no entailment at all. Hence the AFP cannot be rejected on the grounds Charo advances. Even in an age of cloning, the claim that some cells are ‘sacred’ because of their potential does not entail the claim that every cell is sacred. (shrink)

Quantum indeterminism seems incompatible with Kant’s defense of causality in his Second Analogy. The Copenhagen interpretation also takes quantum theory as evidence for anti-realism. This article argues that the law of causality, as transcendental, applies only to the world as observable, not to hypothetical (unobservable) objects such as quarks, detectable only by high energy accelerators. Taking Planck’s constant and the speed of light as the lower and upper bounds of observability provides a way of interpreting the observables of quantum mechanics (...) as empirically real even though they are transcendentally (i.e., preobservationally) ideal.El indeterminismo cuántico parece incompatible con la defensa de la causalidad que hace Kant en su Segunda Analogía. La interpretación de Copenhague de la mecánica cuántica también considera a esta teoría como evidencia a favor del antirrealismo. Este artículo defiende que la ley (trascendental) de la causalidadse aplica solamente al mundo en tanto que observable, y no a objetos hipotéticos (inobservables) como los quarks, detectables solo mediante aceleradores de altas energías. Tomar la constante de Planck y la velocidad de la luz como límites inferior y superior de la observabilidad nos ofrece un modo de interpretar losobservables de la mecánica cuántica como empíricamente reales, incluso aunque estos sean trascendentalmente, es decir, preobservacionalmente, ideales. (shrink)

Clinical and Care Bioethics Committees at Public and Private Healthcare Institutions of Medium and High Complexity Levels in Cities of the Atlantic Coast of Colombia Comitês de Bioética clínico-assistencial nas instituições de saúde públicas e privadas dos níveis de média e alta complexidade das cidades da Costa Atlântica da Colômbia Care bioethics committees are interdisciplinary groups engaged in providing education to members of said committees, all the staff in the hospital —including professors and students in their internship—, and members (...) of the community. The objective of this study is to determine the situation of clinical and care bioethics committees at healthcare institutions in the Atlantic Coast of Colombia between 2010-2016. The study is cross-sectional, descriptive, and retro-prospective. Twenty-six health institutions that met the inclusion criteria were selected and administered a semi-structured survey. The statistical software SPSS version 22 was used to analyze the information. This study adhered to ethical research guidelines. The name most commonly given to committees is Hospital Ethics Committee. Only half have staff trained in ethics or bioethics and the most outstanding function is education in ethics; however, in the same percentage there are committees whose opinion is divided as their operation is unclear. Committees should follow existing ethical and bioethical models, and bills should be brought forward to help committees at healthcare institutions become more effective as regards their structure and operation. Para citar este artículo / To reference this article / Para citar este artigo Carrillo González S, Lorduy-Gómez J, Muñoz-Baldiris R. Comités de Bioética Clínico-Asistencial en las instituciones de salud públicas y privadas de los niveles de mediana y alta complejidad de las ciudades de la Costa Atlántica de Colombia. Pers Bioet. 2019; 23: 122-136. DOI: https://doi.org/10.5294/pebi.2019.23.1.8 Recibido: 23/08/2018 Aceptado: 25/02/2019. (shrink)

Este artículo se postula como un aporte valioso para acercar el cine centroamericano a todas las personas que habitan la región y a los foráneos que sienten un interés particular por el cine que se realiza en Guatemala, Nicaragua, El Salvador, Honduras, Costa Rica y Panamá. ¿Es el cine centroamericano realizado en el siglo xxi un espacio de reflexión sociopolítica?, ¿el tratamiento de sus temáticas conduce a los directores a reivindicar causas?, ¿cómo abordan los directores de cine centroamericano la ética (...) y la estética en sus producciones artísticas? En la respuesta a dichas preguntas se basa la investigación del cine centroamericano. Una importante carga de denuncia acompaña a películas que contemplan las migraciones en sus dos vertientes, forzosa y voluntaria, en búsqueda de una mejor calidad de vida. Las maras son la columna vertebral de la violencia junto a la recreación de las guerras civiles y los desaparecidos. La memoria colectiva, las persecuciones a los pueblos indígenas, la diversidad sexual, el poder de la religión en su versión evangélica y la maternidad como únicarespuesta a los embarazos no deseados, constituyen algunas de estas nuevas miradas. (shrink)

This article presents the findings of an audience research conducted with 86 young Spanish people aged 15 to 29 years. The investigation examines the modes of reception of television fiction, and the impact of the shows on the viewers. Friends’ influence on the choice of program, and the tendency to use social networks to comment on the shows and to talk about themselves, underline the crucial role played by TV fiction and new technologies in socialization processes. While most participants criticized (...) the propensity of television fiction to build extreme stereotypes, they also showed a clear predilection for Spanish programs, and admitted that their characters often offer inspiration to face everyday problems. (shrink)

Positive family functioning during adolescence is usually studied analyzing parents' competences and children's relationship abilities. We present an instrument for the assessment of parental competence, which encompasses both educational style and transmission of values. The objective of the study was to analyze its factor structure and to assess its value in predicting adolescent outcomes. We recruited 2,459 high school students, aged 12–15, in 40 schools from Spain, Peru, Mexico, and Chile. They responded to the instrument and to other questions regarding (...) lifestyles. Exploratory and confirmatory factor analyses were carried out in order to assess the internal structure of the instrument, and internal consistency of the resulting dimensions was calculated. Finally, regression analyses were performed to establish associations between the parenting dimensions and adolescent outcomes. Factor analyses showed a consistent structure, with good fit indices in the four countries. The final four factors include parenting styles and education in values. Regression analyses showed associations with adolescent outcomes. For example, adolescents' life satisfaction was best predicted by Warmth and Education in fortitude. Practical implications are suggested. (shrink)

This research aims to gain insight on the perception that minors have of viral challenges as an entertainment format and the motivations behind their participation in this digital entertainment phenomenon. A qualitative study was performed by way of twelve focus groups with sixty-two minors aged between eleven and seventeen years from Spain. For minors, viral challenges represent a form of entertainment in an interactive context, perceived as innocuous, ephemeral content from which nothing more is required than for the user to (...) have a good time. This appears to lead the minors interviewed to ignore the meaning and origin of the viral challenges they visualise and share, neither do they regard this to be necessary. It is also important to underline the relativisation of risk and danger in favour of spectacularisation and virality. (shrink)

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

The Moral Nexus develops and defends a new interpretation of morality—namely, as a set of requirements that connect agents normatively to other persons in a nexus of moral relations. According to this relational interpretation, moral demands are directed to other individuals, who have claims that the agent comply with these demands. Interpersonal morality, so conceived, is the domain of what we owe to each other, insofar as we are each persons with equal moral standing. The book offers an interpretative argument (...) for the relational approach. Specifically, it highlights neglected advantages of this way of understanding the moral domain; explores important theoretical and practical presuppositions of relational moral duties; and considers the normative implications of understanding morality in relational terms. The book features a novel defense of the relational approach to morality, which emphasizes the special significance that moral requirements have, both for agents who are deliberating about what to do and for those who stand to be affected by their actions. The book argues that relational moral requirements can be understood to link us to all individuals whose interests render them vulnerable to our agency, regardless of whether they stand in any prior relationship to us. It also offers fresh accounts of some of the moral phenomena that have seemed to resist treatment in relational terms, showing that the relational interpretation is a viable framework for understanding our specific moral obligations to other people. (shrink)

This research introduces a copy of al-Rāzī’s work al-Maṭālib al-ʻāliya that contains epistemology, logic, and ontology sections and an index and was not known until today (Süleymaniye Library, Ms Fatih 3145). Thus, the research correct two fundamental noted mistakes about the name and scope of al-Maṭālib al-ʻāliya that had resulted from al-Saqqā’s edition and aims to prove that al-Maṭālib al-ʻāliya is an encyclopedic work containing sections on logic, ontology, physics, and theology.