Neurosteroid 17 beta-estradiol (E2) is a steroid synthesized de novo in the nervous system that might influence neuronal activity and behavior. Nevertheless, the impact of E2 on the functioning of those neural systems in which it is slightly synthesized is less questioned. The vestibulo-ocular reflex (VOR) adaptation, may provide an ideal arena for investigating this issue. Indeed, E2 modulates cerebellar parallel fiber-Purkinje cell synaptic plasticity that underlies encoding of VOR adaptation. Moreover, aromatase expression in the cerebellum of adult rodents is (...) maintained at very low levels and localized to Purkinje cells. The significance of age-related maintenance of low levels of aromatase expression in the cerebellum on behavior, however, has yet to be explored. Our aim in this study was to determine whether E2 synthesis exerts an effective and persistent modulation of VOR adaptation in adult male rats. To answer this question, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in VOR adaptation using an oral dose (2.5 mg/kg) of the aromatase inhibitor Letrozole in peri-pubertal and post-pubertal male rats. We found that Letrozole acutely impaired gain increases and decreases in VOR adaptation without altering basal ocular-motor performance and that these effects were similar in peri-pubertal and post-pubertal rats. Thus, in adult male rats neurosteroid E2 effectively modulates VOR adaptation in both of the periods studied. These findings imply that the adult cerebellum uses E2 synthesis for modulating motor memory formation and suggest that low and extremely localized E2 production may play a role in adaptive phenomena. (shrink)

In the scenario of growing polarization of promises and dangers that surround artificial intelligence (AI), how to introduce responsible AI and robotics in healthcare? In this paper, we develop an ethical–political approach to introduce democratic mechanisms to technological development, what we call “Caring in the In-Between”. Focusing on the multiple possibilities for action that emerge in the realm of uncertainty, we propose an ethical and responsible framework focused on care actions in between fears and hopes. Using the theoretical perspective of (...) Science and Technology Studies and empirical research, “Caring in the In-Between” is based on three movements: the first is a change of focus from the world of promises and dangers to the world of uncertainties; the second is a conceptual shift from assuming a relationship with robotics based on a Human–Robot Interaction to another focused on the network in which the robot is embedded (the “Robot Embedded in a Network”); and the last is an ethical shift from a general normative framework to a discussion on the context of use. Based on these suggestions, “Caring in the In-Between” implies institutional challenges, as well as new practices in healthcare systems. It is articulated around three simultaneous processes, each of them related to practical actions in the “in-between” dimensions considered: monitoring relations and caring processes, through public engagement and institutional changes; including concerns and priorities of stakeholders, with the organization of participatory processes and alternative forms of representation; and making fears and hopes commensurable, through the choice of progressive and reversible actions. (shrink)

In this paper, we explore how the definition of life takes on an essential character in the ethical debates around health technologies, with life thus being manufactured in the tensions and conflicts around the use of such artefacts and devices. We introduce concepts from science and technology studies (STS) to approach bioethics, overcoming the dualistic conception that separates the natural and the technological and questioning the dominant rationality that divides life into dualities. Drawing on two research projects in which we (...) have been involved in recent years, one regarding biobanks and the other regarding social care robots, we explore how the ethical discussions about biobanks and robots imply particular notions of life. We argue that the contemporary epistemic category of life is a manufactured life in which various rationalities coexist: one rationality based on a separation between the technological and the human, focused on pragmatism and functionalities that tend towards a dualized notion of life divided into qualified and non-qualified life, and another rationality based on a non-essentialist ontology, focused on the mediating role of health technologies, that entails a distributed life appearing as a precarious effect of a network. Each of these rationalities allows the emergence of different issues and ethical concerns, thus enriching the bioethical debate. (shrink)

In the scenario of growing polarization of promises and dangers that surround artificial intelligence (AI), how to introduce responsible AI and robotics in healthcare? In this paper, we develop an ethical–political approach to introduce democratic mechanisms to technological development, what we call “Caring in the In-Between”. Focusing on the multiple possibilities for action that emerge in the realm of uncertainty, we propose an ethical and responsible framework focused on care actions in between fears and hopes. Using the theoretical perspective of (...) Science and Technology Studies and empirical research, “Caring in the In-Between” is based on three movements: the first is a change of focus from the world of promises and dangers to the world of uncertainties; the second is a conceptual shift from assuming a relationship with robotics based on a Human–Robot Interaction to another focused on the network in which the robot is embedded (the “Robot Embedded in a Network”); and the last is an ethical shift from a general normative framework to a discussion on the context of use. Based on these suggestions, “Caring in the In-Between” implies institutional challenges, as well as new practices in healthcare systems. It is articulated around three simultaneous processes, each of them related to practical actions in the “in-between” dimensions considered: monitoring relations and caring processes, through public engagement and institutional changes; including concerns and priorities of stakeholders, with the organization of participatory processes and alternative forms of representation; and making fears and hopes commensurable, through the choice of progressive and reversible actions. (shrink)

Your conceptual toolkit for the study of political thoughtPraise for the first edition'This seems really to have been written with the first-year student in mind. The editors write in a way that is clear, intelligent and engaging without being at all condescending.'Politics Studies Review New for this edition* Brand new chapter on international political thought, reflecting one of the most striking developments in contemporary political theoryThis textbook gives you all the vocabulary you need - political, conceptual and historical - to (...) engage confidently and deeply with political thought and the moral and political worlds in which we live.It traces the history of political thought from Plato and Aristotle to Kymlicka and Rorty, following a unique dual structure that introduces key thinkers and core concepts together, making it suitable for any course structure. (shrink)

Both Rawls and Walzer argue for a supreme emergency exemption and are commonly thought to do so for the same reasons. However, far from ‘aping’ Walzer, Rawls engages in a reconstruction of the exemption that changes its focus altogether, making clear its dependence on an account of universal human rights and the idea of a well-ordered society. This paper is therefore, in the first instance, textual, demonstrating that Rawls has been misinterpreted in the case of supreme emergency. In the second (...) instance the approach is reconstructive, providing a reinterpretation of Rawls that fits his treatment of supreme emergency with his broader commitments in just war and international relations. This reinterpretation enables us to draw out a pattern of argument that Rawls appears to share with a much more strident liberal cosmopolitanism. (shrink)

Political Constructivism is concerned with the justification of principles of political justice in the face of pluralism. Contemporary accounts of multiculturalism, pluralism and diversity have challenged the capacity of political theory to impartially justify principles of justice beyond the boundaries of particular communities. In this original account, Peri Roberts argues that political constructivism defends a conception of objective and universal principles that set normative limits to justifiable political practice. _Political Constructivism_ explores this understanding in two ways. Firstly, by engaging (...) with constructivist thinkers such as John Rawls and Onora O’Neill in order to lay out a basic understanding of what constructivism is. Secondly, the author goes on to defend a particular account of political constructivism that justifies a universal primary constructivism alongside the many secondary constructions in which we live our everyday lives. In doing so he outlines an understanding of principled pluralism which accepts diversity whilst at the same time recognising its limits. This volume will be of particular interest to students and researchers of political theory and political philosophy. (shrink)

Explores the actual and possible roles of evil in contemporary political theory.

Introduction -- Constructivism and a theory of justice -- The constructivism of political liberalism -- Primary constructivism and O'Neill -- Reasoning practically: a constructivist understanding of practical reasoning -- Making practice reasonable: political constructivism.

В книге изложены понятия, структуры, функции, основные типы юридического сознания, культуры и антикультуры в обществе. Особое внимание уделено психологическому механизму деятельности, мерам юридической ответственности и правовой защиты людей, их коллективов и организаций. Для юристов (ученых и практиков, аспирантов и адъюнктов), студентов магистратуры и бакалавриата юридических вузов и факультетов. Монография выполнена при финансовой поддержке РФФИ в рамках научного проекта № 18-011-01095.

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Este artículo expone el desarrollo del pensamiento político de Ortega en torno a dos aspectos íntimamente relacionados como son sus consideraciones propiamente sociales y sus planteamientos y reflexiones políticas de liberalismo y socialismo a través de algunas de sus propuestas políticas. Defendemos que para Ortega la economía y la política no son un fin en sí mismo, deben estar siempre al servicio del hombre, a la vez, que deben buscar como objetivo la reforma del hombre.

Late archaic lyric poetry tends to obscure all pathetic and tragic elements of Achilles’ destiny present in the Iliad. The offence against his honour, his grief for Patroclus, his yearning for native Phthia, and a painful awareness of being ὠκύμορος – none of these themes play a role in the passages of Pindar, Bacchylides or Simonides where Achilles is mentioned. Yet each of these three poets operates differently with regard to the epic source, and it is worth investigating how they (...) do so. (shrink)

Psychoanalysis, in its purist mainstream sense, tends to be considered as an isolationist discipline that steers clear of interdisciplinary connections with other psychotherapies. Its drive for purity does not open up to influences that cast as alien and a threat to its core principles. We refer to Hegelian dialectics in an attempt to offer an alternative approach to interdisciplinarity in clinical psychoanalysis. Psychoanalysis entertains a complex dialectical relationship with the major theories it opposes. In this dynamic, psychoanalysis begins by negating (...) the non-psychoanalytic theory as a part of self-negation (Hegel calls this phase self-alienation). But in its own process of growth, it negates this negation and reabsorbs the alienated self part. Reabsorbing the negated component, psychoanalysis does not revert to its original identity but becomes sublated into a different, more complex idea. In this epistemological process, psychoanalysis deals with its own practical and theoretical anomalies and lacunas. The paper illustrates this process using three central developments in the history of psychoanalysis: empathy in self psychology (connection with Rogers' humanist psychology), short-term dynamic psychotherapy (connection with short, intensive therapies), and mentalization-based psychotherapy (connection with cognitive-behavioral therapies). In all of these cases, psychoanalysis integrates components it previously opposed and changes these components to their own, specific characteristics. We address the epistemological shifts in the scientific status of psychoanalysis and show their connection to dialectics. Finally, we conclude that dialectical development is what allows psychoanalysis to remain relevant and up to date, to be open to interdisciplinary influences without its identity and tradition coming under threat. (shrink)

This paper deals with the philosophical questions which gave rise to the traditional realist theories of universals. The main thesis is that these same questions may also be interpreted as scientific-empirical questions. The study of these problems has begun only very recently and the relevance of the results for the traditional problem of intensional entities has only been remarked by few workers aware of the philosophical problem. The approach adopted here is that of regarding man as a perceptual system situated (...) in an environment and showing certain capacities like perception of universals. The possible ways of access to these entities is discussed on the basis of some recent empirical findings related to perception. One conclusion is that in order to answer the basic philosophical question of how properties, particulars and propositions are perceived may be answered within the domains of science, accepting only the usual presuppositions used in it. Basically, such an approach sees the root of the problem in the great complexity of information processing involved in the actual perception of properties, particulars and propositions. (shrink)