BackgroundThe proper and ethical inclusion of PWLHIV and their young children in research is paramount to ensure valid evidence is generated to optimize treatment and care. Little empirical data exists to inform ethical considerations deemed most critical to these populations. Our study aimed to systematically review the empiric literature regarding ethical considerations for research participation of PWLHIV and their young children.MethodsWe conducted this systematic review in partnership with a medical librarian. A search strategy was designed and performed within the following (...) electronic databases: Ovid MEDLINE, Embase and CINAHL. We screened titles and abstracts using the following inclusion criteria: (1) a study population of PWLHIV or children under 5 years of age; and (2) collection of qualitative or quantitative data regarding ethics of research participation. Excluded were reviews, commentaries, policy statements, clinical care-related ethics concerns, abstracts, case studies, or studies unrelated to HIV research. Studies were appraised for quality, data were extracted, and studies were qualitatively analyzed using a principle-based ethical framework within the Belmont Report.ResultsOf the 7470 titles identified, 538 full-text articles were reviewed for eligibility and only three articles met full criteria for inclusion within this review. While we allowed for inclusion of studies involving young children born to mothers with HIV, only articles focused on PWLHIV were identified. Within the results of these studies, four themes emerged: (1) adequacy of informed consent; (2) consideration of paternal involvement; (3) balancing risks; and (4) access to research and treatment. A strength of this review is that it included perspectives of international research investigators, community leaders, and male partners. However, only two studies collected empiric data from PWLHIV regarding their experiences participating in researchConclusionResearchers and funding agencies should be aware of these considerations and appreciate the value of and critical need for formative research to ensure clinical trials involving PWLHIV promote ethical, well-informed research participation and, ultimately, improve care outcomes. More research is needed to create a comprehensive ethical framework for researchers when conducting studies with PWLHIV. (shrink)

Adolescence, defined in the US as 11–21 years of age, is a critical period for prevention, as it marks the onset of risk behaviors. Minor (<18 years) self-consent and inclusion in biomedical resear...

Objective Adolescents have had very limited access to research on biomedical prevention interventions despite high rates of HIV acquisition. One concern is that adolescents are a vulnerable population, and trials carry a possibility of harm, requiring investigators to take additional precautions. Of particular concern is preventive misconception, or the overestimation of personal protection that is afforded by enrolment in a prevention intervention trial. Methods As part of a larger study of preventive misconception in adolescent HIV vaccine trials, we interviewed 33 (...) male and female 16–19-year-olds who have sex with men. Participants underwent a simulated HIV vaccine trial consent process, and then completed a semistructured interview about their understanding and opinions related to enrolment in a HIV vaccine trial. A grounded theory analysis looked for shared concepts, and focused on the content and process of adolescent participants’ understanding of HIV vaccination and the components of preventive misconception, including experiment, placebo and randomisation. Results Across interviews, adolescents demonstrated active processing of information, in which they questioned the interviewer, verbally worked out their answers based upon information provided, and corrected themselves. We observed a wide variety of understanding of research concepts. While most understood experiment and placebo, fewer understood randomisation. All understood the need for safer sex even if they did not understand the more basic concepts. Conclusions Education about basic concepts related to clinical trials, time to absorb materials and assessment of understanding may be necessary in future biomedical prevention trials. (shrink)

Volume 20, Issue 5, June 2020, Page 72-74.

Citizen science is touted as a means of making science more inclusive and democratic. However, when citizens are drawn from societies with significant socioeconomic and racial disparities, citizen...

Volume 20, Issue 7, July 2020, Page 120-122.

What is the origin of the concept of a law of nature? How much does it owe to theology and metaphysics? To what extent do the laws of nature permit contingency? Are there exceptions to the laws of nature? Is it possible to give a reductive analysis of lawhood, or is it a primitive? -/- Twelve brand-new essays by an international team of leading philosophers take up these and other central questions on the laws of nature, whilst also examining some (...) of the most important intuitions and assumptions that have guided the debate over laws of nature since the concept's invention in the seventeenth century. -/- Laws of Nature spans the history of philosophy and of science, contemporary metaphysics, and contemporary philosophy of science. Contents: 1. Intuitions and Assumptions in the Debate over Laws of Nature, Walter Ott and Lydia Patton 2. Early Modern Roots of the Philosophical Concept of a Law of Nature, Helen Hattab 3. Laws of Nature and the Divine Order of Things: Descartes and Newton on Truth in Natural Philosophy, Mary Domski 4. Leges sive natura: Bacon, Spinoza, and a Forgotten Concept of Law, Walter Ott 5. Laws and Powers in the Frame of Nature, Stathis Psillos 6. Laws and Ideal Unity, Angela Breitenbach 7. Becoming Humean, John W. Carroll 8. A Perspectivalist Better Best System Account of Lawhood, Michela Massimi 9. Laws: An Invariance Based Account, James Woodward 10. How the Explanations of Natural Laws Make Some Reducible Physical Properties Natural and Explanatorily Powerful, Marc Lange 11. Laws and their Exceptions, Stephen Mumford 12. Are laws of nature consistent with contingency?, Nancy Cartwright and Pedro Merlussi. (shrink)

«Claros del bosque» es uno de los libros esenciales de la trayectoria filosófica de María Zambrano en el que vemos, por primera vez, en marcha su «razón poética». Nadie mejor que la propia autora para presentarnos el significado de esta obra: “«Claros del bosque» dentro de mi pensamiento vertido en lo impreso, salvo alguna excepción, aparece como algo inédito salido de ese escribir irreprimible que brota por sí mismo y que ha ido a parar a cuadernos y hojas que nadie (...) conoce, ni yo misma, reacia que soy a releerme. Tenía que suceder por fuerza. Mas creo que el carácter de ofrenda de «Claros del bosque» a la persona a quien va dedicado en su tránsito tiene que ver en ello, acentuando así el carácter de ofrenda que todo lo que he publicado tiene desde siempre. Nada es de extrañar que la razón discursiva apenas aparezca. Con anterioridad esbocé una ‘Crítica de la razón discursiva’ que no podría prometerme que salga de ese estado. Creo, pues, que como libro es el que más responde a esa ‘idea’ hace tiempo formulada de que ‘pensar es ante todo –como raíz, como acto–– descifrar lo que se siente’, entendiendo por sentir el ‘sentir originario’, expresión usada por mí desde hace años. Y también que ‘el hombre es el ser que padece su propia trascendencia’ en un incesante proceso de unificación entre pasividad y conocimiento, entre ser y vida. Vida verdadera, sorprendida tan sólo en algunos claros que se abren en la espesura inicial entre cielo y tierra. Y en el remoto horizonte donde cielo y tierra, ser y vida, vida y muerte se anegan”. (shrink)

This collection is the first comprehensive history of Fichte's reception in America, highlighting the existence of a long and strong tradition of Fichtean studies throughout the continent and demonstrating the centrality of Fichtean ideas in contemporary discussions of issues such as feminism, social criticism, and decolonial thought. Read and reinterpreted in the highly diverse circumstances across the American continent, Fichte's ideas are presented in a radically new light, uncovering the Fichtean spirit of self-activity and autonomous thought in an American context.

La cuestión ambiental puede considerarse, sin dudas, el giro político de nuestro tiempo. En todo el mundo, las escenas de devastación de ecosistemas y ambientes pero, sobre todo, la desigualdad con que esa destrucción impacta en las vidas de las personas, hacen que la injusticia ambiental no pueda ya entenderse separada de la cuestión social. Distintas formas de organización y activismo popular estan alcanzando alcanzando creciente visibilidad al alzar sus voces para mostrar que el desastre ecológico no es una fatalidad, (...) sino una elección política. Este libro se dedica a hacer un análisis exhaustivo de los principales conflictos ambientales de las últimas décadas en América Latina. A través del relato de casos como la controversia por la contaminación de la cuenca de los ríos Matanza-Riachuelo, las pasteras en el río Uruguay, el movimiento de pueblos fumigados en la Argentina, el conflicto por un proyecto minero en Peru, la guerra del agua en Bolivia la lucha por la preservación de los paramos en Colombio, o el movimiento de mujeres en 'zonas de sacrificio' en Chile, la autora traza las líneas que unen el activismo ambiental entoda la región: de las acciones públicas de reclamo a la organizacion, de la producción de conocimiento local a la construcción de modos de gestión colectiva de lo común. Pero, sobre todo, plantea formas novedosas de entender el problema ambiental, que incluyen alternativas al modelo del capitalismo extractivo y formas de convivencia con las especies no humanas. La pregunta que la autora pone de relieve es estructural y nos interpela: el crecimiento económico, la rentabilidad o la captación de divisas para estabilizar la economía pueden ser criterios de valor equivalentes a la defensa del agua, del modo de vida local o de la salud de las personas? Así, este libro viene a sumarse a una línea de trabajo en plena construcción en la región, que reúne solidez académica con compromiso político con las luchas sociales y ambientales. Como estas páginas dejan en evidencia, las batallas por una vida digna que se estan librando ahora mismo en todo el planeta confirman que, cuando se piensa la justicia ambiental 'desde abajo', otros mundos son posibles. (shrink)

I. Cuestiones clave -- 2. Cuestiones de salud y biotecnología -.

This volume offers novel views on the precise relation between reference to an object by means of a linguistic expression and our mental representation of that object, long a source of debate in the philosophy of language, linguistics, and cognitive science. Chapters in this volume deal with our devices for singular reference and singular representation, with most focusing on linguistic expressions that are used to refer to particular objects, persons, or places. These expressions include proper names such as Mary (...) and John; indexicals such as I and tomorrow; demonstrative pronouns such as this and that; and some definite and indefinite descriptions such as The Queen of England or a medical doctor. Other chapters examine the ways we represent objects in thought, particularly the first-person perspective and the self, and one explores a notion common to reference and representation: salience. The volume includes the latest views on these complex topics from some of the most prominent authors in the field and will be of interest to anyone working on issues of reference and representation in thought and language. (shrink)

Constituye la primera publicación del Seminario Internacional de Jóvenes Investigadores, foro creado en el Instituto de Filosofía, perteneciente al Consejo Superior de Investigaciones Científicas.

The Politics of Feminist Knowledge Transfer draws together analytical work on gender training and gender expertise. Its chapters critically reflect on the politics of feminist knowledge transfer, understood as an inherently political, dynamic and contested process, the overall aim of which is to transform gendered power relations in pursuit of more equal societies, workplaces, and policies. At its core, the work explores the relationship between gender expertise, gender training, and broader processes of feminist transformation arising from knowledge transfer activities. Examining (...) these in a reflective way, the book brings a primarily practice-based debate into the academic arena. With contributions from authors of diverse backgrounds, including academics, practitioners and representatives of gender training institutions, the editors combine a focus on gender expertise and gender training, with more theory-focused chapters. (shrink)

L'ouvrage nous offre un exposé minutieux de la Poétique de Gaston Bachelard, qui nous mène à un dialogue imaginaire où María Noel Lapoujade exprime ses propres points de vue dérivés de sa Philosophie de l'imagination, des images et des imaginaires et donne ainsi les fondements de sa notion originale d'Homo imaginans. La lecture de cet ouvrage original et fondé nous conduit à un scénario peuplé de résonances inédites de la pensée de Bachelard.

This volume explores the Pre-Columbian Andean concepts of time, space, and the human body through objects, skeletal remains, and language. This interdisciplinary approach to conceptualizing what the Andean concepts of being may have been brings contemporary approaches to past notions of the sacred, with each discipline adding its own unique perspective to the Andean ontology. A particular strength of this volume is that most of the contributors are South American researchers, offering North American scholars entry into scholarship that has been (...) confined to Spanish language publications. (shrink)

Los asuntos de los que se ocupa la estética (el gusto, la contemplación, la producción artística, la relación entre arte y naturaleza o la belleza) siguen suscitando el interés no solo de los filósofos, sino también de los artistas, arquitectos, diseñadores o escritores. En este libro se presenta lo que los filósofos han pensado sobre estos temas, redescubriendo en esta tradición las cuestiones que siguen abiertas en la actualidad.