Explores how moving images both produce and are predicated on place.

Protection against bacterial and viral pathogens by antibodies has always been thought to end at the cell surface. Once inside the cell, a pathogen was understood to be safe from humoral immunity. However, it has now been found that antibodies can routinely enter cells attached to viral particles and mediate an intracellular immune response. Antibody‐coated virions are detected inside the cell by means of an intracellular antibody receptor, TRIM21, which directs their degradation by recruitment of the ubiquitin‐proteasome system. In this (...) article we assess how this discovery alters our view of the way in which antibodies neutralise viral infection. We also consider the antiviral function of TRIM21 in the context of its other reported roles in immune signalling and autoimmunity. Finally, we discuss the conceptual implications of intracellular antibody immunity and how it alters our view of the discrete separation of extracellular and intracellular environments. (shrink)

The republic -- Knowledge -- Reality -- Dialectic -- Value -- Causality and change -- Politics, art and the fate of the soul.

This chapter talks about Ayn Rand's distinctive view of the philosophical roots and meaning of the events of her time ‐ especially the events of the 1960s and 1970s when she was most active as a commentator on current events. It begins with a section on Rand's political writings and activism in the 1930s and (especially) 1940s, which is followed by Rand's essays that provide a broad philosophical and historical context for the issues facing the world. While the third section (...) deals with antitrust and censorship which according to Rand were as the most pressing issues, the fourth discusses the Kennedy administration. The fifth section analyzes the brokering deals between pressure groups by the Johnson and Nixon administrations. Then, Rand's writings focus on the unprincipled nature of American foreign policy, especially during the “Cold War”. Her writings also cover the civil rights, feminist, New Left and Libertarianism movements. (shrink)

The Hungarian émigré Imre Lakatos earned a worldwide reputation through the influential philosophy of science debates involving Thomas Kuhn, Paul Feyerabend, and Sir Karl Popper. In _Imre Lakatos and the Guises of Reason_ John Kadvany shows that embedded in Lakatos’s English-language work is a remarkable historical philosophy rooted in his Hungarian past. Below the surface of his life as an Anglo-American philosopher of science and mathematics, Lakatos covertly introduced novel transformations of Hegelian and Marxist ideas about historiography, skepticism, criticism, (...) and rationality. Lakatos escaped Hungary following the failed 1956 Revolution. Before then, he had been an influential Communist intellectual and was imprisoned for years by the Stalinist regime. He also wrote a lost doctoral thesis in the philosophy of science and participated in what was criminal behavior in all but a legal sense. Kadvany argues that this intellectual and political past animates Lakatos’s English-language philosophy, and that, whether intended or not, Lakatos integrated a penetrating vision of Hegelian ideas with rigorous analysis of mathematical proofs and controversial histories of science. Including new applications of Lakatos’s ideas to the histories of mathematical logic and economics and providing lucid exegesis of many of Hegel’s basic ideas, _Imre Lakatos and the Guises of Reason_ is an exciting reconstruction of ideas and episodes from the history of philosophy, science, mathematics, and modern political history. (shrink)

THE HUMAN RACE IS ON THE VERY OF SUICIDE! Unless man chooses to fight for his continued evolution he is doomed to extinction as a species. In The Moral Society, John David Garcia presents a revolutionary ethical theory much in the spirit of Spinoza and Teilhard de Chardin.The concept of ethics is made operational and developed on a purely rational basis without sentimentality or ideology. The Moral Society unifies ethics, art, science, technology, evolution and souci-political action and shows (...) that through ethical development man can achieve far more than advocates of supernatural utopias ever imagined.A rational alternative to death is presented in the form of a comprehensive political and social program. Every significant contemporary issue is analyzed—nuclear annihilation, environmental pollution, overpopulation, genetic decay, racism, educational inadequacies, the role of women, bureaucratic stagnation, etc. No compromise is made with popular prejudice.John David Garcia shows that evolution and ethics are intertwined. The Moral Society is a lucidly written work of science and philosophy. The conclusions are far-reaching and this may be the final call to action to all those who value humanity. (shrink)

Openness and transparency are becoming hallmarks of responsible data practice in science and governance. Concerns about data falsification, erroneous analysis, and misleading presentation of research results have recently strengthened the call for new procedures that ensure public accountability for data-driven decisions. Though we generally count ourselves in favor of increased transparency in data practice, this Commentary highlights a caveat. We suggest that legislative efforts that invoke the language of data transparency can sometimes function as “Trojan Horses” through which other political (...) goals are pursued. Framing these maneuvers in the language of transparency can be strategic, because approaches that emphasize open access to data carry tremendous appeal, particularly in current political and technological contexts. We illustrate our argument through two examples of pro-transparency policy efforts, one historical and one current: industry-backed “sound science” initiatives in the 1990s, and contemporary legislative efforts to open environmental data to public inspection. Rules that exist mainly to impede science-based policy processes weaponize the concept of data transparency. The discussion illustrates that, much as Big Data itself requires critical assessment, the processes and principles that attend it—like transparency—also carry political valence, and, as such, warrant careful analysis. (shrink)

Dialectic is a method of investigation which has enjoyed a long history and has been invoked and involved in a great variety of intellectual causes. Aristotle was one of the first thinkers to develop a full theory of dialectic, and his account has remained one of the most influential and philosophically substantial. Dr Evans here offers a systematic account of Aristotle's theory. He explores how dialectic is related to other forms of enquiry, both scientific and philosophical, and demonstrates the central (...) part which dialectic occupies in Aristotle's thought; he establishes the importance and originality of the Topics in which this theory is developed, and contrasts Aristotle's account with those of Plato and the Academy. This book will be of interest to philosophers and historians of ideas as well as to specialists in Greek philosophy. All quotations are translated into English and there is a glossary of key Greek terms. (shrink)

The ancient lawgiver Solon of Athens left norms of proper conduct that carry important ethical implications for all manner of human affairs, including commercial activities and the pursuit of wealth. In his extant poetry, he emphasizes the strong connections between individual virtue and its consequences in the social and political sphere. In considering the proper means of obtaining material wealth, he describes multiple ways to earn a living and connects them to proper intellectual and ethical dispositions through a concept of (...) justice. This focus on virtue establishes a long-range ethics that is based on a principle of justice, demands rational intellectual activity, and carries implications for everyone’s self-interest. Solon’s concern for matters of virtue, the proper means of attaining wealth, and the need for long-range awareness of consequences offers a valuable point of historical focus for our own examinations of business ethics today. (shrink)

This provocative book addresses one of the central and most controversial branches of Western thought: the philosophy of origin. In light of recent poststructuralist principles such as alterity, diffe;rance , and dissemination, the philosophy of origin seems to exemplify the repressive, reactionary tendencies of much of the Western philosophical tradition. John Pizer aims to overturn this recent antipathy to the philosophy of origin. He ably summarizes poststructuralist critiques of that earlier philosophical tradition, then turns to five German thinkers (Nietzsche, (...) Benjamin, Rosenzweig, Heidegger, and Adorno) who developed philosophies of origin that effectively anticipate and counter poststructuralist attacks. These are thinkers who, in one way or another, influenced recent generations of poststructuralist thinkers. Pizer argues, however, that rather than do away with the notion of origin altogether (as in the works of the most thoroughgoing poststructuralists), these philosophers developed theories in which origin is always “multiple and plurivalent.” In the writings of these seminal German thinkers, “origin” becomes “origins,” and “authentic origins” are “inherently plural and divergent.” A valuable, engrossing account of a wide range of thinkers and their complex relations, Pizer’s book recovers the notion of origin for an intellectual world that has come to value multiplicity, openness, and diversity. (shrink)

Close attention to the meanings of certain sentences--Counterfactual-Identity sentences--Reveals that no theory in which proper names are simple designators can be a complete and correct semantics of english. An account of connotation is outlined according to which connotation varies with the linguistic environment and with the context of utterance: this accounts for the fact that no proper name is synonymous with a cluster of descriptions.

The essays in this volume reflect the wide-ranging interests of John D. North, distinguished historian of science and philosophy.

When we go back-by means of the epoché of the world, following Michel Henry-towards the originary “how” of all manifestation, we stumble once and again upon the phenomenological situation of the body. The body is, then that originary hinge by means of which I manifest world in a continuous resistance. It will be, as well, within my own body where I am always aware of oneself, according to my own affection. Thus, the material condition of the body will be that (...) of my internal body, or subjective body-as Henry initially read in Maine de Biran-or that of my flesh, as Henry himself would later say. Bearing all this in mind, the intermediate situation of one’s own affection, of this body of mine, with regard to the world and the videor, turns out to be an appropriate medium to attempt a preliminary study of the problematic situation of the internal time of affection. For this purpose, we shall revise the analysis offered by Michel Henry in Material Phenomenology and in Incarnation, indicating possible aporias, as well as alternatives to these last ones.Cuando, siguiendo a Michel Henry, retrocedemos en una epoché hacia el “cómo” originario de toda manifestación, tropezamos una y otra vez con la situación fenomenológica del cuerpo. El cuerpo es, pues, esta bisagra originaria a través de la cual yo manifiesto el mundo en continua resistencia. También será dentro del propio cuerpo donde uno será siempre autoconsciente, de acuerdo con la propia afección. Por eso, la condición material del cuerpo será la de mi cuerpo interior o cuerpo subjetivo, de acuerdo con la lectura inicial que Henry hace de Maine de Biran; o de mi carne, como dirá el mismo Henry más tarde. Teniendo en cuenta todo ello, la situación intermedia, situación de la afección propia y la de mi cuerpo en relación con el mundo y el videor, resulta ser un medio apropiado para emprender un estudio preliminar de la problemática situación del tiempo interno de la afección. Para ello, revisaremos el análisis que Michel Henry ofrece en Material Phenomenology y en Incarnation, indicando las posibles aporías, así como posibles alternativas. (shrink)

Claims that a man-made global warming catastrophe is imminent have two major aspects: the scientific support offered for the claims, and the political proposals brought forth in response to the claims. The central questions are whether non-scientists should accept the claims themselves as true, and whether they should support the political proposals attached to them. Predictions of a coming disaster are shown to be a-historical in both the long term and the short term, to involve shifting predictions that are contrary (...) to evidence, and to be opposed by many scientists. The political proposals to alleviate this alleged problemare shown to offer no alternative to fossil fuels, and to portend a major economic decline and permanent losses of liberty. The anthropogenic global warming claims are largely motivated not by science, but by a desire for socialist intervention on a national and a global scale. Neither the claims to an impending climate catastrophe nor the political proposals attached to those claims should be accepted. (shrink)

Although Ramachandra Guha has demonstrated the importance of cross-cultural dialogue on environmental issues and has much to tell us about the problems of wildemess preservation in the Third World, I argue that Guha is partly wrong in claiming that deep ecology equates environmental protection with wilderness protection and simply wrong in calling wilderness protection untenable or incorrect as aglobal strategy for environmental protection. Moreover, I argue that the deep ecology distinction between anthropocentrism and biocentrism is useful in dealing with the (...) two major problems which Guha identifies as undermining the health of the planetoverconsumption and militarism. Although it is true that preservation of wildemess will not be successful unless human social dynamics are taken into consideration, nevertheless, a biocentrism which integrates critical social theory can provide the basis for an ethic that undercuts the environmental degradation from overconsumption and militarism more effectively than a human-centered system. (shrink)

INTRODUCTION This volume of essays is meant as a tribute to Alistair Crombie by some of those who have studied with him. The occasion of its publication is ...

Although Ramachandra Guha has demonstrated the importance of cross-cultural dialogue on environmental issues and has much to tell us about the problems of wildemess preservation in the Third World, I argue that Guha is partly wrong in claiming that deep ecology equates environmental protection with wilderness protection and simply wrong in calling wilderness protection untenable or incorrect as aglobal strategy for environmental protection. Moreover, I argue that the deep ecology distinction between anthropocentrism and biocentrism is useful in dealing with the (...) two major problems which Guha identifies as undermining the health of the planetoverconsumption and militarism. Although it is true that preservation of wildemess will not be successful unless human social dynamics are taken into consideration, nevertheless, a biocentrism which integrates critical social theory can provide the basis for an ethic that undercuts the environmental degradation from overconsumption and militarism more effectively than a human-centered system. (shrink)