I investigate the extent to which perspectival realism agrees with frequentist statistical methodology and philosophy, with an emphasis on J. Neyman’s views. Based on the example of the stopping rule problem, I show how PR can naturally be associated with frequentist statistics in general. I also show that there are some aspects of Neyman’s thought that seem to confirm PR and others that disconfirm it. I argue that epistemic PR is consistent with Neyman’s frequentism to a satisfactory degree and that (...) on the grounds of Neyman’s frequentist methodology one is dealing with genuine and non-trivial perspectives. I also argue that universality and normativity of PR are weakened when analysed from the point of view of Neyman’s statistical methodology. (shrink)

We show that if among the tested hypotheses the number of true hypotheses is not equal to the number of false hypotheses, then Neyman-Pearson theory of testing hypotheses does not warrant minimal epistemic reliability. We also argue that N-P does not protect from the possible negative effects of the pragmatic value-laden unequal setting of error probabilities on N-P’s epistemic reliability. Most importantly, we argue that in the case of a negative impact no methodological adjustment is available to neutralize it, so (...) in such cases the discussed pragmatic-value-ladenness of N-P inevitably compromises the goal of attaining truth. (shrink)

In this work, we explore the epistemic import of the value-ladenness of Neyman-Pearson’s Theory of Testing Hypotheses by reconstructing and extending Daniel Steel’s argument for the legitimate influence of pragmatic values on scientific inference. We focus on how to properly understand N-P’s pragmatic value-ladenness and the epistemic reliability of N-P. We develop an account of the twofold influence of pragmatic values on N-P’s epistemic reliability and replicability. We refer to these two distinguished aspects as “direct” and “indirect”. We discuss the (...) replicability of experiments in terms of the indirect aspect and the replicability of outcomes in terms of the direct aspect. We argue that the influence of pragmatic values is beneficial to N-P’s epistemic reliability and replicability indirectly. We show that while the direct influence of pragmatic values can be beneficial, its negative effects on reliability and replicability are also unavoidable in some cases, with the direct and indirect aspects possibly being incongruent. (shrink)

In this paper I provide a frequentist philosophical-methodological solution for the stopping rule problem presented by Lindley & Phillips in 1976, which is settled in the ecological realm of testing koalas’ sex ratio. I deliver criteria for discerning a stopping rule, an evidence and a model that are epistemically more appropriate for testing the hypothesis of the case studied, by appealing to physical notion of probability and by analyzing the content of possible formulations of evidence, assumptions of models and meaning (...) of the ecological hypothesis. First, I show the difference in the evidence taken into account in different frequentist sampling procedures presented in the problem. Next, I discuss the inapplicability of the Carnapian principle of total evidence in deciding which formulation of evidence associated with a given sampling procedure and statistical model is epistemically more appropriate for testing the hypothesis in question. Then I propose a double-perspective (evidence and model) frequentist solution based on the choice of evidence which better corresponds to the investigated ecological hypothesis, as well as on the choice of a model that embraces less unrealistic ontological assumptions. Finally, I discuss two perspectives of the stopping rule dependence. (shrink)

Bertrand Russell in his essay On Denoting [1905] presented a theory of description developed in response to the one proposed by Gottlob Frege in his paper Über Sinn und Bedeutung [1892]. The aim of our work will be to show that Russell underestimated Frege three times over in presenting the latter’s work: in relation to the Gray’s Elegy argument, to the Ferdinand argument, and to puzzles discussed by Russell. First, we will discuss two claims of Russell’s which do not do (...) justice to Frege: that we speak of a sense by means of quotation marks, and that all Frege does to cope with phrases that might denote nothing is define an arbitrary object as their reference. Second, we will show that Russell omitted the fact that Frege’s theory provided some answers for the puzzles presented by Russell in his essay. (shrink)

In our paper we investigate a difficulty arising when one tries to reconsiliateessentialis t’s thinking with classification practice in the biological sciences. The article outlinessome varieties of essentialism with particular attention to the version defended by Brian Ellis. Weunderline the basic difference: Ellis thinks that essentialism is not a viable position in biology dueto its incompatibility with biological typology and other essentialists think that these two elementscan be reconciled. However, both parties have in common metaphysical starting point and theylack explicit (...) track of methodological procedures. Methodological inquiry involves less demandingassumptions than metaphysical, and therefore it is justified to analyse abovementioned discrepancy between Ellis and other essentialist in this context. We do it by bottom-up investigation whichfocuses on the practice of taxonomists in the particular field of biology. A case study helps us todiscover four characteristics of biological typology practice: impossibility of algorithmization,relativity, subjectivity and conventionality. These features prove non-realistic and therefore anti-essentialistic character of biological classification. We conclude by saying that any essentialismrelated to the notion of biological kind cannot be regarded as justified by scientific enterprise of creating typologies. (shrink)

The aim of this paper was to prove that reduction of social, cultural and spiritual explanation of religion, to the purely biological one, is unattainable, and what is more, that such efforts are redundant and give threat to the quality of science, as well as to the quality of religious beliefs. With regard to elementary methodological scientific criteria, the examples of limitation in biological investigating and explaining of religion was shown. Subsequently, the paper presents a few important logical mistakes (pseudoarguments) (...) as examples of ontological underinterpretation of scientific facts. Finally, the discourse concentrates on the threats (to science and religion) that are associated with biological investigation of religion. (shrink)

The study area was a small lowland river valley within a range of 4750 m length and approx. 150 m width (about 62 ha), situated in the south-east of Poland, in the middle of Sandomierz Basin (Fig. 1). Flora and the chosen most valuable plant communities of the river bed with adjacent ecotone zone were investigated in 2007. During the study 291 species of vascular plants were found. Among them 10 are protected: Batrachium peltatum, Convallaria majalis, Dactylorhiza majalis, Daphne mezereum, (...) Frangula alnus, Hedera helix, Lycopodium annotium, Nuphar lutea, Utricularia vulgaris, and Viburnum opulus. Other species were considered to be value-raising, e.g. Achillea ptarmica, Batrachium circinatum, Calla palustris, Crepis paludosa, Hottonia palustris, Hypochoeris glabra, Senecio ovatus or Valeriana dioica. The number of antropophytes with the amount of 10% is relatively low. Most valuable plant communities represent 3 types of Nature 2000 habitats: natural eutrophic lakes with Magnopotamion or Hydrocharition – code 3150, transition and quaking bogs – code 7140-1, and alluvial forests with Alnus glutinosa and Fraxinus excelsior – code 91E0-3. Human activities brought about the emergence of 3 different areas within the valley: channeled river site (K), natural river bed site (N) and agricultural field site (P). Those areas differ significantly in terms of the composition of flora, vegetation and biological diversity. Most valuable is (P) and the least is (K). The greatest potential source of danger for biodiversity is the wrong forester’s management, especially interference in the natural processes (the planned building of the extra pond) and preventing wooden biomass accumulation. (shrink)

The study area was a small lowland river valley (the Łęg river) located in the south-east of Poland. The object of investigation was the macrophytes of 10 river lakes with corresponding active river channel stretches of the same length as the cut-offs. The aim was to check the difference in species diversity between cut-off and active river channels. The second aim was to test the following hypothesis: vegetation of river lake has been shaped under the influence of contiguous river stretch (...) which has left a measurable mark in species abundance and composition. To test this, we checked whether a cut-off channel’s flora is more similar to flora of the contiguous river stretch, than to flora of a farther river stretch. During the course of the study it was found that the average species richness was approximately two times higher in the cut-off channels than in the river stretches. The number of the species exclusive for the river lakes was nine times higher in comparison with the river’s exclusives (not found in the cut-offs). The Shannon diversity index definitely spoke in favor of the river lakes. These results clearly show the significance of river lakes in maintaining biodiversity of aquatic ecosystems in a small river valley. We did not confirm our hypothesis concerning floristic relation between an active channel and its cut-offs. The floristic similarity between a given cut-off channel and the contiguous active river channel stretch is not stronger than the similarity between this lake and more distant river stretches. The cause of such a state of affairs may be high natural dynamics of investigated habitats and anthropogenic transformation of the river valley. (shrink)

Issues of nature conservation, and socio-cultural movement called ecologism, are vivid becouse of it’s many controvertions and actual validity in terms of sustainable development. This paper presents contemporary motives of preserving the nature, scientific ways of it’s realization, and chosen issues of so called „ecological spirituality”. Reflection on the abilities and perils of science and spirituality, with reference to philosophy and practical conservation activity, will be led. Finally, there will be an attemption to answer the question about relation between nature (...) preservation, science and ecological spirituality, and to define the spiritual condition and trends in contemporary ecologism. (shrink)

Aim of this paper was to fi nd and explicate similarities between science and religion with respect to classical criteria of scientifi cognition. The discourse was led within the following aspects: knowledge, method, language, institution and limits. The derived conclusion is that religion can be interpreted as satisfying all general conditions of scientific enterprise. Such a conclusion is interpreted as supporting two possible thesis: (1) religion as a scientifi c discipline ought to be implemented into scientific enterprise in the way (...) of interdisciplinary cooperation; (2) the presented similarity remains constructed, not discovered – there is no sense in comparing religion to science, since these two notions are too general and vague. Regardless which interpretation one would prefer, it shows, that anti-theistic arguments based on showing religion as opposed to science, does not sounds. (shrink)

This paper is an attempt to meta-subjective revision of contemporary “ecological” issues concerning glorification of science (called by the Author „science-centrism) present in paradigm and practice of nature protection. Assuming that science can be often treated as conditio sine qua non of effective pro-ecological activity, and that such approach isn’t in fact appropriate, the Author led diverse arguments supporting the thesis that the presence of science isn’t necessary in theoretical and applied protection of nature. Within the discourse he tried to (...) defend the possibilities of the wide spectrum of environmental-friendly approaches and appreciate alterscientific paradigms and tools of nature protection. The Author attempted to emphasize that science-based tools of nature protection aren’t of absolute type. He tried to present a relativized scientific approach (possibility against necessity) as an opportunity to create wiser and more rational vision of nature protection, not based on idolatry of science. (shrink)

We analyse the issue of using prior information in frequentist statistical inference. For that purpose, we scrutinise different kinds of sampling designs in Jerzy Neyman’s theory to reveal a variety of ways to explicitly and objectively engage with prior information. Further, we turn to the debate on sampling paradigms (design-based vs. model-based approaches) to argue that Neyman’s theory supports an argument for the intermediate approach in the frequentism vs. Bayesianism debate. We also demonstrate that Neyman’s theory, by allowing non-epistemic values (...) to influence evidence collection and formulation of statistical conclusions, does not compromise the epistemic reliability of the procedures and may improve it. This undermines the value-free ideal of scientific inference. (shrink)

In this perspectives article, we maintain that the current local to global sustainable development predicaments we face are the result of humanity's impact on the Earth System (ES)—that is to say, on the very systemic fabric of the ES (i.e., its functioning and configuration), combined with an insufficiently coherent application of sustainable development policy to address and resolve this systemic problem. In response to what is an urgent crisis, we propose four foundational guiding principles, which we contend provide an overarching (...) framing that, if implemented, would offer an approach to steer global sustainable development policy in a manner that would be to the benefit of the ES and the securing of a flourishing future for all. Our principles are applicable at the levels from a local business ecosystem, national‐regional networks, to global policy. (shrink)

Attempts to understand farmer conservation behavior based on quantitative socio-demographic, attitude, and awareness variables have been largely inconclusive. In order to understand fully how farmers are making conservation decisions, 32 in-depth interviews were conducted in the Eagle Creek watershed in central Indiana. Coding for environmental attitudes and practice adoption revealed several dominant themes, representing multi-dimensional aspects of environmental attitudes. Farmers who were motivated by off-farm environmental benefits and those who identified responsibilities to others (stewardship) were most likely to adopt conservation (...) practices. Those farmers who focused on the farm as business and were most concerned about profitability were less likely to adopt practices. The notion of environmental stewardship in particular was found to be much more complex than the way it is traditionally measured in quantitative studies. The interplay between on-farm and off-farm benefits to practice adoption is an issue that quantitative studies largely do not address. This study seeks to increase understanding of farmers’ environmental attitudes and the connections to conservation behavior. (shrink)

We argue that animalism is the only materialist account of personal identity that can account for the autonomy that we typically think of ourselves as possessing. All the rival materialist theories suffer from a moral version of the problem of too many thinkers when they posit a human person that overlaps a numerically distinct human animal. The different persistence conditions of overlapping thinkers will lead them to have interests that conflict, which in many cases prevents them both from autonomously forming (...) and acting on the same intentions. These problems are exacerbated by problems of self-reference plaguing the overlapping thinkers. We contend that the impossibility of simultaneous autonomous action by animals and persons provides a reason to favor animalism over Neo-Lockeanism, Four-Dimensionalism, Constitution theory, and brain-size views of the person. We anticipate and reject arguments that the autonomy of the person and the animal can be shown to be compatible by relying upon either the Parfitian thesis that identity isn’t what matters or claiming that animals acquire the interests of the person they constitute. (shrink)

Split brains that result in two simultaneous streams of consciousness cut off from each other are wrongly held to be grounds for doubting the existence of the divinely created soul. The mistake is based on two related errors: first, a failure to appreciate the soul's dependence upon neurological functioning; second, a fallacious belief that if the soul is simple, i.e. without parts, then there must be a unity to its thought, all of its thoughts being potentially accessible to reflection or (...) even unreflective causal interactions. But a soul theorist can allow neurological events to keep some conscious thoughts unavailable to others. (shrink)

We argue that the secular cannot offer a materialist response to “The Problem of Too Many Thinkers” that makes autonomy possible. The materialist can accommodate what truths about respecting personal freedom and autonomy only by accepting a counterintuitive sparse ontology. Immaterial accounts of the person look good by comparison. However, those immaterialist theories that don’t posit a divinely created soul suffer from certain metaphysical puzzles avoided by those who do claim divine creation. A soul that requires divine creation strongly suggests (...) that such immaterial beings were made for a purpose. Such purposeful creation makes theistic ethics seem far more plausible. (shrink)

This paper concludes a special feature of Sustainability Science that explores a broad range of social value theoretical traditions, such as religious studies, social psychology, indigenous knowledge, economics, sociology, and philosophy. We introduce a novel transdisciplinary conceptual framework that revolves around concepts of 'lenses' and 'tensions' to help navigate value diversity. First, we consider the notion of lenses: perspectives on value and valuation along diverse dimensions that describe what values focus on, how their sociality is envisioned, and what epistemic and (...) procedural assumptions are made. We characterise fourteen of such dimensions. This provides a foundation for exploration of seven areas of tension, between: (1) the values of individuals vs collectives; (2) values as discrete and held vs embedded and constructed; (3) value as static or changeable; (4) valuation as descriptive vs normative and transformative; (5) social vs relational values; (6) different rationalities and their relation to value integration; (7) degrees of acknowledgment of the role of power in navigating value conflicts. In doing so, we embrace the 'mess' of diversity, yet also provide a framework to organise this mess and support and encourage active transdisciplinary collaboration. We identify key research areas where such collaborations can be harnessed for sustainability transformation. Here it is crucial to understand how certain social value lenses are privileged over others and build capacity in decision-making for understanding and drawing on multiple value, epistemic and procedural lenses. (shrink)

This paper concludes a special feature of Sustainability Science that explores a broad range of social value theoretical traditions, such as religious studies, social psychology, indigenous knowledge, economics, sociology, and philosophy. We introduce a novel transdisciplinary conceptual framework that revolves around concepts of ‘lenses’ and ‘tensions’ to help navigate value diversity. First, we consider the notion of lenses: perspectives on value and valuation along diverse dimensions that describe what values focus on, how their sociality is envisioned, and what epistemic and (...) procedural assumptions are made. We characterise fourteen of such dimensions. This provides a foundation for exploration of seven areas of tension, between: (1) the values of individuals vs collectives; (2) values as discrete and held vs embedded and constructed; (3) value as static or changeable; (4) valuation as descriptive vs normative and transformative; (5) social vs relational values; (6) different rationalities and their relation to value integration; (7) degrees of acknowledgment of the role of power in navigating value conflicts. In doing so, we embrace the ‘mess’ of diversity, yet also provide a framework to organise this mess and support and encourage active transdisciplinary collaboration. We identify key research areas where such collaborations can be harnessed for sustainability transformation. Here it is crucial to understand how certain social value lenses are privileged over others and build capacity in decision-making for understanding and drawing on multiple value, epistemic and procedural lenses. (shrink)

Although written consent forms are standard in clinical research, there is little regulatory or empirical guidance regarding how to most effectively review consent forms with potential participants. We developed an algorithm for embedding five questions with corrective feedback while reading consent forms with potential participants, and then applied it in the context of seven clinical research studies. A substantial proportion of participants within each protocol displayed initially inadequate responses to at least one question, but after the protocol elements were explained (...) again, most people demonstrated adequate understanding of them. These data illustrate the need for more attention not just to the content of consent forms, but also to the manner in which the forms are incorporated into the consent process. Embedding explicit inquiries about key protocol elements during consent form review and giving corrective feedback appears to be a simple yet effective way to foster better understanding of disclosed information. (shrink)

The nature of light is a focus of Thomas Hobbes’s natural philosophical project. Hobbes’s explanation of the light of lucid bodies differs across his works, from dilation and contraction in Elements of Law to simple circular motions in De corpore. However, Hobbes consistently explains perceived light by positing that bodily resistance generates the phantasm of light. In Letters I.XIX–XX of Philosophical Letters, fellow materialist Margaret Cavendish attacks the Hobbesian understanding of both lux and lumen by claiming that Hobbes has illicitly (...) made abstractions from matter. In this paper, I argue that Cavendish’s criticisms rely on an incorrect understanding of the nature of Hobbesian geometry and the role it plays in Hobbes’s natural philosophy. Rather than understanding geometry as wholly abstract, Hobbes attempts to ground geometry in different ways of considering bodies and their motions. Furthermore, Hobbes’s own criticisms of abstraction suggest that he would share many of the worries she raises but deny that he falls prey to them. (shrink)

When a disaster occurs, adults over age 65 may be disproportionately impacted due to sensory deficits, chronic health conditions, diminished social support and isolation, and financial limitations. Although older adults comprised approximately 15 percent of the New Orleans population, they accounted for over 70 percent of the fatalities associated with Hurricane Katrina in 2005. Disasters can also impact older adults’ morbidity, as a disaster may disrupt established habits and routines and result in removal from a familiar environment, promoting disorientation. This (...) may raise particular challenges for older adults with mental and physical co-morbidities, and subsequently for their formal and informal caregivers.While some older adults may need care for physical health problems following a disaster, mental health needs are often overlooked or unmet. One study of Hurricane Katrina survivors found that, compared to older adults, middle-aged individuals were twice as likely to have received mental health services in the eight months after the hurricane. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Disasters may disproportionately impact older adults due to sensory deficits, diminished social support networks, financial limitations, and displacement from familiar environments. During and shortly after a disaster, older adults' mental health needs may be overlooked for varied reasons, including concerns about stigma and lack of information about available services. Law can protect the mental health of older adults in disaster and non-disaster circumstances, but it sometimes may frustrate efforts to address older adults' mental health concerns. This article analyzes three areas (...) — Medicare services, staffing shortages, and continuity of prescription medications — in which the law has the potential to promote the mental health of older adults during disasters. (shrink)

Alan M. Turing’s last published work and some posthumously published manuscripts were dedicated to the development of his theory of organic pattern formation. In “The Chemical Basis of Morphogenesis” (1952), he provided an elaborated mathematical formulation of the theory of the origins of biological form that had been first proposed by Sir D’Arcy Wendworth Thompson in On Growth and Form (1917/1942). While arguably his most mathematically detailed and his systematically most ambitious effort, Turing’s morphogenetical writings also form the most thematically (...) self-contained and least philosophically explored part of his work. We dedicate our inquiry to the reasons and the implications of Turing’s choice of biological topic and viewpoint. We will probe for possible factors in Turing’s choice that go beyond availability and acquaintance with On Growth and Form. On these grounds, we will explore how and to what extent his theory of morphogenesis actually ties in with his concept of mechanistic computation. Notably, Thompson’s pioneering work in biological ‘structuralism’ was organicist in outlook and explicitly critical of the Darwinian approaches that were popular with Turing’s cyberneticist contemporaries—and partly used by Turing himself in his proto-connectionist models of learning. Resolving this apparent dichotomy, we demonstrate how Turing’s quest for mechanistic explanations of how organisation emerges in nature leaves room for a non-mechanist view of nature. (shrink)

Issues of nature conservation, and socio-cultural movement called ecologism, are vivid becouse o f it’s many controvertions and actual validity in terms o f sustainable development. This paper presents contemporary motives o f preserving the nature, scientific ways of it’s realization, and chosen issues o f so called „ecological spirituality”. Reflection on the abilities and perils of science and spirituality, with reference to philosophy and practical conservation activity, will be led. Finally, there will be an attemption to answer the question (...) about relation between nature preservation, science and ecological spirituality, and to define the spiritual condition and trends in contemporary ecologism. (shrink)

Offers comprehensive treatment of Thomas Hobbes’s thought, providing readers with different ways of understanding Hobbes as a systematic philosopher As one of the founders of modern political philosophy, Thomas Hobbes is best known for his ideas regarding the nature of legitimate government and the necessity of society submitting to the absolute authority of sovereign power. Yet Hobbes produced a wide range of writings, from translations of texts by Homer and Thucydides, to interpretations of Biblical books, to works devoted to geometry, (...) optics, morality, and religion. Hobbes viewed himself as presenting a unified method for theoretical and practical science—an interconnected system of philosophy that provides many entry points into his thought. A Companion to Hobbes is an expertly curated collection of essays offering close textual engagement with the thought of Thomas Hobbes in his major works while probing his ideas regarding natural philosophy, mathematics, human nature, civil philosophy, religion, and more. The Companion discusses the ways in which scholars have tried to understand the unity and diversity of Hobbes’s philosophical system and examines the reception of the different parts of Hobbes’s philosophy by thinkers such as René Descartes, Margaret Cavendish, David Hume, and Immanuel Kant. Presenting a diversity of fresh perspectives by both emerging and established scholars, this volume: Provides a comprehensive treatment of Hobbes’s thought in his works, including Elements of Law, Elements of Philosophy, and Leviathan Explores the connecting points between Hobbes’ metaphysics, epistemology, mathematics, natural philosophy, morality, and civil philosophy Offers readers strategies for understanding how the parts of Hobbes’s philosophical system fit together Examines Hobbes’s philosophy of mathematics and his attempts to understand geometrical objects and definitions Considers Hobbes’s philosophy in contexts such as the natural state of humans, gender relations, and materialist worldviews Challenges conceptions of Hobbes’s moral theory and his views about the rights of sovereigns Part of the acclaimed Blackwell Companions to Philosophy series, A Companion to Hobbes is an invaluable resource for scholars and advanced students of Early modern thought, particularly those from disciplines such as History of Philosophy, Political Philosophy, Intellectual History, History of Politics, Political Theory, and English. (shrink)

This chapter discusses Thomas Hobbes's statements about the structure of philosophy and suggests that a focus on these reflections has led some scholars to understand Hobbes as an armchair speculative philosopher, both in his own natural‐philosophy endeavors and his well‐known criticisms of Robert Boyle and other experimental philosophers. Beyond Hobbes's statements about natural philosophy, it argues that a more complete understanding of his natural philosophy must also consider his practice of explaining in natural philosophy and optics. Hobbes divides all human (...) knowledge into two parts: scientia, and cognition. These two parts provide different levels of certainty to knowers. The chapter shows that explanations in optics and natural philosophy are ideally a mixture of appeals to everyday sense experience and Hobbes's own a priori geometry by providing two case studies: a case study from Hobbes's optics in De homine II and a case study of Hobbes's explanation of sense in De corpora XXV. (shrink)

Kv10.1 is a voltage‐gated potassium channel relevant for tumor biology, but the underlying mechanism is still unclear. We propose that Kv10.1 plays a role coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base. Most non‐dividing cells display a primary cilium, an antenna‐like structure important for cell physiology. The cilium is disassembled when the cell divides, which requires an increase of Ca2+ concentration and a redistribution of phospholipids in its basal region, both (...) of which would be facilitated by local hyperpolarization. Cells lacking Kv10.1 show impaired ciliary disassembly and delayed entrance into mitosis. Kv10.1 is predominantly expressed during G2/M, a critical period for ciliary resorption, and localizes to the ciliary base and vesicles associated with the centrosome. This could explain the influence of Kv10.1 in cell proliferation, as well as phenotypic features of patients carrying gain of function mutations in the gene. (shrink)

Pompey has been treacherously killed, his body decapitated and thrown into the surf. The faithful Cornelia cannot give her husband a proper funeral, but must be content to place on the pyre all that is left of his greatness. Commentators are not of much help in this place, most caught up in tralatician glossing and hence content to echo the scholiastic reference to Pompey's three triumphs. Thomas Farnaby thought of the funeral of Misenus in Aeneid 6; but one looks in (...) vain to Grotius , Oudendorp , Burman , Bentley , Weber , Francken , Heitland-Haskins , Housman , Bourgery-Ponchont , and Luck for the most important parallel, which is to Dido in Aeneid. I adduce the passages Heinze well described as examples of ‘das Idealbild eines heroischen Weibes’: tu secreta pyram tecto interiore sub auras erige, et arma uiri thalamo quae fixa reliquit impius exuuiasque omnis lectumque iugalem, quo perii, super imponas: 494–7) super exuuias ensemque relictum effigiemque toro locat haud ignata futuri. hie, postquam Iliacas uestis notumque cubile conspexit, paulum lacrimis et mente morata incubuitque toro dixitque nouissima uerba: ‘dulces exuuiae…’. (shrink)

Exclusionary defeat is Joseph Raz’s proposal for understanding the more complex, layered structure of practical reasoning. Exclusionary reasons are widely appealed to in legal theory and consistently arise in many other areas of philosophy. They have also been subject to a variety of challenges. I propose a new account of exclusionary reasons based on their justificatory role, rejecting Raz’s motivational account and especially contrasting exclusion with undercutting defeat. I explain the appeal and coherence of exclusionary reasons by appeal to commonsense (...) value pluralism and the intermediate space of public policies, social roles, and organizations. We often want our choices to have a certain character or instantiate a certain value and in order to do so, that choice can only be based on a restricted set of reasons. Exclusion explains how pro tanto practical reasons can be disqualified from counting towards a choice of a particular kind without being outweighed or undercut. (shrink)

Standard accounts of civil disobedience include nonviolence as a necessary condition. Here I argue that such accounts are mistaken and that civil disobedience can include violence in many aspects, primarily excepting violence directed at other persons. I base this argument on a novel understanding of civil disobedience: the special character of the practice comes from its combination of condemnation of a political practice with an expressed commitment to the political. The commitment to the political is a commitment to engaging with (...) others as co-members in the on-going political project of living together. I show how such an understanding of civil disobedience is superior to the Rawlsian strain of thought, which focuses on fidelity to law. Rawls was concerned with civil disobedience solely in the context of overriding political obligation. The project of characterizing a contestatory political practice that can be distinguished and used in a wider variety of contexts than Rawls is concerned with, including under illegitimate regimes, beyond the nation-state, or on behalf of anarchism, requires a different understanding of civil disobedience. (shrink)

a collection of articles by philosophers of mathematics on themes associated with the work of Paul Benacceraf.

Political legitimacy is best understood as one type of a broader notion, which I call institutional legitimacy. An institution is legitimate in my sense when it has the right to function. The right to function correlates to a duty of non-interference. Understanding legitimacy in this way favorably contrasts with legitimacy understood in the traditional way, as the right to rule correlating to a duty of obedience. It helps unify our discourses of legitimacy across a wider range of practices, especially including (...) the many evaluations we increasingly make of international institutions of various sorts, but also including domestic institutions. (shrink)