Introduction.--Aristotle.--The seventeenth century.--The eighteenth century.--Biology.--Nature.--Evolution.--The problem.--The three elements.--The teleological order.--Appendix: Clerk Maxwell on determinism and free will. Fechner on the tendency to stability.

The basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; more.

In Socrates among Strangers, Joseph P. Lawrence reclaims the enigmatic sage from those who have seen him either as a prophet of science, seeking the security of knowledge, or as a wily actor who shed light on the dangerous world of politics while maintaining a prudent distance from it. The Socrates Lawrence seeks is the imprudent one, the man who knew how to die. The institutionalization of philosophy in the modern world has come at the cost of (...) its most vital concern: the achievement of life wisdom. Those who have ceased to grow (those who think they know) close their ears to the wisdom of strangers—and Socrates, who stood face to face with death, is the archetypal stranger. His avowal of ignorance, Lawrence suggests, is more needed than ever in an age defined by technical mastery and expert knowledge. (shrink)

The philosophy of Schelling has for too long been lost in the shadows of Fichte and Hegel. While one might dispute Martin Heidegger’s judgment that Schelling was actually the most creative and far-reaching thinker of German Idealism, it betrays both ignorance and intellectual indolence to simply deny his importance. Schelling was not only a significant co-author of “Hegelian” idealism, he was also its first and perhaps most penetrating critic. He outlived Hegel by over 20 years and, as Manfred Frank demonstrates (...) in one of the following essays, developed the arguments against Hegel that were subsequently taken up by Feuerbach, Marx, and Kierkegaard. (shrink)

This paper explores Schelling's life-long fascination with Spinoza. Through moments of ambivalence and enthusiasm, one aspect of the latter's thought remains central for Schelling: the intellectual intuition of God/Nature. While he consistently emphasizes the non-objectifiable nature of the intuition (as constituting the ground of freedom), the influence of Spinoza is still apparent in what Schelling calls the Ullvordellklichkeit des Seills. Freedom is a response to an ungroundable necessity that consciousness lives out of, but behind which it can never penetrate. This (...) insight provokes a reading of Spinoza that departs from the conventional rationalist interpretation and gestures to an a-theological, yet mystical, understanding, which awakens a feeling not only for the sublime in nature, but for the sublime that lies at "the heart of what is." In the ensuing silence of the self, substance reveals itself as living spirit. Through this interpretation, the Neoplatonic truth of Spinoza becomes visible. (shrink)

The problem of the relationship between art and philosophy is deeply rooted in the philosophical tradition. When Plato excluded artists from the philosophers’ mythical republic, he seemed to be assuming a strict opposition between art and philosophy. Artists do not know what they are saying. Because their creation is grounded in the madness of inspiration, they would be unable to give accounts for their doctrines even if doctrines could be gleaned from their works. Philosophers, on the other hand, must be (...) able to provide such accounts. They commit themselves to providing reasons for their conclusions. (shrink)

Environmental philosophers tend to be particularly wary of the language of “transcendence.” From Heidegger to contemporary feminism, we find the idea that the failure to respect nature is grounded in Platonism and Abrahamic religion. The denial of earth began, we are told, with the separation of the intelligible form from the actual thing, or, even worse, of the creator from the created. From this point of view what we need is a restored pantheistic sense, a new and revitalized paganism. I (...) counter this assertion by a reading of Plato’s Phaedrus that shows that respect itself is grounded in the recognition of transcendence. With the Bookof Job, I maintain that the voice of the transcendent God is what enables Job not only to see past his sufferings but for the first time to encounter the beauty of nature. Overcoming anthropocentrism requires a relationship to transcendence as such. (shrink)

If Lewis prefers the political Plato to the apolitical Socrates, I take my stand with Socrates. I also regard Plato as having been more profoundly invested in establishing a philosophical religion than in establishing a philosophical politics. Cultivating trust in the Good is ultimately of more importance than arming a state against potential enemies. Courage is a virtue greater than prudence. Plato’s Laws, on my reading, is less concerned with maintaining the order of the state than with civilizing its inhabitants. (...) In light of this contention, I understand Plato as being more Socratic—more open to question and thus more flexible—than Lewis’s reading seems to allow. This is why I think Plato provides more attention to his extended preambles to the laws than to the laws themselves. As seriously as Plato took the quest for true law, he realized that any positive code of law has to be subject to constant revision. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

Toshihiko Izutzu’s Ishiki to Honshitsu, recently translated into German under the title of Bewusstsein und Wesen, represents a Zen-inspired clarification of a deep underlying tension that characterizes the figure of Socrates: on the one hand a commitment to a fully public form of discourse and on the other hand a recognition of the elusively private dimension of language . Izutzu lets his philosophical encounter between East and West find its focal point in that tradition of Persian Sufism which culminates in (...) the thought of Mulla Sadra. It is here that Wesen takes on flesh. Remarkably enough, Plato too had his Persian encounter, as can be inferred from the “Myth of the True Earth” that comes at the end of the Phaedo and represents the last recorded words of Socrates. The ancient Persian legend of Hūrqalyā, the Celestial Earth of emerald cities that Henri Corbin recounted a generation ago, is almost certainly Plato’s source. The resurrection world it depicts is a world of Wesen that can be cognitively appropriated only through the kind of direct intuition that is the goal of Zen meditation. (shrink)

When Emmanuel Levinas writes (in the preface of Totality and Infinity) that Franz Rosenzweig’s Stern der Erlösung is “a work too often present in this book to be cited,” he effectively names his debt to F. W. J. Schelling as well, for Rosenzweig’s work was a sustained attempt to carry to completion Schelling’s great philosophical fragment, the Weltalter. Scholars of Levinas have explored Levinas’s relationship to Schelling, but I confess that, as a Schelling scholar, I knew nothing of this connection (...) until rather recently. I credit above all the energetic work of Jason Wirth for helping me see its importance — and more generally the importance of reading Schelling in the context of recent work in continental philosophy. None of this has been easy. The very thing that Schelling and Levinas have in common, their resistance to the implicit solipsism of overcoming mystery with clarity, make them poor candidates for quick appropriation and comparison. Indeed, Schelling anticipated Nietzsche by openly mocking the scholars who make it their business to “appropriate and compare.” Mockery and ridicule is, ofcourse, not Levinas’s way of going about things. Even so, he too is so relentless in his polemic against the totalizing desire to know that he forces his reader to pause and question just what a proper scholarly response to his work might be. As such, the very first result of taking up the question of Schelling and Levinas might be that we are forced to set aside the scholarly mask, testimony of one’s acquiescence to the order of the same, in order to step forth as the human beings that we are. Whether this is an act of humility or of arrogance is not at all clear. Dispensing with the pretense of knowledge takes a kind of boldness on our part — for what but knowledge might give us a claim to the attention of others? (shrink)

The philosophy of Schelling has for too long been lost in the shadows of Fichte and Hegel. While one might dispute Martin Heidegger’s judgment that Schelling was actually the most creative and far-reaching thinker of German Idealism, it betrays both ignorance and intellectual indolence to simply deny his importance. Schelling was not only a significant co-author of “Hegelian” idealism, he was also its first and perhaps most penetrating critic. He outlived Hegel by over 20 years and, as Manfred Frank demonstrates (...) in one of the following essays, developed the arguments against Hegel that were subsequently taken up by Feuerbach, Marx, and Kierkegaard. (shrink)

This paper explores Schelling's life-long fascination with Spinoza. Through moments of ambivalence and enthusiasm, one aspect of the latter's thought remains central for Schelling: the intellectual intuition of God/Nature. While he consistently emphasizes the non-objectifiable nature of the intuition (as constituting the ground of freedom), the influence of Spinoza is still apparent in what Schelling calls the Ullvordellklichkeit des Seills. Freedom is a response to an ungroundable necessity that consciousness lives out of, but behind which it can never penetrate. This (...) insight provokes a reading of Spinoza that departs from the conventional rationalist interpretation and gestures to an a-theological, yet mystical, understanding, which awakens a feeling not only for the sublime in nature, but for the sublime that lies at "the heart of what is." In the ensuing silence of the self, substance reveals itself as living spirit. Through this interpretation, the Neoplatonic truth of Spinoza becomes visible. (shrink)

The metaphysics of presence has led not only to the closure of rationalized systems that define modernity, but also to what can appear as its opposite, the freely flowing movement of information (and of capital) characteristic of the post-modern “de-centered” world. Ideas, after all, require a depth dimension that ultimately proves irreconcilable with the one-dimensionality of the purely present. It is for this reason that the rejection of metaphysics (which is only the final consequence of the metaphysics of presence) fails (...) to solve our dilemma. An alternative strategy is to attempt the recovery of the living heart of metaphysics, its open and ecstatic gaze, rather than its final consequence, the constrictive will to closure, determination, and power. This is the genuinely Socratic possibility, a metaphysics not of presence but of radical transcendence. To clarify that possibility, it is necessary to show how Socrates himself was characterized less by practical and political concerns than by a metaphysical vision directed not to presence but to the unknowable region that opens with death. Socrates’ irony and courage have the same source, what I call a metaphysics of “silence.”. (shrink)

These two volumes represent a preliminary publication of texts that will ultimately find their place in the slowly emerging historical-critical edition of Schelling that is being published by the Bavarian Academy of Sciences and Humanities. Given the significance of the Weltalter-project as Schelling’s projected main work, the publication is clearly an important one. It supplements the three separate versions of the first book of the Weltalter, which have long been available. While these older versions will remain definitive, they do not (...) adequately reflect the sheer dimensions of what is probably the most dramatic shipwrecked project in the history of philosophy: Schelling’s intended systematic response to Hegel’s contemporaneous system of the whole. The materials gathered in these two new volumes approach the 400-plus pages previously available. Even this still pales in comparison to the 1000 or so pages that still remain in the Berlin Nachlass and the roughly 2000 pages that were destroyed during the World War II bombing of the University of Munich library. Eight thick volumes of dense philosophical prose, written and abandoned by a figure heralded by Martin Heidegger as the true genius of German philosophy, is indeed a shipwreck worth understanding more closely. These new materials will help make that possible. (shrink)

This is the second paper in a two-part series describing subject and family perspectives from the CENTURY-S (CENtral Thalamic Deep Brain Stimulation for the Treatment of Traumatic Brain InjURY-Safety) first-in-human invasive neurological device trial to achieve cognitive restoration in moderate to severe traumatic brain injury (msTBI). To participate, subjects were independently assessed to formally establish decision-making capacity to provide voluntary informed consent. Here, we report on post-operative interviews conducted after a successful trial of thalamic stimulation. All five msTBI subjects met (...) a pre-selected primary endpoint of at least a 10% improvement in completion time on Trail-Making-Test Part B, a marker of executive function. We describe narrative responses of subjects and family members, refracted against that success. Interviews following surgery and the stimulation trial revealed the challenge of adaptation to improvements in cognitive function and emotional regulation as well as altered (and restored) relationships and family dynamics. These improvements exposed barriers to social reintegration made relevant by recoveries once thought inconceivable. The study’s success sparked concerns about post-trial access to implanted devices, financing of device maintenance, battery replacement, and on-going care. Most subjects and families identified the need for supportive counseling to adapt to the new trajectory of their lives. (shrink)

This is the first article in a two-part series describing subject and family perspectives from the central thalamic deep brain stimulation for the treatment of traumatic brain injury using the Medtronic PC + S first-in-human invasive neurological device trial to achieve cognitive restoration in moderate to severe traumatic brain injury, with subjects who were deemed capable of providing voluntary informed consent. In this article, we report on interviews conducted prior to surgery wherein we asked participants about their experiences recovering from (...) brain injury and their perspectives on study enrollment and participation. We asked how risks and benefits were weighed, what their expectations and fears were, and how decisions were reached about trial participation. We found that informed consent and enrollment decisions are fraught. Subjects and families were often split, with subjects more focused on putative benefits and families concerned about incremental risk. Both subjects and families viewed brain injury as disruptive to personal identity and relationships. As decisions were made about study enrollment, families struggled with recognizing the re-emergent agency of subjects and ceding decision-making authority to subjects who had previously been dependent upon them for protection and guidance. Subjects and family members reported a hope for the relief of cognitive disabilities, improved quality of life, normalization of interpersonal interactions, and a return to work or school as reasons for study participation, along with altruism and a desire to advance science. Despite these aspirations, both subjects and families appreciated the risks of the intervention and did not suffer from a therapeutic misconception. A second essay to be published in the next issue of Cambridge Quarterly of Healthcare Ethics—Clinical Neuroethics will describe interviews conducted after surgery, the effects of cognitive restoration for subjects, families, and challenges presented to the social structures they will call upon to support them through recovery. This subsequent article will be available online prior to its formal publication in October 2023. (shrink)

In dynamic epistemic logic and other fields, it is natural to consider relativization as an operator taking sentences to sentences. When using the ideas and methods of dynamic logic, one would like to iterate operators. This leads to iterated relativization. We are also concerned with the transitive closure operation, due to its connection to common knowledge. We show that for three fragments of the logic of iterated relativization and transitive closure, the satisfiability problems are fi1 11–complete. Two of these fragments (...) do not include transitive closure. We also show that the question of whether a sentence in these fragments has a finite (tree) model is fi0 01–complete. These results go via reduction to problems concerning domino systems. (shrink)

Pediatric psychopharmacology is a relatively new science. Although the use of psychotropic medications in children has risen in the past decade, there are few standard treatments for serious psychiatric or developmental disorders of childhood. The relative absence of standard treatments is further complicated by the fact that many of the agents used in pediatric psychopharmacology have been adapted from other fields. Therefore, investigators have a responsibility to make incremental progress from concept through pilot studies and large-scale, multisite efficacy and safety (...) trials. Thus, although there is a pressing need to conduct medication trials that can guide clinical practice, there are scientific and ethical considerations to bear in mind when designing clinical trials in pediatric psychopharmacology. This article reviews essential ethical and scientific issues that are relevant to designing clinical trials in children with psychiatric and developmental disorders. Using examples from recently published literature, the article describes the challenges and pitfalls of various clinical trial study designs. The application of sound ethical and scientific principles is necessary to ensure that clinical trials are properly conducted and to guard against ambiguous results that can not guide practice. (shrink)