BackgroundThe process of peer-review in academia has attracted criticism surrounding issues of bias, fairness, and professionalism; however, frequency of occurrence of such comments is unknown.MethodsWe evaluated 1491 sets of reviewer comments from the fields of “Ecology and Evolution” and “Behavioural Medicine,” of which 920 were retrieved from the online review repository Publons and 571 were obtained from six early career investigators. Comment sets were coded for the occurrence of “unprofessional comments” and “incomplete, inaccurate or unsubstantiated critiques” using an a-prior rubric (...) based on our published research. Results are presented as absolute numbers and percentages.ResultsOverall, 12% of comment sets included at least one unprofessional comment towards the author or their work, and 41% contained incomplete, inaccurate of unsubstantiated critiques.ConclusionsThe large number of unprofessional comments, and IIUCs observed could heighten psychological distress among investigators, particularly those at an early stage in their career. We suggest that development and adherence to a universally agreed upon reviewer code of conduct is necessary to improve the quality and professional experience of peer review. (shrink)

Our recent paper reported that 43% of reviewer comment sets shared with authors contained at least one unprofessional comment or an incomplete, inaccurate of unsubstantiated critique. Publication of this work sparked an online conversation surrounding professionalism in peer review. We collected and analyzed these social media comments as they offered real-time responses to our work and provided insight into the views held by commenters and potential peer-reviewers that would be difficult to quantify using existing empirical tools. Overall, 75% of comments (...) were positive, of which 59% were supportive and 16% shared similar personal experiences. However, a subset of negative comments emerged, that provided potential insight into the reasons underlying unprofessional comments were made during the peer-review process. These comments were classified into three main themes: forced niceness will adversely impact the peer-review process and allow for publication of poor-quality science ; dismissing comments as not offensive to another person because they were not deemed personally offensive to the reader ; and authors brought unprofessional comments upon themselves as they submitted substandard work. Here, we argue against these themes as justifications for directing unprofessional comments towards authors during the peer review process. We argue that it is possible to be both critical and professional, and that no author deserves to be the recipient of demeaning ad hominem attacks regardless of supposed provocation. Suggesting otherwise only serves to propagate a toxic culture within peer review. While we previously postulated that establishing a peer-reviewer code of conduct could help improve the peer-review system, we now posit that priority should be given to repairing the negative cultural zeitgeist that exists in peer-review. (shrink)

Indoleamine 2,3‐dioxygenase (IDO) is the rate‐limiting enzyme in conversion of tryptophan to kynurenines, feeding de novo nicotinamide synthesis. IDO orchestrates materno‐foetal tolerance, increasing human reproductive fitness. IDO mediates immune suppression through depletion of tryptophan required by T lymphocytes and other mechanisms. IDO is expressed by alternatively activated macrophages, suspected to play a key role in tuberculosis (TB) pathogenesis. Unlike its human host, Mycobacterium tuberculosis can synthesize tryptophan, suggesting possible benefit to the host from infection with the microbe. Intriguingly, nicotinamide analogues (...) are used to treat TB. In reviewing this field, it is postulated that flux through the nicotinamide synthesis pathway reflects switching between aerobic glycolysis and oxidative phosphorylation in M. tuberculosis‐infected macrophages. The evolutionary cause of such shifts may be ancient mitochondrial behavior related to reproductive fitness. Evolutionary perspectives on the IDO pathway may elucidate why, after centuries of co‐existence with the Tubercle bacillus, humans still remain susceptible to TB disease. (shrink)

Consider the following argument for the non-existence of God: Some men are morally reprehensible for failing to perform certain actions, e.g. actions of abolishing suffering which is destructive of character. Concentrate, for simplicity, just on actions of this latter sort. If there is an omnipotent and omniscient being, then he, too, fails to perform actions of this sort, and, hence, he is also morally reprehensible unless some such difference obtains between him and the men mentioned in as his being unable (...) to abolish this suffering, while M is able to abolish it, or his not knowing that this suffering is in fact destructive of character, while M does know this. But being omnipotent and omniscient is incompatible with any such difference obtaining. (shrink)

This essay examines Étienne Balibar's readings of Jacques Derrida and deconstruction. The text is framed as a review of two books by Balibar: 'Equaliberty' and 'Violence and Civility'. After describing the context of those readings, I propose a broader reflection on the ambiguous relationship between 'post-Marxism' and 'deconstruction', focusing on concepts such as 'violence', 'cruelty', 'sovereignty' and 'property'. I also raise methodological questions related to the 'use' of deconstructive notions in political theory debates.

In the last twenty years, a large number of studies have investigated judgments of the identity of various objects (e.g., persons, material objects, institutions) over time. One influential strand of research has found that identity judgments are shaped by normative considerations. People tend to believe that moral improvement is more compatible with the continuity of identity of a person than moral deterioration, suggesting that persons are taken to be essentially morally good. This asymmetry is often referred to as the “Phineas (...) Gage effect”. However, normativity extends beyond morality. In particular, it is unknown whether changes in aesthetic value have a similar impact on identity judgments. We investigate whether works of art would be analogously seen as essentially aesthetically valuable. We ran four studies (N=1264) to explore whether aesthetic considerations have a similar influence on judgments of the identity of artworks. We presented the participants with stories describing either a painting or a musical work which undergoes changes and becomes either more or less aesthetically valuable. Overall, we found only mixed evidence for the Phineas Gage effect in relation to the aesthetic value of artworks. Other factors, such as moral value, seem to have a bigger impact on judgments of persistence. (shrink)

Science fiction has often been at the forefront of popular renderings and exploration of various “subaltern” groups, including that of nonhuman animals. I argue that science fiction’s freedom from the boundaries of what is currently possible allows writers such as Mary Shelley, H. G. Wells, Philip K. Dick, Olaf Stapledon, Daniel Keyes, Octavia Butler, Cordwainer Smith, and H. Beam Piper to explore ethical possibilities regarding animals that are diverse from those of the context in which they wrote. It is also (...) notable that the earlier science fiction writers only critique majority views regarding animals, whereas their antecessors go so far as to suggest the empowerment of the “Other,” in this case, nonhuman animals. (shrink)

The mechanism(s) by which lentiviruses and related non‐oncogenic retroviruses (e.g. HTLV‐III, the etiologic agent of AIDS) escape immune surveillance, and thereby create long term progressive disease conditions, has been unknown until recently. Studies with two lentiviruses have begun to illuminate the mechanisms. In one, antigenic drift in the virus appears to be the primary mechanism of escape from immune surveillance; in the second, selective masking of the viral envelope glycoprotein epitope, which normally elicits neutralizing anti‐body, appears to provide the means (...) of escape. (shrink)

A very slight reading of Clement of Alexandria is enough to prove how deeply he is indebted to Plato both in respect of language and of thought. Quotations from Plato are to be found throughout Clement's works, and in many cases acknowledgment is made of their origin. In addition there are frequent allusions, which for the most part the student of Plato can easily recognize. Clement invariably shows a profound respect for the Greek philosopher, whom he looks (...) upon as a seeker after truth and as an authority, we may almost say, second only to the Scriptures. A careful comparison of the Protrepticus with the Phaedrus, results of which are given below, will furnish a striking illustration of the close dependence of Clement upon Plato. The Protrepticus is a short work, occupying in space not more than one–twelfth of Clement's extant writings, while the Phaedrus is even smaller in proportion to the whole of Plato. It is remarkable that so much inter-connexion should be found in so small a field, especially when we remember that the references to the Phaedrus represent by no means the whole of Clement's drawing upon Plato in the Protrepticus. There are allusions also to the Theaetetus, Republic, Charmides, Laws and Epistles, and possibly to the Politicus, Cratylus, Philebus, Symposium and Apology. (shrink)

This paper introduces freely improvised joint actions, a class of joint actions characterized by highly unspecific goals and the unavailability of shared plans. For example, walking together just for the sake of walking together with no specific destination or path in mind provides an ordinary example of FIJAs, along with examples in the arts, e.g., collective free improvisation in music, improv theater, or contact improvisation in dance. We argue that classic philosophical accounts of joint action such as Bratman’s rule them (...) out because the latter require a capacity for planning that is idle in the case of FIJAs. This argument is structurally similar to arguments for minimalist accounts of joint action, and this invites a parallel minimalist account, which we provide in terms of a specific kind of shared intentions that do not require plan states. We further argue that the resulting minimalist account is different in kind from the sort of minimalism suggested by developmental considerations and conclude in favor of a pluralistic minimalism, according to which there are several ways for an account of joint action to be minimal. (shrink)

When describing motion along both the horizontal and vertical axes, languages from different families express the elements encoding verticality before those coding for horizontality (e.g., going up right instead of right up). In light of the motor grounding of language, the present study investigated whether the prevalence of verticality in Path expression also governs the trajectory of arm biological movements. Using a 3D virtual-reality setting, we tracked the kinematics of hand pointing movements in five spatial directions, two of which implied (...) the vertical and horizontal vectors equally (i.e., up right +45° and bottom right −45°). Movement onset could be prompted by visual or auditory verbal cues, the latter being canonical in French (“en haut à droite”/up right) or not (“à droite en haut”/right up). In two experiments, analyses of the index finger kinematics revealed a significant effect of gravity, with earlier acceleration, velocity, and deceleration peaks for upward (+45°) than downward (−45°) movements, irrespective of the instructions. Remarkably, confirming the linguistic observations, we found that vertical kinematic parameters occurred earlier than horizontal ones for upward movements, both for visual and congruent verbal cues. Non-canonical verbal instructions significantly affected this temporal dynamic: for upward movements, the horizontal and vertical components temporally aligned, while they reversed for downward movements where the kinematics of the vertical axis was delayed with respect to that of the horizontal one. This temporal dynamic is so deeply anchored that non-canonical verbal instructions allowed for horizontality to precede verticality only for movements that do not fight against gravity. Altogether, our findings provide new insights into the embodiment of language by revealing that linguistic path may reflect the organization of biological movements, giving priority to the vertical axis. (shrink)

It seems worth while giving some account of this MS., because in recent years it has been said to contain certain pieces of the Moralia which it does not, and not to contain others which it does. At the foot of the first page of the text the MS. carries the pontifical shield with the arms of the Medici, and from this it is reasonable to suppose that there was a time when it belonged either to Leo X., who was (...) Pope from 1513 to 1521, or to Clement VII., who was Pope from 1523 to 1534. This being so, 1534 is established as the terminus ante quem of its writing. Towards the end of this century, about 1598, it was acquired by the Spanish Cardinal Saverio de Zelada. In 1801 the Cardinal Archbishop Antonio de Lorenzana bought in Rome a certain number of Greek and Oriental manuscripts which had formerly been in the collection of Cardinal Saverio de Zelada, and placed them in the Chapter Library at Toledo. Included with these was this MS. of the Moralia, which remains there to this day. (shrink)

Arthur G. Tansley never accepted Frederic E. Clements’ view that succession is a developmental process whose final stage, the climax formation, is determined primarily by regional climate and that all other types of vegetation are some kind of successional stage or arrested successional stage. Tansley was convinced that in a given region a variety of environmental factors could produce different kinds of climax formations. At the heart of their dispute was Clements’ organicist view of succession, i.e., the formation was a (...) complex organism with an ontogeny and phylogeny. As early as 1905, Tansley offered an alternative to Clements’ complex organism, the quasi-organism, but Clements in private and public rejected this compromise. Tansley and other plant ecologists continued to criticize Clements’ theories for the next 20 years, but with no impact on Clements. John Phillips, a South African plant ecologist who was a follower of Clements, published a series of papers in 1934 and 1935 defending Clementsian ecology. These papers were triggered by the publication of a letter by another ecologist working in Africa who claimed that there was a strong correlation between soils and various kinds of climax vegetation, which was contrary to what was predicted by Phillips and Clements. In 1935, Tansley published an attack on Phillips and Clements and their developmental theory of succession. In it, he proposed the concept of the ecosystem as a way to get around Clements’ monoclimax theory by making the physical environment (e.g., soil chemistry, soil texture, soil moisture) as important a factor as climate, plants and other organisms in determining the composition and characteristics of ecological entities, i.e., ecosystems. Tansley’s ecosystem concept quickly replaced Clements’ monoclimax theory as a dominant paradigm in ecology. (shrink)

Arthur G. Tansley never accepted Frederic E. Clements’ view that succession is a developmental process whose final stage, the climax formation, is determined primarily by regional climate and that all other types of vegetation are some kind of successional stage or arrested successional stage. Tansley was convinced that in a given region a variety of environmental factors could produce different kinds of climax formations. At the heart of their dispute was Clements’ organicist view of succession, i.e., the formation was a (...) complex organism with an ontogeny and phylogeny. As early as 1905, Tansley offered an alternative to Clements’ complex organism, the quasi-organism, but Clements in private and public rejected this compromise. Tansley and other plant ecologists continued to criticize Clements’ theories for the next 20 years, but with no impact on Clements. John Phillips, a South African plant ecologist who was a follower of Clements, published a series of papers in 1934 and 1935 defending Clementsian ecology. These papers were triggered by the publication of a letter by another ecologist working in Africa who claimed that there was a strong correlation between soils and various kinds of climax vegetation, which was contrary to what was predicted by Phillips and Clements. In 1935, Tansley published an attack on Phillips and Clements and their developmental theory of succession. In it, he proposed the concept of the ecosystem as a way to get around Clements’ monoclimax theory by making the physical environment (e.g., soil chemistry, soil texture, soil moisture) as important a factor as climate, plants and other organisms in determining the composition and characteristics of ecological entities, i.e., ecosystems. Tansley’s ecosystem concept quickly replaced Clements’ monoclimax theory as a dominant paradigm in ecology. (shrink)

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book explores, inter alia, the strategy employed by Augustine in using Plato as a pseudo-prophet against later Platonists and explores Eusebius’ reception of Porphyry’s daemonology. It examines Plotinus’ claim that matter is absolute badness and focuses on Maximus the Confessor’s doctrine of creation and asks whether one may detect any influence on Maximus from Philoponus. The book addresses Christian receptions of Platonic metaphysics (...) and also examines the philosophy of number in Augustine’s early works. It argues that the aspect of Augustine’s philosophy must be read in context with the intellectual problems that occupied him at the beginning of his career as a writer. It draws on a number of sources to investigate the development of the doctrine and the various intellectual issues it confronted, including Plato’s Timaeus, Philo of Alexandria, Clement of Alexandria, Origen, Plotinus and, finally, Athanasius. (shrink)

En el presente artí- culo abordamos la situación sociohistórica subyacente a 1 Clemente y basándonos en los estudios socioló- gicos sobre 1 Cor, en particular los de G. Theissen, demostramos cómo 1 Clem. 3, 3 describe el conflicto de Corinto en categorías esencialmente socio-económicas, considerando que el motivo que propició la revuelta obedece básicamente al enfrentamiento entre grupos de distinto estatus para alcanzar el liderazgo y evitar la vergüenza. Ello indica que Clemente presenta el conflicto como una lucha de poder (...) para conseguir el prestigio social, en un mundo estrechamente marcado por la cultura del honor y la institución del patronazgo. (shrink)