Class I PI 3‐kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid‐binding domains. The class I PI 3‐kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3‐kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have (...) demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform‐specific signaling by PI 3‐kinases.Editor's suggested further reading in BioEssays: Phosphatidylinositol 4,5‐bisphosphate: Targeted production and signaling AbstractHow does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? Abstract. (shrink)

Contributors to this collection examine the Turners’ most important theoretical contributions to anthropology, from their work on pilgrimages, liminality, and communitas to insights from their fieldwork. They illustrate the Turners’ enduring theoretical contributions and their profound effects on the anthropological perspective.

Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)

In this paper I argue that from the point of view of a theist, inclusivism with respect to the issue whether adherents of different religious traditions can have veridical experience of God (or Ultimate Reality) now, is more plausible than the Alstonian exclusivism. I suggest that mystical inclusivism of the kind I imply in this paper may contribute to the development of cross-cultural philosophy of religion, as well as to the theoretical framework for inter-religious dialogue, because (1) it allows for (...) the possibility of veridical experience of God in a variety of religious traditions, but (2) it avoids the radical revisionist postulates of Hickian pluralism and (3) it leaves open the question whether the creed of any specific tradition is a better approximation to the truth about God than the creeds of other traditions. (edited). (shrink)

Peter Millican and Branden Thornhill-Miller have recently argued that contradictions between different religious belief systems, in conjunction with the host of defeaters based on empirical research concerning alleged sources of evidence for ‘perceived supernatural agency’, render all ‘first-order’, that is actual, religious traditions positively irrational, and a source of discord on a global scale. However, since the authors recognise that the ‘secularisation thesis’ appears to be incorrect, and that empirical research provides evidence that religious belief also has beneficial individual and (...) social effects, they put forward a hypothesis of a ‘second-order religious belief ’, with Universalist overtones and thus free of intergroup conflict, and free of irrationality, since supported (solely) by the Fine-Tuning Argument. While granting most of their arguments based on empirical research and embracing the new paradigm of the atheism/religion debate implicit in their paper, I contend that Millican’s and Thornhill-Miller’s proposal is unlikely to appeal to religious believers, because it misconstrues the nature and grounds of religious belief. I suggest that their hypothesis may be refined by taking into account a view of axiologically grounded religious belief that I refer to as ‘agatheism’, since it identifies God or the Ultimate Reality with the ultimate good (to agathon). (shrink)

By exploring and giving equal weight to transgendered subjectivities, however, Gayle Salamon upends these certainties.

This essay considers what is critical in critical phenomenology, and asks what features critical and phenomenological methods share. I suggest three fundamentally significant resonances between the critical and phenomenological enterprises. First is the suggestion that critique, like phenomenology, is an attempt to move beyond a dualism of inside and outside in order to extend into outer regions of what is known. Second is the insistence that what at first appears to be a purely negative endeavor, a finding of limit, is (...) incomplete if, upon finding that limit, it comes to a stop. Just as the reduction is not a means to banish or negate the world, but rather the condition through which it can more fully emerge, critique cannot be merely a cataloguing of the limitations of the present situation. Third is the openness to the possibilities of the world, a wonder or curiosity, that is revealed through the work of description in phenomenology, or Foucault’s characterization of philosophy not as an unmasking, but a making visible of what is visible. Finally I consider critical phenomenology’s futures: How is a newly enlivened kind of scholarship emerging from these two forms of thinking, both of which have been dismissed as outmoded or irrelevant? The new work currently emerging in phenomenology, with its emphasis on its own reflexive self-consideration and decolonization, offers hope that it might yet be capacious enough to simultaneously encompass the revelation of its limitations as well as the expansion of its reach. (shrink)

Ontologies have been successfully used to assign semantics in the Semantic Web context, to support integration of data from different systems or different sources, and to enable reasoning. However, building ontologies is not a trivial task. Ontology reuse can help in this matter. The search and selection of ontologies to be reused should consider the alignment between their scope and the scope of the ontology being developed. In this paper, we discuss how goal modeling can be helpful in this context (...) and we present GO-FOR, a framework in which goals are the central elements to promote ontology reuse. GO-FOR comprises a conceptual architecture, a goal-oriented ontology development process and a supporting tool. In GO-FOR we introduce Goal-Oriented Ontology Patterns as a new type of pattern to be applied to develop ontologies in a goal-oriented approach. Results of the use of GO-FOR to build an ontology used to integrate patient examination data are also shown in this paper. (shrink)

This paper charts the concepts of grip and the bodily auxiliary in Maurice Merleau-Ponty to consider how they find expression in disability narratives. Arguing against the notion of “maximal grip” that some commentators have used to explicate intentionality in Merleau-Ponty, I argue that grip in his texts functions instead as a compensatory effort to stave off uncertainty, lack of mastery, and ambiguity. Nearly without exception in Phenomenology of Perception, the mobilization of “grip” is a signal of impending loss, and is (...) offered as a strategy for managing failure rather than as an example of sure-footed mastery. I read Merleau-Ponty alongside Mary Felstiner's Out of Joint: A Public and Private Story of Arthritis to explore these other, attenuated dimensions of grip. Finally, the paper turns to Harriet McBryde Johnson's memoir Too Late to Die Young as an example of a way of thinking disabled embodiment otherwise. (shrink)

Early analytic philosophy -- Radical translation and intersubjective practice -- Critical outcome.

The paper is a response to recent criticisms of agatheism, a new pluralistic interpretation of religious belief put forward by Janusz Salamon with the aim of accommodating the epistemological challenge of religious diversity. Agatheism is an axiologically grounded religious belief which identifies God, the Absolute or the ultimate reality religiously conceived with the ultimate good as the ultimate end of all human agency and thus an explanation of its irreducibly teleological character and a source of its meaning. Janusz (...) class='Hi'>Salamon argues that this grounding of religious belief in the human axiological consciousness makes it immune to falsification by any future science. Replying to the concerns of the critics about about irrationality of doxastic commitment to a particular religious tradition, Janusz Salamon argues that to the extent the fundamental agatheistic religious belief is presupposed in such tradition as its doxastic core, its belief system - if internally coherent and aligned with a worldview that is consistent with undisputed scientific findings - may be considered rational, despite there being a plurality of such belief systems. (shrink)

This article argues that the existence of horrendous evil calls into question not just the plausibility of the most popular theodicies on offer, notably sceptical theism, but the coherence of any agatheology–that is, any theology which identifies God or the ultimate reality with the ultimate good or with a maximally good being. The article contends that the only way an agatheologian can ‘save the face of God’ after Auschwitz and Kolyma is by endorsing a non-interventionist interpretation of the Divine providence (...) which will amount to naturalisation of the discourse on evil by localising entirely in nature the causes of evil and the possible ways of its prevention. ‘Theodicy of justice as fairness’ is then presented as consistent with such naturalistic account of evils and yet compatible with a religious worldview. It justifies the Divine non-intervention by suggesting that it would not be just or fair for God to intervene on only some occasions to avert evil, if God is apparently prevented from intervening in all such cases. Since for Agatheos it is metaphysically impossible to do what is unjust or unfair, God never intervenes to avert evil. (shrink)

This paper charts the concepts of grip and the bodily auxiliary in Maurice Merleau-Ponty to consider how they find expression in disability narratives. Arguing against the notion of “maximal grip” that some commentators have used to explicate intentionality in Merleau-Ponty, I argue that grip in his texts functions instead as a compensatory effort to stave off uncertainty, lack of mastery, and ambiguity. Nearly without exception in Merleau-Ponty’s Phenomenology of Perception, the mobilisation of “grip” is a signal of impending loss and (...) is offered as a strategy for managing failure rather than as an example of sure-footed mastery. I read Merleau-Ponty alongside Mary Felstiner’s Out of Joint: A Public and Private Story of Arthritis to explore these other, attenuated dimensions of grip as an example of a way of thinking disabled embodiment otherwise. (shrink)

Writing from a scientifically and philosophically informed perspective, the authors provide a critical overview of the conceptual difficulties encountered in many current neuroscientific and psychological theories.

_Philosophy and the Vision of Language_ explores the history and enduring significance of the twentieth-century turn to language as a specific object of investigation and resource for philosophical reflection. It traces the implications of the access to language in some of the most prominent projects and results of the historical and contemporary tradition of analytic philosophy, including the projects of Frege, Wittgenstein, Sellars, Quine, Brandom, and Cavell. Additionally, it demonstrates the deep and enduring connections between the analytic tradition’s inquiry into (...) language and the parallel inquiries of phenomenology, critical theory, and deconstruction over the course of the twentieth century. Finally, it documents some of the enduring consequences of philosophy’s inquiry into language for contemporary questions of social and political life. The book provides a clear, accessible and widely inclusive introduction to the relevance of language for analytic and continental philosophy in the twentieth century and is readable by non-specialist audiences. It should contribute to a growing historical sense of the location of the analytic tradition in a broader geography of social, political and critical thought. Furthermore, it contributes to building bridges between this tradition and the neighboring continental ones from which it has all too often been estranged. (shrink)

In this interview, Judith Butler remembers her teacher, the phenomenologist Maurice Natanson. Natanson observed that learning how to see is central to both teaching and learning, and Professor Butler reflects on Natanson’s views of the relation between perception, pedagogy, and world-making. She discusses the possibilities and limits of phenomenology, and its engagements with intentionality, reason, and faith. Professor Butler also reflects on the influence of phenomenology on her theory of gender performativity as well as her recent work on bodies in (...) alliance. (shrink)

In this interview, Judith Butler remembers her teacher, the phenomenologist Maurice Natanson. Natanson observed that learning how to see is central to both teaching and learning, and Professor Butler reflects on Natanson’s views of the relation between perception, pedagogy, and world-making. She discusses the possibilities and limits of phenomenology, and its engagements with intentionality, reason, and faith. Professor Butler also reflects on the influence of phenomenology on her theory of gender performativity as well as her recent work on bodies in (...) alliance. (shrink)

Rezultaty badan filozofów religii związanych z nurtem analitycznym są w naszym kraju mało znane, w każdym razie znacznie mniej, niż na to zasługują. Tłumaczenia prac zaliczanych już do klasyki w tej dziedzinie badan filozoficznych można policzyć na palcach jednej ręki. Są to następujące pozycje: Ludwig Wittgenstein, Uwagi o religii i etyce; John L. Mackie, Cud teizmu; John Hick, Argumenty za istnieniem Boga; Alvin C. Plantinga, Bóg, wolność, zło; Richard Swinburne, Spójność teizmu, oraz cenna antologia ważniejszych esejów wydana w serii: Fragmenty (...) filozofii analitycznej pod zbiorczym tytułem: Filozofia religii. Niedawno nakładem PWN, w cyklu publikacji z szeroko pojętego religioznawstwa, ukazał się przekład pierwszej pracy, którą można traktować jako elementarne wprowadzenie do zagadnień podejmowanych przez analityczną filozofię religii. (shrink)

The paper is devoted to the question of the principle of individuation in Bl. John Duns Scotus. This question is found in his commentary to Aristotle’s Metaphysics, namely the Quaestiones super libros Metaphysicorum Aristotelis VII, qu. 13. The first part of the paper discusses problems connected with the chronology and structure of the text, whereas the second one is presented as Scotus’s teaching on individuation. S. Dumont and T. Noone argue today on the traditional thesis about the origin of this (...) question and the remaining philosophical writings from the juvenile stage of Scotus’s philosophical work. They claim that some questions from the In Metaph., including also qu. 13 from the book, were written later or in the same time as the commentaries to Peter Lombard’s Sentences. The authors support their views by indicating the following: 1) the text the In Metaph. is better organised, 2) the vocabulary used with reference to the principle of individuation, especially the term haecceitas, is employed twice in the text In Metaph., 3) the quotations from the later works of Scotus and the works of authors who wrote somewhat later than that date of the In Metaph. hitherto presumed, 4) some stylistic terms indicate that the author of the text was a mature person. The traditional thesis is defended by I. Modrić on behalf of the Scotistic Commission. Having made a detailed analysis, Modrić rejected all the arguments from the introduction to the critical edition of the In Metaph. The author of this paper agrees with Modrić’s view. Therefore as long as we do not have a thesis to the contrary we shall hold the traditional opinion about the earlier origin of the In Metaph. in comparison to Peter Lombard’s commentaries on the Sentences. Scotus opens his lecture on individuation with a discussion of various standpoints on this issue. He divides them into positive and negative theories of individuation. This ordering ensures a clear exposition of various views without unnecessary repetitions and vagueness. Eventually, Doctor Subtilis rejects all hitherto views and provides his own solution. The principle of individuation is for him an individuating entity, the ultimate reality of the individual being. In combination with common nature it determines the most individual of possible characterisation of the individuum. This positive individuating entity is called an individual form (forma individualis) in the In Metaph., a degree of entity (gradus entis) and haecceitas. The latter became a technical term to define the Scotist principle of individuation. (shrink)

W maju 1998 roku odbyła się w Monachium międzynarodowa konferencja poświęcona zagadnieniu racjonalności teizmu. Temat to szeroko dyskutowany w ostatnich czasach, stąd wydawać by się mogło, że zorganizowanie jeszcze jednej sesji, która przyciągnęłaby uwagę środowiska filozofów religii, będzie przedsięwzięciem wyjątkowo trudnym. Tymczasem monachijska debata zasłużyła sobie na miano wydarzenia. O jej atrakcyjności zadecydował fakt, że została pomyślana jako próba ożywienia dialogu pomiędzy filozofami nawiązującymi do tradycji kontynentalnej z przedstawicielami filozofii analitycznej. Tego rodzaju ekumeniczne inicjatywy nalezą w tej dziedzinie do rzadkości. (...) Ten swoisty izolacjonizm ma wiele przyczyn, a kością niezgody jest między innymi stosunek do Kanta. Postkantowska kontynentalna filozofia religii, kładąca nacisk na epistemologię i fenomenologię doświadczenia religijnego, postrzega anglosaski renesans badań nad klasycznymi problemami teodycealnymi jako nawrót do przedkrytycznego dogmatyzmu. Z kolei niektórzy analityczni filozofowie religii zdają się uprawiać swą dyscyplinę w taki sposób, jak gdyby kopernikański przewrót Kanta uważali za niebyły, a czasem nazywają expressis verbis epoką nowożytną okresem błędów i wypaczeń. Epistemologiczne zagadnienie racjonalności religii należy do kręgu zainteresowań obydwu wymienionych tradycji, stad możliwe jest tu połączenie wysiłków w celu uporządkowania tematyki i oceny aktualnego stanu refleksji. (shrink)

The object of this paper is to demonstrate the philological relation between justice, law and equality in ancient Greek or, that is the same, the philosophical relation between ethics, politics and economics. Actually it is interesting to examine the etymology of the word dikē which derives from the Sanskrit diś-(dik) and it refers more than to the generic idea of the «straight line» to the specific and astronomical concept of the «horizon (or skyline)», the apparent line that separates the cosmos (...) into two equal parts, the earth from the sky, meaning the same idea of equality which should be a rule of just law and ethical perfection. Moreover, according to my hypothesis Plato may have used the analogy of the horizon to explain his cosmological Doctrine of Ideas. (shrink)

The philosophical challenge that religious diversity poses for religious belief has become in recent years the focal point of a very engaging theological and philosophical debate. The debate began in the Christian context and it would be fair to say that its main issue remains the relationship of Christianity to other major religions. Traditionally Christian thinkers faced with the fact of religious plurality have assumed that Christianity is the only way to salvation, and the truth-claims of other religions can be (...) refuted by way of argument. This position is described today as 'exclusivist'. John Hick's name has become synonymous with a radically different approach to the whole issue. Hick argues that all religious traditions make contact with the same Ultimate Reality, each encountering it through a variety of culturally shaped forms of thought and experience, but all offering equally effective paths to 'salvation/liberation'. Hick's pluralistic hypothesis, although very popular in some quarters, appears to many Christian and non-Christian thinkers as highly controversial. (shrink)

The philosophical challenge that religious diversity poses for religious belief has become in recent years the focal point of a very engaging theological and philosophical debate. The debate began in the Christian context and it would be fair to say that its main issue remains the relationship of Christianity to other major religions. Traditionally Christian thinkers faced with the fact of religious plurality have assumed that Christianity is the only way to salvation, and the truth-claims of other religions can be (...) refuted by way of argument. This position is described today as 'exclusivist'. John Hick's name has become synonymous with a radically different approach to the whole issue. Hick argues that all religious traditions make contact with the same Ultimate Reality, each encountering it through a variety of culturally shaped forms of thought and experience, but all offering equally effective paths to 'salvation/liberation'. Hick's pluralistic hypothesis, although very popular in some quarters, appears to many Christian and non-Christian thinkers as highly controversial. (shrink)

Ogłoszenie papieskiej encykliki „Fides et ratio" ożywiło dawny spór o stosunek wiary i rozumu. Pewnym przyczynkiem do dyskusji precyzującym stanowisko, które zmierza de godzenia pozornej sprzeczności wymogów wiary i rozumu może być analiza dziewiętnastowiecznej polemiki Newmana z Lockiem. Filozofia religii obydwu myślicieli jest osadzona w szerszym teoriopoznawczym horyzoncie, co pozwala pokazać, iż rozwiązania dylematów wiary i rozumu należy szukać u samych podstaw ludzkiego bycia i poznania, w warstwie metafizycznej i epistemologicznej.

Ogłoszenie papieskiej encykliki „Fides et ratio" ożywiło dawny spór o stosunek wiary i rozumu. Pewnym przyczynkiem do dyskusji precyzującym stanowisko, które zmierza de godzenia pozornej sprzeczności wymogów wiary i rozumu może być analiza dziewiętnastowiecznej polemiki Newmana z Lockiem. Filozofia religii obydwu myślicieli jest osadzona w szerszym teoriopoznawczym horyzoncie, co pozwala pokazać, iż rozwiązania dylematów wiary i rozumu należy szukać u samych podstaw ludzkiego bycia i poznania, w warstwie metafizycznej i epistemologicznej.

This volume is an introduction to both newer and more established ideas in the growing field of critical phenomenology from a number of disciplinary perspectives.