Data from magnetic resonance imaging, autopsy, endocranial measurements, and other techniques show that: brain size correlates 0.40 with cognitive ability; average brain size varies by race; and average cognitive ability varies by race. These results are as replicable as one will find in the social and behavioral sciences. They pose serious problems for Rose 's claim that reductionistic science is inadequate, inefficient, and/or unproductive.

The first edition of The Mismeasure of Man appeared in 1981 and was quickly praised in the popular press as a definitive refutation of 100 years of scientific work on race, brain-size and intelligence. It sold 125,000 copies, was translated into 10 languages, and became required reading for undergraduate and even graduate classes in anthropology, psychology, and sociology. The second edition is not truly revised, but rather only expanded, as the author claims the book needed no updating as any new (...) research would only be plagued with the same philosophical errors revealed in the first edition. Thus it continues a political polemic, whose author engages in character assassination of long deceased scientists whose work he misrepresents despite published refutations, while studiously witholding from his readers fifteen years of new research that contradicts every major scientific argument he puts forth. Specific attention in this review are given to the following topics: the relationship between brain size and IQ, the importance of the scientific contributions of Sir Francis Galton, S. G. Morton, H. H. Goddard, and Sir Cyril Burt, the role of early IQ testers in determining U.S. immigration policy, The Bell Curve controversy and the reality of g, race /sex/social class differences in brain size and IQ, Cesare Lombroso and the genetic basis of criminal behavior, between-group heritabilities, inter-racial adoption studies, and IQ why evolutionary theory predicts group differences, and the extent to which Gould's political ideology has affected his scientific work. (shrink)

In so far as the Tao Te Ching and the Chuang Tzu are life-philosophies, they are philosophies of solitude. My aim in the following pages is to explain and defend this claim, clarifying the distinctive kind of solitude that is taught by Lao Tzu and Chuang Tzu.

The Declaration of Helsinki and the Council of the International Organization of Medical Sciences provide guidance on standards of care and prevention in clinical trials. In the current and increasingly challenging research environment, the ethical status of a trial design depends not only on protection of participants, but also on social value, feasibility, and scientific validity. Using the example of a study assessing efficacy of a vaccine to prevent human papilloma virus in HIV-1 infected adolescent girls in low resource countries (...) without access to the vaccine, we compare several trial designs which rank lower on some criteria and higher on others, giving rise to difficult trade-offs. This case demonstrates the need for developing more nuanced guidance documents to help researchers balance these often conflicting criteria. (shrink)

Rnd3/RhoE has two distinct functions, regulating the actin cytoskeleton and cell proliferation. This might explain why its expression is often altered in cancer and by multiple stimuli during development and disease. Rnd3 together with its relatives Rnd1 and Rnd2 are atypical members of the Rho GTPase family in that they do not hydrolyse GTP. Rnd3 and Rnd1 both antagonise RhoA/ROCK‐mediated actomyosin contractility, thereby regulating cell migration, smooth muscle contractility and neurite extension. In addition, Rnd3 has been shown to have a (...) separate role in inhibiting cell cycle progression by reducing translation of cell cycle regulators, including cyclin D1 and Myc. We propose that Rnd3 could act as a tumour suppressor to limit proliferation, but when mutations bypass this activity of Rnd3, it can promote cancer invasion through its effects in the actin cytoskeleton. (shrink)

This article explores the conceptual and practical gap existing between the developed and developing countries in relation to corporate social responsibility (CSR), or the North-South ' CSR Divide', through the analysis of possible impact on the competitiveness of developing countries' and economies' SMEs and MNEs in globalization. To do so, this article first reviewed the traditional wisdom on the concept of strategic CSR developed in the North and the role that CSR engagement can play in corporate competitiveness, and compare with (...) the impact on the competitive advantage of the South through the supply chains. It points out that among the many factors that could explain the ' CSR Divide', the negative impact of CSR on comparative advantage is the final resort where developing countries are reluctant and defensive toward western-style CSR. It did point out that developing countries are changing their approaches to make CSR work in favor of their competitive position in global trade, such as China who has started to adopt proactive approach by becoming CSR standards-setter. This article concludes with two policy proposals that aim to bridge the CSR gap, the first is to improve CSR standard-setting participation from both sides, and the second to search for solutions in the international investment legal framework which will define corporate obligations in relating to CSR in a more explicit way. (shrink)

The increasing availability of brain data within and outside the biomedical field, combined with the application of artificial intelligence (AI) to brain data analysis, poses a challenge for ethics and governance. We identify distinctive ethical implications of brain data acquisition and processing, and outline a multi-level governance framework. This framework is aimed at maximizing the benefits of facilitated brain data collection and further processing for science and medicine whilst minimizing risks and preventing harmful use. The framework consists of four primary (...) areas of regulatory intervention: binding regulation, ethics and soft law, responsible innovation, and human rights. (shrink)