Autoinhibition is a design principle realized in many molecular mechanisms in biology. After explicating the notion of a design principle and showing that autoinhibition is such a principle, we focus on how researchers discovered instances of autoinhibition, using research establishing the autoinhibition of the molecular motors kinesin and dynein as our case study. Research on kinesin and dynein began in the fashion described in accounts of mechanistic explanation but, once the mechanisms had been discovered, researchers discovered that they exhibited a (...) second phenomenon, autoinhibition. The discovery of autoinhibition not only reverses the pattern in terms of which philosophers have understood mechanism discovery but runs counter to the one phenomenon-one mechanism principle assumed to relate mechanisms and the phenomena they explain. The ubiquity of autoinhibition as a design principle, therefore, necessitates a philosophical understanding of mechanisms that recognizes how they can participate in more than one phenomenon. Since mechanisms with this design are released from autoinhibition only when they are acted on by control mechanisms, we advance a revised account of mechanisms that accommodates attribution of multiple phenomena to the same mechanism and distinguishes them from other processes that control them. (shrink)

Solving the “new demarcation problem” requires a distinction between epistemically legitimate and illegitimate roles for non-epistemic values in science. This paper addresses one ‘half’ (i.e. a sub-problem) of the new demarcation problem articulated by the Gretchenfrage: What makes the role of a non-epistemic value in science epistemically illegitimate? I will argue for the Explaining Epistemic Errors (EEE) account, according to which the epistemically illegitimate role of a non-epistemic value is defined via an explanatory claim: the fact that an epistemic agent (...) is motivated by a non-epistemic value explains why the epistemic agent commits a particular epistemic error. The EEE account is inspired by Douglas’ and Steel’s “functionalist” or “epistemic constraint” accounts of epistemic illegitimacy. I will suggest that the EEE account is able to meet two challenges that these two accounts face, while preserving the key intuition underlying both accounts. If my arguments succeed, then the EEE account provides a solution to one half of the new demarcation problem (by providing a definition of what makes the role of a non-epistemic value epistemically illegitimate) and it opens up new ways for addressing the other half (i.e. characterizing an epistemically legitimate role of non-epistemic values). (shrink)

Philosophers of biology and biologists themselves for the most part assume that the concept of kin is progenerative: what makes two individuals kin is a direct or indirect function of reproduction. Derivatively, kinship might likewise be presumed to be progenerative in nature. Yet a prominent view of kinship in contemporary cultural anthropology is a kind of constructivism or performativism that rejects such progenerativist views. This paper critically examines an influential line of thinking used to critique progenerativism and support performativism that (...) cites cross-cultural diversity in what I will call kinmaking. I challenge several key assumptions made in moving from this appeal to ethnography to conclusions about kinship and progeneration, arguing that closer scrutiny of both the ethnographic record and inferences that draw on it in fact support progenerative views of both kinship and kinmaking. (shrink)