Results for 'Jason Karlawish'

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  1.  45
    Community equipoise and the architecture of clinical research.Jason H. T. Karlawish & John Lantos - 1997 - Cambridge Quarterly of Healthcare Ethics 6 (4):385-.
    Equipoise is an essential condition to justify a clinical trial. The term, describes a state of uncertainty: the data suggest but do not prove a drug's safety and efficacy The only way to resolve this uncertainty is further study In many cases, a clinical trial seems to be the most efficient way to prove safety and efficacy Equipoise is therefore not an esoteric philosophic construct applied to research ethics. Rather, since it is vital for the justification of clinical trials, it (...)
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  2.  21
    Community Equipoise and the Architecture of Clinical Research.Jason H. T. Karlawish & John Lantos - 1997 - Cambridge Quarterly of Healthcare Ethics 6 (4):385-396.
    Equipoise is an essential condition to justify a clinical trial. The term, describes a state of uncertainty: the data suggest but do not prove a drug's safety and efficacy The only way to resolve this uncertainty is further study In many cases, a clinical trial seems to be the most efficient way to prove safety and efficacy Equipoise is therefore not an esoteric philosophic construct applied to research ethics. Rather, since it is vital for the justification of clinical trials, it (...)
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  3.  26
    Supported Decision Making With People at the Margins of Autonomy.Andrew Peterson, Jason Karlawish & Emily Largent - 2020 - American Journal of Bioethics 21 (11):4-18.
    This article argues that supported decision making is ideal for people with dynamic cognitive and functional impairments that place them at the margins of autonomy. First, we argue that guardianship and similar surrogate decision-making frameworks may be inappropriate for people with dynamic impairments. Second, we provide a conceptual foundation for supported decision making for individuals with dynamic impairments, which integrates the social model of disability with relational accounts of autonomy. Third, we propose a three-step model that specifies the necessary conditions (...)
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  4.  15
    Where Do You End, and I Begin? How Relationships Confound Advance Directives in the Care of Persons Living with Dementia.David M. Lyreskog, Jason Karlawish & Saskia K. Nagel - 2020 - American Journal of Bioethics 20 (8):83-85.
    Volume 20, Issue 8, August 2020, Page 83-85.
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  5.  19
    A Case of Patient Abandonment, or an Abandonment of Patients?Jason Karlawish, Andrew Peterson, Justin T. Clapp & Emily A. Largent - 2022 - American Journal of Bioethics 22 (7):86-87.
    First—before you define the dilemma, parse out principles, or vocalize about virtues—consider what caused this case.The COVID-19 pandemic has challenged us all, but particularly caregivers and the...
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  6.  9
    Creating the Truth with Persons Living with Advanced Dementia.Jason Karlawish - 2021 - Journal of Law, Medicine and Ethics 49 (2):266-268.
    Truth telling to persons living with dementia is a nuanced problem that demands negotiating between the hazards of principlism and the loving deceiver’s demand to lie as needed. To ban deception, as we do restraints, would be misguided and cruel. So too to demand we always tell the truth. We ought to adopt a practice called “creative care.” It begins with the premise that person’s living with dementia are capable of creativity. Creative care breaks down the mysterious fourth wall we (...)
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  7.  15
    Decision-Making Capacity Will Have a Limited Effect on Civil Commitment Practices.Jason Karlawish, Dominic A. Sisti & Rocksheng Zhong - 2019 - American Journal of Bioethics 19 (10):86-88.
    Volume 19, Issue 10, October 2019, Page 86-88.
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  8.  11
    Informed Consent for Alzheimer's Disease Clinical Trials: A Survey of Clinical Investigators.Jason H. T. Karlawish, David Knopman, Christopher M. Clark, John C. Morris, Daniel Marson, Peter J. Whitehouse & Claudia H. Kawas - 2002 - IRB: Ethics & Human Research 24 (5):1.
  9.  7
    Please, Don’t Fly Me to the Moon.Jason Karlawish - 2021 - American Journal of Bioethics 21 (12):20-22.
    Years after the publication of “Helpful Lessons and Cautionary Tales: How Should COVID-19 Drug Development and Access Inform Approaches to Non-Pandemic Disease?” I hope it continues to animate and...
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  10.  9
    Research on Cognitively Impaired Adults.Jason Karlawish - 2009 - In Bonnie Steinbock (ed.), The Oxford Handbook of Bioethics. Oxford University Press.
    The preeminence of informed consent in human subjects protections reflects Western democratic societies' ethical and political commitments to secure each citizen against both coercive and paternalistic influences of other people. Society permits adults extensive personal discretion in choices such as where to live, what to eat, how to dress, and whether to be in research. In short, individuals are afforded extensive discretion in choosing what to do and what is in their own best interests. Informed consent to enroll in research (...)
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  11.  7
    A Taxonomy of Value in Clinical Research.David J. Casarett, Jason H. T. Karlawish & Jonathan D. Moreno - 2002 - IRB: Ethics & Human Research 24 (6):1.
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  12.  6
    Open Label Extension Studies & the Ethical Design of Clinical Trials.David Casarett, Jason Karlawish, Pamela Sankar, Karen B. Hirschman & David A. Asch - 2001 - IRB: Ethics & Human Research 23 (4):1.
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  13.  21
    Supported Decision Making with People at the Margins of Autonomy: Response to Commentaries.Emily A. Largent, Jason Karlawish & Andrew Peterson - 2022 - American Journal of Bioethics 22 (1):W1-W4.
    Supported decision making is a model of decision making in which an adult with impaired capacity enters freely into an agreement with a closely trusted person or persons (the “s...
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  14.  30
    Journeying to Ixtlan: Ethics of Psychedelic Medicine and Research for Alzheimer’s Disease and Related Dementias.Andrew Peterson, Emily A. Largent, Holly Fernandez Lynch, Jason Karlawish & Dominic Sisti - 2023 - American Journal of Bioethics Neuroscience 14 (2):107-123.
    In this paper, we examine the case of psychedelic medicine for Alzheimer’s disease and related dementias (AD/ADRD). These “mind-altering” drugs are not currently offered as treatments to persons with AD/ADRD, though there is growing interest in their use to treat underlying causes and associated psychiatric symptoms. We present a research agenda for examining the ethics of psychedelic medicine and research involving persons living with AD/ADRD, and offer preliminary analyses of six ethical issues: the impact of psychedelics on autonomy and consent; (...)
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  15.  22
    The Proactive Patient: Long-Term Care Insurance Discrimination Risks of Alzheimer's Disease Biomarkers.Jalayne J. Arias, Ana M. Tyler, Benjamin J. Oster & Jason Karlawish - 2018 - Journal of Law, Medicine and Ethics 46 (2):485-498.
    Previously diagnosed by symptoms alone, Alzheimer's disease is now also defined by measures of amyloid and tau, referred to as “biomarkers.” Biomarkers are detectible up to twenty years before symptoms present and open the door to predicting the risk of Alzheimer's disease. While these biomarkers provide information that can help individuals and families plan for long-term care services and supports, insurers could also use this information to discriminate against those who are more likely to need such services. In this article, (...)
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  16.  27
    Alive inside.Andrew Peterson, Adrian M. Owen & Jason Karlawish - 2019 - Bioethics 34 (3):295-305.
    This article provides an ethical analysis of the U.S. practice guideline update on disorders of consciousness. Our analysis focuses on the guideline’s recommendations regarding the use of investigational neuroimaging methods to assess brain‐injured patients. Complex and multifaceted ethical issues have emerged because these methods alter the clinical understanding of consciousness. We address issues of false hope, patient suffering, and cost. We argue that, in spite of these concerns, there is significant benefit to using neuroimaging to assess brain‐injured patients in most (...)
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  17.  14
    Deciding with Others: Interdependent Decision‐Making.Emily A. Largent, Justin Clapp, Jennifer S. Blumenthal-Barby, Christine Grady, Amy L. McGuire, Jason Karlawish, Joshua D. Grill, Shana D. Stites & Andrew Peterson - 2022 - Hastings Center Report 52 (6):23-32.
    Over the course of human life, health care decision‐making is often interdependent. In this article, we use “interdependence” to refer to patients’ engagement of nonclinicians—for example, family members or trusted friends—to reach health care decisions. Interdependence, we suggest, is common for patients in all stages of life, from early childhood to late adulthood. This view contrasts with the common bioethical assumption that medical decisions are either wholly independent or dependent and that independence or dependence is tightly coupled with a person's (...)
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  18.  56
    Patient and physician views about protocolized dialysis treatment in randomized trials and clinical care.Ashley Kraybill, Laura M. Dember, Steven Joffe, Jason Karlawish, Susan S. Ellenberg, Vanessa Madden & Scott D. Halpern - 2016 - AJOB Empirical Bioethics 7 (2):106-115.
  19.  3
    “A Raw Blessing” – Caregivers’ Experiences Providing Care to Persons Living with Dementia in the COVID-19 Pandemic.Emily A. Largent, Andrew Peterson, Kristin Harkins, Cameron Coykendall, Melanie Kleid, Maramawit Abera, Shana D. Stites, Jason Karlawish & Justin T. Clapp - 2023 - Journal of Law, Medicine and Ethics 51 (3):626-640.
    The COVID-19 pandemic has been devastating for people living with dementia (PLWD) and their caregivers. While prior research has documented these effects, it has not delved into their specific causes or how they are modified by contextual variation in caregiving circumstances.
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  20. pt. VII. Research ethics. Clinical equipoise: foundational requirement or fundamental error / Alex John London ; Research on cognitively impaired adults / Jason Karlawish ; Research in developing countries / Florencia Luna ; Animal experimentation. [REVIEW]Alastair Norcross - 2007 - In Bonnie Steinbock (ed.), The Oxford Handbook of Bioethics. Oxford University Press.
  21.  18
    Democracy: a guided tour.Jason Brennan - 2023 - New York, NY: Oxford University Press.
    Democracy is both an obvious and dubious idea. Here's why democracy is an obvious idea: For most of history, most governments divided people into the few who rule and the many who obey. The few then used the state to advance their own private interests at the expense of the many. Rulers were less like noble protectors appointed by God and more like intestinal parasites. The obvious solution is to eliminate the distinction between those who rule and those who obey. (...)
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  22.  3
    Emergency research.J. H. Karlawish - 2008 - In Ezekiel J. Emanuel (ed.), The Oxford textbook of clinical research ethics. New York: Oxford University Press. pp. 280.
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  23. Ontological Nihilism.Jason Turner - 2011 - Oxford Studies in Metaphysics 6:3-54.
    Ontological nihilism is the radical-sounding thesis that there is nothing at all. This chapter first discusses how the most plausible forms of this thesis aim to be slightly less radical than they sound and what they will have to do in order to succeed in their less radical ambitions. In particular, they will have to paraphrase sentences of best science into ontologically innocent counterparts. The chapter then points out the defects in two less plausible strategies, before going on to argue (...)
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  24. Bergmann’s dilemma: exit strategies for internalists.Jason Rogers & Jonathan Matheson - 2011 - Philosophical Studies 152 (1):55-80.
    Michael Bergmann claims that all versions of epistemic internalism face an irresolvable dilemma. We show that there are many plausible versions of internalism that falsify this claim. First, we demonstrate that there are versions of ‘‘weak awareness internalism’’ that, contra Bergmann, do not succumb to the ‘‘Subject’s Perspective Objection’’ horn of the dilemma. Second, we show that there are versions of ‘‘strong awareness internalism’’ that do not fall prey to the dilemma’s ‘‘vicious regress’’ horn. We note along the way that (...)
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  25. Philosophical Foundations of Wisdom.Jason Swartwood & Valerie Tiberius - 2019 - In Robert Sternberg & Judith Gluek (eds.), A Handbook of Wisdom, 2nd Edition. Cambridge University Press. pp. 10-39.
    Practical wisdom (hereafter simply ‘wisdom’), which is the understanding required to make reliably good decisions about how we ought to live, is something we all have reason to care about. The importance of wisdom gives rise to questions about its nature: what kind of state is wisdom, how can we develop it, and what is a wise person like? These questions about the nature of wisdom give rise to further questions about proper methods for studying wisdom. Is the study of (...)
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  26. God’s Love is Irrelevant to the Euthyphro Problem.Jason Thibodeau - 2019 - Sophia 58 (3):437-453.
    One prominent response, based on the work of Robert Adams, Edward Wierenga, and others, to the Euthyphro objection to the divine command theory is to point out that God is essentially omnibenevolent. The commands of an essentially loving being will not be arbitrary since they are grounded in his nature, nor is it possible for a loving God to issue horrendous commands such as the gratuitous torture of infants. This paper argues that this response is inadequate. The divine command theory (...)
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  27. Hermeneutic fictionalism.Jason Stanley - 2001 - Midwest Studies in Philosophy 25 (1):36–71.
    Fictionalist approaches to ontology have been an accepted part of philosophical methodology for some time now. On a fictionalist view, engaging in discourse that involves apparent reference to a realm of problematic entities is best viewed as engaging in a pretense. Although in reality, the problematic entities do not exist, according to the pretense we engage in when using the discourse, they do exist. In the vocabulary of Burgess and Rosen (1997, p. 6), a nominalist construal of a given discourse (...)
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  28. Internal Perspectivalism: The Solution to Generality Problems About Proper Function and Natural Norms.Jason Winning - 2020 - Biology and Philosophy 35 (33):1-22.
    In this paper, I argue that what counts as the proper function of a trait is a matter of the de facto perspective that the biological system, itself, possesses on what counts as proper functioning for that trait. Unlike non-perspectival accounts, internal perspectivalism does not succumb to generality problems. But unlike external perspectivalism, internal perspectivalism can provide a fully naturalistic, mind-independent grounding of proper function and natural norms. The attribution of perspectives to biological systems is intended to be neither metaphorical (...)
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  29. Foundation for a Natural Right to Health Care.Jason T. Eberl, Eleanor K. Kinney & Matthew J. Williams - 2011 - Journal of Medicine and Philosophy 36 (6):537-557.
    Discussions concerning whether there is a natural right to health care may occur in various forms, resulting in policy recommendations for how to implement any such right in a given society. But health care policies may be judged by international standards including the UN Universal Declaration of Human Rights. The rights enumerated in the UDHR are grounded in traditions of moral theory, a philosophical analysis of which is necessary in order to adjudicate the value of specific policies designed to enshrine (...)
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  30. Knowing (How).Jason Stanley - 2011 - Noûs 45 (2):207-238.
  31. Doing Practical Ethics: A Skills-Based Approach to Moral Reasoning.Jason Swartwood & Ian Stoner - 2021 - New York, NY, USA: Oxford University Press. Edited by Jason Swartwood.
    Doing Practical Ethics supports the deliberate practice of philosophical skills relevant to understanding, evaluating, and developing arguments in forms commonly used in the field of practical ethics. Each chapter includes an explanation of a specific moral reasoning skill, demonstration exercises with sample solutions that offer students immediate feedback on their initial practice attempts, and extensive sets of practice exercises. It is suitable for any ethics course that centrally features argument from principle, argument from analogy, or inference to the best explanation. (...)
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  32.  14
    The nature of human persons: metaphysics and bioethics.Jason T. Eberl - 2020 - Notre Dame, Indiana: University of Notre Dame Press.
    The questions of whether there is a shared nature common to all human beings and, if so, what essential qualities define this nature are among the most widely discussed topics in the history of philosophy and remain the subject of perennial interest and controversy. This book offers a metaphysical investigation of the composition of the human essence-that is, with what is a human being identical or what types of parts are necessary for a human being to exist: an immaterial mind, (...)
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  33.  35
    Equality, Community, and Diversity in Cohen’s Socialist Ideal.Jason Brennan - 2015 - Analyse & Kritik 37 (1-2):113-130.
    The ‘community principle’ is crucial to G. A. Cohen’s argument for socialism, because it is the best independent argument he has adduced for his strongly egalitarian conclusions. Cohen argues that even small differences in wealth ought to be prohibited because they bring us out of community with one another. In this paper, I show that his underlying premises lead to some repugnant conclusions, and thus should be rejected. If Cohen is right that even small differences in wealth can upset community, (...)
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  34. Mechanistic Causation and Constraints: Perspectival Parts and Powers, Non-perspectival Modal Patterns.Jason Winning - 2020 - British Journal for the Philosophy of Science 71 (4):1385-1409.
    Any successful account of the metaphysics of mechanistic causation must satisfy at least five key desiderata. In this article, I lay out these five desiderata and explain why existing accounts of the metaphysics of mechanistic causation fail to satisfy them. I then present an alternative account that does satisfy the five desiderata. According to this alternative account, we must resort to a type of ontological entity that is new to metaphysics, but not to science: constraints. In this article, I explain (...)
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  35.  3
    Religious but not religious: living a symbolic life.Jason E. Smith - 2020 - Asheville, North Carolina: Chiron Publications.
    In Religious but Not Religious, Jungian analyst Jason E. Smith explores the idea, expressed by C. G. Jung, that the religious sense is a natural and vital function of the human psyche. We suffer from its lack.
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  36.  41
    Moderating Racism: The Attempt to Restrain Anti-Japanese Racism in World War II Propaganda Films.Gary James Jason - 2024 - Reason Papers 44 (1):92-106.
    In this essay, I want to explore one of the most ironic episodes in the history of propaganda, the attempt by various federal agencies to moderate American WWII anti-Japanese propaganda films. My texts will be four films, two produced by the military, and two by Hollywood: December 7th (1943), directed by Gregg Toland and revised by John Ford; Air Force (1943), directed Howard Hawks; Know Your Enemy: Japan (1945), directed by Frank Capra; and Betrayal for the East (1945), directed by (...)
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  37.  81
    Epistemic Autonomy and the Shaping of Our Epistemic Lives.Jason Kawall - forthcoming - Social Epistemology.
    I present an account of epistemic autonomy as a distinctively wide-ranging epistemic virtue, one that helps us to understand a range of phenomena that might otherwise seem quite disparate – from the appropriate selection of epistemic methods, stances and topics of inquiry, to the harms of epistemic oppression, gaslighting and related phenomena. The account draws on four elements commonly incorporated into accounts of personal autonomy: (i) self-governance, (ii) authenticity, (iii) self-creation and (iv) independence. I further argue that for a distinctively (...)
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  38.  13
    Process and the Authentic Life: Toward a Psychology of Value.Jason W. Brown - 2005 - De Gruyter.
    The thesis advanced in this book is that feeling and cognition actualize through a process that originates in older brain formations and develops outward through limbic and cortical fields through the self-concept and private space into (as) the world. An iteration of this transition deposits acts, objects, feelings and utterances. Value is a mode of conceptual feeling that depends on the dominant phase in this transition: from desire through interest to object worth. Among the topics covered are subjective time and (...)
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  39.  12
    Metamodernism: The Future of Theory.Jason Ananda Josephson Storm - 2021 - University of Chicago Press.
    For decades, scholars have been calling into question the universality of disciplinary objects and categories. The coherence of defined autonomous categories—such as religion, science, and art—has collapsed under the weight of postmodern critiques, calling into question the possibility of progress and even the value of knowledge. Jason Ānanda Josephson Storm aims to radicalize and move beyond these deconstructive projects to offer a path forward for the humanities and social sciences using a new model for theory he calls metamodernism. Metamodernism (...)
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  40. Zombie Nationalism: The Sexual Politics of White Evangelical Christian Nihilism.Jason A. Springs - 2023 - In Atalia Omer & Joshua Lupo (eds.), Religion, Populism, and Modernity: Confronting White Christian Nationalism and Racism. University of Notre Dame Press. pp. 51-99.
    Despite their purported demographic and institutional decline, White evangelical voters were instrumental in the election of Donald Trump in 2016, and even more so in his 2020 loss. The story of Trump’s electoral successes among Christian voters in the last two elections is in large part the story of religious nationalism—and White Christian nationalism in particular—because Trump personifies the convergence of nationalism-infused forms of messianism and apocalypticism intrinsic to White evangelicalism, which culminate in QAnon cultic ideology. However, these same ethnoreligious/nationalist (...)
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  41.  16
    Educating for Good Thinking: Virtues, Skills, or Both?Jason Baehr - 2023 - Informal Logic 44 (1):173-203.
    This paper explores the relationship between intellectual virtues and critical thinking, both as such and as educational ends worth pursuing. The first half of the paper examines the intersection of intellectual virtue and critical thinking. The second half addresses a recent argument to the effect that educating for intellectual virtues (in contrast to educating for critical thinking) is insufficiently action-guiding and therefore lacks a suitable pedagogy.
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  42. Becoming a Christian in Christendom.Jason A. Mahn - 2010 - In Robert L. Perkins, Marc Alan Jolley & Edmon L. Rowell (eds.), Why Kierkegaard matters: a festschrift in honor of Robert L. Perkins. Macon, Ga.: Mercer University Press.
     
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  43.  20
    Divine and human agency in Second Temple Judaism and Paul: a comparative study.Jason Maston - 2010 - Tübingen: Mohr Siebeck.
    Obedience and the law of life in Sirach -- God's gracious acts of deliverance in the Hodayot -- Sin, the Spirit, and human obedience in Romans 7-8.
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  44.  7
    Zen and the Unspeakable God: Comparative Interpretations of Mystical Experience.Jason N. Blum - 2015 - Pennsylvania State University Press.
    Zen and the Unspeakable God reevaluates how we study mystical experience. Forsaking the prescriptive epistemological box that has constrained the conversation for decades, ensuring that methodology has overshadowed subject matter, Jason Blum proposes a new interpretive approach—one that begins with a mystic’s own beliefs about the nature of mystical experience. Blum brings this approach to bear on the experiential accounts of three mystical exemplars: Meister Eckhart, Ibn al-ʿArabi, and Hui-neng. Through close readings of their texts, he uncovers the mystics’ (...)
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  45.  24
    Surviving Corruptionist Arguments: Response to Nevitt.Jason T. Eberl - 2020 - Quaestiones Disputatae 10 (2):145-160.
    Turner Nevitt’s elucidates and critically engages with what he describes as the “deeper and more problematic disagreements between survivalists and corruptionists about how to understand some of the most basic principles of Aquinas’s metaphysics,” his goal being to “advance some more systematic reasons for thinking that corruptionists are right and survivalists are wrong—both about how to understand the basic principles of Aquinas’s metaphysics, and about how to apply them to the question about the status of human beings or persons between (...)
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  46.  7
    Philosophical Biology in Aristotle's Parts of Animals.Jason A. Tipton - 2014 - Cham: Imprint: Springer.
    This book provides a detailed analysis of Aristotle's Parts of Animals. It takes its bearings from the detailed natural history observations that inform, and in many ways penetrate, the philosophical argument. This analysis raises the question of how easy it is to clearly disentangle what some might describe as the "merely" biological from the philosophical. This book explores the notion and consequences of describing the activity in which Aristotle is engaged as philosophical biology. Do readers of Aristotle have in mind (...)
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  47.  45
    The Evolutionary Foundations of Strong Reciprocity.Jason McKenzie Alexander - 2005 - Analyse & Kritik 27 (1):106-112.
    Strong reciprocators possess two behavioural dispositions: they are willing to bestow benefits on those who have bestowed benefits, and they are willing to punish those who fail to bestow benefits according to some social norm. There is no doubt that peoples' behaviour, in many cases, agrees with what we would expect if people are strong reciprocators, and Fehr and Henrich argue that many people are, in fact, strong reciprocators. They also suggest that strongly reciprocal behaviour may be brought about by (...)
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  48.  15
    Climate Change, Energy Policy and Justice: A Systematic Review.Jason Byrne & Chloe Portanger - 2014 - Analyse & Kritik 36 (2):315-344.
    Energy efficiency and energy security are emerging concerns in climate change policy. But. there is little acknowledgment of energy justice issues. Marginalised and vulnerable communities may be disproportionately exposed to both climate change impacts (e.g. heat, flooding) and costs associated with energy transitions related to climate change mitigation and adaptation (e.g. particulate exposure from biofuel combustion). Climate change is producing energy-related impacts such as increased cooling costs. In some cases it threatens energy security. Higher electricity costs associated with ‘climate proofing’ (...)
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  49.  21
    Citizenship Regimes and Post-Neoliberal Environments in Bolivia.Jason Tockman - 2012 - In Alex Latta & Hannah Wittman (eds.), Environment and citizenship in Latin America: natures, subjects and struggles. New York: Berghahn Books. pp. 101--129.
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  50. Fallibility for infallibilists.Jason Leddington - 2018 - In Johan Gersel, Rasmus Thybo Jensen, Morten S. Thaning & Søren Overgaard (eds.), In the light of experience: new essays on perception and reasons. Oxford, United Kingdom: Oxford University Press.
     
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