The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data (...) from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. (shrink)

Uma das principais preocupações de Ludwig Wittgenstein, presente já desde as suas primeiras observações, é a autonomia do pensamento próprio. Nosso objetivo neste texto é indicar alguns aspectos metodológicos do diagnóstico e da crítica que o filósofo vienense opera em relação à tradição filosófica ocidental com vistas a possibilitar a obtenção de resultados seguros e pacíficos no universo polêmico da filosofia. Para tanto, indicaremos a importância de recuperar o papel que a tradição filosófica desempenha para o pensamento próprio, assim como (...) a importância de conscientizar-se de que a principal dificuldade da filosofia é estar diante dos conceitos sem pré-conceitos. Além disso, ressaltaremos a necessidade de superação das dificuldades humanas como a da vontade mostrando na filosofia de Wittgenstein a presença da atividade destruidora dos vícios, adornos e ídolos herdados bem como a sua importância para a averiguação das condições lingüísticas do próprio pensar. (shrink)

Cinema is commonly hailed as "the universal language," but how does it communicate so effortlessly across cultural and linguistic borders? Drawing on a lifetime's worth of viewing an reviewing, influential critic Gilberto Perez invokes a dizzying array of masters past and present includin Chaplin, Ford, Kiarostami, Eisenstein, Malick, Mizoguchi, Haneke, Hitchcock, and Godard--to explore the transaction between filmmaker and audience. The Eloquent Screen shows how cinema, as the consummate contemporary art form, establishes a thoroughly modern rhetoric in which different (...) points of view are brought into clear focus.". (shrink)

Resumo O objetivo deste artigo é apresentar os temas do “novo método” filosófico e da “Filosofia da Psicologia”, nos escritos tardios de Ludwig Wittgenstein, como relacionados prática e necessariamente. Para o proposto, a estratégia expositiva segue a seguinte ordem: analisam-se os pressupostos filosóficos relativamente irrefletidos que determinam a visão que o jovem Wittgenstein tinha do “método correto da Filosofia” e da “Filosofia da Psicologia”; interpreta-se a volta filosófica de 1929 como comprometida em apresentar o rosto ainda informe do “novo método” (...) e retomar criticamente os alvos do TLP, sob essa nova perspectiva metodológica; e considera-se a Filosofia da psicologia de Wittgenstein inserida numa perspectiva diferente da perspectiva da ciência psicológica do fim do século XIX e início do século XX, fundamentada em investigações empíricas. Essas observações constituem propriamente uma prática do “novo método” de apresentação perspícua e se caracteriza como um aspecto-chave e necessário, um filtro, para a compreensão das observações do filósofo em torno da psicologia e de seu objetivo em dissolver os problemas metafísicos ali presentes.The main purpose of this article is to present the themes of the philosophical “new method” and the “philosophy of psychology” in Ludwig Wittgenstein’s late writings as practically and necessarily related. For the proposed, our expository strategy follows the following order: we analyzed the relatively unreasonable philosophical presuppositions that determine the young Ludwig’s view of the “correct method of philosophy” and of “philosophy of psychology”; we interpreted the philosophical turn of 1929 as committed to presenting the still-informed face of the “new method” and to critically revisiting the TLP targets under this new methodological perspective; and we considered Wittgenstein’s philosophy of psychology inserted in a different perspective from the perspective of the psychological science of the late nineteenth and early twentieth century based on empirical investigations. These observations are properly a practice of the “new method” of perspicuous presentation and they are characterized as a key and necessary aspect, a filter, for the understanding of the philosopher’s observations about psychology, and his goal in dissolving the metaphysical problems present there. (shrink)

Deliberative scholars have suggested that citizens should be able to exchange arguments in public forums. A key element in this exchange is the rational mode of communication, which means speaking through objective argumentation. However, some feminists argue that this mode of communication may create or intensify epistemic injustices. Furthermore, we should not assume that everyone is equally equipped to take part in deliberation. Certain groups, such as Indigenous peoples, for instance, who may not be versed in rational forms of argumentation, (...) may not be listened to or involved sufficiently in the deliberative process. Therefore, it seems we need an alternative mode of communication, such as storytelling, which is a first-person or collective narrative. Given this, how should we pursue this goal? This article aims to answer this question by analysing a local conflict involving an Indigenous tribe and a neighbouring community in Brazil and exploring the underlying testimonial and hermeneutical injustices. I argue that storytelling has an important normative and institutional role in public deliberation and show that its applied version could overcome epistemic injustices and lead to better public policies. (shrink)

This paper investigates whether 'even if A, B' is pragmatically polysemic, so that a nonconcessive conditional may have 'even if', and whether concessive conditionals, pragmatically defined, can fail to have 'even if' or a non-temporal 'still'. Different paraphrases are used to help elucidate pragmatic meanings. A theory of the pragmatic meanings of concessive and implicative conditionals is presented. The semantic meaning of 'even if' and the question of whether concessive conditionals imply the truth of their consequents are also discussed.

O presente ensaio se empenha em problematizar elementos contidos nos conceitos de illness e disease proposto pelo Dr. Arthur Kleinman ; especificamente no capítulo II do seu livro “The illness narratives: surfering, healing and the human condition. Nesta obra Kleinman vai dissecar o fenômeno da enfermidade e suas aflições tendo reflexos nas reações psicológicas e sociais. Ou seja, a disease tendo desdobramento na illness. A questão fundamental a que esse ensaio propõe é pensar uma inversão e refletir se illness altera (...) disease? Minha proposta é adentrar neste caminho pela via das reações emocionais e homeostasia. (shrink)

Hay casos en los que se transforman y trastocan los objetivos de las instituciones por resoluciones y jurisprudencia de los tribunales, situación que se presentó en el análisis de una sentencia del 15 de mayo de 2019, por la 1ª Sala de la Suprema Corte de Justicia de la Nación (México), derivado del amparo en revisión 1388/ 2015, por la negativa del hospital de realizar la interrupción del embarazo, por motivos de salud, a pesar de que el niño tendría una (...) vida relativamente normal, perturbando el derecho a la salud, la conciencia social y el valor ético sobre la terapia y de la dignidad humana de todas las personas, discriminando al feto bajo un paradigma eugenésico. (shrink)

Este artigo tem o objetivo de desvelar o núcleo da forma das relações socioeconômicas no sistema capitalista de exploração para acumulação de propriedade privada. Referido núcleo deriva nos sujeitos de direito, no Estado e nas demais instituições que derivam do modo de produção posto pela classe socioeconômica dominante que detém a propriedade privada dos meios de produção. Por meio do método materialismo histórico-dialética em Karl Marx e sob a ótica da interpretação filosófica e científica de Evguiéni Bronislavovitch Pachukanis e especialistas (...) contemporâneos. A derivação do modo de produção interpela a forma das relações socioeconômicas. A forma direito forjada com a ideologia capitalista trata formalmente todos os sujeitos como se fossem iguais, equivalendo-os como sujeitos de direito, com a autorização ideológica da forma Estado, em que ambas as formas conformam-se ao poder político da burguesia. O núcleo das relações socioeconômicas tem como átomo a mercadoria, as mercadorias não possuem valor de uso, mas sim valor de troca. Ninguém tem o direito de usar um bem necessário para sua vida, mas somente se puder contratar essa mercadoria. Logo, não somos sujeitos de direito, somos sujeitos pelo direito, ou seja, somos uma mercadoria no sistema capitalista a ser explorada pela classe proprietária dos meios de produção. (shrink)

An extended examination of Libet's works led to a comprehensive reinterpretation of his results. According to this reinterpretation, the Minimum Train Duration of electrical brain stimulation should be considered as the time needed to create a brain stimulus efficient for producing conscious sensation and not as a basis for inferring the latency for conscious sensation of peripheral origin. Latency for conscious sensation with brain stimulation may occurafterthe Minimum Train Duration. Backward masking with cortical stimuli suggests a 125-300 ms minimum value (...) for the latency for conscious sensation of threshold skin stimuli. Backward enhancement is not suitable for inferring this latency. For determining temporal relations between stimuli that correspond to subjects' reports, theendof cerebral Minimum Train Duration should be used as reference, rather than its onset. Results of coupling peripheral and cortical stimuli are explained by a latency after the cortical Minimum Train Duration, having roughly the same duration as the latency for supraliminal skin stimuli. Results of coupling peripheral stimuli and stimuli to medial lemniscus (LM) are explained by a shorter LM latency and/or a longer peripheral latency. This interpretation suggests a 230 ms minimum value for the latency for conscious sensation of somatosensory near-threshold stimuli. The backward referral hypothesis, as formulated by Libet, should not be retained. Long readiness potentials preceding spontaneous conscious or nonconscious movements suggest that both kinds of movement are nonconsciously initiated. The validity of Libet's measures of W and M moments (Libet et al., 1983a) is questionable due to problems involving latencies, training, and introspective distinction of W and M. Veto of intended actions may be initially nonconscious but dependent on conscious awareness. (shrink)

"Tough, smart, superbly engaging, The Material Ghost is a terrific book." -- Edward W. Said In The Material Ghost , Gilberto Perez draws on his lifelong love of the movies as well as his work as a film scholar to write a lively, wide-ranging, penetrating study of films and filmmakers and the nature of the art form. For Perez, film is complex and richly contradictory, lifelike and dreamlike at once, a peculiar mix of reality and imagination. "The images on (...) the screen," he writes, "carry in them something of the world itself, something material, and yet something transposed, transformed into another world: the material ghost." "Dazzling... The sheer intelligence at work in these lucid pages is exhilarating." -- Alfred Guzzetti, Boston Book Review "A pleasure. Gilberto Perez is one of the smartest film critics writing anywhere." -- Jonathan Rosenbaum "Strikes an ideal balance between insightful analysis and graceful writing... A model of thoughtful criticism." -- David Sterritt, Christian Science Monitor "Brilliantly polemical in his critique of cynical reason ('the official philosophy of late capitalism'), no less passionate in defending the truth-value of cinema, Perez seems to be the clearest heir to the great humanist critic André Bazin." -- Sight & amp Sound "The chapters on Keaton and Renoir are stunning, full of perceptive remarks the chapter on Godard is a persuasive rehabilitation none of the chapters is without memorable insights." -- Michael Wood, London Review of Books "Gilberto Perez's ambitious, abundant, and cultivated book--the fruit of decades of thinking and teaching -- accompanies readers on a journey of discovery into the wonder of film." -- Stanley Cavell "Few books of film criticism in the past twenty-five years have been so enjoyable or instructive... [Perez] has excellent things to say about authorship, about documentaries, about popular genres, about cinematic point of view and narrative technique, about actors, and above all about camera style... He makes us want to look once more at the remarkable pictures he discusses." -- James Naremore, Cineaste. (shrink)

It is argued that contraposition is valid for a class of natural language conditionals, if some modifications are allowed to preserve the meaning of the original conditional. In many cases, implicit temporal indices must be considered, making a change in verb tense necessary. A suitable contrapositive for implicative counterfactual conditionals can also usually be found. In some cases, the addition of certain words is necessary to preserve meaning that is present in the original sentence and would be lost or changed (...) in the contrapositive without them. A distinction is made between adding new meaning and adding new words to preserve existing meaning. For concessive conditionals and relevance conditionals, however, no valid contrapositive can be found. They do not belong to the class of contraposable conditionals, which can be independently defined. Difficult cases are also discussed in which the contradictory of the consequent semantically entails the truth of the antecedent. In such cases the content of the antecedent is implicit in the meaning of the consequent. Contraposition becomes possible if what is implicit in the original consequent is made explicit in the contrapositive antecedent. (shrink)

Hoy se vive una grave crisis de valores. A la inmensa mayoría de la humanidad le resulta difícil saber lo que es correcto de lo que no lo es. Es una costumbre utilizar los principios bioéticos expuestos por Beauchamp y Childress, autonomia, no maleficencia, beneficencia y justicia, mismos que deben estar dentro de la ética y del derecho y más aún en la biojurídica. En ese sentido, el presente trabajo realiza un breve recorrido desde la sindéresis, la regla de oro, (...) los principios éticos: mal menor, doble efecto, totalidad, libertad y responsabilidad, sociabilidad y subsidiariedad en conjunción con los principialistas; por último los que debe utilizar la biojurídica ya reconocidos por Ulpiano junto a sus dos pilares: de prevención y precaución.Today there is a serious values crisis. The vast majority of humanity finds it difficult to know what is right from what is not. It is frequent to use the bioethical principles set out by Beauchamp and Childress: autonomy, non maleficence, beneficence and justice, that are a must in ethics and law and more so in biojuridics. In that sense, this paper provides a short view from the good judgment, the golden rule, and the ethical principles: the lesser evil, double effect, completeness, freedom and responsibility, sociability and subsidiarity in conjunction with the principlism and finally those who must use the already recognized by Ulpian biojuridics with the two pillars of prevention and precaution. (shrink)

1. Introduction The readiness potential was found to precede voluntary acts by about half a second or more (Kornhuber & Deecke, 1965). Kornhuber (1984) discussed the readiness potential in terms of volition, arguing that it is not the manifestation of an attentional processes. Libet discussed it in relation to consciousness and to free will (Libet et al. 1983a; 1983b; Libet, 1985, 1992, 1993). Libet asked the following questions. Are voluntary acts initiated by a conscious decision to act? Are the physiological (...) facts compatible with the belief that free will determines our voluntary acts? What is the role of consciousness in voluntary action? In this paper I will discuss these questions and the answers that Libet gave to them. (shrink)

In the Poetics of Aristotle there is a definition of the human being that perhaps has not yet been well considered in educational theory and practice. This definition calls into question a dynamism that according to Plato was unavoidable for an appropriate understanding of the educational process that turns a human being into a beautiful, good and just citizen: mimesis. The paper's intent is to reconsider the definition of the human being, centred on mimesis, presented by Aristotle in the Poetics (...) to demonstrate if, and how, it might establish new paradigms for human coexistence. Aristotle's anthropological statement is included in a much wider discourse concerning philosophy of art; but if isolated from the context, it is an essential definition of human beings that can be synthesised as follows: human beings are the mimetic animal par excellence, and their process of understanding has a fundamental connection with such excellence. Ignorance and/or negligence of how relevant mimesis might be in the educational process may have decisively contributed to separate human beings from this core aspect of their humanity and therefore produced painful consequences in human coexistence. As long as education does not pay attention to the pedagogical implications of the definition taken from the Poetics, how can human flourishing be safeguarded? I argue that recognition of the centrality of mimesis in the educational process allows human edification to proceed devoid of ideological basis, be it secular or confessional; and overcomes the risk of relativism. Mimesis, formerly recognised by Plato as a link between what is expressed and what really is, is masterfully reinterpreted by Aristotle. Aristotle recognised its positive pedagogic value in the Poetics, and nowadays we can recognise how it offers existential dynamics that restore the vital human relationship between self and other. The sense of this proposal lies in giving mimesis the role it deserves in education, by raising the significance of how coexistence might benefit from a vast human dimension, capable of recognising our humanity beyond our rational capacity. (shrink)

Claims that necessary and sufficient conditions are not converse relations are discussed, as well as the related claim that If A, then B is not equivalent to A only if B . The analysis of alleged counterexamples has shown, among other things, how necessary and sufficient conditions should be understood, especially in the case of causal conditions, and the importance of distinguishing sufficient-cause conditionals from necessary-cause conditionals. It is concluded that necessary and sufficient conditions, adequately interpreted, are converse relations in (...) all cases. (shrink)

The purpose of this essay is to explain what kind of responsibility citizens should assume for structural corruption. To delve into this topic, we analyze the components of a concept of structure as applied to the features of corruption, as well as the notions of guilt, responsibility and political responsibility. Thus, we argue that citizens who do not participate directly in acts of bribery are politically responsible for systemic corruption. Assuming political responsibility implies taking actions in the public sphere to (...) combat the structure of corruption in conjunction with other citizens. (shrink)

Libet's (2000) arguments in defense of his interpretation of his experimental results are insufficient. The claims of my critical review (Gomes, 2008) do not suffer with his new statements.

O autor apresenta alguns princípios da clínica winnicottiana através da discussão do artigo de Winnicott de 1941 intitulado "A observação de bebês em uma situação estabelecida". Enfatiza a dimensão do tempo como fator fundamental na situação clínica. A situação clínica organiza-se ao redor do gesto, da ação, do acontecer do self. Por essa razão a intervenção do analista aborda fundamentalmente a ação no mundo. Desde as primeiras sessões é importante permitir que o gesto do paciente crie o final da sessão, (...) para que haja um trabalho de construção da finalização da análise e do morrer, como parte da saúde.The author presents some of the principles of the winnicottian clinic through the discussion of Winnicott's article of 1941 "The observation of Infants in a Set Situation". It is stressed the dimension of time as a fundamental factor in the clinical situation. The clinical situation organizes itself around the gesture, the action, the happening of the self. For this reason the analyst's intervention fundamentally approaches the action in the world. From the first sessions it is important to allow the patient's gesture that creates the end of the session this permits that a work of the ending of analysis of dying as part of health. (shrink)

This paper investigates the implicative conditional, a connective intended to describe the logical behavior of an empirically defined class of natural language conditionals, also named implicative conditionals, which excludes concessive and some other conditionals. The implicative conditional strengthens the strict conditional with the possibility of the antecedent and of the contradictory of the consequent. $${p\Rightarrow q}$$ p ⇒ q is thus defined as $${\lnot } \Diamond {(p \wedge \lnot q) \wedge } \Diamond {p \wedge } \Diamond {\lnot q}$$ ¬ ◊ (...) ( p ∧ ¬ q ) ∧ ◊ p ∧ ◊ ¬ q. We explore the logical properties of this conditional in a reflexive normal Kripke semantics, provide an axiomatic system and prove it to be sound and complete for our semantics. The implicative conditional validates transitivity and contraposition, which we take to be integral parts of reasoning and communication. But it only validates restricted versions of strengthening the antecedent, right weakening, simplification, and rational monotonicity. Apparent counterexamples to some of these properties are explained as due to contextual factors. Finally, the implicative conditional avoids the paradoxes of material and strict implication, and validates some connexive principles such as Aristotle’s theses and weak Boethius’ thesis, as well as some highly entrenched principles of conditionals, such as conjunction of consequents, disjunction of antecedents, modus ponens, cautious monotonicity and cut. (shrink)

A commentary on articles by Klein, Pockett, and Trevena and Miller, in this issue, is given. Average shift in the point of subjective equality , calculated by Klein on Libet's data, and corresponding change in mean shift, calculated by Libet et al. , may be “corrected,” taking as a reference point the end of the minimum train duration. Values obtained, if significant, indicate a latency for conscious sensation of the skin stimulus of at least 230 ms. Pockett's main conclusions are (...) favored, but her explanation of peripheral–lemniscal couplings is found to be unconvincing. Trevena and Miller's article unsuccessfully tries to rescue a dualist interactionist view. Libet's method of timing intentions is thoroughly criticized. (shrink)

The analysis is restricted to the architectural aspect. It puts in evidence a dialectical procedure which makes the gnoseological importance of the verb to look stand out clearly. The pharisee's knowledge is based on religious convictions ; that of the blind man on his experience.

A theory of necessary and sufficient conditions is presented, as well as a theory of necessary and sufficient causes and effects, viewed as a particular case of the former. Ambiguities of the terms 'condition' and 'necessary condition' are explored, and a neutral meaning for 'condition' is favoured. The relation between necessary and sufficient conditions and implicative conditionals (including counterfactuals) is also discussed. Two problems of counterfactual theories of causal explanation are indicated, concerning (i) how to account for causes that are (...) not necessary and (ii) how to interpret the counterfactual from the negation of the effect to the negation of the cause. Application of the theory of necessary and sufficient conditions to Euler’s explanation of the Königsberg bridge problem is discussed. The theory of necessary and sufficient causes and effects is then applied to the flagpole shadow explanation and to two biological explanations, one involving a sufficient but not necessary cause and the other a necessary but not sufficient cause. Causes that are neither sufficient nor necessary are also recognized. Finally, a probabilistic approach to causes that are either not sufficient or not necessary is explored, including its application to examples of such cases. (shrink)

El orden geométrico consiste en partir de definiciones y axiomas evidentes por sí mismos. El paralelismo entre ambos órdenes en el sistema de Spinoza, el ordo cognoscendi y el ordo essendi, hace posible postular la intensidad total de lo real, implicando necesariamente una semejanza entre el entendimiento finito, en cuanto productor del primer orden, y el entendimiento infinito, en cuanto productor del segundo orden, ausente en el cartesianismo. Martial Gueroult afirma el método como geométrico en Descartes porque obedece estrictamente a (...) la regla que asegura a la Geometría todo su rigor; mientras que en Spinoza lo es porque, como Geometría, construye los conceptos de los objetos. (shrink)

Spinoza concebe a natureza humana em sua obra Ethica como constituída por modos de dois dos infinitos atributos de Deus, o pensamento e a extensão, ou a ideia e seu objeto, o corpo, respectivamente. A mente humana, enquanto essencialmente uma ideia, e o objeto desta ideia, o corpo, pressupõe uma relação não causal entre um modo finito do atributo pensamento e do atributo extensão. O corpo, enquanto certa relação composta ou complexa de movimento e de repouso se mantém através de (...) todas as mudanças que afetam suas partes, está continuamente sujeito ao acaso dos encontros, ou ao impacto dos múltiplos e variados corpos a sua volta. A mente reflete estes encontros e através deles, ou das afecções corporais, conhece os corpos externos. É a ideia-afecção. É o conhecimento imaginativo, ou o conhecimento condicionado pela situação de nosso próprio corpo, por nosso temperamento, nossa experiência prévia e nossos preconceitos. (shrink)