Clathrin and the endocytosis machinery has recently been described as being required in mammalian cells for the internalization of large particles including pathogenic bacteria, fungi, and large viruses. These apparently unexpected observations, within the framework of the classical mechanisms for the formation of clathrin‐coated vesicles, are now considered as examples of a new non‐classical function of clathrin, which can promote the internalization of membrane domains associated to planar clathrin lattices. The role of actin downstream of clathrin seems to be critical (...) for this still poorly characterized process. The historical frontier between endocytosis and phagocytosis is vanishing in the light of this new role for clathrin. (shrink)

The first comprehensive account of Platonism in Antiquity, from the foundation of Plato's Academy in the fourth century BC to Late Antiquity. Written in a clear language, the book shows that Platonism is philosophically engaging and very influential in the history of philosophy. Useful for both students and scholars.

A long-standing theme in discussion of perception and thought has been that our primary cognitive contact with individual objects and events in the world derives from our perceptual contact with them. When I look at a duck in front of me, I am not merely presented with the fact that there is at least one duck in the area, rather I seem to be presented withthisthing (as one might put it from my perspective) in front of me, which looks to (...) me to be a duck. Furthermore, such a perception would seem to put me in a position not merely to make the existential judgment that there is some duck or other present, but rather to make a singular, demonstrative judgment, that that is a duck. My grounds for an existential judgment in this case derives from my apprehension of the demonstrative thought and not vice versa. (shrink)

This book defends antitheodicism, arguing that theodicies, seeking to excuse God for evil and suffering in the world, fail to ethically acknowledge the victims of suffering. The authors argue for this view using literary and philosophical resources, commencing with Immanuel Kant's 1791 "Theodicy Essay" and its reading of the Book of Job. Three important twentieth century antitheodicist positions are explored, including "Jewish" post-Holocaust ethical antitheodicism, Wittgensteinian antitheodicism exemplified by D.Z. Phillips and pragmatist antitheodicism defended by William James. The authors argue (...) that these approaches to evil and suffering are fundamentally Kantian. Literary works such as Franz Kafka'sThe Trial, Samuel Beckett's Waiting for Godot, and George Orwell's Nineteen Eighty-Four, are examined in order to crucially advance the philosophical case for antitheodicism. (shrink)

Contrary to what is often assumed since the seminal studies of Puech, I argue that Numenius’ interest in Oriental Wisdom is part of his Platonist stance. The most important testimony is fr. 1a des Places, which shows that Plato is not only the reference‑point but also the criterion and measure to judge the truthfulness of the other philosophical traditions and religions. Numenius’ dualism therefore can be explained as an attempt to preserve the transcendence of the first principle, the typical problem (...) of Middle Platonists as opposed to Hellenistic philosophies such as Stoicism. (shrink)

Temporal Logic: From Ancient Ideas to Artificial Intelligence deals with the history of temporal logic as well as the crucial systematic questions within the field. The book studies the rich contributions from ancient and medieval philosophy up to the downfall of temporal logic in the Renaissance. The modern rediscovery of the subject, which is especially due to the work of A. N. Prior, is described, leading into a thorough discussion of the use of temporal logic in computer science and the (...) understanding of natural language. Temporal Logic: From Ancient Ideas to Artificial Intelligence thus interweaves linguistic, philosophical and computational aspects into an informative and inspiring whole. (shrink)

ABSTRACT The image of Plato captured in Raphael’s School of Athens as the champion of contemplative life has been celebrated for centuries. Such a description of Plato, however, would probably be surprising for most readers who are used to a very different Plato. For many current readers, Plato is a political philosopher. The contrast could not be sharper. The goal of this paper is to reconstruct the origins of the political interpretation of Plato’s thought. Prior to Popper, this interpretation was (...) first developed into a mainstream presentation by some important Hellenists in Germany in the first 30 years of the twentieth century, and it quickly became dominant outside the universitiies. One interesting example of the attempts to popularize Plato’s political thought is that of K. Hildebrandt, a member of the George Kreis, who sought to harmonize Plato and Nietzsche in order to derive a new politics of the German state. (shrink)

In his last book, David Armstrong sets out his metaphysical system in a set of concise and lively chapters each dealing with one aspect of the world. He begins with the assumption that all that exists is the physical world of space-time. On this foundation he constructs a coherent metaphysical scheme that gives plausible answers to many of the great problems of metaphysics. He gives accounts of properties, relations, and particulars; laws of nature; modality; abstract objects such as numbers; and (...) time and mind. (shrink)

399 a.C.: la città di Atene condanna a morte uno dei suoi figli più autorevoli, Socrate. Cosa è successo davvero nei mesi in cui si è svolta la vicenda giudiziaria? Si ripete spesso che si trattò di un processo politico mascherato, per colpire le simpatie oligarchiche dell'anziano filosofo. Ma forse il vero oggetto del contendere in questa vicenda fu proprio il pensiero di Socrate. Fino a che punto una comunità--ieri come oggi--può tollerare che i principi e i valori su cui (...) si fonda siano messi radicalmente in discussione? E davvero le ragioni della filosofia e quelle della città non sono compatibili? Una lettura originale di uno dei più celebri processi della storia. (shrink)