Plato's Euthyphro is a dialogue about the virtue of piety. It is also one of the aporetic dialogues, ending in apparent failure to discover what piety is. It is common to understand the dialogue as teaching lessons about other things, about definition, for instance, or about the logic of refutation. About piety, however, it is thought to teach us only negatively, showing a few of the many things which piety is not.My thesis, on the contrary, is that there is a (...) positive account of the nature of piety in the dialogue; it is, moreover, an account which cannot be separated from the other lessons which the dialogue teaches. I shall find it necessary to expose the structure of the logical lessons in order to develop my account of the holy. (shrink)

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

Already known for his penetrating, and sometimes idiosyncratic, interpretations of the later Wittgenstein, John Hunter, of University College, Toronto, now offers eight essays on independent topics. Each of the essays stands on its own, but they are clearly the work of a single mind and together constitute a sustained contribution to current discussion of that area of metaphysics sometimes called philosophy of mind. Although the debts to, and the insight into, Wittgenstein are substantial, I do not wish to document them.

In this paper, I present some ruminations on Hume's argument from miracles and the distorted view of rationality that it reflects (along with religious skepticism generally) contrasting it with what I take to be a better account of rationality, one more sympathetic - at least less hostile - to religious claims.

We propose a causal model theory to explain asymmetries in judgments of the intentionality of a foreseen side-effect that is either negative or positive (Knobe, 2003). The theory is implemented as a Bayesian network relating types of mental states, actions, and consequences that integrates previous hypotheses. It appeals to two inferential routes to judgment about the intentionality of someone else's action: bottom-up from action to desire and top-down from character and disposition. Support for the theory comes from three experiments that (...) test the prediction that bottom-up inference should occur only when the actor's primary objective is known. The model fits intentionality judgments reasonably well with no free parameters. (shrink)

This study introduces a human empowerment framework to better understand why some businesses are more socially oriented than others in their policies and activities. Building on Welzel’s theory of emancipation, we argue that human empowerment—comprised of four components: action resources, emancipative values, social movement activity, and civic entitlements—enables, motivates, and entitles individuals to pursue social goals for their businesses. Using a sample of over 15,000 entrepreneurs from 43 countries, we report strong empirical evidence for two ecological effects of the framework (...) components on prosociality. We find that human empowerment lifts entrepreneurs’ willingness to choose a social orientation for their business, and reinforces the gender effect on prosociality in business activity. We discuss the human empowerment framework’s added value in understanding how modernization processes fully leverage the potential of social business activities for societies. (shrink)

We highlight one way in which Jones & Love (J&L) misconstrue the Bayesian program: Bayesian models do not represent a rejection of mechanism. This mischaracterization obscures the valid criticisms in their article. We conclude that computational-level Bayesian modeling should not be rejected or discouraged a priori, but should be held to the same empirical standards as other models.

This study assessed several ethical issues and judgments facing graduate teaching assistants. Psychology GTAs judged the ethics of a number of teaching-related behaviors and rated how frequently they practiced those behaviors. Judgments of how ethical GTAs believed various behaviors to be, and the frequency with which they engaged in them, varied somewhat based on age, gender, training, and other factors. Moreover, several discrepancies were found between ethical judgments and practice. For example, most GTAs judged it unethical to teach without adequate (...) preparation and to ignore unethical behavior of faculty, but most reported practicing these behaviors at least on occasion. These data highlight the risk for unethical behavior among GTAs and the lack of preparation for dealing with that risk. (shrink)

This paper presents a preliminary analysis of the first participatory budgeting experiment in the United States, in Chicago's 49th Ward. There are two avenues of inquiry: First, does participatory budgeting result in different budgetary priorities than standard practices? Second, do projects meet normative social justice outcomes? It is clear that allowing citizens to determine municipal budget projects results in very different outcomes than standard procedures. Importantly, citizens in the 49th Ward consistently choose projects that the research literature classifies as low (...) priority. The results are mixed, however, when it comes to social justice outcomes. While there is no clear pattern in which projects are located only in affluent sections of the ward, there is evidence of geographic clustering. Select areas are awarded projects like community gardens, dog parks, and playgrounds, while others are limited to street resurfacing, sidewalk repairs, bike racks, and bike lanes. Based on our findings, we offer suggestions for future programmatic changes. (shrink)

Significant progress has been made over the last decade in elucidating the mechanisms employed by receptor protein tyrosine kinases (RTKs) in transducing extracellular signals critical for the regulation of diverse cellular activities. Nevertheless, revealing the biological significance of a subset of the RTKs that contain catalytically inactive protein tyrosine kinase domains has proven more elusive. ErbB3 has served as the prototype for models of catalytically inactive RTK function, performing the role of signal diversification in heterodimeric receptor complexes with other ErbB (...) subfamily members. The receptor related to tyrosine kinases (RYK) is unique amongst the catalytically inactive RTKs. Based on structural or functional properties of the extracellular domain, RYK cannot be classified into an existing RTK subfamily. Recent genetic analyses of mouse Ryk and its Drosophila orthologue derailed have defined a role for this novel subfamily of receptors in the control of craniofacial development and neuronal pathway selection, respectively. Recent biochemical data lead us to propose a model that involves RYK in signal crosstalk and scaffold assembly with Eph receptors. This model is consistent with the established roles of Eph receptors and ephrins in craniofacial and nervous system morphogenesis. BioEssays 23:34–45, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Protein splicing is an extraordinary post‐translational reaction that removes an intact central “spacer” domain (Sp) from precursor proteins (N‐Sp‐C) while splicing together the N‐ and C‐domains of the precursor, via a peptide bond, to produce a new protein (N‐C). All of the available data on protein splicing fit a model in which these intervening sequences excise at the protein level via a self‐splicing mechanism. Several proteins have recently been discovered that undergo protein splicing, and in two such cases, the excised (...) spacer protein is an endonuclease. Such endonucleases are capable of conferring genetic mobility upon the intervening sequences that encodes them. These intervening sequences define a new family of mobile genetic elements that are translated yet remain phenotypically silent by excising at the protein rather than the RNA level. (shrink)

Gender inequity is a persistent problem in the United States. While the high school social studies classroom should be an important space for addressing gender inequity, there is significant underrepresentation of women in the curriculum. Thus, it is crucial that we understand how self-described feminist social studies teachers present women and gender-equity in their classrooms. In this mixed-methods study, the researchers examined the beliefs and practices of six feminist-identifying teachers. The results reveal commonalities across teachers related to classroom discourses, curricular (...) modifications, and professional practice, yet there were compelling differences based on whether or not the teacher subscribed to a critical feminist perspective or a liberal feminist perspective. While all the teachers in the study saw themselves as change agents, teachers who operated from a critical feminist lens focused more on structural gender inequity as a means to eliminate sexism, whereas teachers who operated from a liberal lens focused more on individual acts of sexism and greater inclusion of women—often individual women—in the curriculum. This study contributes to the scarce research on feminism in social studies and provides tools for practitioners who want practices that are more inclusive. (shrink)

This work explores the underlying issues and problems surrounding reflection, describing a selection of initiatives and fulfilling a need for novice reflectors to increase their knowledge. The theoretical underpinnings are presented, along with the realities of using reflection in practice.

In this open peer commentary, we categorize the possible “neuroscience in national security” definitions of misuse of science and identify which, if any, are uniquely presented by advances in neuroscience. To define misuse, we first define what we would consider appropriate use: the application of reasonably safe and effective technology, based on valid and reliable scientific research, to serve a legitimate end. This definition presents distinct opportunities for assessing misuse: misuse is the application of invalid or unreliable science, or is (...) the use of reliable scientific methods to serve illegitimate ends. Ultimately, we conclude that while national security is often a politicized issue, assessing the state of scientific progress should not be. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

To address the complex challenge of global antimicrobial resistance (AMR), a pandemic treaty should include mechanisms that 1) equitably address the access gap for antimicrobials, diagnostic technologies, and alternative therapies; 2) equitably conserve antimicrobials to sustain effectiveness and access across time and space; 3) equitably finance the investment, discovery, development, and distribution of new technologies; and 4) equitably finance and establish greater upstream and midstream infection prevention measures globally. Biodiversity, climate, and nuclear governance offer lessons for addressing these challenges.

From beginning to end, the ethical vision of The Good Place is shaped by creator Mike Schur's reading of T.M. Scanlon's What We Owe to Each Other. The characters on The Good Place become better people not because they have figured out a system for getting along with each other. Rather, the moral journey of the characters on The Good Place changes them into fundamentally different people. Levinasian ethics focuses on the encounter with other people and the response to that (...) encounter. For Emmanuel Levinas, the act of preserving an understanding of the world or self is always done at the expense of other people. Contrary to Scanlon, on The Good Place the responsibility for the other is not met in agreement or in respecting disagreement. It is met in the willingness to cede one's place to the other. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

Baruch Spinoza (1632-1677) was one of the most important philosophers of all time; he was also one of the most radical and controversial. The story of Spinoza's life takes the reader into the heart of Jewish Amsterdam in the seventeenth century and, with Spinoza's exile from Judaism, into the midst of the tumultuous political, social, intellectual, and religious world of the young Dutch Republic. This new edition of Steven Nadler's biography, winner of the Koret Jewish Book Award for biography (...) and translated into a dozen languages, is enhanced by exciting new archival discoveries about his family background, his youth, and the various philosophical, political, and religious contexts of his life and works. There is more detail about his family's business and communal activities, about his relationships with friends and correspondents, and about the development of his writings, which were so scandalous to his contemporaries. (shrink)

This is a study of the effects of a number of background variables on ethical perceptions of Mexican and U.S. marketers. This research investigates how a marketer's personal religiousness, relativism, and the ethical values influence in perceptions of the degree of ethical problems in hypothetical marketing scenarios. It also examines differences between Mexican and U.S. marketers on these variables. The results show significant differences in perception between the countries, and we discuss the implications of these differences for cross-cultural business activities.

From Pulitzer Prize-finalist Steven Nadler, an engaging guide to what Spinoza can teach us about life’s big questions In 1656, after being excommunicated from Amsterdam’s Portuguese-Jewish community for “abominable heresies” and “monstrous deeds,” the young Baruch Spinoza abandoned his family’s import business to dedicate his life to philosophy. He quickly became notorious across Europe for his views on God, the Bible, and miracles, as well as for his uncompromising defense of free thought. Yet the radicalism of Spinoza’s views has (...) long obscured that his primary reason for turning to philosophy was to answer one of humanity’s most urgent questions: How can we lead a good life and enjoy happiness in a world without a providential God? In Think Least of Death, Pulitzer Prize–finalist Steven Nadler connects Spinoza’s ideas with his life and times to offer a compelling account of how the philosopher can provide a guide to living one’s best life. In the Ethics, Spinoza presents his vision of the ideal human being, the “free person” who, motivated by reason, lives a life of joy devoted to what is most important—improving oneself and others. Untroubled by passions such as hate, greed, and envy, free people treat others with benevolence, justice, and charity. Focusing on the rewards of goodness, they enjoy the pleasures of this world, but in moderation. “The free person thinks least of all of death,” Spinoza writes, “and his wisdom is a meditation not on death but on life." An unmatched introduction to Spinoza’s moral philosophy, Think Least of Death shows how his ideas still provide valuable insights about how to live today. (shrink)

Programmatic concepts have elements that point in a valued direction or name a desired goal. We provide a detailed analysis of the nature of programmatic concepts and cite examples of the programmatic elements found in conceptions of scientific literacy. Next we describe what values underlie these elements and what theories of value might be brought to bear in assessing them. We present an analysis of approximately 70 conceptions of scientific literacy found in the literature since the year 2000. We identify (...) the goals that each of these conceptions of scientific literacy implies and uncover the programmatic elements that are used to justify these goals. Our purpose is to present a sufficiently wide range of views to have a good representation of goals and programmatic elements. Third, we point to a number of pitfalls in any attempt to make preferential selections among the programmatic elements of conceptions of scientific literacy. (shrink)

A biographical and philosophical study of Louis de La Forge (1632-1666) and his contributions to the fortunes of Cartesianism in the seventeenth century. La Forge was instrumental in making Descartes' philosophy the dominant philosophical paradigm of the period. He contributed illustrations and a commentary to the 1664 edition of Descartes' Traité de l'homme; and then, in 1666, he published his own account of the human mind and its relation to the body on Cartesian principles, the Traité de l'esprit de l'homme. (...) La Forge's most innovative and influential philosophical contribution consists in his doctrine of occasionalism, which accords God a substantial, if not unique, causal role in the world. (shrink)

New and Emerging Science and Technology (NEST) based innovations, e.g. in the field of Life Sciences or Nanotechnology, frequently raise societal and political concerns. To address these concerns NEST researchers are expected to deploy socially responsible R&D practices. This requires researchers to integrate social and ethical aspects (SEAs) in their daily work. Many methods can facilitate such integration. Still, why and how researchers should and could use SEAs remains largely unclear. In this paper we aim to relate motivations for NEST (...) researchers to include SEAs in their work, and the requirements to establish such integration from their perspectives, to existing approaches that can be used to establish integration of SEAs in the daily work of these NEST researchers. Based on our analyses, we argue that for the successful integration of SEAs in R&D practice, collaborative approaches between researchers and scholars from the social sciences and humanities seem the most successful. The only way to explore whether that is in fact the case, is by embarking on collaborative research endeavours. (shrink)